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Research Article

More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design

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Pages 350-359 | Received 04 Aug 2012, Accepted 03 Sep 2012, Published online: 01 Nov 2012

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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava & Claudiu T. Supuran. (2016) Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 132-136.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Daniela Vullo, Semra Isik, Murat Bozdag, Fabrizio Carta & Claudiu T. Supuran. (2015) 7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. Journal of Enzyme Inhibition and Medicinal Chemistry 30:5, pages 773-777.
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Derya Osmaniye, Cüneyt Türkeş, Yeliz Demir, Yusuf Özkay, Şükrü Beydemir & Zafer A. Kaplancıklı. (2022) Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors. Archiv der Pharmazie 355:8, pages 2200132.
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Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Oya Büyükemir, Deniz Nezir, Abdullah Burak Karaduman, Yusuf Özkay, Ali Savaş Koparal, Şükrü Beydemir & Zafer Asım Kaplancıklı. (2020) Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate. European Journal of Medicinal Chemistry 198, pages 112392.
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Soumajit Ghorai, Sravani Pulya, Kalyan Ghosh, Parthasarathi Panda, Balaram Ghosh & Shovanlal Gayen. (2020) Structure-activity relationship of human carbonic anhydrase-II inhibitors: Detailed insight for future development as anti-glaucoma agents. Bioorganic Chemistry 95, pages 103557.
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Murat Bozdag, Marta Ferraroni, Carol Ward, Fabrizio Carta, Silvia Bua, Andrea Angeli, Simon P. Langdon, Ian H. Kunkler, Abdul-Malek S. Al-Tamimi & Claudiu T. Supuran. (2019) Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. European Journal of Medicinal Chemistry 182, pages 111600.
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Joanna Matysiak, Alicja Skrzypek, Paweł Tarasiuk & Mariusz Mojzych. (2017) QSAR study of pyrazolo[4,3-e][1,2,4]triazine sulfonamides against tumor-associated human carbonic anhydrase isoforms IX and XII. Computational Biology and Chemistry 71, pages 57-62.
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Murat Bozdag, Ahmed Mahmoud Alafeefy, Abdul Malik Altamimi, Fabrizio Carta, Claudiu T. Supuran & Daniela Vullo. (2017) Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25:10, pages 2782-2788.
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Fabrizio Carta, Alexander Birkmann, Tamara Pfaff, Helmut Buschmann, Wilfried Schwab, Holger Zimmermann, Alfonso Maresca & Claudiu T. Supuran. (2017) Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action. Journal of Medicinal Chemistry 60:7, pages 3154-3164.
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Behnam Rasti, Mohsen Namazi, M. H. Karimi-Jafari & Jahan B. Ghasemi. (2017) Proteochemometric Modeling of the Interaction Space of Carbonic Anhydrase and its Inhibitors: An Assessment of Structure-based and Sequence-based Descriptors. Molecular Informatics 36:4, pages 1600102.
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Silvia Bua, Lorenzo Di Cesare Mannelli, Daniela Vullo, Carla Ghelardini, Gianluca Bartolucci, Andrea Scozzafava, Claudiu T. Supuran & Fabrizio Carta. (2017) Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis. Journal of Medicinal Chemistry 60:3, pages 1159-1170.
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Daniela Vullo, Claudiu T. Supuran, Andrea Scozzafava, Giuseppina De Simone, Simona Maria Monti, Vincenzo Alterio & Fabrizio Carta. (2016) Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors. Bioorganic & Medicinal Chemistry 24:16, pages 3643-3648.
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Daniela Vullo, Mariaconcetta Durante, Francesco Saverio Di Leva, Sandro Cosconati, Emanuela Masini, Andrea Scozzafava, Ettore Novellino, Claudiu T. Supuran & Fabrizio Carta. (2016) Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma. Journal of Medicinal Chemistry 59:12, pages 5857-5867.
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Benedetta Cornelio, Marie Laronze-Cochard, Mariangela Ceruso, Marta Ferraroni, Graham A. RanceFabrizio Carta, Andrei N. KhlobystovAntonella Fontana, Claudiu T. Supuran & Janos Sapi. (2016) 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. Journal of Medicinal Chemistry 59:2, pages 721-732.
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Marta Ferraroni, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2015) Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins. Journal of Medicinal Chemistry 59:1, pages 462-473.
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Marco Bragagni, Murat Bozdag, Fabrizio Carta, Andrea Scozzafava, Cecilia Lanzi, Emanuela Masini, Paola Mura & Claudiu T. Supuran. (2015) Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents. Bioorganic & Medicinal Chemistry 23:18, pages 6223-6227.
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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Atilla Akdemir, Semra Isik, Cecilia Lanzi, Andrea Scozzafava, Emanuela Masini & Claudiu T. Supuran. (2015) Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action. Bioorganic & Medicinal Chemistry 23:10, pages 2368-2376.
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Murat Bozdag, Marta Ferraroni, Fabrizio Carta, Daniela Vullo, Laura Lucarini, Elisabetta Orlandini, Armando Rossello, Elisa Nuti, Andrea Scozzafava, Emanuela Masini & Claudiu T. Supuran. (2014) Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups. Journal of Medicinal Chemistry 57:21, pages 9152-9167.
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