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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 8, 2011 - Issue 3
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ORIGINAL RESEARCH

Neuromodulatory Effect of Endogenous Opioids on the Intensity and Unpleasantness of Breathlessness during Resistive Load Breathing in COPD

Alex H. GiffordSection of Pulmonary & Critical Care Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA,
,
Donald A. MahlerSection of Pulmonary & Critical Care Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA,Correspondence[email protected]
,
Laurie A. WatermanPulmonary Function & Cardiopulmonary Exercise Laboratories, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA,
,
Joseph WardPulmonary Function & Cardiopulmonary Exercise Laboratories, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA,
,
William J. KraemerDepartment of Kinesiology and Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT,
,
Brian R. KupchakDepartment of Kinesiology and Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT,
&
John C. Baird
 show all
Pages 160-166 | Published online: 22 Apr 2011

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Diana H Ferreira, Slavica Kochovska, Richard McNeill & David C Currow. (2023) Current pharmacological strategies for symptomatic reduction of persistent breathlessness – a literature review. Expert Opinion on Pharmacotherapy 24:2, pages 233-244.
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Donald A Mahler. (2013) Opioids for refractory dyspnea. Expert Review of Respiratory Medicine 7:2, pages 123-135.
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Articles from other publishers (32)

Xin XU, Danfeng MA & Feng ZHOU. (2022) Efficacy of naloxone combined with noninvasive ventilator in the treatment of COPD complicated with type II respiratory failure. Minerva Surgery 77:6.
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Vijay Hadda, Pradipta Bhakta, Habib Md Reazaul Karim, Edoardo Piervincenzi, Irena Šarc, Camilla Calandra, Savino Spadaro, Bushra Mina, Laura D Ciobanu, Gil Gonçalves, Vania Caldeira, Bruno Cabrita, Andreas Perren, Giuseppe Fiorentino, Tughan Utku, Mohamad El-Khatib, Nilgün Alpay, Rodolfo Ferrari, Mohamed EA Abdelrahim, Haitham Saeed, Yasmin M Madney, Hadeer S Harb, Nicola Vargas, Hilmi Demirkiran, Peter Papadakos, Manuel Á Gómez-Ríos, Alfredo Abad, Jaber S Alqahtani, Subrata K Singha & Antonio M Esquinas. (2022) Role of Sedation and Analgesia during Noninvasive Ventilation: Systematic Review of Recent Evidence and Recommendations. Indian Journal of Critical Care Medicine 26:8, pages 938-948.
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Andrew P. Binks. 2022. Respiratory Neurobiology - Physiology and Clinical Disorders, Part I. Respiratory Neurobiology - Physiology and Clinical Disorders, Part I 309 338 .
Gregory Reychler, Marc Beaumont, Anne-Claire Latiers, Thierry Pieters & Antoine Fremault. (2021) Dyspnea could be accurately assessed by a caregiver in hospitalized patients with respiratory diseases: Interrater reliability and agreement study. Brazilian Journal of Physical Therapy 25:6, pages 735-740.
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Joachim H. Ficker & Wolfgang M. Brückl. (2021) Refraktäre Dyspnoe bei fortgeschrittener COPD: Palliative Therapie mit Opioiden. Geriatrie up2date 3:02, pages 95-103.
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Annie Massart & Daniel P. Hunt. (2021) Management of Refractory Breathlessness: a Review for General Internists. Journal of General Internal Medicine 36:4, pages 1035-1040.
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Ali M. Albarrati, Nichola S. Gale, Maggie M. Munnery, John R. Cockcroft & Dennis J. Shale. (2020) Daily physical activity and related risk factors in COPD. BMC Pulmonary Medicine 20:1.
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Miriam J Johnson & David C. Currow. (2020) Opioids for breathlessness: a narrative review. BMJ Supportive & Palliative Care 10:3, pages 287-295.
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Miriam J. Johnson, Sarah Cockayne, David C. Currow, Kerry Bell, Kate Hicks, Caroline Fairhurst, Rhian Gabe, David Torgerson, Laura Jefferson, Stephen Oxberry, Justin Ghosh, Karen J. Hogg, Jeremy Murphy, Victoria Allgar, John G.F. Cleland & Andrew L. Clark. (2019) Oral modified release morphine for breathlessness in chronic heart failure: a randomized placebo‐controlled trial. ESC Heart Failure 6:6, pages 1149-1160.
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David C. Currow, Toby Hunt, Sandra Louw, Danny Eckert, Peter Allcroft, Tim H.M. To, Aine Greene, Malgorzata Krajnik, Don Mahler & Magnus Ekström. (2019) Isolating peripheral effects of endogenous opioids in modulating exertional breathlessness in people with moderate or severe COPD: a randomised controlled trial. ERJ Open Research 5:4, pages 00153-2019.
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Donald A. Mahler. (2017) Evaluation of Dyspnea in the Elderly. Clinics in Geriatric Medicine 33:4, pages 503-521.
