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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 6
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Research Article

Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization

Max Seidy SaitoLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol) – Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil, ;Programa de Pós-Graduação em Patologia (PPG-UFF) – Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brazil,
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André Luiz LourençoLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol) – Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil, ;Programa de Pós-Graduação em Patologia (PPG-UFF) – Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brazil,
,
Luiza Rosaria Sousa DiasLaboratório de Química Medicinal (LQMed) – Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, Brazil,
,
Antônio Carlos Carreira FreitasLaboratório de Química Medicinal (LQMed) – Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, Brazil,
,
Maíra Ingrid VitorinoLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol) – Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil,
,
Magaly Girão AlbuquerqueLaboratório de Modelagem Molecular (LabMMol) – Instituto de Química,
,
Carlos Rangel RodriguesLaboratório de Modelagem Molecular e QSAR (ModMolQSAR) – Faculdade de Farmácia, and
,
Lúcio Mendes CabralLaboratório de Tecnologia Industrial Farmacêutica (LabTIF) – Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
,
Eliane Pedra DiasPrograma de Pós-Graduação em Patologia (PPG-UFF) – Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brazil,
,
Helena Carla CastroLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol) – Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil, ;Programa de Pós-Graduação em Patologia (PPG-UFF) – Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brazil,
&
Plínio Cunha SatlherLaboratório de Antibióticos, Bioquímica, Ensino e Modelagem Molecular (LABiEMol) – Instituto de Biologia, Universidade Federal Fluminense, Niterói, Brazil, ;Laboratório de Tecnologia Industrial Farmacêutica (LabTIF) – Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilCorrespondence[email protected] [email protected]
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Pages 1591-1601 | Received 22 Nov 2015, Accepted 16 Feb 2016, Published online: 22 Mar 2016

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Seyedeh Fatemeh Hojati, Amirhassan Amiri & Sara Ghavidel. (2023) Copolymer-Coated Magnetic Graphene Oxide: A Reusable Catalyst for the Preparation of 2,4,6-Triaryl Pyridines via Four-Component Reaction. Polycyclic Aromatic Compounds 0:0, pages 1-15.
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Chunlei Wu, Jian Liu, Du Kui, Yu Lemao, Xu Yingjie, Xiang Luo, Xi Meiyang & Runpu Shen. (2022) Efficient Multicomponent Synthesis of Spirooxindole Derivatives Catalyzed by Copper Triflate. Polycyclic Aromatic Compounds 42:1, pages 277-289.
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Sundaravel Vivek Kumar, Shanmugam Muthusubramanian & Subbu Perumal. (2019) Recent Progress in the Synthesis of Pyrazolopyridines and Their Derivatives. Organic Preparations and Procedures International 51:1, pages 1-89.
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Articles from other publishers (11)

Dongping Cheng, Huafang Gu, Hongshuang Xia, Yawei Wang, Jing-Hua Li & Xiaoliang Xu. (2023) Tandem Oxidative Reaction of 1,3-Diarylpropenes and 5-Aminopyrazoles. Synlett 34:19, pages 2309-2314.
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Priscila de Souza Furtado, Alana Agnes Silva Camargo de Oliveira, Pryscila Santiago Rodrigues, Anna Rita Santiago de Paula Gonçalves, Anna Raphaella Autran Colaço, Sandro Pinheiro da Costa, Mariana Muniz da Paz, Paloma Wetler Meireles Carreiros Assumpção, Luciana Pereira Rangel, Alice Simon, Flávia Almada do Carmo, Lucio Mendes Cabral & Plínio Cunha Sathler. (2023) In vivo evaluation of time-dependent antithrombotic effect of rivaroxaban-loaded poly(lactic-co-glycolic acid)/sodium lauryl sulfate or didodecyl dimethylammonium bromide nanoparticles in Wistar rats. European Journal of Pharmaceutics and Biopharmaceutics 190, pages 184-196.
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Mohamed R. Elmorsy, Ehab Abdel-Latif, Hatem E. Gaffer, Samar E. Mahmoud & Ahmed A. Fadda. (2023) Anticancer evaluation and molecular docking of new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives. Scientific Reports 13:1.
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Samvel N Sirakanyan, Marcel Hrubša, Domenico Spinelli, Patrícia Dias, Victor Kartsev, Alejandro Carazo, Anush A Hovakimyan, Jana Pourová, Elmira K Hakobyan, Jana Karlíčková, Shamima Parvin, Jaka Fadraersada, Kateřina Macáková, Athina Geronikaki & Přemysl Mladěnka. (2022) Synthesis of 3,3-dimethyl-6-oxopyrano[3,4- c ]pyridines and their antiplatelet and vasodilatory activity . Journal of Pharmacy and Pharmacology 74:6, pages 887-895.
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Max S. Saito, Kelly C. Zatta, Plínio C. Sathler, Priscila S. Furtado, Nádia C.O. Miguel, Flávia S. Frattani, Markus Berger, Vladimir Lavayen, Adriana R. Pohlmann & Sílvia S. Guterres. (2022) Therapeutic implementation in arterial thrombosis with pulmonary administration of fucoidan microparticles containing acetylsalicylic acid. International Journal of Pharmaceutics 622, pages 121841.
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Xiaotong Gu & Shutao Ma. (2022) Recent Advances in the Development of Pyrazolopyridines as Anticancer Agents. Anti-Cancer Agents in Medicinal Chemistry 22:9, pages 1643-1657.
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Aleksandr A. Zubenko, Anatolii S. Morkovnik, Lyudmila N. Divaeva, Vadim S. Sochnev, Oleg P. Demidov, Aleksandr I. Klimenko, Leonid N. Fetisov, Anatolii N. Bodryakov, Mariya A. Bodryakova & Gennadii S. Borodkin. (2022) New type of recyclization in 3,4-dihydroisoquinolines in the synthesis of β-(o-indazolylaryl)ethylamines and their 7-azaindazolyl analogues. Mendeleev Communications 32:2, pages 271-273.
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Aleksandr A. Zubenko, Anatolii S. Morkovnik, Lyudmila N. Divaeva, Vadim S. Sochnev, Oleg P. Demidov, Aleksandr I. Klimenko, Leonid N. Fetisov, Anatolii N. Bodryakov, Mariya A. Bodryakova & Gennadii S. Borodkin. (2022) New type of recyclization in 3,4-dihydroisoquinolines in the synthesis of β-(o-indazolylaryl)ethylamines and their 7-azaindazolyl analogues. Mendeleev Communications 32:2, pages 265-267.
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Janos Sapi & Stéphane Gérard. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 212 382 .
Marcos V.P. Mello, Thaisa F.S. Domingos, Davis F. Ferreira, Mariana M.J. Ribeiro, Thayssa P. Ribeiro, Carlos R. Rodrigues & Alessandra M.T. Souza. (2020) Antiviral Drug Discovery and Development for Mayaro Fever – What do we have so far?. Mini-Reviews in Medicinal Chemistry 20:10, pages 921-928.
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N.S. El-Gohary & M.I. Shaaban. (2018) Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives. European Journal of Medicinal Chemistry 157, pages 729-742.
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