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Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period

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Pages 207-221 | Received 07 Dec 2010, Accepted 07 Mar 2011, Published online: 11 May 2011

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Fady M. El-Gendy, Mahmoud A. El-Hawy & Mohamed G. Hassan. (2018) Beneficial effect of melatonin in the treatment of neonatal sepsis. The Journal of Maternal-Fetal & Neonatal Medicine 31:17, pages 2299-2303.
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Nahid Azarmehr, Roghayeh Porhemat, Narges Roustaei, Esmat Radmanesh, Zahra Moslemi, Razieh Vanda, Zahra Barmoudeh, Parvinsadat Eslamnik & Amir Hossein Doustimotlagh. (2023) Melatonin-Attenuated Oxidative Stress in High-Risk Pregnant Women Receiving Enoxaparin and Aspirin. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-6.
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Magdalena Markowska, Stanisław Niemczyk & Katarzyna Romejko. (2023) Melatonin Treatment in Kidney Diseases. Cells 12:6, pages 838.
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Xin-Ying Wang, Xin-Ge Zhang, Yong-Juan Sang, Dan-Yang Chong, Xiao-Qiang Sheng, Hai-Quan Wang, Chao-Fan Yang, GuiJun Yan, Hai-Xiang Sun & Chao-Jun Li. (2022) The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice. Life Metabolism 1:2, pages 149-160.
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You-Lin Tain & Chien-Ning Hsu. (2022) Perinatal Oxidative Stress and Kidney Health: Bridging the Gap between Animal Models and Clinical Reality. Antioxidants 12:1, pages 13.
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Deanna M. Minich, Melanie Henning, Catherine Darley, Mona Fahoum, Corey B. Schuler & James Frame. (2022) Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients 14:19, pages 3934.
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Marissa J. DeFreitas, Chryso P. Katsoufis, Merline Benny, Karen Young, Shathiyah Kulandavelu, Hyunyoung Ahn, Anna Sfakianaki & Carolyn L. Abitbol. (2022) Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney. Frontiers in Pediatrics 10.
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Inna I. Evsyukova. (2022) Melatonin in the treatment of perinatal pathology. Journal of obstetrics and women's diseases 71:1, pages 119-128.
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Thorsten Mikoteit & Martin Hatzinger. 2022. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 3985 4012 .
Xie Peng, Xuelin Cai, Jian Li, Yingyan Huang, Hao Liu, Jiaqi He, Zhengfeng Fang, Bin Feng, Jiayong Tang, Yan Lin, Xuemei Jiang, Liang Hu, Shengyu Xu, Yong Zhuo, Lianqiang Che & De Wu. (2021) Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model. Antioxidants 10:12, pages 1867.
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Inna I. Evsyukova. (2021) Premature newborns: Actual problems of raising and prevention of adverse consequences. Journal of obstetrics and women's diseases 70:3, pages 93-102.
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James DS. Aridas, Tamara Yawno, Amy E. Sutherland, Ilias Nitsos, Flora Y. Wong, Rod W. Hunt, Michael Ditchfield, Michael C. Fahey, Atul Malhotra, Euan M. Wallace, Alistair J. Gunn, Graham Jenkin & Suzanne L. Miller. (2021) Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia. Journal of Pineal Research 71:1.
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I. I. Evsyukova. (2021) The Role of Melatonin in Prenatal Ontogenesis. Journal of Evolutionary Biochemistry and Physiology 57:1, pages 33-45.
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Andrii M. Berbets, Igor S. Davydenko, Adrian M. Barbe, Dmytro H. Konkov, Olena M. Albota & Oleksandr M. Yuzko. (2020) Melatonin 1A and 1B Receptors’ Expression Decreases in the Placenta of Women with Fetal Growth Restriction. Reproductive Sciences 28:1, pages 197-206.
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Thorsten Mikoteit & Martin Hatzinger. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 1 28 .
Cristina Rodríguez-Varela & Elena Labarta. (2020) Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review. Antioxidants 9:12, pages 1197.