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David Currow, Gareth John Watts, Miriam Johnson, Christine F McDonald, John O Miners, Andrew A Somogyi, Linda Denehy, Nicola McCaffrey, Danny J Eckert, Philip McCloud, Sandra Louw, Lawrence Lam, Aine Greene, Belinda Fazekas, Katherine C Clark, Kwun Fong, Meera R Agar, Rohit Joshi, Sharon Kilbreath, Diana Ferreira & Magnus Ekström. (2017) A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol. BMJ Open 7:7, pages e018100.
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Giulia Scioscia, Isabel Blanco, Ebymar Arismendi, Felip Burgos, Concepci?n Gistau, Maria Pia Foschino Barbaro, Bartolome Celli, Denis E O'Donnell & Alvar Agust?. (2017) Different dyspnoea perception in COPD patients with frequent and infrequent exacerbations. Thorax 72:2, pages 117-121.
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Miriam J. Johnson, Carlo Barbetta, David C. Currow, Matthew Maddocks, Vanessa McDonald, Ravi Mahadeva & Martina Mason. 2016. Palliative Care in Respiratory Disease. Palliative Care in Respiratory Disease 153 171 .
Dennis Jensen, Kyle Pattinson & Caroline Jolley. 2016. Palliative Care in Respiratory Disease. Palliative Care in Respiratory Disease 111 133 .
Miriam J. Johnson, David Hui & David C. Currow. (2014) Opioids, Exertion, and Dyspnea. American Journal of Hospice and Palliative Medicine® 33:2, pages 194-200.
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Donald A. Mahler. (2016) A Perspective on Acupuncture Techniques for Relief of Dyspnea in Chronic Obstructive Pulmonary Disease. Medical Acupuncture 28:1, pages 28-32.
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D. C. Currow, S. Quinn, M. Ekstrom, S. Kaasa, M. J. Johnson, A. A. Somogyi & P. Klepstad. (2015) Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?. BMJ Open 5:5, pages e006818-e006818.
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Thomas J. Smith. (2015) Symptom Management in the Older Adult. Clinics in Geriatric Medicine 31:2, pages 155-175.
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Donald A. Mahler & Denis E. O'Donnell. (2015) Recent Advances in Dyspnea. Chest 147:1, pages 232-241.
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Richella Ryan, Anna Spathis & Sara Booth. (2014) Correlates between basic science and therapeutic interventions. Current Opinion in Supportive & Palliative Care 8:3, pages 200-207.
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Peijun Gui, Takae Ebihara, Ryuhei Sato, Kumiko Ito, Masahiro Kohzuki & Satoru Ebihara. (2014) Gender differences in the effect of urge-to-cough and dyspnea on perception of pain in healthy adults. Physiological Reports 2:8, pages e12126.
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. (2014) Consider opioid therapy for chronic refractory breathlessness. Drugs & Therapy Perspectives 30:8, pages 294-297.
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Donald A. Mahler, Alex H. Gifford, Aamir Gilani, Laurie A. Waterman, Jennifer Hilton, Andrew S. Chang, Brian R. Kupchak & William J. Kraemer. (2014) Antagonism of substance P and perception of breathlessness in patients with chronic obstructive pulmonary disease. Respiratory Physiology & Neurobiology 196, pages 1-7.
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David C. Currow, Magnus Ekstrom & Amy P. Abernethy. (2013) Opioids for Chronic Refractory Breathlessness: Right Patient, Right Route?. Drugs 74:1, pages 1-6.
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David C. CurrowStephen QuinnAine GreeneJanet BullMiriam J. JohnsonAmy P. Abernethy. (2013) The Longitudinal Pattern of Response When Morphine Is Used To Treat Chronic Refractory Dyspnea. Journal of Palliative Medicine 16:8, pages 881-886.
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Donald A. Mahler, Alex H. Gifford, Laurie A. Waterman, Joseph Ward, William J. Kraemer, Brian R. Kupchak & Andrew Harver. (2013) Effect of Increased Blood Levels of ?-Endorphin on Perception of Breathlessness. Chest 143:5, pages 1378-1385.
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Meera Agar & Tim Luckett. (2012) Outcome measures for palliative care research. Current Opinion in Supportive & Palliative Care 6:4, pages 500-507.
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Richard J. Bodnar. (2012) Endogenous opiates and behavior: 2011. Peptides 38:2, pages 463-522.
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James Hallenbeck. (2012) Pathophysiologies of Dyspnea Explained: Why Might Opioids Relieve Dyspnea and Not Hasten Death?. Journal of Palliative Medicine 15:8, pages 848-853.
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. (2012) Current World Literature. Current Opinion in Supportive & Palliative Care 6:2, pages 289-298.
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Claudine Peiffer. (2011) Morphine-induced Relief of Dyspnea: What Are the Mechanisms?. American Journal of Respiratory and Critical Care Medicine 184:8, pages 867-869.
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