1,546
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells

, , , , , , , & show all
Pages 328-336 | Received 13 Sep 2013, Accepted 02 Jan 2014, Published online: 10 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Olav Dahl, Jon Espen Dale & Marianne Brydøy. (2019) Rationale for combination of radiation therapy and immune checkpoint blockers to improve cancer treatment. Acta Oncologica 58:1, pages 9-20.
Read now
Katrien De Wolf, Karim Vermaelen, Gert De Meerleer, Bart N Lambrecht & Piet Ost. (2015) The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy. OncoImmunology 4:10.
Read now

Articles from other publishers (56)

Qiuxia Lu, Weisi Yan, Alan Zhu, Slavisa Tubin, Waleed F. Mourad & Jun Yang. (2024) Combining spatially fractionated radiation therapy (SFRT) and immunotherapy opens new rays of hope for enhancing therapeutic ratio. Clinical and Translational Radiation Oncology 44, pages 100691.
Crossref
Luigi Buonaguro & Maria Tagliamonte. (2023) Peptide-based vaccine for cancer therapies. Frontiers in Immunology 14.
Crossref
Liqiang Zhong, Yi Li, Tobias Muluh & Yongsheng Wang. (2023) Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review). Oncology Letters 26:1.
Crossref
Jiabao Yang, Pengfei Xing, Yuehong Kong, Meiling Xu & Liyuan Zhang. (2023) PD-1 inhibitor combined with radiotherapy and GM-CSF in MSS/pMMR metastatic colon cancer: a case report. Frontiers in Oncology 13.
Crossref
Mengyuan Shi, Yongkang Chen & Dengbo Ji. (2022) The implications from the interplay of neoadjuvant chemoradiotherapy and the immune microenvironment in rectal cancer. Future Oncology 18:28, pages 3229-3244.
Crossref
Hongshan Ji & Zhiguo Zhou. (2022) A ‘Hybrid’ Radiotherapy Regimen Designed for Immunomodulation: Combining High-Dose Radiotherapy with Low-Dose Radiotherapy. Cancers 14:14, pages 3505.
Crossref
Ernest Osei, Ruth Francis & Lyba Sheraz. (2020) A review of radiation induced abscopal effect: combining radiotherapy and immunotherapy to treat the untreated distant metastatic tumours. Journal of Radiotherapy in Practice 21:1, pages 117-124.
Crossref
Maria Tagliamonte & Gennaro Ciliberto. 2022. Cancer Vaccines as Immunotherapy of Cancer. Cancer Vaccines as Immunotherapy of Cancer 137 154 .
Lu Wen, Fan Tong, Ruiguang Zhang, Lingjuan Chen, Yu Huang & Xiaorong Dong. (2021) The Research Progress of PD-1/PD-L1 Inhibitors Enhancing Radiotherapy Efficacy. Frontiers in Oncology 11.
Crossref
Elizabeth Appleton, Jehanne Hassan, Charleen Chan Wah Hak, Nanna Sivamanoharan, Anna Wilkins, Adel Samson, Masahiro Ono, Kevin J. Harrington, Alan Melcher & Erik Wennerberg. (2021) Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade. Frontiers in Immunology 12.
Crossref
Michael Hader, Simon Streit, Andreas Rosin, Thorsten Gerdes, Martin Wadepohl, Sander Bekeschus, Rainer Fietkau, Benjamin Frey, Eberhard Schlücker, Stephan Gekle & Udo S. Gaipl. (2021) In Vitro Examinations of Cell Death Induction and the Immune Phenotype of Cancer Cells Following Radiative-Based Hyperthermia with 915 MHz in Combination with Radiotherapy. Cells 10:6, pages 1436.
Crossref
Richard A. Lin, Jessica K. Lin & Shiaw‐Yih Lin. (2021) Mechanisms of immunogenic cell death and immune checkpoint blockade therapy. The Kaohsiung Journal of Medical Sciences 37:6, pages 448-458.
Crossref
Yuehong Kong, Yifu Ma, Xiangrong Zhao, Jie Pan, Zhi Xu & Liyuan Zhang. (2021) Optimizing the Treatment Schedule of Radiotherapy Combined With Anti-PD-1/PD-L1 Immunotherapy in Metastatic Cancers. Frontiers in Oncology 11.
Crossref
Aisling B. Heeran, Margaret R. Dunne, Maria E. Morrissey, Croí E. Buckley, Niamh Clarke, Aoife Cannon, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Niamh Lynam-Lennon & Jacintha O’Sullivan. (2021) The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses. Cancers 13:3, pages 571.
