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Original Article

Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD)

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Pages 855-862 | Received 29 Dec 2014, Accepted 22 Feb 2015, Published online: 20 Apr 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Michael J. Kupferminc, Chagit Kliger, Eli Rimon, Jessica Asher-Landsberg, Avital Skornick-Rapaport, Ronni Gamzu & Yariv Yogev. (2022) Pravastatin is useful for prevention of recurrent severe placenta-mediated complications – a pilot study. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 8055-8061.
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Tinnakorn Chaiworapongsa, Roberto Romero, Steven J. Korzeniewski, Piya Chaemsaithong, Edgar Hernandez-Andrade, James H. Segars, Alan H. DeCherney, M. Cathleen McCoy, Chong Jai Kim, Lami Yeo & Sonia S. Hassan. (2017) Pravastatin for the prevention of adverse pregnancy outcome: preeclampsia and more?. The Journal of Maternal-Fetal & Neonatal Medicine 30:1, pages 3-3.
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Articles from other publishers (39)

Meryam Cheloufi, Aurore Coulomb, Noémie Abisror, Gilles Kayem, Olivier Fain, Jaume Alijotas-Reig & Arsène Mekinian. (2024) Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment. European Journal of Obstetrics & Gynecology and Reproductive Biology 292, pages 125-132.
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Maged M. Costantine, Rebecca G. Clifton, Trisha M. Boekhoudt, Kirsten Lawrence, Cynthia Gyamfi-Bannerman, Katherine L. Wisner, William Grobman, Steve N. Caritis, Hyagriv N. Simhan, Mary F. Hebert, Monica Longo & George R. Saade. (2023) Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero. American Journal of Obstetrics and Gynecology 229:2, pages 153.e1-153.e12.
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Andrea Dagelic, Vedran Stefanovic, Jasminka Resic Karara, Ivana Kuzmic Prusac, Damir Roje, Indira Kosovic & Sandra Zekic Tomas. (2023) Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?. Journal of Perinatal Medicine 51:5, pages 607-613.
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Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez & Adi L. Tarca. (2023) Preeclampsia at term can be classified into 2 clusters with different clinical characteristics and outcomes based on angiogenic biomarkers in maternal blood. American Journal of Obstetrics and Gynecology 228:5, pages 569.e1-569.e24.
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Adi L. Tarca, Roberto Romero, Gaurav Bhatti, Francesca Gotsch, Bogdan Done, Dereje W. Gudicha, Dahiana M. Gallo, Eunjung Jung, Roger Pique-Regi, Stanley M. Berry, Tinnakorn Chaiworapongsa & Nardhy Gomez-Lopez. (2022) Human Plasma Proteome During Normal Pregnancy. Journal of Proteome Research 21:11, pages 2687-2702.
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Swati Agrawal, W. Tony Parks, Helen Dehui Zeng, Anjana Ravichandran, Eran Ashwal, Rory C. Windrim, Sebastian R. Hobson, Nir Melamed & John C. Kingdom. (2022) Diagnostic utility of serial circulating placental growth factor levels and uterine artery Doppler waveforms in diagnosing underlying placental diseases in pregnancies at high risk of placental dysfunction. American Journal of Obstetrics and Gynecology 227:4, pages 618.e1-618.e16.
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Roberto Romero, Eunjung Jung, Tinnakorn Chaiworapongsa, Offer Erez, Dereje W. Gudicha, Yeon Mee Kim, Jung-Sun Kim, Bomi Kim, Juan Pedro Kusanovic, Francesca Gotsch, Andreea B. Taran, Bo Hyun Yoon, Sonia S. Hassan, Chaur-Dong Hsu, Piya Chaemsaithong, Nardhy Gomez-Lopez, Lami Yeo, Chong Jai Kim & Adi L. Tarca. (2022) Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology. American Journal of Obstetrics and Gynecology 227:4, pages 615.e1-615.e25.
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Baris Karadas, Nusret Uysal, Hilal Erol, Selin Acar, Meltem Koc, Tijen Kaya‐Temiz, Gideon Koren & Yusuf C. Kaplan. (2022) Pregnancy outcomes following maternal exposure to statins: A systematic review and meta‐analysis. British Journal of Clinical Pharmacology 88:9, pages 3962-3976.
