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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 3
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Research Article

Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine − synthesis, cytostatic, antiviral and antioxidative studies

Ivana PerkovićFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
,
Sara TršinarFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
,
Jelena ŽanetićFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
,
Marijeta KraljDivision of Molecular Medicine, Rudjer Bošković Institute, Zagreb, Croatia
,
Irena Martin-KleinerDivision of Molecular Medicine, Rudjer Bošković Institute, Zagreb, Croatia
,
Jan BalzariniRega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
,
Dimitra Hadjipavlou-LitinaDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Anna Maria KatsoriDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
&
Branka ZorcFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, CroatiaCorrespondence[email protected]
 show all
Pages 601-610 | Received 26 Dec 2011, Accepted 27 Jan 2012, Published online: 01 Mar 2012

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Josipa Vlainić, Ivan Kosalec, Kristina Pavić, Dimitra Hadjipavlou-Litina, Eleni Pontiki & Branka Zorc. (2018) Insights into biological activity of ureidoamides with primaquine and amino acid moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 376-382.
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Articles from other publishers (20)

Ivana Perković, Maja Beus, Dominique Schols, Leentje Persoons & Branka Zorc. (2020) Itaconic acid hybrids as potential anticancer agents. Molecular Diversity 26:1, pages 1-14.
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Boris А. Gostevskii, Aleksander I. Albanov, Aleksander V. Vashchenko & Nataliya F. Lazareva. (2020) Formation of 1,2,4-triazole derivatives by oxidation of 4-phenyl-1-pivaloylsemicarbazide. Chemistry of Heterocyclic Compounds 56:8, pages 1015-1020.
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Süreyya Ölgen. 2020. Drug Repurposing in Cancer Therapy. Drug Repurposing in Cancer Therapy 395 437 .
Branka Zorc, Zrinka Rajić & Ivana Perković. (2019) Antiproliferative evaluation of various aminoquinoline derivatives. Acta Pharmaceutica 69:4, pages 661-672.
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Branka Zorc, Ivana Perković, Kristina Pavić, Zrinka Rajić & Maja Beus. (2019) Primaquine derivatives: Modifications of the terminal amino group. European Journal of Medicinal Chemistry 182, pages 111640.
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Sureyya Olgen & Lakshmi P. Kotra. (2019) Drug Repurposing in the Development of Anticancer Agents. Current Medicinal Chemistry 26:28, pages 5410-5427.
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Kristina Pavić, Zrinka Rajić, Hana Michnová, Josef Jampílek, Ivana Perković & Branka Zorc. (2018) Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents. Molecular Diversity 23:3, pages 657-667.
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Maja Beus, Diana Fontinha, Jana Held, Zrinka Rajić, Miguel Prudêncio & Branka Zorc. (2019) Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides. Acta Pharmaceutica 69:2, pages 233-248.
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Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen & Branka Zorc. (2018) SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents. ChemistryOpen 7:8, pages 624-638.
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Jurica Levatić, Kristina Pavić, Ivana Perković, Lidija Uzelac, Katja Ester, Marijeta Kralj, Marcel Kaiser, Matthias Rottmann, Fran Supek & Branka Zorc. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European Journal of Medicinal Chemistry 146, pages 651-667.
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Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac & Branka Zorc. (2018) Primaquine hybrids as promising antimycobacterial and antimalarial agents. European Journal of Medicinal Chemistry 143, pages 769-779.
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Anna Pachuta-Stec, Anna Biernasiuk, Anna Malm & Monika Pitucha. (2017) Synthesis and Antimicrobial Evaluation of Novel Derivatives of Semicarbazide and 1,2,4-triazole. Journal of Heterocyclic Chemistry 54:5, pages 2867-2873.
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Kristina Pavić, Ivana Perković, Petra Gilja, Filip Kozlina, Katja Ester, Marijeta Kralj, Dominique Schols, Dimitra Hadjipavlou-Litina, Eleni Pontiki & Branka Zorc. (2016) Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type. Molecules 21:12, pages 1629.
Crossref
I. Perković, M. Antunović, I. Marijanović, K. Pavić, K. Ester, M. Kralj, J. Vlainić, I. Kosalec, D. Schols, D. Hadjipavlou-Litina, E. Pontiki & B. Zorc. (2016) Novel urea and bis -urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation. European Journal of Medicinal Chemistry 124, pages 622-636.
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Ewa Kedzierska, Jolanta Orzelska, Ivana Perković, Danijel Knežević, Sylwia Fidecka, Marcel Kaiser & Branka Zorc. (2016) Pharmacological effects of primaquine ureas and semicarbazides on the central nervous system in mice and antimalarial activity in vitro. Fundamental & Clinical Pharmacology 30:1, pages 58-69.
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Rachel A. Jones, Siva S. Panda & C. Dennis Hall. (2015) Quinine conjugates and quinine analogues as potential antimalarial agents. European Journal of Medicinal Chemistry 97, pages 335-355.
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Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Yurii V. Dmytriv, Sergey E. Pipko, Liudmyla N. Babichenko, Anzhelika I. Konovets & Andrey Tolmachev. (2015) Facile one-pot synthesis of 4-substituted semicarbazides. RSC Advances 5:2, pages 1063-1069.
Crossref
Cátia Teixeira, Nuno Vale, Bianca Pérez, Ana Gomes, José R. B. Gomes & Paula Gomes. (2014) “Recycling” Classical Drugs for Malaria. Chemical Reviews 114:22, pages 11164-11220.
Crossref
K. Pavić, I. Perković, M. Cindrić, M. Pranjić, I. Martin-Kleiner, M. Kralj, D. Schols, D. Hadjipavlou-Litina, A.-M. Katsori & B. Zorc. (2014) Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: Synthesis, cytostatic and antioxidative activity. European Journal of Medicinal Chemistry 86, pages 502-514.
Crossref
Rebecca Hron & Branko S. Jursic. (2014) Preparation of substituted semicarbazides from corresponding amines and hydrazines via phenyl carbamates. Tetrahedron Letters 55:9, pages 1540-1543.
Crossref

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