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The Journal of Maternal-Fetal & Neonatal Medicine Volume 29, 2016 - Issue 5
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Original Article

The metabolomics of necrotising enterocolitis in preterm babies: an exploratory study

Amy WilcockFaculty of Medical and Human Sciences, University of Manchester, Manchester, UK,
,
Paul BegleyFaculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK, ;Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK,
,
Adam StevensFaculty of Medical and Human Sciences, Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK, ;Manchester Academic Health Sciences Centre (MAHSC), Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK, and
,
Andrew WhatmoreFaculty of Medical and Human Sciences, Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK, ;Manchester Academic Health Sciences Centre (MAHSC), Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK, and
&
Suresh VictorFaculty of Medical and Human Sciences, Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK, ;Manchester Academic Health Sciences Centre (MAHSC), Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK, and ;Neonatology Center of Excellence, Sidra Medical and Research Center, Doha, QatarCorrespondence[email protected]
Pages 758-762 | Received 10 Sep 2014, Accepted 05 Feb 2015, Published online: 19 Mar 2015

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Lauren C Beck, Claire L Granger, Andrea C Masi & Christopher J Stewart. (2021) Use of omic technologies in early life gastrointestinal health and disease: from bench to bedside. Expert Review of Proteomics 18:4, pages 247-259.
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Bhawan Deep Garg, Deepak Sharma & Anju Bansal. (2018) Biomarkers of necrotizing enterocolitis: a review of literature. The Journal of Maternal-Fetal & Neonatal Medicine 31:22, pages 3051-3064.
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Angelica Dessì, Roberta Pintus, Silvia Marras, Flaminia Cesare Marincola, Anna De Magistris & Vassilios Fanos. (2016) Metabolomics in necrotizing enterocolitis: the state of the art. Expert Review of Molecular Diagnostics 16:10, pages 1053-1058.
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Articles from other publishers (27)