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Alejandro Gonzaléz‐Candia, Alejandro A. Candia, Esteban G. Figueroa, Elisenda Feixes, Cristopher Gonzalez‐Candia, Simón A. Aguilar, Germán Ebensperger, Roberto V. Reyes, Aníbal J. Llanos & Emilio A. Herrera. (2019) Melatonin long‐lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates. Journal of Pineal Research 68:1.
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Ji Yeon Lee, Su Li, Na E. Shin, Quan Na, Jie Dong, Bei Jia, Kimberly Jones‐Beatty, Michael W. McLane, Maide Ozen, Jun Lei & Irina Burd. (2019) Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation‐induced oxidative stress in a mouse model. Journal of Pineal Research 67:3.
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Rafael Genario, Ediane Morello, Allain Amador Bueno & Heitor Oliveira Santos. (2019) The usefulness of melatonin in the field of obstetrics and gynecology. Pharmacological Research 147, pages 104337.
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Xiaoyu Zhang, Qin Xia, Rui Wei, Hongfei Song, Jiaqi Mi, Zhaoyu Lin, Yang Yang, Zijie Sun & Kang Zou. (2019) Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free Radical Biology and Medicine 137, pages 74-86.
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Anna Tarocco, Natascia Caroccia, Giampaolo Morciano, Mariusz R. Wieckowski, Gina Ancora, Giampaolo Garani & Paolo Pinton. (2019) Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Cell Death & Disease 10:4.
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Alejandro Gonzalez-Candia, Marcelino Veliz, Catalina Carrasco-Pozo, Rodrigo L. Castillo, J. Cesar Cárdenas, Germán Ebensperger, Roberto V. Reyes, Aníbal J. Llanos & Emilio A. Herrera. (2019) Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep. Redox Biology 22, pages 101128.
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Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh & Josip Car. (2018) Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Medicine 16:1.
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Fernanda Rodrigues Helmo, Renata Margarida Etchebehere, Natália Bernardes, Maria Flávia Meirelles, Caetano Galvão Petrini, Laura Penna Rocha, Maria Luíza Gonçalves dos Reis Monteiro, Camila Souza de Oliveira Guimarães, Vicente de Paula Antunes Teixeira, Marlene Antônia dos Reis, Juliana Reis Machado & Rosana Rosa Miranda Corrêa. (2018) Melatonin treatment in fetal and neonatal diseases. Pathology - Research and Practice 214:12, pages 1940-1951.
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Rachel L. Darché, Elizabeth H. Ruder, Jeffrey Blumberg, Terryl J. Hartman & Marlene B. Goldman. 2017. Nutritional Antioxidant Therapies: Treatments and Perspectives. Nutritional Antioxidant Therapies: Treatments and Perspectives 113 136 .
Marina Colella, Valérie Biran & Olivier Baud. (2016) Melatonin and the newborn brain. Early Human Development 102, pages 1-3.
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Lucia Marseglia, Gabriella D’Angelo, Sara Manti, Russel J. Reiter & Eloisa Gitto. (2016) Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia. Reproductive Sciences 23:8, pages 970-977.
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Dominic Wilkinson, Emily Shepherd & Euan M Wallace. (2016) Melatonin for women in pregnancy for neuroprotection of the fetus. Cochrane Database of Systematic Reviews 2016:3.
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Kristina S. Ermolenko, V. E. Radzinsky & S. I. Rapoport. (2016) Stateof-the-art of realization of the fertility potential in the women of late reproductive age. Clinical Medicine (Russian Journal) 94:1, pages 10-15.
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Ruslán Álvarez-Diduk, Annia Galano, Dun Xian Tan & Russel J. Reiter. (2016) The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds. Theoretical Chemistry Accounts 135:2.
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Lucien C. Manchester, Ana Coto-Montes, Jose Antonio Boga, Lars Peter H. Andersen, Zhou Zhou, Annia Galano, Jerry Vriend, Dun-Xian Tan & Russel J. Reiter. (2015) Melatonin: an ancient molecule that makes oxygen metabolically tolerable. Journal of Pineal Research 59:4, pages 403-419.
