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ORIGINAL RESEARCH

Respiratory Effects of Insulin Sensitisation with Metformin: A Prospective Observational Study

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Raju Bishwakarma, Wei Zhang, Yu-Li Lin, Yong-Fang Kuo, Victor J Cardenas & Gulshan Sharma. (2018) Metformin use and health care utilization in patients with coexisting chronic obstructive pulmonary disease and diabetes mellitus. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 793-800.
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Joanna Miłkowska-Dymanowska, Adam J Białas, Joanna Makowska, Aleksandra Wardzynska, Paweł Górski & Wojciech J Piotrowski. (2017) Geroprotectors as a therapeutic strategy for COPD – where are we now?. Clinical Interventions in Aging 12, pages 1811-1817.
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Andrew W. Hitchings, John R.H. Archer, Shelley A. Srivastava & Emma H. Baker. (2015) Safety of Metformin in Patients with Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus. COPD: Journal of Chronic Obstructive Pulmonary Disease 12:2, pages 126-131.
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Articles from other publishers (37)

Leonardo M Fabbri, Bartolome R Celli, Alvar Agustí, Gerard J Criner, Mark T Dransfield, Miguel Divo, Jamuna K Krishnan, Lies Lahousse, Maria Montes de Oca, Sundeep S Salvi, Daiana Stolz, Lowie E G W Vanfleteren & Claus F Vogelmeier. (2023) COPD and multimorbidity: recognising and addressing a syndemic occurrence. The Lancet Respiratory Medicine 11:11, pages 1020-1034.
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Hayder Mutter Al-Kuraishy, Ali Ismail Al-Gareeb, Gomaa Mostafa-Hedeab, Rupal Dubey, Pranav Kumar Prabhakar & Gaber El-Saber Batiha. (2023) COVID-19 and Diabetes: will Novel Drugs for Diabetes Help in COVID-19?. Current Molecular Pharmacology 16:4, pages 494-506.
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Turab Mohammed, Michael Bowe, Alexandria Plant, Mario Perez, Carlos A Alvarez & Eric M Mortensen. (2023) Metformin Use Is Associated With Lower Mortality in Veterans With Diabetes Hospitalized With Pneumonia. Clinical Infectious Diseases 76:7, pages 1237-1244.
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Tzu-Yu Cheng, Chih-Cheng Chang, Ching-Shan Luo, Kuan-Yuan Chen, Yun-Kai Yeh, Jing-Quan Zheng & Sheng-Ming Wu. (2023) Targeting Lung–Gut Axis for Regulating Pollution Particle–Mediated Inflammation and Metabolic Disorders. Cells 12:6, pages 901.
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Ziting Liang, Mengge Yang, Changjuan Xu, Rong Zeng & Liang Dong. (2022) Effects and safety of metformin in patients with concurrent diabetes mellitus and chronic obstructive pulmonary disease: a systematic review and meta-analysis. Endocrine Connections 11:9.
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Sangmi S. Park, Jessica L. Perez Perez, Brais Perez Gandara, Christina W. Agudelo, Romy Rodriguez Ortega, Huma Ahmed, Itsaso Garcia-Arcos, Cormac McCarthy & Patrick Geraghty. (2022) Mechanisms Linking COPD to Type 1 and 2 Diabetes Mellitus: Is There a Relationship between Diabetes and COPD?. Medicina 58:8, pages 1030.
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Melissa Rivas, Gayatri Gupta, Louis Costanzo, Huma Ahmed, Anne E. Wyman & Patrick Geraghty. (2022) Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease. Medicina 58:6, pages 817.
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Ling Qian, Entezar Mehrabi NasabSeyyede Masoume AthariSeyyed Shamsadin Athari. (2023) Mitochondria Signaling Pathways in Allergic Asthma. Journal of Investigative Medicine 70:4, pages 863-882.
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Rajeswari Raguraman, Akhil Srivastava, Anupama Munshi & Rajagopal Ramesh. (2021) Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer. Advanced Drug Delivery Reviews 178, pages 113918.
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Niki Katsiki, Paschalis Steiropoulos, Nikolaos Papanas & Dimitri P. Mikhailidis. (2019) Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview. Experimental and Clinical Endocrinology & Diabetes 129:10, pages 699-704.
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Elena Massimino, Anna Izzo, Gabriele Riccardi & Giuseppe Della Pepa. (2021) The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms. Cells 10:8, pages 1958.
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Meng-Ting Wang, Jyun-Heng Lai, Ya-Ling Huang, Feng-Chih Kuo, Yun-Han Wang, Chen-Liang Tsai & Min-Yu Tu. (2020) Use of antidiabetic medications and risk of chronic obstructive pulmonary disease exacerbation requiring hospitalization: a disease risk score-matched nested case–control study. Respiratory Research 21:1.
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Yanfeng Shi, Josevata Werelagi Batibawa, Modibo Maiga, Baiyang Sun, Yang Li, Junchao Duan & Zhiwei Sun. (2020) Identification and validation of metformin protects against PM2.5-induced macrophages cytotoxicity by targeting toll like receptor pathway. Chemosphere 251, pages 126526.
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Fu-Shun Yen, James Cheng-Chung Wei, Yu-Cih Yang, Chih-Cheng Hsu & Chii-Min Hwu. (2020) Respiratory outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease. Scientific Reports 10:1.
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Chaitanya Mamillapalli, Ramesh Tentu, Nitesh Kumar Jain & Ramanath Bhandari. (2019) COPD and Type 2 Diabetes. Current Respiratory Medicine Reviews 15:2, pages 112-119.
