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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 6
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Research Article

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

Liang-Peng SunKey Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, China
,
Wei-Ping MaNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, China
,
Li-Xin GaoNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, China
,
Ling-Ling YangNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, China
,
Ying-Chun QuanKey Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, China
,
Jia LiNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai, ChinaCorrespondence[email protected] [email protected]
&
Hu-Ri PiaoKey Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, ChinaCorrespondence[email protected] [email protected]
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Pages 1199-1204 | Received 24 Apr 2012, Accepted 17 Aug 2012, Published online: 26 Sep 2012

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Carina Proença, Daniela Ribeiro, Marisa Freitas, Félix Carvalho & Eduarda Fernandes. (2022) A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis. Critical Reviews in Food Science and Nutrition 62:15, pages 4095-4151.
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Articles from other publishers (10)

Mineyuki Mizuguchi, Yusuke Nakagawa, Kishin Inui, Wakana Katayama, Yurika Sawai, Ayaka Shimane, Ryota Kitakami, Takuya Okada, Yuko Nabeshima, Takeshi Yokoyama, Kayoko Kanamitsu, Shinsaku Nakagawa & Naoki Toyooka. (2022) Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. Journal of Medicinal Chemistry 65:24, pages 16218-16233.
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Shaochun Shi, Xin Zheng, Ryosuke Suzuki, Ziyue Li, Tomoyuki Shiota, Jiayin Wang, Asuka Hirai-Yuki, Qingbo Liu, Masamichi Muramatsu & Shao-Jiang Song. (2022) Novel flavonoid hybrids as potent antiviral agents against hepatitis A: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 238, pages 114452.
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Sukhbir Singh, Ajmer Singh Grewal, Rupanshi Grover, Neelam Sharma, Bhawna Chopra, Ashwani Kumar Dhingra, Sandeep Arora, Sonika Redhu & Viney Lather. (2022) Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders. Bioorganic Chemistry 121, pages 105626.
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Shaochun Shi, Jichong Li, Xuemei Zhao, Qingbo Liu & Shao-Jiang Song. (2021) A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids. Phytochemistry 191, pages 112895.
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Qing-Hao Jin, Wen-Bo Chen, Ya-Nan Xia, Bing-Yu Liu & Li-Ping Guan. (2020) Biological evaluation of 2,3-dioxoindolin-N-phenylacetamide derivatives as potent CDC25B and PTP1B phosphatase inhibitors. Brazilian Journal of Pharmaceutical Sciences 56.
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G. Lori, L. Cecchi, N. Mulinacci, F. Melani, A. Caselli, P. Cirri, L. Pazzagli, S. Luti, L. Mazzoli & P. Paoli. (2019) Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells. Biomedicine & Pharmacotherapy 113, pages 108752.
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Şafak Özhan Kocakaya, Mehmet Karakaplan & Rosario Scopelliti. (2017) Synthesis and crystal structure of a chiral lactam and three amino alcohols as potential protein tyrosine phosphates 1B inhibitors. Tetrahedron: Asymmetry 28:10, pages 1342-1349.
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Xing Zhang, Omar Khalidi, So Young Kim, Ruitong Wang, Victor Schultz, Brady F. Cress, Richard A. Gross, Mattheos A.G. Koffas & Robert J. Linhardt. (2016) Synthesis and biological evaluation of 5,7-dihydroxyflavanone derivatives as antimicrobial agents. Bioorganic & Medicinal Chemistry Letters 26:13, pages 3089-3092.
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Shui-Lian Zhao, Zhou Peng, Xing-Hua Zhen, Hong-Guo Jin, Yan Han, You-Le Qu & Li-Ping Guan. (2014) Potent CDC25B and PTP1B phosphatase inhibitors: 2′,4′,6′-trihydroxylchalcone derivatives. Medicinal Chemistry Research 24:6, pages 2573-2579.
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Jian Chen, Sven Mangelinckx, An Adams, Zheng-tao Wang, Wei-lin Li & Norbert De Kimpe. (2015) Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and its Complications. Natural Product Communications 10:1, pages 1934578X1501000.
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