Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 4
Submit an article Journal homepage
1,632
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor

Diego Magno AssisDepartment of Biophysics, Federal University of São Paulo, São Paulo, SP, BrazilCorrespondence[email protected] [email protected]
,
Vanessa Silva GontijoInstitute of Exact Science, Federal University of Alfenas, Alfenas, MG, Brazil
,
Ivan de Oliveira PereiraInstitute of Exact Science, Federal University of Alfenas, Alfenas, MG, Brazil
,
Jorge Alexandre Nogueira SantosDepartment of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil
,
Ihosvany CampsInstitute of Exact Science, Federal University of Alfenas, Alfenas, MG, Brazil
,
Tanus Jorge NagemICEB-LAPRONA, Federal University of Ouro Preto, Ouro Preto, MG, Brazil
,
Javier EllenaDepartment of Physics and Informatics, Institute of Physics, University of São Paulo, São Carlos, SP, Brazil
,
Mario Augusto IzidoroDepartment of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil
,
Ivarne Luis dos Santos TersariolDepartment of Biochemistry, Federal University of São Paulo, São Paulo, SP, Brazil
,
Nilana Meza Tenório de BarrosDepartment of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil
,
Antonio Carlos DoriguettoInstitute of Exact Science, Federal University of Alfenas, Alfenas, MG, Brazil
,
Marcelo Henrique dos SantosInstitute of Exact Science, Federal University of Alfenas, Alfenas, MG, Brazil
&
Maria Aparecida JulianoDepartment of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil
 show all
Pages 661-670 | Received 24 Nov 2011, Accepted 13 Feb 2012, Published online: 02 Apr 2012

Citations (22)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Daniel Gedder Silva, Josmar Rodrigues Rocha, Geraldo Rodrigues Sartori & Carlos Alberto Montanari. (2017) Highly predictive hologram QSAR models of nitrile-containing cruzain inhibitors. Journal of Biomolecular Structure and Dynamics 35:15, pages 3232-3249.
Read now

Articles from other publishers (21)