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Velin Stratev, Valentina Dimitrova & Diana Petkova. (2019) COPD and Comorbidities: Relating Mechanisms and Treatment. Current Respiratory Medicine Reviews 15:2, pages 90-101.
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Te-Wei Ho, Chun-Ta Huang, Yi-Ju Tsai, Angela Shin-Yu Lien, Feipei Lai & Chong-Jen Yu. (2019) Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease. Respiratory Research 20:1.
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Angelico Mendy, Radha Gopal, John F. Alcorn & Erick Forno. (2019) Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin. Respirology 24:7, pages 646-651.
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Stanley M.H. Chan, Stavros Selemidis, Steven Bozinovski & Ross Vlahos. (2019) Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pharmacology & Therapeutics 198, pages 160-188.
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C.-H. Tseng. (2019) Metformin and risk of chronic obstructive pulmonary disease in diabetes patients. Diabetes & Metabolism 45:2, pages 184-190.
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Fu-Shun Yen, Weishan Chen, James Cheng-Chung Wei, Chih-Cheng Hsu & Chii-Min Hwu. (2018) Effects of metformin use on total mortality in patients with type 2 diabetes and chronic obstructive pulmonary disease: A matched-subject design. PLOS ONE 13:10, pages e0204859.
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Louise H. Rayner, Andrew P. McGovern, Julian Sherlock, Piers Gatenby, Ana Correa, Ben Creagh-Brown & Simon de Lusignan. (2018) Type 2 diabetes: A protective factor for COPD?. Primary Care Diabetes 12:5, pages 438-444.
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Jodie Birch, Peter J. Barnes & Joao F. Passos. (2018) Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease. Pharmacology & Therapeutics 183, pages 34-49.
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Albert Lecube, Rafael Simó, Maria Pallayova, Naresh M Punjabi, Carolina López-Cano, Cecilia Turino, Cristina Hernández & Ferran Barbé. (2017) Pulmonary Function and Sleep Breathing: Two New Targets for Type 2 Diabetes Care. Endocrine Reviews 38:6, pages 550-573.
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Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, J?rgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra S?hler, Emiel F. M. Wouters, Claus Vogelmeier & Rudolf A. J?rres. (2017) Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort. Respiratory Research 18:1.
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Mu-Tzu Ko, Hui-Chun Huang, Wen-Shin Lee, Chiao-Lin Chuang, I-Fang Hsin, Shao-Jung Hsu, Fa-Yauh Lee, Ching-Chih Chang & Shou-Dong Lee. (2017) Metformin reduces intrahepatic fibrosis and intrapulmonary shunts in biliary cirrhotic rats. Journal of the Chinese Medical Association 80:8, pages 467-475.
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Claude A. PiantadosiHagir B. Suliman. (2017) Mitochondrial Dysfunction in Lung Pathogenesis. Annual Review of Physiology 79:1, pages 495-515.
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Deborah L. Baines & Emma H. Baker. 2017. Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease. Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease 33 57 .
Lowie E G W Vanfleteren, Martijn A Spruit, Emiel F M Wouters & Frits M E Franssen. (2016) Management of chronic obstructive pulmonary disease beyond the lungs. The Lancet Respiratory Medicine 4:11, pages 911-924.
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Claire E Wells, Michael I Polkey & Emma H Baker. (2016) Insulin resistance is associated with skeletal muscle weakness in COPD. Respirology 21:4, pages 689-696.
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Cheng Peng, Heike Luttmann-Gibson, Antonella Zanobetti, Allison Cohen, Celine De Souza, Brent A. Coull, Edward S. Horton, Joel Schwartz, Petros Koutrakis & Diane R. Gold. (2015) Air pollution influences on exhaled nitric oxide among people with type II diabetes. Air Quality, Atmosphere & Health 9:3, pages 265-273.
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Anurag Agrawal & Ulaganathan Mabalirajan. (2016) Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria. American Journal of Physiology-Lung Cellular and Molecular Physiology 310:2, pages L103-L113.
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Paola Rogliani, Gabriella Lucà & Davide Lauro. (2015) Chronic obstructive pulmonary disease and diabetes. COPD Research and Practice 1:1.
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Serge Adnot, Valérie Amsellem, Laurent Boyer, Elisabeth Marcos, Mirna Saker, Amal Houssaini, Kanny Kebe, Maylis Dagouassat, Larissa Lipskaia & Jorge Boczkowski. (2015) Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential. Pharmacology & Therapeutics 153, pages 125-134.
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Lowie E.G.W. Vanfleteren. (2014) Does COPD stand for “COmorbidity with Pulmonary Disease”?. European Respiratory Journal 45:1, pages 14-17.
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Gregory L Kinney & Emma H Baker. (2014) Type 2 diabetes mellitus and chronic obstructive pulmonary disease: need for a double-pronged approach. Diabetes Management 4:4, pages 307-310.
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Turab Mohammed, Michael Bowe, Alexandria Plant, Mario Perez, Carlos Alvarez & Eric M. Mortensen. (2022) Metformin Use is Associated with Lower Mortality in Veterans with Diabetes Hospitalized with Pneumonia. SSRN Electronic Journal.
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