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Original Article

A high LDH to AST ratio helps to differentiate pregnancy-associated thrombotic thrombocytopenic purpura (TTP) from HELLP syndrome

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Pages 1059-1063 | Received 17 Mar 2011, Accepted 30 Aug 2011, Published online: 14 Oct 2011

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James Nello Martin$suffix/text()$suffix/text() & James Martin Tucker. (2022) Missing or making the timely diagnosis of acute fatty liver of pregnancy (AFLP): lessons learned. The Journal of Maternal-Fetal & Neonatal Medicine 35:18, pages 3595-3601.
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Articles from other publishers (37)

Adam Morton. (2023) Investigating gastrointestinal disorders in pregnancy. Obstetric Medicine.
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James Nello MartinJr.Jr. & James Martin Tucker. (2022) Maternal morbidity and mortality in pregnant/postpartum women with suspected HELLP syndrome identifiable as probable thrombotic thrombocytopenic purpura or atypical hemolytic uremic syndrome by high LDH to AST ratio . International Journal of Gynecology & Obstetrics 159:3, pages 870-874.
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Wendy Groenendijk, Delia Bogdanet, Louise Dervan, Oisin Finn, Md Nahidul Islam, Helen Doheny, Tomás P. Griffin, Liam Blake, Mark Lyons, Mary Kilcooley, Janusz Krawczyk, Ruth Gilmore, Damian G. Griffin, Geraldine Gaffney, Fidelma P. Dunne & Paula M. O’Shea. (2022) Reference intervals for clinical biochemistry and haematology tests during normal pregnancy. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 59:6, pages 433-446.
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Vasilios Pergialiotis, Michail Panagiotopoulos, Ioannis Bellos, Marianna Theodora, Sofoklis Stavros, Ekaterini Ntomali, Angeliki Papapanagiotou & Georgios Daskalakis. (2021) Serum LDH values in hypertensive disorders of pregnancy and their association with maternal and neonatal morbidity: A meta‐analysis. International Journal of Clinical Practice 75:12.
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A. Nicole Wade, Rikesh Panchmatia & Pamela Calderon. (2021) Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome With Severe Thrombocytopenia and Severe ADAMTS13 Activity Deficiency. Obstetrics & Gynecology 137:5, pages 873-876.
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Kerina Duri, Felicity Z. Gumbo, Privilege T. Munjoma, Precious Chandiwana, Kudakwashe Mhandire, Asaph Ziruma, Andrew Macpherson, Simbarashe Rusakaniko, Exnevia Gomo, Benjamin Misselwitz, Lovemore Ronald Mazengera, M. Altfeld, M. Bunders, S. Rowland Jones, C. Dandara, V. Mleya, J. Mutambara, G. Kandawasvika, P. Kuona, S. Chimhuya, R. Nyamakura, S. Mtapuri-Zinyowera, S. P. Chandiwana, C. Marashiki, H. Mataramvura, E. Mazengera & N. Taremeredzwa. (2020) The University of Zimbabwe College of Health Sciences (UZ-CHS) BIRTH COHORT study: rationale, design and methods. BMC Infectious Diseases 20:1.
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Chris Wynick, Joanne Britto, Daniel Sawler, Arabesque Parker, Mohammad Karkhaneh, M. Dawn Goodyear & Haowei (Linda) Sun. (2020) Validation of the PLASMIC score for predicting ADAMTS13 activity <10% in patients with suspected thrombotic thrombocytopenic purpura in Alberta, Canada. Thrombosis Research 196, pages 335-339.
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Barbara Ferrari & Flora Peyvandi. (2020) How I treat thrombotic thrombocytopenic purpura in pregnancy. Blood 136:19, pages 2125-2132.
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Rasha A. El-Gamal, Mohamed A. Mekawy, Ayman M. Abd Elkader, Haitham M. Abdelbary & Mary Z. Fayek. (2019) Combined Immature Platelet Fraction and Schistocyte Count to Differentiate Pregnancy-Associated Thrombotic Thrombocytopenic Purpura from Severe Preeclampsia/Haemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome (SPE/HELLP). Indian Journal of Hematology and Blood Transfusion 36:2, pages 316-323.
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James A. Van Rhee. (2019) Hemolytic Anemia. Physician Assistant Clinics 4:3, pages 649-662.
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Stefano Michelassi. (2019) Preeclampsia: Parte 1°: clinica, anatomia patologica e fisiologia. Giornale di Tecniche Nefrologiche e Dialitiche 31:1, pages 4-11.
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Shruti Chaturvedi & Keith R. McCrae. 2019. Platelets. Platelets 795 812 .
Stephanie Teasdale & Adam Morton. (2018) Changes in biochemical tests in pregnancy and their clinical significance. Obstetric Medicine 11:4, pages 160-170.
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Ning Tang, Xiong Wang, Dengju Li & Ziyong Sun. (2018) Validation of the PLASMIC score, a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis, in Chinese patients. Thrombosis Research 172, pages 9-13.
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Adam Morton & Stephanie Teasdale. (2018) Review article: Investigations and the pregnant woman in the emergency department - part 1: Laboratory investigations. Emergency Medicine Australasia 30:5, pages 600-609.