Crossref
Ziqi Zhou, Jing Zhao, Ke Hu, Xiaorong Hou, Xiansong Sun, Xiaoli Pan, Xiaohui Wang, Nan Li, Zhiwei Yang, Fuquan Zhang, Qianqian Zhou & Linsheng Zhan. (2021) Single High-Dose Radiation Enhances Dendritic Cell Homing and T Cell Priming by Promoting Reactive Oxygen Species-Induced Cytoskeletal Reorganization. International Journal of Radiation Oncology*Biology*Physics 109:1, pages 95-108.
Crossref
Ajinkya Madhukar Thanekar, Sri Amruthaa Sankaranarayanan & Aravind Kumar Rengan. (2021) Role of nano-sensitizers in radiation therapy of metastatic tumors. Cancer Treatment and Research Communications 26, pages 100303.
Crossref
Jacob Gadwa & Sana D. Karam. (2020) Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer. International Journal of Radiation Oncology*Biology*Physics 108:1, pages 46-55.
Crossref
Anne Ernst, Roman Hennel, Julia Krombach, Heidi Kapfhammer, Nikko Brix, Gabriele Zuchtriegel, Bernd Uhl, Christoph A. Reichel, Benjamin Frey, Udo S. Gaipl, Nicolas Winssinger, Senji Shirasawa, Takehiko Sasazuki, Markus Sperandio, Claus Belka & Kirsten Lauber. (2020) Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90. Frontiers in Oncology 10.
Crossref
Slavisa Tubin, Weisi Yan, Waleed F Mourad, Piero Fossati & Mohammad K Khan. (2020) The future of radiation-induced abscopal response: beyond conventional radiotherapy approaches. Future Oncology 16:16, pages 1137-1151.
Crossref
Faya Zhang, Subrata Manna, Laurentiu M. Pop, Zhijian J. Chen, Yang-Xin Fu & Raquibul Hannan. (2020) Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity. Seminars in Radiation Oncology 30:2, pages 129-138.
Crossref
Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano & Francesco M Marincola. (2020) Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer 8:1, pages e000337.
Crossref
Michael Hader, Benjamin Frey, Rainer Fietkau, Markus Hecht & Udo S. Gaipl. (2020) Immune biological rationales for the design of combined radio- and immunotherapies. Cancer Immunology, Immunotherapy 69:2, pages 293-306.
Crossref
Simona Kranjc Brezar, Ajda Prevc, Martina Niksic Zakelj, Andreja Brozic, Maja Cemazar, Primoz Strojan & Gregor Sersa. (2020) Synergistic effect of cisplatin chemotherapy combined with fractionated radiotherapy regimen in HPV-positive and HPV-negative experimental pharyngeal squamous cell carcinoma. Scientific Reports 10:1.
Crossref
Bodo E. Lippitz & Robert A. Harris. (2019) A translational concept of immuno-radiobiology. Radiotherapy and Oncology 140, pages 116-124.
Crossref
Aisling B. Heeran, Helen P. Berrigan & Jacintha O'Sullivan. (2019) The Radiation-Induced Bystander Effect (RIBE) and its Connections with the Hallmarks of Cancer. Radiation Research 192:6, pages 668.
Crossref
Yuzi Wang, Junko Zenkoh, Ariungerel Gerelchuluun, Lue Sun, Songjie Cai, Xiaokang Li & Koji Tsuboi. (2019) Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines. International Journal of Radiation Oncology*Biology*Physics 103:4, pages 958-969.
Crossref
Franziska Eckert, Karin Schilbach, Lukas Klumpp, Lilia Bardoscia, Efe Cumhur Sezgin, Matthias Schwab, Daniel Zips & Stephan M. Huber. (2018) Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer. Frontiers in Immunology 9.
Crossref
Zachary S. Buchwald, Jacob Wynne, Tahseen H. Nasti, Simeng Zhu, Waleed F. Mourad, Weisi Yan, Seema Gupta, Samir N. Khleif & Mohammad K. Khan. (2018) Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation. Frontiers in Oncology 8.
Crossref
S. Bockel, B. Durand & E. Deutsch. (2018) Combining radiation therapy and cancer immune therapies: From preclinical findings to clinical applications. Cancer/Radiothérapie 22:6-7, pages 567-580.
Crossref
Giovanni Fucà, Filippo de Braud & Massimo Di Nicola. (2018) Immunotherapy-based combinations: an update. Current Opinion in Oncology 30:5, pages 345-351.
