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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 2
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Short Communication

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study

Melgious J. Y. AngExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Qiu Ying LauExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Fui Mee NgExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Siew Wen ThenExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Anders PoulsenExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Yuen Kuen CheongExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Zi Xian NgohExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Yong Wah TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, and
,
Jianhe PengExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Thomas H. KellerExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Jeffrey HillExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore,
,
Justin J. H. ChuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, and ;Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, National University of Singapore, Singapore
&
C. S. Brian ChiaExperimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Correspondence[email protected]
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Pages 332-339 | Received 03 Jan 2015, Accepted 02 Feb 2015, Published online: 20 Mar 2015

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Hyemin Lee, Eun Ah Shin, Jae Hee Lee, Deoksoo Ahn, Chang Geun Kim, Ju-Ha Kim & Sung-Hoon Kim. (2018) Caspase inhibitors: a review of recently patented compounds (2013-2015). Expert Opinion on Therapeutic Patents 28:1, pages 47-59.
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Articles from other publishers (9)

Shuqi Wang, Zehan Pang, Huahao Fan & Yigang Tong. (2023) Advances in anti-EV-A71 drug development research. Journal of Advanced Research.
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Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, Qin Yao Oh, Qi An Ang, Boping Liu, Hong Yun Chang, Judice Koh, Xiaoying Koh, Qian Wen Tan, Joma Joy & Cheng San Brian Chia. (2022) A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir. ACS Medicinal Chemistry Letters 13:8, pages 1345-1350.
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Debarati Ghosh, Karan Sehgal, Babasaheb Sodnar, Nikhil Bhosale, Deepaneeta Sarmah, Aishika Datta, Antra Chaudhary, Kiran Kalia, Xin Wang & Pallab Bhattacharya. (2022) Drug repurposing for stroke intervention. Drug Discovery Today 27:7, pages 1974-1982.
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A. S. Volobueva, V. V. Zarubaev & K. S. Lantseva. (2021) Development of antiviral therapeutics combating coxsackievirus type B3 infection. Russian Journal of Infection and Immunity 11:1, pages 57-67.
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Sako Mirzaie, Fatemeh Abdi, Amin GhavamiNejad, Brian Lu & Xiao Yu Wu. 2021. Antiviral Drug Discovery and Development. Antiviral Drug Discovery and Development 285 312 .
Yixuan Wang, Huiqiang Wang, Xinbei Jiang, Zhi Jiang, Tingting Guo, Xingyue Ji, Yanping Li, Yuhuan Li & Zhuorong Li. (2019) Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates. Molecules 24:5, pages 985.
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Quandeng Nie, Xiaoyi Xu, Qi Zhang, Yuying Ma, Zheng Yin & Luqing Shang. (2018) 3D-quantitative structure-activity relationship study for the design of novel enterovirus A71 3C protease inhibitors. Chemical Biology & Drug Design 92:4, pages 1750-1762.
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Guang-Hui Ma, Yan Ye, Dan Zhang, Xin Xu, Pei Si, Jian-Long Peng, Yong-Long Xiao, Rui-Yuan Cao, Yu-Ling Yin, Jing Chen, Lin-Xiang Zhao, Yu Zhou, Wu Zhong, Hong Liu, Xiao-Min Luo, Li-Li Chen & Xu Shen. (2016) Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. European Journal of Medicinal Chemistry 124, pages 981-991.
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Yong Wah Tan, Melgious Jin Yan Ang, Qiu Ying Lau, Anders Poulsen, Fui Mee Ng, Siew Wen Then, Jianhe Peng, Jeffrey Hill, Wan Jin Hong, Cheng San Brian Chia & Justin Jang Hann Chu. (2016) Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease. Scientific Reports 6:1.
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