George S. Bethell & Nigel J. Hall. (2023) Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach. Frontiers in Pediatrics 11.
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Nicholas D. Embleton, Thomas Sproat, Sabita Uthaya, Gregory R. Young, Shalabh Garg, Vimal Vasu, Andrea C. Masi, Lauren Beck, Neena Modi, Christopher J. Stewart & Janet E. Berrington. (2023) Effect of an Exclusive Human Milk Diet on the Gut Microbiome in Preterm Infants. JAMA Network Open 6:3, pages e231165.
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Tyler Leiva, Shiloh Lueschow, Kathryn Burge, Christa Devette, Steven McElroy & Hala Chaaban. (2023) Biomarkers of necrotizing enterocolitis in the era of machine learning and omics. Seminars in Perinatology 47:1, pages 151693.
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James J. Ashton, Aneurin Young, Mark J. Johnson & R. Mark Beattie. (2022) Using machine learning to impact on long-term clinical care: principles, challenges, and practicalities. Pediatric Research 93:2, pages 324-333.
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Fusheng Wang, Guanghuan Wang, Weizhong Li, Chenbin Xu, Zailin Zeng & Yongcui Zhou. (2022) Analysis of serum metabolism in premature infants before and after feeding using GC–MS and the relationship with necrotizing enterocolitis. Biomedical Chromatography 37:1.
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N. Deianova, S. el Manouni el Hassani, E. A. Struijs, E. E. W. Jansen, A. Bakkali, M. A. van de Wiel, W. P. de Boode, C. V. Hulzebos, A. H. van Kaam, B. W. Kramer, E. d’Haens, D. C. Vijlbrief, M. M. van Weissenbruch, W. J. de Jonge, M. A. Benninga, H. J. Niemarkt, N. K. H. de Boer & T. G. J. de Meij. (2022) Fecal amine metabolite analysis before onset of severe necrotizing enterocolitis in preterm infants: a prospective case–control study. Scientific Reports 12:1.
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Laura Moschino, Giovanna Verlato, Miriam Duci, Maria Elena Cavicchiolo, Silvia Guiducci, Matteo Stocchero, Giuseppe Giordano, Francesco Fascetti Leon & Eugenio Baraldi. (2022) The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review. Nutrients 14:18, pages 3859.
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Agathi Thomaidou, Olga Deda, Olga Begou, Artemis Lioupi, Angeliki Kontou, Helen Gika, Eleni Agakidou, Georgios Theodoridis & Kosmas Sarafidis. (2022) A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis. Journal of Clinical Medicine 11:18, pages 5270.
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Victoria L. Renwick & Christopher J. Stewart. (2021) Exploring functional metabolites in preterm infants. Acta Paediatrica 111:1, pages 45-53.
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Jean-Charles Picaud, Anna De Magistris, Michele Mussap, Sara Corbu, Angelica Dessì, Antonio Noto, Vassilios Fanos & Flaminia Cesare Marincola. (2021) Urine NMR Metabolomics Profile of Preterm Infants With Necrotizing Enterocolitis Over the First Two Months of Life: A Pilot Longitudinal Case-Control Study. Frontiers in Molecular Biosciences 8.
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Yan-Nan Jiang, Yong-Xin Ye, Per Torp Sangild, Thomas Thymann, Søren Balling Engelsen, Bekzod Khakimov & Ping-Ping Jiang. (2021) Plasma Metabolomics to Evaluate Progression of Necrotising Enterocolitis in Preterm Pigs. Metabolites 11:5, pages 283.
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Alessandra Coscia, Flaminia Bardanzellu, Elisa Caboni, Vassilios Fanos & Diego Giampietro Peroni. (2021) When a Neonate Is Born, So Is a Microbiota. Life 11:2, pages 148.
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Eleni Agakidou, Charalampos Agakidis, Helen Gika & Kosmas Sarafidis. (2020) Emerging Biomarkers for Prediction and Early Diagnosis of Necrotizing Enterocolitis in the Era of Metabolomics and Proteomics. Frontiers in Pediatrics 8.
Crossref
Mohan Pammi, Isabelle G. De Plaen & Akhil Maheshwari. (2020) Recent Advances in Necrotizing Enterocolitis Research. Clinics in Perinatology 47:2, pages 383-397.
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Fusheng Wang, Weizhong Li, Guanghuan Wang, Menglu Yu, Jun Zhong, Chenbin Xu, Danli Li & Yongcui Zhou. (2019) Gas chromatography-mass spectrometry based serum metabolic analysis for premature infants and the relationship with necrotizing enterocolitis: a cross-sectional study. Italian Journal of Pediatrics 45:1.
Crossref
Tatyana N. Shishkina, I. E. Smirnov, A. G. Kucherenko, Yu. I. Kucherov & M. G. Rekhviashvili. (2019) Serum calprotectin, C-reactive protein and procalcitonin in preterm infants with necrotizing enterocolitis. Russian Pediatric Journal 19:4, pages 217-222.
Crossref
Lee Call, Barbara Stoll, Berthe Oosterloo, Nadim Ajami, Fariha Sheikh, Anja Wittke, Rosaline Waworuntu, Brian Berg, Joseph Petrosino, Oluyinka Olutoye & Douglas Burrin. (2018) Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC. Microbiome 6:1.
Crossref
Josef Neu & Mohan Pammi. (2018) Necrotizing enterocolitis: The intestinal microbiome, metabolome and inflammatory mediators. Seminars in Fetal and Neonatal Medicine 23:6, pages 400-405.
Crossref
Darla R. Shores & Allen D. Everett. (2018) Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers. The Journal of Pediatrics 193, pages 14-20.e31.
Crossref
Christopher J. Stewart, Nicholas D. Embleton, Emma C. L. Marrs, Daniel P. Smith, Tatiana Fofanova, Andrew Nelson, Tom Skeath, John D. Perry, Joseph F. Petrosino, Janet E. Berrington & Stephen P. Cummings. (2017) Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls. Microbiome 5:1.
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Ying Yao, Valentin Voillet, Maeva Jegou, Magali SanCristobal, Samir Dou, Véronique Romé, Yannick Lippi, Yvon Billon, Marie-Christine Père, Gaëlle Boudry, Laure Gress, Nathalie Iannucelli, Pierre Mormède, Hélène Quesnel, Laurianne Canario, Laurence Liaubet & Isabelle Le Huërou-Luron. (2017) Comparing the intestinal transcriptome of Meishan and Large White piglets during late fetal development reveals genes involved in glucose and lipid metabolism and immunity as valuable clues of intestinal maturity. BMC Genomics 18:1.
Crossref
Brigida Rusconi, Misty Good & Barbara B. Warner. (2017) The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?. The Journal of Pediatrics 189, pages 40-47.e2.
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Margaret Gilfillan & Vineet Bhandari. (2017) Biomarkers for the diagnosis of neonatal sepsis and necrotizing enterocolitis: Clinical practice guidelines. Early Human Development 105, pages 25-33.
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Jean-Charles Picaud. 2017. Bases Scientifiques en Néonatologie. Bases Scientifiques en Néonatologie 499 515 .
Christopher J. Stewart, Nicholas D. Embleton, Emma C. L. Marrs, Daniel P. Smith, Andrew Nelson, Bashir Abdulkadir, Tom Skeath, Joseph F. Petrosino, John D. Perry, Janet E. Berrington & Stephen P. Cummings. (2016) Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease. Microbiome 4:1.
Crossref
Christopher J Stewart, Andrew Nelson, Achim Treumann, Tom Skeath, Stephen P Cummings, Nicholas D Embleton & Janet E Berrington. (2015) Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis. Pediatric Research 79:3, pages 425-431.
Crossref
. 2016. Metabolomics and Microbiomics. Metabolomics and Microbiomics 107 124 .

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