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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 6
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Research Article

Synthesis and anticancer and lipophilic properties of 10-dialkylaminobutynyl derivatives of 1,8- and 2,7-diazaphenothiazines

Beata Morak-MłodawskaSchool of Pharmacy with the Division of Laboratory Medicine, Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland and
,
Krystian PlutaSchool of Pharmacy with the Division of Laboratory Medicine, Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland and
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Małgorzata LatochaSchool of Pharmacy with the Division of Laboratory Medicine, Department of Cell Biology, The Medical University of Silesia, Sosnowiec, Poland
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Małgorzata JeleńSchool of Pharmacy with the Division of Laboratory Medicine, Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland and
&
Dariusz KuśmierzSchool of Pharmacy with the Division of Laboratory Medicine, Department of Cell Biology, The Medical University of Silesia, Sosnowiec, PolandCorrespondence[email protected]
Pages 1132-1138 | Received 12 Dec 2014, Accepted 31 Aug 2015, Published online: 02 Nov 2015

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Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba & Magdalena Jurzak. (2019) 10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1298-1306.
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Małgorzata Jeleń, Krystian Pluta, Michał Zimecki, Beata Morak-Młodawska, Jolanta Artym, Maja Kocięba & Iwona Kochanowska. (2016) Synthesis and biological evaluation of novel propargylquinobenzothiazines and their derivatives as potential antiproliferative, anti-inflammatory, and anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 83-88.
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Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Kinga Suwińska, Małgorzata Jeleń & Dariusz Kuśmierz. (2016) 3,6-Diazaphenothiazines as potential lead molecules – synthesis, characterization and anticancer activity. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1512-1519.
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Articles from other publishers (20)

Beyza Çelik, Sümeyye Buran Uğur, Münevver Baran, Miyase Gözde Gündüz, Selbi Keskin, Gözde Özge Önder, Nazmiye Bitgen, Serdal Kaya & Şengül Dilem Doğan. (2023) Semicarbazides Carrying Indole Core: Synthesis, Cytotoxicity Evaluation against Human Breast Cancer Cell Lines, and Molecular Modeling Studies. Chemistry & Biodiversity 20:8.
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Himshikha Sharma, Archana Gupta, Reshma Kumari, May Lee Low, Wie Meng Lim & Marilyn Daisy Milton. (2023) Substituted 1 ‐Azaphenothiazines and Their 10 ‐( 2 ′‐Morpholinylethyl) Derivatives: Synthesis, Characterization and Anticancer Evaluation . ChemistrySelect 8:26.
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Arun Kumar, Chiara Vigato, Donatella Boschi, Marco Lucio Lolli & Deepak Kumar. (2023) Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies. European Journal of Medicinal Chemistry 254, pages 115337.
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Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula & Rafał Korlacki. (2023) Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action. International Journal of Molecular Sciences 24:8, pages 6970.
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Selbi Keskin, Şengül Dilem Doğan, Miyase Gözde Gündüz, Ivana Aleksic, Sandra Vojnovic, Jelena Lazic & Jasmina Nikodinovic-Runic. (2022) Indole-based hydrazone derivatives: Synthesis, cytotoxicity assessment, and molecular modeling studies. Journal of Molecular Structure 1270, pages 133936.
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Jamelah S. Al-Otaibi, Y. Sheena Mary, Y. Shyma Mary, R. Niranjana Devi & Sreejit Soman. (2022) Experimental spectra, electronic properties (liquid and gaseous phases) and activity against SARS-CoV-2 main protease of Fluphenazine dihydrochloride: DFT and MD simulations. Journal of Molecular Structure 1267, pages 133633.
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Gheorghe Roman. (2022) Anticancer Activity of Mannich Bases: A Review of Recent Literature. ChemMedChem 17:16.
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Beata Morak-Młodawska & Małgorzata Jeleń. (2022) Lipophilicity and Pharmacokinetic Properties of New Anticancer Dipyridothiazine with 1,2,3-Triazole Substituents. Molecules 27:4, pages 1253.
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Anji Chen & Guijun Wang. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 635 719 .
Kritika Laxmikeshav, Pooja Kumari & Nagula Shankaraiah. (2021) Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update. Medicinal Research Reviews 42:1, pages 513-575.
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Beata Morak-Młodawska, Małgorzata Jeleń & Krystian Pluta. (2021) Phenothiazines Modified with the Pyridine Ring as Promising Anticancer Agents. Life 11:3, pages 206.
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Aljawhara H. Almuqrin, Jamelah S. Al-Otaibi, Y. Sheena Mary & Y. Shyma Mary. (2021) DFT computational study towards investigating psychotropic drugs, promazine and trifluoperazine adsorption on graphene, fullerene and carbon cyclic ring nanoclusters. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 246, pages 119012.
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Beata Morak-Młodawska, Krystian Pluta & Małgorzata Jeleń. (2020) Evaluation of the Lipophilicity of New Anticancer 1,2,3-Triazole-Dipyridothiazine Hybrids Using RP TLC and Different Computational Methods. Processes 8:7, pages 858.
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Jakub Jończyk, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta & Barbara Malawska. (2020) Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity. Molecules 25:11, pages 2604.
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Małgorzata Szymańska & Irena Majerz. (2020) Geometry and electron density of phenothazines. Journal of Molecular Structure 1200, pages 127095.
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Morak-Młodawska, Pluta, Latocha, Jeleń & Kuśmierz. (2019) Design, Synthesis, and Structural Characterization of Novel Diazaphenothiazines with 1,2,3-Triazole Substituents as Promising Antiproliferative Agents. Molecules 24:23, pages 4388.
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Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń & Dariusz Kuśmierz. (2019) Synthesis, Anticancer Activity, and Apoptosis Induction of Novel 3,6-Diazaphenothiazines. Molecules 24:2, pages 267.
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Anna K. Laskowska, Anna K. Puszko, Piotr Sosnowski, Krzysztof Różycki, Piotr Kosson, Joanna Matalińska, Marek Durlik & Aleksandra Misicka. (2017) Opioid Tripeptides Hybridized with trans -1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models . ChemMedChem 12:19, pages 1637-1644.
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Krystian Pluta, Małgorzata Jeleń, Beata Morak-Młodawska, Michał Zimecki, Jolanta Artym, Maja Kocięba & Ewa Zaczyńska. (2017) Azaphenothiazines – promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties. European Journal of Medicinal Chemistry 138, pages 774-806.
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Beata Morak-Młodawska, Krystian Pluta, Kinga Suwińska & Małgorzata Jeleń. (2017) The double Smiles rearrangement in neutral conditions leading to one of 10-(nitropyridinyl)dipyridothiazine isomers. Journal of Molecular Structure 1133, pages 398-404.
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