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Jumpei Saito, Kayoko Kaneko, Sawako Abe, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago & Atsuko Murashima. (2021) Pravastatin concentrations in maternal serum, umbilical cord serum, breast milk and neonatal serum during pregnancy and lactation: A case study. Journal of Clinical Pharmacy and Therapeutics 47:5, pages 703-706.
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Emily F. Cornish, Thomas McDonnell & David J. Williams. (2022) Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome. Frontiers in Immunology 13.
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Devin D. Smith & Maged M. Costantine. (2022) The role of statins in the prevention of preeclampsia. American Journal of Obstetrics and Gynecology 226:2, pages S1171-S1181.
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Jill K. Tjon, Phillis Lakeman, Elisabeth Leeuwen, Quinten Waisfisz, Marjan M. Weiss, Gita M. B. Tan‐Sindhunata, Peter G. J. Nikkels, Patrick J. P. Voorn, Gajja S. Salomons, George L. Burchell, Ingeborg H. Linskens, Bloeme J. Knoop & Johanna I. P. Vries. (2021) Fetal akinesia deformation sequence and massive perivillous fibrin deposition resulting in fetal death in six fetuses from one consanguineous couple, including literature review. Molecular Genetics & Genomic Medicine 9:11.
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Sainan Zhang, Jinli Ding, Jiayu Wang, Tailang Yin, Yan Zhang & Jing Yang. (2021) CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion. Frontiers in Immunology 12.
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Drucilla J. Roberts & Carolyn Polizzano. 2021. Atlas of Placental Pathology. Atlas of Placental Pathology 445 474 .
Veena Mangesh Panat. (2021) Massive Perivillous Fibrinoid Degeneration of Placenta/ Maternal Floor Infarct: A Case Report. Journal of Fetal Medicine 8:1, pages 81-84.
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Anita Virtanen, Outi Huttala, Kati Tihtonen, Tarja Toimela, Tuula Heinonen, Hannele Laivuori & Jukka Uotila. (2021) Angiogenic Effect of Pravastatin Alone and with Sera from Healthy and Complicated Pregnancies Studied by in vitro Vasculogenesis/Angiogenesis Assay. Journal of Vascular Research 58:3, pages 139-147.
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Jiawu Zhao, Rebecca P. Chow, Rebecca H. McLeese, Michelle B. Hookham, Timothy J. Lyons & Jeremy Y. Yu. (2020) Modelling preeclampsia: a comparative analysis of the common human trophoblast cell lines. FASEB BioAdvances 3:1, pages 23-35.
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Marwan Ma’ayeh & Maged M. Costantine. (2020) Prevention of preeclampsia. Seminars in Fetal and Neonatal Medicine 25:5, pages 101123.
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Deviana Soraya Riu, Isharyah Sunarno, Efendi Lukas, Ellen T. Wewengkang & Rizki Amalia. (2020) The effect of pravastatin on endothelin-1 levels and pregnancy outcomes in women who have a high risk for preeclampsia: A randomized control trial. Enfermería Clínica 30, pages 499-505.
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Isaac Gibbs, Katherine Leavey, Samantha J. Benton, David Grynspan, Shannon A. Bainbridge & Brian J. Cox. (2019) Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia. American Journal of Obstetrics and Gynecology 220:1, pages 110.e1-110.e21.
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Philip J. Katzman, Linda M. Ernst & Irene B. Scheimberg. 2019. Pathology of the Placenta. Pathology of the Placenta 77 82 .
Wanda Gajzlerska-Majewska, Dorota A. Bomba-Opon & Miroslaw Wielgos. (2018) Is pravastatin a milestone in the prevention and treatment of preeclampsia?. Journal of Perinatal Medicine 46:8, pages 825-831.
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Athena Chen & Drucilla J. Roberts. (2018) Placental pathologic lesions with a significant recurrence risk - what not to miss!. APMIS 126:7, pages 589-601.
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Mai He, Alison Migliori, Nisreen S Maari & Niharika D Mehta. (2017) Follow-up and management of recurrent pregnancy losses due to massive perivillous fibrinoid deposition. Obstetric Medicine 11:1, pages 17-22.