Artur Barros, Leonardo de Araújo, Nelson Silveira & Breno Santos. (2023) An <i>in silico</i> study involving Mangiferin, 7-Epiclusianone, Fukugetin, Lapachol, Plumbagin and Guttiferone-A against <i>C. albicans</i> proteins. Natural Resources for Human Health 3:2, pages 228-236.
Crossref
André Gonzaga dos Santos, Kátia Sivieri, Bárbara Paes Miglioli da Mata, Isabela Jacob Moro, Mateus Kawata Salgaço & Luis Vitor Silva do Sacramento. 2022. Handbook of Phytonutrients in Indigenous Fruits and Vegetables. Handbook of Phytonutrients in Indigenous Fruits and Vegetables 298 310 .
Viviane Corrêa Santos, Augusto César Broilo Campos, Birgit J. Waldner, Klaus R. Liedl & Rafaela Salgado Ferreira. (2022) Impact of different protonation states on virtual screening performance against cruzain. Chemical Biology & Drug Design 99:5, pages 703-716.
Crossref
Leandro da Costa Clementino, Guilherme Felipe Santos Fernandes, Igor Muccilo Prokopczyk, Wilquer Castro Laurindo, Danyelle Toyama, Bruno Pereira Motta, Amanda Martins Baviera, Flávio Henrique-Silva, Jean Leandro dos Santos & Marcia A. S. Graminha. (2021) Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity. PLOS ONE 16:11, pages e0259008.
Crossref
Raymond Muganga, Joanne Bero, Joëlle Quetin-Leclercq, Luc Angenot, Monique Tits, Ange Mouithys-Mickalad, Thierry Franck & Michel Frédérich. (2020) In vitro Antileishmanial, Antitrypanosomal, and Anti-inflammatory-like Activity of Terminalia mollis Root Bark. Planta Medica 87:09, pages 724-731.
Crossref
Ming Xu, Hong Liang, Sha-Sha Meng & Zhi-Yuan Gu. (2021) Enhancing the enzymatic inhibition performance of Cu-based metal–organic frameworks by shortening the organic ligands. The Analyst 146:13, pages 4235-4241.
Crossref
Anely Maciel de Melo, Francisco Lucas Chaves Almeida, Atacy Maciel de Melo Cavalcante, Mônica Ikeda, Rafaela Cristina Turola Barbi, Bruno Patrício Costa & Rosemary Hoffmann Ribani. (2021) Garcinia brasiliensis fruits and its by-products: Antioxidant activity, health effects and future food industry trends – A bibliometric review. Trends in Food Science & Technology 112, pages 325-335.
Crossref
Yustina Hartini, Bakti Saputra, Bryan Wahono, Zerlinda Auw, Friska Indayani, Lintang Adelya, Gabriel Namba & Maywan Hariono. (2021) Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus. Results in Chemistry 3, pages 100087.
Crossref
Ming Xu, Sha-Sha Meng, Hong Liang & Zhi-Yuan Gu. (2020) A metal–organic framework with tunable exposed facets as a high-affinity artificial receptor for enzyme inhibition. Inorganic Chemistry Frontiers 7:19, pages 3687-3694.
Crossref
Tian-Ran Chen, Ling-Hua Wei, Xiao-Qing Guan, Chao Huang, Zhe-Yi Liu, Fang-Jun Wang, Jie Hou, Qiang Jin, Yi-Fan Liu, Pei-Hao Wen, Shui-Jun Zhang, Guang-Bo Ge & Wen-Zhi Guo. (2019) Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorganic Chemistry 92, pages 103199.
Crossref
Pone Kamdem Boniface & Elizabeth Igne Ferreira. (2019) Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue. Phytotherapy Research 33:10, pages 2473-2517.
Crossref
Patrícia de Almeida Machado, Monique Pacheco Duarte Carneiro, Ariane de Jesus Sousa-Batista, Francisco Jose Pereira Lopes, Ana Paula Cabral de Araujo Lima, Suzana Passos Chaves, Ana Carolina Rennó Sodero & Herbert Leonel de Matos Guedes. (2019) Leishmanicidal therapy targeted to parasite proteases. Life Sciences 219, pages 163-181.
Crossref
Maria Gessi Teixeira, Marília Carvalho, Marco Aurélio Leite, Sandro Barbosa, Plinio Rodrigues dos Santos filho & Breno Régis Santos. (2019) Effect of Salicylic Acid, 2,4-D and 2i-P on the Production of Secondary Metabolites in Garcinia brasiliensis Mart. Callus. Brazilian Archives of Biology and Technology 62.
Crossref
Xingyue Wei & Lin Zhuo. (2017) Development of a Novel Electrochemical Monitoring Method of Enzymic Hydrolysis. International Journal of Electrochemical Science 12:4, pages 2669-2678.
Crossref
Nanthaphong Khamthong & Nongporn Hutadilok-Towatana. (2017) Phytoconstituents and Biological Activities of Garcinia Dulcis (Clusiaceae): A Review . Natural Product Communications 12:3, pages 1934578X1701200.
Crossref
Jorge A.N. Santos, Márcia Y. Kondo, Renato F. Freitas, Marcelo H. dos Santos, Teodorico C. Ramalho, Diego M. Assis, Luiz Juliano, Maria A. Juliano & Luciano Puzer. (2016) The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1485-1489.
Crossref
Phanuel Saroni Arwa, Maria Luiza Zeraik, Valdecir Farias Ximenes, Luiz Marcos da Fonseca, Vanderlan da Silva Bolzani & Dulce Helena Siqueira Silva. (2015) Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage. Journal of Ethnopharmacology 174, pages 410-418.
Crossref
Letícia de Almeida, Karina Ferreira Alves, Claudia Mara Maciel-Rezende, Larissa de Oliveira Passos Jesus, Francieli Ribeiro Pires, Claudio Viegas Junior, Mario Augusto Izidoro, Wagner Alves de Souza Júdice, Marcelo Henrique dos Santos & Marcos José Marques. (2015) Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes. Biomedicine & Pharmacotherapy 75, pages 93-99.
Crossref
Silva Gontijo Vanessa, Pereira Januario Jaqueline, Alves de Souza Judice Wagner, Alexandrino Antunes Alyne, Ribeiro Cabral Ingridy, Magno Assis Diego, Aparecida Juliano Maria, Camps Ihosvany, Jose Marques Marcos, Viegas Junior Claudio & Henrique dos Santos Marcelo. (2015) Morelloflavone and its semisynthetic derivatives as potential novel inhibitors of cysteine and serine proteases. Journal of Medicinal Plants Research 9:13, pages 426-434.
Crossref
Rosan Barbosa de Matos, Suzana Braga-de-Souza, Bruno Pena Seara Pitanga, Victor Diógenes Amaral da Silva, Erica Etelvina Viana de Jesus, Alexandre Morales Pinheiro, Maria de Fátima Dias Costa, Ramon dos Santos El-Bacha, Cátia Suse de Oliveira Ribeiro & Silvia Lima Costa. (2014) Flavonoids Modulate the Proliferation of Neospora caninum in Glial Cell Primary Cultures. The Korean Journal of Parasitology 52:6, pages 613-619.
Crossref
Valerie Vranova, Klement Rejsek & Pavel Formanek. (2013) Proteolytic activity in soil: A review. Applied Soil Ecology 70, pages 23-32.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.