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Toxicology Methods Volume 3, 1993 - Issue 4
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Research Article

Interleukin 6 (IL-6) Production by Lymph Node Cells: An Alternative Endpoint for the Murine Local Lymph Node Assay

R. J. Dearman ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
,
J. C. Hope Rheumatic Diseases Centre, Hope Hospital, Salford, UK
,
S. J. Hopkins Rheumatic Diseases Centre, Hope Hospital, Salford, UK
,
R. J. Debicki ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
&
I. Kimber ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
Pages 268-278 | Received 19 Mar 1993, Accepted 03 Jun 1993, Published online: 27 Sep 2008

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Rodney R. Dietert & Alan Hedge. (1996) Toxicological Considerations in Evaluating Indoor Air Quality and Human Health: Impact of New Carpet Emissions. Critical Reviews in Toxicology 26:6, pages 633-707.
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Gregory S. Ladies, Charlene Smith, Karen L. Heaps & Scott E. Loveless. (1995) Comparison of 125-Iododeoxyuridine (125IUdR) and [3H]Thymidine ([3H]TdR) for Assessing Cell Proliferation in the Murine Local Lymph Node Assay. Toxicology Methods 5:3, pages 143-152.
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Articles from other publishers (16)

Olugbenga Shadrak Alebiosu & Olusola Helen Adekanmbi. (2022) Aerofloral studies and allergenicity of dominant pollen types in Taraba and Bauchi States of Northeastern Nigeria. Science of The Total Environment 845, pages 157076.
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O. H. Adekanmbi, O. S. Alebiosu & A. A. Adeiga. (2018) Aerofloral investigation and allergenic potentials of two dominant airborne pollen types at selected sites in South-western Nigeria. Aerobiologia 35:1, pages 27-44.
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A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 927 936 .
David Basketter, Amanda Cockshott, Emanuela Corsini, G. Frank Gerberick, Kenji Idehara, Ian Kimber, Henk Van Loveren, Joanna Matheson, Annette Mehling, Takashi Omori, Costanza Rovida, Takashi SozuMasahiro Takeyoshi & Silvia Casati. (2008) An Evaluation of Performance Standards and Non-radioactive Endpoints for the Local Lymph Node Assay. Alternatives to Laboratory Animals 36:2, pages 243-257.
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D. Bickers, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes, R.L. Smith & H. Tagami. (2005) A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food and Chemical Toxicology 43:6, pages 799-836.
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Ann C.A. De Smedt, Rosette L. Van Den Heuvel, Vigor F.I. Van Tendeloo, Zwi N. Berneman & Greet E.R. Schoeters. (2005) Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitizers and irritants. Toxicology Letters 156:3, pages 377-389.
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Ian Kimber & Rebecca Dearman. 2005. Investigative Immunotoxicology. Investigative Immunotoxicology 291 302 .
Ian Kimber, R. J. Dearman, D. A. Basketter, C. A. Ryan & G. F. Gerberick. (2003) The local lymph node assay: past, present and future. Contact Dermatitis 47:6, pages 315-328.
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Isaak Effendy, Harald L�ffler & Howard I. Maibach. (2000) Epidermal cytokines in murine cutaneous irritant responses. Journal of Applied Toxicology 20:4, pages 335-341.
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R. J. Dearman, D. A. Basketter & I. Kimber. (1999) Local lymph node assay: use in hazard and risk assessment. Journal of Applied Toxicology 19:5, pages 299-306.
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R. J. Dearman, J. Hilton, D. A. Basketter & I. Kimber. (1999) Cytokine endpoints for the local lymph node assay: consideration of interferon-γ and interleukin 12. Journal of Applied Toxicology 19:3, pages 149-135.
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M.R. Holliday, R.J. Dearman, D.A. Basketter & I. Kimber. (1996) Stimulation by oxazolone of increased IL-6, but not IL-10, in the skin of mice. Toxicology 106:1-3, pages 237-242.
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Ian Kimber, Mark R. Holliday & Rebecca J. Dearman. (1995) Cytokine regulation of chemical sensitization. Toxicology Letters 82-83, pages 491-496.
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I. Kimber, R.J. Dearman, E.W. Scholes & D.A. Basketter. (1994) The local lymph node assay: developments and applications. Toxicology 93:1, pages 13-31.
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R. J. Dearman, L. S. P. Ramdin, I. Kimber, E. W. Scholes & D. A. Basketter. (2006) The local lymph node assay: An interlaboratory evaluation of Interleukin 6 (IL‐6) production by draining lymph node cells. Journal of Applied Toxicology 14:4, pages 287-291.
Crossref
I. Kimber. 1994. Use of Mechanistic Information in Risk Assessment. Use of Mechanistic Information in Risk Assessment 87 94 .

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