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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 30, 2015 - Issue 2
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Short Communication

Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases

Daniela VulloPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Florence), Italy,
,
Mladen MilosDepartment of Biochemistry, Faculty of Chemistry and Technology, University of Split, Split, Croatia,
,
Borivoj GalicDepartment of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina, and
,
Andrea ScozzafavaPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Florence), Italy,
&
Claudiu T. SupuranNeurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino (Florence), ItalyCorrespondence[email protected]
Pages 341-344 | Received 02 Apr 2014, Accepted 23 Apr 2014, Published online: 18 Jun 2014

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Ana Maravić, Tomislav Rončević, Lucija Krce, Nada Ilić, Borivoj Galić, Vedrana Čulić Čikeš & Ivana Carev. (2019) Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens. Drug Development and Industrial Pharmacy 45:11, pages 1770-1776.
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Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
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Maja Marasovic, Sinisa Ivankovic, Ranko Stojkovic, Damir Djermic, Borivoj Galic & Mladen Milos. (2017) In vitro and in vivo antitumour effects of phenylboronic acid against mouse mammary adenocarcinoma 4T1 and squamous carcinoma SCCVII cells. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1299-1304.
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Sinisa Ivankovic, Ranko Stojkovic, Milka Maksimovic, Borivoj Galic & Mladen Milos. (2016) Impact of calcium ion on cytotoxic effect of the boroxine derivative, K2[B3O3F4OH]. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 70-74.
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Lejla Pojskic, Sanin Haveric, Naida Lojo-Kadric, Maida Hadzic, Anja Haveric, Zoran Galic, Borivoj Galic, Daniela Vullo, Claudiu T. Supuran & Mladen Milos. (2016) Effects of dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], on cell viability and gene expression of common human cancer drug targets in a melanoma cell line. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 999-1004.
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Articles from other publishers (24)

Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran & Jean-Yves Winum. (2024) Boron-containing carbonic anhydrases inhibitors. Bioorganic Chemistry 143, pages 106976.
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Giulia Paties Montagner, Silvia Dominici, Simona Piaggi, Alfonso Pompella & Alessandro Corti. (2023) Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open. Antioxidants 12:6, pages 1302.
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Nikolina Elez-Burnjaković, Lejla Pojskić, Anja Haverić, Naida Lojo-Kadrić, Maida Hadžić Omanović, Jasmin Ramić, Ajla Smajlović, Milka Maksimović & Sanin Haverić. (2023) New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells . Archives of Industrial Hygiene and Toxicology 74:1, pages 16-21.
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Anja Haveric, Sanin Haveric, Maida Hadzic, Jasmin Ezic, Tamara Cetković & Borivoj Galic. (2023) Moderate Toxicity of Potential Boron-containing Therapeutic, Dipotassium-trioxohydroxytetrafl uorotriborate -K2(B3O3F4OH) in Rats and Mice. Brazilian Journal of Pharmaceutical Sciences 59.
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Maida Hadzic, Yitong Sun, Nikolina Tomic, Eirini Tsirvouli, Martin Kuiper & Lejla Pojskic. (2022) Halogenated boroxine increases propensity to apoptosis in leukemia ( UT ‐7) but not non‐tumor cells in vitro . FEBS Open Bio 13:1, pages 143-153.
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Tarik Corbo, Abdurahim Kalajdzic, Dzelila Delic, Sumaia Suleiman & Naris Pojskic. (2022) In silico prediction suggests inhibitory effect of halogenated boroxine on human catalase and carbonic anhydrase. Journal of Genetic Engineering and Biotechnology 20:1.
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Maida Hadzic, Lejla Pojskic, Naida Lojo‐Kadric, Anja Haveric, Jasmin Ramic, Borivoj Galic & Sanin Haveric. (2022) Novel boron‐containing compound, halogenated boroxine, induces selective cytotoxicity through apoptosis triggering in UT‐7 leukemia. Journal of Biochemical and Molecular Toxicology 36:5.
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Anja Haverić, Adaleta Durmić-Pašić, Amer Alić, Indira Mujezinović, Ahmed Smajlović, Jelena Ostojić, Anesa Ahatović, Maida Hadžić, Senad Prašović, Sanin Haverić & Borivoj Galić. (2020) Biochemical and histomorphological findings in Swiss Wistar rats treated with potential boron-containing therapeutic - K2[B3O3F4OH]. Journal of Trace Elements in Medicine and Biology 62, pages 126642.
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Maida Hadzic, Sanin Haveric, Anja Haveric, Naida Lojo-Kadric, Borivoj Galic, Jasmin Ramic & Lejla Pojskic. (2019) Bioflavonoids protect cells against halogenated boroxine-induced genotoxic damage by upregulation of hTERT expression . Zeitschrift für Naturforschung C 74:5-6, pages 125-129.
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Safija Herenda, Jelena Ostojić, Edhem Hasković, Denis Hasković, Mladen Miloš & Borivoj Galić. (2018) Electrochemical Investigation of the Influence of K2[B3O3F4OH] on the Activity of Immobilized Superoxide Dismutase. International Journal of Electrochemical Science 13:4, pages 3279-3287.
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Andrea Angeli, Alaa A.-M. Abdel-Aziz, Alessio Nocentini, Adel S. El-Azab, Paola Gratteri & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties. Bioorganic & Medicinal Chemistry 25:20, pages 5373-5379.
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Claudiu T. Supuran. (2017) Bortezomib inhibits mammalian carbonic anhydrases. Bioorganic & Medicinal Chemistry 25:19, pages 5064-5067.
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Jelena Ostojić, Safija Herenda, Zerina Bešić, Mladen Miloš & Borivoj Galić. (2017) Advantages of an Electrochemical Method Compared to the Spectrophotometric Kinetic Study of Peroxidase Inhibition by Boroxine Derivative. Molecules 22:7, pages 1120.
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Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks, Kaspars Tars, Raivis Žalubovskis & Claudiu T. Supuran. (2017) N -Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25:13, pages 3583-3589.
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Alaa A.-M. Abdel-Aziz, Andrea Angeli, Adel S. El-Azab, Mohamed A. Abu El-Enin & Claudiu T. Supuran. (2017) Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors. Bioorganic & Medicinal Chemistry 25:5, pages 1666-1671.
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Daniela Vullo, Sonia Del Prete, Alessio Nocentini, Sameh M. Osman, Zeid AlOthman, Clemente Capasso, Murat Bozdag, Fabrizio Carta, Paola Gratteri & Claudiu T. Supuran. (2017) Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa. Bioorganic & Medicinal Chemistry 25:3, pages 1260-1265.
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Jekaterīna Ivanova, Agnese Balode, Raivis Žalubovskis, Janis Leitans, Andris Kazaks, Daniela Vullo, Kaspars Tars & Claudiu T. Supuran. (2017) 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations. Bioorganic & Medicinal Chemistry 25:3, pages 857-863.
Crossref
Jelena Ostojic, Safija Herenda, Semira Galijasevic, Borivoj Galic & Mladen Milos. (2017) Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate K 2 [B 3 O 3 F 4 OH] . Journal of Chemistry 2017, pages 1-7.
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Srinivas Angapelly, P.V. Sri Ramya, Andrea Angeli, Simona Maria Monti, Martina Buonanno, Mallika Alvala, Cladiu T. Supuran & Mohammed Arifuddin. (2017) Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors. Bioorganic & Medicinal Chemistry 25:2, pages 539-544.
Crossref
Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4184-4190.
Crossref
Claudiu T. Supuran. (2016) Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. Bioorganic & Medicinal Chemistry 24:18, pages 4406-4409.
Crossref
Murat Bozdag, Ahmed M. Alafeefy, Fabrizio Carta, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Abdulla A. Al-Kahtani, Fatmah A.S. Alasmary & Claudiu T. Supuran. (2016) Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties. Bioorganic & Medicinal Chemistry 24:18, pages 4100-4107.
Crossref
Sanin Haveric, Maida Hadzic, Anja Haveric, Mirjana Mijanovic, Rifat Hadziselimovic & Borivoj Galic. (2016) Genotoxicity Evaluation of Dipotassium -Trioxohydroxytetrafluorotriborate, K2(B3O3F4OH), in Human Lymphocyte Cultures and Mice Reticulocytes. Brazilian Archives of Biology and Technology 59:0.
Crossref
Maida Hadžić, Sanin Haverić, Anja Haverić & Borivoj Galić. (2015) Inhibitory effects of delphinidin and luteolin on genotoxicity induced by K2B3O3F4OH) in human lymphocytes in vitro. Biologia 70:4, pages 553-558.
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