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Journal of Pain & Palliative Care Pharmacotherapy Volume 24, 2010 - Issue 4
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Dexmedetomidine: Exploring Its Potential Role and Dosing Guideline for Its Use in Intractable Pain in the Palliative Care Setting

Patrick J. Coyne Patrick J Coyne, MSN, APRN, FAAN, is Clinical Director; Colin Wozencraft, MD, is a Fellow in Palliative Medicine; Barton Bobb, NP, is an Advanced Practice Nurse; and Thomas J. Smith, MD, is Medical Director, Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. Seth Roberts, MD, PhD, is a physician on the Palliative Medicine Service at Bon Secours Richmond Health System, Richmond, Virginia, USA.
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Colin P. Wozencraft Patrick J Coyne, MSN, APRN, FAAN, is Clinical Director; Colin Wozencraft, MD, is a Fellow in Palliative Medicine; Barton Bobb, NP, is an Advanced Practice Nurse; and Thomas J. Smith, MD, is Medical Director, Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. Seth Roberts, MD, PhD, is a physician on the Palliative Medicine Service at Bon Secours Richmond Health System, Richmond, Virginia, USA.
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Seth B. Roberts Patrick J Coyne, MSN, APRN, FAAN, is Clinical Director; Colin Wozencraft, MD, is a Fellow in Palliative Medicine; Barton Bobb, NP, is an Advanced Practice Nurse; and Thomas J. Smith, MD, is Medical Director, Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. Seth Roberts, MD, PhD, is a physician on the Palliative Medicine Service at Bon Secours Richmond Health System, Richmond, Virginia, USA.
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Barton Bobb Patrick J Coyne, MSN, APRN, FAAN, is Clinical Director; Colin Wozencraft, MD, is a Fellow in Palliative Medicine; Barton Bobb, NP, is an Advanced Practice Nurse; and Thomas J. Smith, MD, is Medical Director, Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. Seth Roberts, MD, PhD, is a physician on the Palliative Medicine Service at Bon Secours Richmond Health System, Richmond, Virginia, USA.
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Thomas J. Smith Patrick J Coyne, MSN, APRN, FAAN, is Clinical Director; Colin Wozencraft, MD, is a Fellow in Palliative Medicine; Barton Bobb, NP, is an Advanced Practice Nurse; and Thomas J. Smith, MD, is Medical Director, Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA. Seth Roberts, MD, PhD, is a physician on the Palliative Medicine Service at Bon Secours Richmond Health System, Richmond, Virginia, USA.
Pages 384-386 | Received 17 Aug 2010, Accepted 20 Aug 2010, Published online: 06 Dec 2010

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Jennifer M. Byrne, Paula Mesarwi, Kyle P. Edmonds & Rabia S. Atayee. (2022) Dexmedetomidine Continuous Infusion for Refractory Cancer Pain at End of Life: A Case Report. Journal of Pain & Palliative Care Pharmacotherapy 36:3, pages 200-206.
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Rana Yamout, Marcel-Louis Viallard, Samer Hoteit, Hicham Abou-Zeid, Fadia Shebbo & Nicole Naccache. (2021) Does the addition of dexmedetomidine to morphine have any clinical benefit on the treatment of pain in patients with metastatic cancer? A pilot study. Progress in Palliative Care 29:5, pages 272-277.
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Russell Jeffrey Seymore, Melanie M. Manis & Patrick J. Coyne. (2019) Dexmedetomidine Use in a Case of Severe Cancer Pain. Journal of Pain & Palliative Care Pharmacotherapy 33:1-2, pages 34-41.
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John Bodnar. (2017) A Review of Agents for Palliative Sedation/Continuous Deep Sedation: Pharmacology and Practical Applications. Journal of Pain & Palliative Care Pharmacotherapy 31:1, pages 16-37.
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Articles from other publishers (14)

Chloé Prod'homme, Xavier Werbrouck, Magali Pierrat, Luc Chevalier, Helene Lesaffre, Claire Pasqualini & Licia Touzet. (2023) Dexmedetomidine and clonidine in palliative medicine: multicentric qualitative evaluation. BMJ Supportive & Palliative Care, pages spcare-2023-004193.
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Rafael Lemus, Natalie L. Jacobowski, Lisa Humphrey & Joseph D. Tobias. (2022) Applications of Dexmedetomidine in Palliative and Hospice Care. The Journal of Pediatric Pharmacology and Therapeutics 27:7, pages 587-594.
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Yayun Lu, Yaping Gu, Lihua Liu, Xuefeng Tang, Qing Xia & Zhiyue Xu. (2021) Intravenous Dexmedetomidine Administration Prior Anesthesia Induction With Propofol at 4°C Attenuates Propofol Injection Pain: A Double-Blind, Randomized, Placebo-Controlled Trial. Frontiers in Medicine 8.
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Mara Lacy HofherrJanet L. AbrahmElizabeth Rickerson. (2020) Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life. Journal of Palliative Medicine 23:11, pages 1515-1517.
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Charles T. MupamombeDebra LuczkiewiczChristopher Kerr. (2019) Dexmedetomidine as an Option for Opioid Refractory Pain in the Hospice Setting. Journal of Palliative Medicine 22:11, pages 1478-1481.
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Rachel ThienprayoonMark MeyerHilary FlintNorbert WeidnerRussel Hirsch. (2019) Use of Continuous Dexmedetomidine at Home for Nearly Three Years in a Young Woman with End-Stage Cyanotic Congenital Heart Disease and Cyclic Vomiting. Journal of Palliative Medicine 22:10, pages 1289-1292.
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Robert Twycross. (2019) Reflections on palliative sedation. Palliative Care: Research and Treatment 12, pages 117822421882351.
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Julien Cobert, Jennifer Hauck, Ellen Flanagan, Nancy Knudsen & Anthony Galanos. (2018) Anesthesia-Guided Palliative Care in the Perioperative Surgical Home Model. Anesthesia & Analgesia 127:1, pages 284-288.
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Jamie BurnsKevin JacksonKathy A. SheehyJulia C. FinkelZenaide M. Quezado. (2017) The Use of Dexmedetomidine in Pediatric Palliative Care: A Preliminary Study. Journal of Palliative Medicine 20:7, pages 779-783.
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Neil Hilliard, Stuart Brown & Steve Mitchinson. (2014) A case report of dexmedetomidine used to treat intractable pain and delirium in a tertiary palliative care unit. Palliative Medicine 29:3, pages 278-281.
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Joseph D. Tobias. 2015. Pediatric Sedation Outside of the Operating Room. Pediatric Sedation Outside of the Operating Room 275 328 .
David P. Reardon, Kevin E. Anger, Christopher D. Adams & Paul M. Szumita. (2013) Role of dexmedetomidine in adults in the intensive care unit: An update. American Journal of Health-System Pharmacy 70:9, pages 767-777.
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Keira P. Mason & Jerrold Lerman. (2011) Dexmedetomidine in Children. Anesthesia & Analgesia 113:5, pages 1129-1142.
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C. A. HuxtableL. J. RobertsA. A. SomogyiP. E. Macintyre. (2011) Acute Pain Management in Opioid-Tolerant Patients: A Growing Challenge. Anaesthesia and Intensive Care 39:5, pages 804-823.
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