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International Journal of Audiology Volume 53, 2014 - Issue 10
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Research Article

Betahistine metabolites, Aminoethylpyridine, and Hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo

Mattis Bertlich *Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Germany;Walter Brendel Centre of Experimental Medicine, University Hospital Munich, Germany
,
Fritz Ihler *Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Germany;Department of Neurology and German Center for Vertigo and Balance Disorders, University Hospital Munich, Germany;Walter Brendel Centre of Experimental Medicine, University Hospital Munich, Germany
,
Kariem SharafWalter Brendel Centre of Experimental Medicine, University Hospital Munich, Germany
,
Bernhard G. Weiss *Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Germany
,
Michael StruppDepartment of Neurology and German Center for Vertigo and Balance Disorders, University Hospital Munich, Germany
&
Martin Canis *Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Germany;Department of Neurology and German Center for Vertigo and Balance Disorders, University Hospital Munich, Germany;Walter Brendel Centre of Experimental Medicine, University Hospital Munich, GermanyCorrespondence[email protected]
Pages 753-759 | Received 16 Jan 2014, Accepted 14 Apr 2014, Published online: 11 Jul 2014

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Juan Manuel Espinosa-Sanchez & José A. Lopez-Escamez. (2020) The pharmacological management of vertigo in Meniere disease. Expert Opinion on Pharmacotherapy 21:14, pages 1753-1763.
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Articles from other publishers (19)

Lingyi Kong, Ewa Domarecka & Agnieszka J. Szczepek. (2023) Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review. Brain Sciences 13:7, pages 1101.
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Benjamin Philipp Ernst, Ulf-Rüdiger Heinrich, Mathias Fries, Regina Meuser, Tobias Rader, Jonas Eckrich, Roland H. Stauber & Sebastian Strieth. (2023) Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs. Frontiers in Cellular Neuroscience 17.
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Benedikt Kloos, Mattis Bertlich, Jennifer L. Spiegel, Saskia Freytag, Susanne K. Lauer, Martin Canis, Bernhard G. Weiss & Friedrich Ihler. (2022) Low Dose Betahistine in Combination With Selegiline Increases Cochlear Blood Flow in Guinea Pigs. Annals of Otology, Rhinology & Laryngology 132:5, pages 519-526.
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Bernhard G. Weiss, Saskia Freytag, Benedikt Kloos, Frank Haubner, Kariem Sharaf, Jennifer Lee Spiegel, Martin Canis, Friedrich Ihler & Mattis Bertlich. (2021) Cannabinoid Receptor 2 Agonism is Capable of Preventing Lipopolysaccharide Induced Decreases of Cochlear Microcirculation – A Potential Approach for Inner Ear Pathologies. Otology & Neurotology 42:9, pages e1396-e1401.
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Friedrich Ihler, Saskia Freytag, Benedikt Kloos, Jennifer Lee Spiegel, Frank Haubner, Martin Canis, Bernhard G. Weiss & Mattis Bertlich. (2021) Lipopolysaccharide decreases cochlear blood flow dose dependently in a guinea pig animal model via TNF signaling. Microcirculation 28:4.
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Gregory J. Basura, Meredith E. Adams, Ashkan Monfared, Seth R. Schwartz, Patrick J. Antonelli, Robert Burkard, Matthew L. Bush, Julie Bykowski, Maria Colandrea, Jennifer Derebery, Elizabeth A. Kelly, Kevin A. Kerber, Charles F. Koopman, Amy Angie Kuch, Evie Marcolini, Brian J. McKinnon, Michael J. Ruckenstein, Carla V. Valenzuela, Alexis Vosooney, Sandra A. Walsh, Lorraine C. Nnacheta, Nui Dhepyasuwan & Erin M. Buchanan. (2020) Clinical Practice Guideline: Ménière’s Disease. Otolaryngology–Head and Neck Surgery 162:S2.
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Martin Canis & Mattis Bertlich. 2019. Pericyte Biology in Different Organs. Pericyte Biology in Different Organs 115 123 .
V. Kirsch, B. Ertl-Wagner, A. Berman, J. Gerb, M. Dieterich & S. Becker-Bense. (2018) High-resolution MRI of the inner ear enables syndrome differentiation and specific treatment of cerebellar downbeat nystagmus and secondary endolymphatic hydrops in a postoperative ELST patient. Journal of Neurology 265:S1, pages 48-50.
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Brahim Tighilet, Jacques Léonard, Isabelle Watabe, Laurence Bernard-Demanze & Michel Lacour. (2018) Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches. Frontiers in Neurology 9.
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Flóra Jozefíková, Milan Mazúr, Miroslava Puchoňová & Dušan Valigura. (2018) Nitrosalicylatocopper(II) complexes with chelating pyridine derivatives. Acta Chimica Slovaca 11:1, pages 21-25.
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S. K. Zyryanov, O. I. Butranova, G. V. Ramenskaya, G. N. Gildeeva & I. E. Shohin. (2018) In vitro equivalence evaluation of betahistine generic medicinal products as a tool potentially determining the efficacy of pharmacotherapy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 118:11, pages 43.
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Mattis Bertlich, Friedrich Ihler, Bernhard G. Weiss, Saskia Freytag, Michael Strupp & Martin Canis. (2017) Cochlear Pericytes Are Capable of Reversibly Decreasing Capillary Diameter In Vivo After Tumor Necrosis Factor Exposure. Otology & Neurotology 38:10, pages e545-e550.
Crossref
Mattis Bertlich, Friedrich Ihler, Bernhard G. Weiss, Saskia Freytag, Michael Strupp, Mark Jakob & Martin Canis. (2017) Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model. Life Sciences 187, pages 17-21.
Crossref
Mattis Bertlich, Friedrich Ihler, Bernhard G. Weiss, Saskia Freytag, Mark Jakob, Michael Strupp, Hannah Pellkofer & Martin Canis. (2017) Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. Otology & Neurotology 38:8, pages 1213-1216.
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J.M. Espinosa-Sanchez & J.A. Lopez-Escamez. 2016. Neuro-Otology. Neuro-Otology 257 277 .
M. Strupp, M. Dieterich, A. Zwergal & T. Brandt. (2015) Periphere, zentrale und funktionelle SchwindelsyndromePeripheral, central and functional vertigo syndromes. Der Nervenarzt 86:12, pages 1573-1587.
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Michael Strupp, Andreas Zwergal, Katharina Feil, Tatiana Bremova & Thomas Brandt. (2015) Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research. Annals of the New York Academy of Sciences 1343:1, pages 27-36.
Crossref
Friedrich Ihler, Mattis Bertlich, Bernhard Weiss, Steffen Dietzel & Martin Canis. (2015) Two-Photon Microscopy Allows Imaging and Characterization of Cochlear Microvasculature In Vivo. BioMed Research International 2015, pages 1-8.
Crossref
Michael Strupp. (2014) Schwindel, Nystagmus und zerebelläre Ataxien. CME 11:12, pages 5-15.
Crossref

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