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Richard M. BurwickMonica RinconSridivya S. BeerakaMegha GuptaBruce B. Feinberg. (2018) Evaluation of Hemolysis as a Severe Feature of Preeclampsia. Hypertension 72:2, pages 460-465.
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AbdAllah Khaled M. (2018) Body Mass Index Impact and Predictability on Preeclamptic Toxemia. Journal of Gynecological Research and Obstetrics, pages 009-014.
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M. Gupta, B.B. Feinberg & R.M. Burwick. (2018) Thrombotic microangiopathies of pregnancy: Differential diagnosis. Pregnancy Hypertension 12, pages 29-34.
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Leila kheirkhah. (2018) Management of Concurrent Severe Preeclampsia and Thrombotic Thrombocytopenic Purpura (TTP). International Clinical Pathology Journal 6:1.
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Jailan Elayoubi, Kavitha Donthireddy & Divyesh Reddy Nemakayala. (2018) Microangiopathies in pregnancy. BMJ Case Reports, pages bcr-2017-221648.
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Adam Morton. (2017) Acute Fatty Liver of Pregnancy—Differential Diagnosis. American Journal of Gastroenterology 112:8, pages 1342.
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Mohammed Salhab, Andrew Hsu, Elizabeth Ryer, Juliet Appiah & Bradley Switzer. (2017) Microangiopathic hemolytic anemia in pregnancy. Transfusion and Apheresis Science 56:3, pages 354-356.
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Mari R. Thomas, Susan Robinson & Marie A. Scully. (2016) How we manage thrombotic microangiopathies in pregnancy. British Journal of Haematology 173:6, pages 821-830.
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Adam Morton. (2016) Imitators of preeclampsia: A review. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 6:1, pages 1-9.
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Yahsou Delmas, Sébastien Helou, Pierre Chabanier, Anne Ryman, Fanny Pelluard, Dominique Carles, Pierre Boisseau, Agnès Veyradier, Jacques Horovitz, Paul Coppo & Christian Combe. (2015) Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease. BMC Pregnancy and Childbirth 15:1.
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Chiara Savignano, Cristina Rinaldi & Vincenzo De Angelis. (2015) Pregnancy associated thrombotic thrombocytopenic purpura: Practical issues for patient management. Transfusion and Apheresis Science 53:3, pages 262-268.
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Frauke Bergmann & Werner Rath. (2015) The Differential Diagnosis of Thrombocytopenia in Pregnancy. Deutsches Ärzteblatt international.
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C. Tellez-Hinojosa, A. Vazquez-Mellado & D. Gómez-Almaguer. (2015) Thrombotic thrombocytopenic purpura. Medicina Universitaria 17:69, pages 234-239.
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O. Pourrat, R. Coudroy & F. Pierre. (2015) Differentiation between severe HELLP syndrome and thrombotic microangiopathy, thrombotic thrombocytopenic purpura and other imitators. European Journal of Obstetrics & Gynecology and Reproductive Biology 189, pages 68-72.
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Chris Gardiner & Manu Vatish. 2015. Disorders of Thrombosis and Hemostasis in Pregnancy. Disorders of Thrombosis and Hemostasis in Pregnancy 159 171 .
Laura A. Magee, Anouk Pels, Michael Helewa, Evelyne Rey & Peter von Dadelszen. (2014) Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 4:2, pages 105-145.
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Boby Varkey Maramattom. (2014) Anterior Ischemic Optic Neuropathy as a Manifestation of HELLP Syndrome. Case Reports in Critical Care 2014, pages 1-3.
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Felipe A. Zuniga, Valeska Ormazabal, Nicolas Gutierrez, Valeria Aguilera, Claudia Radojkovic, Carlos Veas, Carlos Escudero, Liliana Lamperti & Claudio Aguayo. (2014) Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia. BioMed Research International 2014, pages 1-11.
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Tanu Mehta, Geeta P. Parikh & Veena R. Shah. (2014) Triad of Idiopathic Thrombocytopenic Purpura, Preeclampsia, and HELLP Syndrome in a Parturient: A Rare Confrontation to the Anesthetist. Case Reports in Anesthesiology 2014, pages 1-3.
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Olivier Pourrat, Rémi Coudroy & Fabrice Pierre. (2013) ADAMTS13 deficiency in severe postpartum HELLP syndrome. British Journal of Haematology 163:3, pages 409-410.
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Danielle M. Townsley. (2013) Hematologic Complications of Pregnancy. Seminars in Hematology 50:3, pages 222-231.
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James Nello MartinJr.Jr.. (2013) Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia). International Journal of Gynecology & Obstetrics 121:3, pages 202-207.
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