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Research Article

Safety and toxicological evaluation of Aflapin®: A novel Boswellia-derived anti-inflammatory product

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Pages 556-563 | Received 13 Apr 2010, Accepted 15 May 2010, Published online: 29 Sep 2010

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Eda Becer, Hilal Kabadayı, K. Hüsnü Can Başer & Hafize Seda Vatansever. (2021) Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure. Journal of Essential Oil Research 33:1, pages 53-62.
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Zhiqiang Wang, Ambrish Singh, Graeme Jones, Dawn Aitken, Laura L Laslett, Salman Hussain, Pablo García-Molina, Changhai Ding & Benny Antony. (2022) Boswellia for osteoarthritis. Cochrane Database of Systematic Reviews 2022:10.
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Amy M. Zimmermann-Klemd, Jakob K. Reinhardt, Moritz Winker & Carsten Gründemann. (2022) Phytotherapy in Integrative Oncology—An Update of Promising Treatment Options. Molecules 27:10, pages 3209.
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Thomas Efferth & Franz Oesch. (2022) Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities. Seminars in Cancer Biology 80, pages 39-57.
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Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Paola Manini, Fabiola Pizzo & Birgit Dusemund. (2022) Safety and efficacy of a feed additive consisting of an extract of olibanum from Boswellia serrata Roxb. ex Colebr. for use in dogs and horses (FEFANA asbl). EFSA Journal 20:3.
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Adel A. Gomaa, Hanan A. Farghaly, Yasmin A. Abdel-Wadood & Ghada A. Gomaa. (2021) Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer’s disease. Naunyn-Schmiedeberg's Archives of Pharmacology 394:11, pages 2167-2185.
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Adel A. Gomaa, Hamdy S. Mohamed, Rasha Bakheet Abd-ellatief & Mohamed A. Gomaa. (2021) Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly. Inflammopharmacology 29:4, pages 1033-1048.
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Théo Brillatz, Maxime Jacmin, Emerson F. Queiroz, Laurence Marcourt, Hugo Morin, Nargess Shahbazi, Nathalie Boulens, Antonella Riva, Alexander D. Crawford, Eric Allémann & Jean-Luc Wolfender. (2021) Identification of Potential Antiseizure Agents in Boswellia sacra using In Vivo Zebrafish and Mouse Epilepsy Models . ACS Chemical Neuroscience 12:10, pages 1791-1801.
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Ganpeng Yu, Wang Xiang, Tianqing Zhang, Liuting Zeng, Kailin Yang & Jun Li. (2020) Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies 20:1.
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Erin Miscioscia, Justin Shmalberg & Karen C. Scott. (2019) Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs. BMC Veterinary Research 15:1.
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Venkata Krishnaraju Alluri, Sundararaju Dodda, Eswar Kumar Kilari, Trimurtulu Golakoti & Krishanu Sengupta. (2019) Toxicological Assessment of a Standardized Boswellia serrata Gum Resin Extract . International Journal of Toxicology 38:5, pages 423-435.
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Raju Vaishya, Amit Kumar Agarwal, Amish Shah, Vipul Vijay & Abhishek Vaish. (2018) Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India. Journal of Clinical Orthopaedics and Trauma 9:4, pages 338-348.
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ManojA Suva, DharmeshB Kheni & VarunP Sureja. (2018) Aflapin®: A novel and selective 5-lipoxygenase inhibitor for arthritis management. Indian Journal of Pain 32:1, pages 16.
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Vladimir Badmaev, Hogne Vik, Sidney J Stohs & Frank Galluzzo. (2018) Safety and toxicological evaluation of NXT15906F6 (TamaFlex ® ) . Toxicology Research and Application 2, pages 239784731774924.
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Ding Xia, Weiwei Lou, Kar-Ming Fung, Cole L. Wolley, Mahmoud M. Suhail & Hsueh-Kung Lin. (2016) Cancer Chemopreventive Effects of Boswellia sacra Gum Resin Hydrodistillates on Invasive Urothelial Cell Carcinoma: Report of a Case . Integrative Cancer Therapies 16:4, pages 605-611.
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Neeta .Harish Dureja. (2014) Role of Boswellic Acids in Cancer Treatment. Journal of Medical Sciences 14:6-8, pages 261-269.
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Melainie Cameron & Sigrun Chrubasik. (2014) Oral herbal therapies for treating osteoarthritis. Cochrane Database of Systematic Reviews 2016:4.
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Daniel Leong, Marwa Choudhury, David Hirsh, John Hardin, Neil Cobelli & Hui Sun. (2013) Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis. International Journal of Molecular Sciences 14:11, pages 23063-23085.
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J. Hall & R. Bravo-Clouzet. 2013. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases 619 631 .
Xiao Ni, Mahmoud M Suhail, Qing Yang, Amy Cao, Kar-Ming Fung, Russell G Postier, Cole Woolley, Gary Young, Jingzhe Zhang & Hsueh-Kung Lin. (2012) Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complementary and Alternative Medicine 12:1.
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