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Nouf Al-Rasheed, Laila Faddah, Hanan Ibrahim, Azza M Mohamed, Nawal Al-Rasheed & Nayira Abdelbaky. (2015) Role of Carnosine and Melatonin in Ameliorating Cardiotoxicity of Titanium Dioxide Nanoparticles in the Rats. Brazilian Archives of Biology and Technology 58:4, pages 577-586.
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Flavio Torres, Alejandro González-Candia, Camilo Montt, Germán Ebensperger, Magdalena Chubretovic, María Serón-Ferré, Roberto V. Reyes, Aníbal J. Llanos & Emilio A. Herrera. (2015) Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep. Journal of Pineal Research 58:3, pages 362-373.
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Elena M. Kuklina. (2014) Melatonin as potential inducer of Th17 cell differentiation. Medical Hypotheses 83:3, pages 404-406.
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You-Lin Tain, Steve Leu, Kay L. H. Wu, Wei-Chia Lee & Julie Y. H. Chan. (2014) Melatonin prevents maternal fructose intake-induced programmed hypertension in the offspring: roles of nitric oxide and arachidonic acid metabolites. Journal of Pineal Research 57:1, pages 80-89.
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Emilio A. Herrera, Roberto Macchiavello, Camilo Montt, Germán Ebensperger, Marcela Díaz, Santiago Ramírez, Julian T. Parer, María Serón-Ferré, Roberto V. Reyes & Aníbal J. Llanos. (2014) Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs. Journal of Pineal Research 57:1, pages 33-42.
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Valérie Biran, An Phan Duy, Fabrice Decobert, Nathalie Bednarek, Corinne Alberti & Olivier Baud. (2014) Is melatonin ready to be used in preterm infants as a neuroprotectant?. Developmental Medicine & Child Neurology 56:8, pages 717-723.
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C.-S. Wong, G.-M. Jow, A. Kaizaki, L.-W. Fan & L.-T. Tien. (2014) Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats. Neuroscience 267, pages 147-156.
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Lucia Marseglia, Gabriella D’Angelo, Sara Manti, Teresa Arrigo, Ignazio Barberi, Russel J. Reiter & Eloisa Gitto. (2014) Oxidative Stress-Mediated Aging during the Fetal and Perinatal Periods. Oxidative Medicine and Cellular Longevity 2014, pages 1-8.
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Wichaporn Lerdweeraphon, James Michael Wyss, Thidarut Boonmars & Sanya Roysommuti. (2013) Perinatal taurine exposure affects adult oxidative stress. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305:2, pages R95-R97.
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Russel Reiter, Sergio Rosales-Corral, Lucien Manchester & Dun-Xian Tan. (2013) Peripheral Reproductive Organ Health and Melatonin: Ready for Prime Time. International Journal of Molecular Sciences 14:4, pages 7231-7272.
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Yu-Chieh Chen, Jiunn-Ming Sheen, Miao-Meng Tiao, You-Lin Tain & Li-Tung Huang. (2013) Roles of Melatonin in Fetal Programming in Compromised Pregnancies. International Journal of Molecular Sciences 14:3, pages 5380-5401.
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Ifigenia Kostoglou-Athanassiou. (2013) Therapeutic applications of melatonin. Therapeutic Advances in Endocrinology and Metabolism 4:1, pages 13-24.
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José L. Mauriz, Pilar S. Collado, Christiano Veneroso, Russel J. Reiter & Javier González‐Gallego. (2012) A review of the molecular aspects of melatonin’s anti‐inflammatory actions: recent insights and new perspectives. Journal of Pineal Research 54:1, pages 1-14.
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George Anderson & Michael Maes. (2012) Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metabolic Brain Disease 27:2, pages 113-119.
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Yu-Chieh Chen, You-Lin Tain, Jiunn-Ming Sheen & Li-Tung Huang. (2012) Melatonin utility in neonates and children. Journal of the Formosan Medical Association 111:2, pages 57-66.
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Tamara Yawno, Margie Castillo-Melendez, Graham Jenkin, Euan M. Wallace, David W. Walker & Suzanne L. Miller. (2012) Mechanisms of Melatonin-Induced Protection in the Brain of Late Gestation Fetal Sheep in Response to Hypoxia. Developmental Neuroscience 34:6, pages 543-551.
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