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Jing Huai, Zi Yang, Yan-Hong Yi & Guang-Jiao Wang. (2018) Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models. Chinese Medical Journal 131:4, pages 461-470.
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Ona Faye-Petersen, Adrienne Sauder, Ydamis Estrella & Debra S. Heller. (2017) Dichorionic Twins Discordant for Massive Perivillous Fibrinoid Deposition: Report of a Case and Review of the Literature. International Journal of Surgical Pathology 26:1, pages 41-46.
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John C. Kingdom, Melanie C. Audette, Sebastian R. Hobson, Rory C. Windrim & Eric Morgen. (2018) A placenta clinic approach to the diagnosis and management of fetal growth restriction. American Journal of Obstetrics and Gynecology 218:2, pages S803-S817.
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Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Natàlia Gil-Aliberas, Antònia Baraldès-Farré, Elisa Llurba & Jaume Alijotas-Reig. (2018) Pravastatin for Preventing and Treating Preeclampsia: A Systematic Review. Obstetrical & Gynecological Survey 73:1, pages 40-55.
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Tinnakorn Chaiworapongsa, Roberto Romero, Offer Erez, Adi L. Tarca, Agustin Conde-Agudelo, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S. Hassan, Lami Yeo & Steven J. Korzeniewski. (2017) The prediction of fetal death with a simple maternal blood test at 24-28 weeks: a role for angiogenic index-1 (PlGF/sVEGFR-1 ratio). American Journal of Obstetrics and Gynecology 217:6, pages 682.e1-682.e13.
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Kia Lannaman, Roberto Romero, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Steven J. Korzeniewski, Eli Maymon, Nardhy Gomez-Lopez, Bogdan Panaitescu, Sonia S. Hassan, Lami Yeo, Bo Hyun Yoon, Chong Jai Kim & Offer Erez. (2017) Fetal death: an extreme manifestation of maternal anti-fetal rejection. Journal of Perinatal Medicine 45:7, pages 851-868.
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Sahar Abdulghani, Felipe Moretti, Andree Gruslin & David Grynspan. (2017) Recurrent Massive Perivillous Fibrin Deposition and Chronic Intervillositis Treated With Heparin and Intravenous Immunoglobulin: A Case Report. Journal of Obstetrics and Gynaecology Canada 39:8, pages 676-681.
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Roberto Romero, Offer Erez, Eli Maymon, Piya Chaemsaithong, Zhonghui Xu, Percy Pacora, Tinnakorn Chaiworapongsa, Bogdan Done, Sonia S. Hassan & Adi L. Tarca. (2017) The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study. American Journal of Obstetrics and Gynecology 217:1, pages 67.e1-67.e21.
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Drucilla J. Roberts. 2018. Placental and Gestational Pathology. Placental and Gestational Pathology 181 187 .
CAROLINE C. MARRS & MAGED M. COSTANTINE. (2017) Should We Add Pravastatin to Aspirin for Preeclampsia Prevention in High-risk Women?. Clinical Obstetrics & Gynecology 60:1, pages 161-168.
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Douglas B. Kell & Louise C. Kenny. (2016) A Dormant Microbial Component in the Development of Preeclampsia. Frontiers in Medicine 3.
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Maged M. Costantine. (2016) Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome. Journal of Clinical Investigation 126:8, pages 2792-2794.
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Eleftheria Lefkou, Apostolos Mamopoulos, Themistoklis Dagklis, Christos Vosnakis, David Rousso & Guillermina Girardi. (2016) Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy. Journal of Clinical Investigation 126:8, pages 2933-2940.
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Steven J. Korzeniewski, Roberto Romero, Tinnakorn Chaiworapongsa, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S. Hassan & Lami Yeo. (2016) Maternal plasma angiogenic index-1 (placental growth factor/soluble vascular endothelial growth factor receptor-1) is a biomarker for the burden of placental lesions consistent with uteroplacental underperfusion: a longitudinal case-cohort study. American Journal of Obstetrics and Gynecology 214:5, pages 629.e1-629.e17.
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Stefan Kostadinov, Karen A. Robbins & Anthony Hayward. (2016) Abnormal TREC-Based Newborn Screening Test in a Premature Neonate with Massive Perivillous Fibrin Deposition of the Placenta. Case Reports in Immunology 2016, pages 1-4.
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