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The Journal of Maternal-Fetal & Neonatal Medicine Volume 27, 2014 - Issue 16
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Research Article

Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series

Irena KesselDepartment of Neonatology, Carmel Medical CenterHaifa, Israel;Rappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsraelCorrespondence[email protected]
,
Dan WaismanDepartment of Neonatology, Carmel Medical CenterHaifa, Israel;Rappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsrael
,
Karen Lavie-NevoDepartment of Neonatology, Carmel Medical CenterHaifa, Israel;Rappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsrael
,
Marcelo GolzmanRappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsrael;Department of Pharmacy, Carmel Medical Center HaifaIsrael
,
Avraham LorberRappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsrael;Pediatric Cardiology Institute, Meyer Children's Hospital, Rambam Health Care Campus HaifaIsrael
&
Avi RotschildDepartment of Neonatology, Carmel Medical CenterHaifa, Israel;Rappaport School of Medicine, Technion – Israel Institute of Technology HaifaIsrael
Pages 1719-1721 | Received 23 Aug 2013, Accepted 30 Nov 2013, Published online: 07 Feb 2014

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L. A. Dowd, B. J. Wheeler, H. S. Al-Sallami, R. S. Broadbent, L. K. Edmonds & N. J. Medlicott. (2019) Paracetamol treatment for patent ductus arteriosus: practice and attitudes in Australia and New Zealand. The Journal of Maternal-Fetal & Neonatal Medicine 32:18, pages 3039-3044.
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Laura Cuzzolin, Flamina Bardanzellu & Vassilios Fanos. (2018) The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution?. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 855-868.
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Articles from other publishers (34)

Samaher Al-Shaibi, Dina Abushanab, Fouad Abounahia, Ahmed Awaisu & Daoud Al-Badriyeh. (2023) Cost-Effectiveness Analysis of Ibuprofen Versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates. Current Problems in Cardiology 48:9, pages 101751.
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Bonny Jasani, Souvik Mitra & Prakeshkumar S Shah. (2022) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2022:12.
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Jasmine Cendejas-Hernandez, Joshua T. Sarafian, Victoria G. Lawton, Antara Palkar, Lauren G. Anderson, Vincent Larivière & William Parker. (2022) Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking. European Journal of Pediatrics 181:5, pages 1835-1857.
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Aimann Surak, Amish Jain & Abbas Hyderi. (2022) Different approaches for patent ductus arteriosus in premature infants using acetaminophen. World Journal of Pediatrics 18:4, pages 243-250.
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Reza Bahrami, Aida Ezzatabadi, Nima Mehdizadegan, Hamid Mohammadi, Hamid Amoozgar & Mohammadreza Edraki. (2021) Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?. Italian Journal of Pediatrics 47:1.
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Kannan Sridharan, Eman Al Ansari, Mwila Mulubwa, Arun Prasath Raju, Abdulraoof Al Madhoob, Muna Al Jufairi, Zakariya Hubail, Reem Al Marzooq, Sadeq Jaafar Radhi Hasan & Surulivelrajan Mallaysamy. (2021) Population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant patent ductus arteriosus. European Journal of Pharmaceutical Sciences 167, pages 106023.
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Kannan Sridharan, Muna Al Jufairi, Eman Al Ansari, Reem Al Marzooq, Zakariya Hubail, Sadeq Jaafar Radhi Hasan & Abdulraoof Al Madhoob. (2021) Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. Journal of Clinical Pharmacy and Therapeutics 46:4, pages 1010-1019.
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Clyde J. Wright. (2021) Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. The Journal of Pediatrics 235, pages 264-276.e1.
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Dimitrios Angelis, Rashmin C. Savani, Jawahar Jagarapu, June Hu, Phyllis Wan-Huen & Lina Chalak. (2021) Part I. Mechanisms of actions and metabolism of acetaminophen related to the neonatal brain. Early Human Development 159, pages 105406.
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Manfred Hauben, Stephen Bai, Eric Hung, Kasia Lobello, Charles Tressler & Vincent P. Zucal. (2021) Maternal paracetamol intake and fetal ductus arteriosus constriction/closure: comprehensive signal evaluation using the Austin Bradford Hill criteria. European Journal of Clinical Pharmacology 77:7, pages 1019-1028.
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Maika Manalastas, Fatima Zaheer, Pamela Nicoski, Marc G. Weiss & Sachin Amin. (2021) Acetaminophen Therapy for Persistent Patent Ductus Arteriosus. NeoReviews 22:5, pages e320-e331.
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Ana García-Robles, Ana Gimeno Navarro, María del Mar Serrano Martín, María José Párraga Quiles, Anna Parra Llorca, José Luis Poveda-Andrés, Máximo Vento Torres & Marta Aguar Carrascosa. (2020) Paracetamol vs. Ibuprofen in Preterm Infants With Hemodynamically Significant Patent Ductus Arteriosus: A Non-inferiority Randomized Clinical Trial Protocol. Frontiers in Pediatrics 8.
Crossref
Sean AinsworthSean Ainsworth. 2020. Neonatal Formulary. Neonatal Formulary.
Arne Ohlsson & Prakeshkumar S Shah. (2020) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews 2020:1.
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Tim Schindler, John Smyth, Srinivas Bolisetty, Joanna Michalowski & Kei Lui. (2019) Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants. BMJ Open 9:10, pages e031428.
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Hellmann Adrián Escobar, Gyhill Meneses-Gaviria, Nataly Revelo-Jurado, Julián Felipe Villa-Rosero, Jhon Edison Ijají Piamba, Alexander Burbano-Imbachí & Anuar Alonso Cedeño-Burbano. (2019) Tratamiento farmacológico del conducto arterioso permeable en recién nacidos prematuros. Revista de la Facultad de Medicina 67:2, pages 333-339.
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Tim Hundscheid, Wes Onland, Bart van Overmeire, Peter Dijk, Anton H. L. C. van Kaam, Koen P. Dijkman, Elisabeth M. W. Kooi, Eduardo Villamor, André A. Kroon, Remco Visser, Daniel C. Vijlbrief, Susanne M. de Tollenaer, Filip Cools, David van Laere, Anne-Britt Johansson, Catheline Hocq, Alexandra Zecic, Eddy Adang, Rogier Donders, Willem de Vries, Arno F. J. van Heijst & Willem P. de Boode. (2018) Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial). BMC Pediatrics 18:1.
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Maria Gillam-Krakauer & Jeff Reese. (2018) Diagnosis and Management of Patent Ductus Arteriosus. NeoReviews 19:7, pages e394-e402.
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Alona Bin-Nun, Daniel Fink, Francis B. Mimouni, Nurit Algur & Cathy Hammerman. (2018) Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study. The Journal of Pediatrics 198, pages 304-307.
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B. Jasani, D.E. Weisz & P.J. McNamara. (2018) Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants. Seminars in Perinatology 42:4, pages 243-252.
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Arne Ohlsson & Prakeshkumar S Shah. (2018) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database of Systematic Reviews.
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Carlo Dani, Chiara Poggi, Ilaria Cianchi, Iuri Corsini, Venturella Vangi & Simone Pratesi. (2018) Effect on cerebral oxygenation of paracetamol for patent ductus arteriosus in preterm infants. European Journal of Pediatrics 177:4, pages 533-539.
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Ines Tofe, Maria Dolores Ruiz-González, Maria Dolores Cañete, Asuncion Pino, Rosa Lorena Rueda, Maria Jose Parraga & Juan Luis Perez-Navero. (2018) Efficacy of Paracetamol in Closure of Ductus Arteriosus in Infants under 32 Weeks of Gestation. Frontiers in Pediatrics 6.
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Clarissa de Albuquerque Botura, Bruno Ambrósio da Rocha, Thiely Balensiefer, Franciele Queiroz Ames, Ciomar Aparecida Bersani-Amado & Roberto Kenji Nakamura Cuman. (2017) Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions. Asian Pacific Journal of Tropical Medicine 10:11, pages 1080-1083.
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Carlo Dani, Chiara Poggi, Fabio Mosca, Federico Schena, Gianluca Lista, Luca Ramenghi, Costantino Romagnoli, Enrica Salvatori, Maria Teresa Rosignoli, Paola Lipone & Alessandro Comandini. (2016) Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial. Trials 17:1.
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D E Weisz, F F Martins, L E Nield, A El-Khuffash, A Jain & P J McNamara. (2016) Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus. Journal of Perinatology 36:8, pages 649-653.
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Sindhu Sivanandan & Ramesh Agarwal. (2016) Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration. Pediatric Drugs 18:2, pages 123-138.
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Gianluca Terrin, Francesca Conte, Mehmet Yekta Oncel, Antonella Scipione, Patrick J McNamara, Sinno Simons, Rahul Sinha, Omer Erdeve, Kadir S Tekgunduz, Mustafa Dogan, Irena Kessel, Cathy Hammerman, E Nadir, Sadik Yurttutan, Bonny Jasani, Serdar Alan, Francesco Manguso & Mario De Curtis. (2016) Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of Disease in Childhood - Fetal and Neonatal Edition 101:2, pages F127-F136.
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Hannes Sallmon, Petra Koehne & Georg Hansmann. (2016) Recent Advances in the Treatment of Preterm Newborn Infants with Patent Ductus Arteriosus. Clinics in Perinatology 43:1, pages 113-129.
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Daniëlla W. E. Roofthooft, Ingrid M. van Beynum, Johan C. A. de Klerk, Monique van Dijk, John N. van den Anker, Irwin K. M. Reiss, Dick Tibboel & Sinno H. P. Simons. (2015) Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure. European Journal of Pediatrics 174:11, pages 1433-1440.
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Kadir Şerafettin Tekgündüz, Naci Ceviz, İbrahim Caner, Haşim Olgun, Yaşar Demirelli, Canan Yolcu, İrfan Oğuz Şahin & Mustafa Kara. (2014) Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants. Cardiology in the Young 25:6, pages 1060-1064.
Crossref
Arne Ohlsson & Prakeshkumar S Shah. (2015) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants. Cochrane Database of Systematic Reviews.
Crossref
Jennifer Le, Mark A. Gales & Barry J. Gales. (2014) Acetaminophen for Patent Ductus Arteriosus. Annals of Pharmacotherapy 49:2, pages 241-246.
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. (2014) Paracetamol. Reactions Weekly 1525:1, pages 95-95.
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