Crossref
Isabella Maund, Anna Bowzyk Al-Naeeb, Sarah J. Welsh, Tim Eisen & Kate Fife. (2018) Intensity Modulated Radiotherapy is a Well-Tolerated and Effective Treatment for the Long-Term Control of Intra-Abdominal and Retroperitoneal Oligometastatic Renal Cell Cancer. Kidney Cancer 2:2, pages 103-113.
Crossref
Xinyue Liang, Shirong Zheng, Jiuwei Cui, Dehai Yu, Guozi Yang, Lei Zhou, Brain Wang, Lu Cai & Wei Li. (2018) Alterations of MicroRNA Expression in the Liver, Heart, and Testis of Mice Upon Exposure to Repeated Low-Dose Radiation. Dose-Response 16:3, pages 155932581879956.
Crossref
Megan Morisada, Michael Chamberlin & Clint Allen. (2018) Exploring the rationale for combining ionizing radiation and immune checkpoint blockade in head and neck cancer. Head & Neck 40:6, pages 1321-1334.
Crossref
Arif Ali Chishti, Christa Baumstark-Khan, Kristina Koch, Waldemar Kolanus, Sebastian Feles, Bikash Konda, Abid Azhar, Luis F. Spitta, Bernd Henschenmacher, Sebastian Diegeler, Claudia Schmitz & Christine E. Hellweg. (2018) Linear Energy Transfer Modulates Radiation-Induced NF-kappa B Activation and Expression of its Downstream Target Genes. Radiation Research 189:4, pages 354-370.
Crossref
Dietrich Averbeck, Sisko Salomaa, Simon Bouffler, Andrea Ottolenghi, Vere Smyth & Laure Sabatier. (2018) Progress in low dose health risk research. Mutation Research/Reviews in Mutation Research 776, pages 46-69.
Crossref
Sang-Won Kim, Ji Woon Yea, Jae Hwang Kim, Mi Jin Gu & Min Kyu Kang. (2017) Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer. International Journal of Clinical Oncology 23:2, pages 287-297.
Crossref
Seo Hee ChoiJinsil Seong. (2018) Stereotactic Body Radiotherapy: Does It Have a Role in Management of Hepatocellular Carcinoma?. Yonsei Medical Journal 59:8, pages 912.
Crossref
Benjamin Frey, Michael Rückert, Lisa Deloch, Paul F. Rühle, Anja Derer, Rainer Fietkau & Udo S. Gaipl. (2017) Immunomodulation by ionizing radiation—impact for design of radio‐immunotherapies and for treatment of inflammatory diseases. Immunological Reviews 280:1, pages 231-248.
Crossref
Sebastian Diegeler & Christine E. Hellweg. (2017) Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities. Frontiers in Immunology 8.
Crossref
Vaidotas Stankevicius, Karolina Kuodyte, Diana Schveigert, Danute Bulotiene, Tomas Paulauskas, Kristina Daniunaite & Kestutis Suziedelis. (2017) Gene and miRNA expression profiles of mouse Lewis lung carcinoma LLC1 cells following single or fractionated dose irradiation. Oncology Letters 13:6, pages 4190-4200.
Crossref
J.P. Nesseler, D. Peiffert, G. Vogin & P. Nickers. (2017) Cancer, radiothérapie et système immunitaire. Cancer/Radiothérapie 21:4, pages 307-315.
Crossref
Qiuji Wu, Awatef Allouch, Isabelle Martins, Catherine Brenner, Nazanine Modjtahedi, Eric Deutsch & Jean-Luc Perfettini. (2017) Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness. Frontiers in Immunology 8.
Crossref
Erik Wennerberg, Claire Lhuillier, Claire Vanpouille-Box, Karsten A. Pilones, Elena García-Martínez, Nils-Petter Rudqvist, Silvia C. Formenti & Sandra Demaria. (2017) Barriers to Radiation-Induced In Situ Tumor Vaccination. Frontiers in Immunology 8.
Crossref
Dan Ishihara, Laurentiu Pop, Tsuguhide Takeshima, Puneeth Iyengar & Raquibul Hannan. (2016) Rationale and evidence to combine radiation therapy and immunotherapy for cancer treatment. Cancer Immunology, Immunotherapy 66:3, pages 281-298.
Crossref
Daniel K. Ebner, Walter Tinganelli, Alexander Helm, Alessandra Bisio, Shigeru Yamada, Tadashi Kamada, Takashi Shimokawa & Marco Durante. (2017) The Immunoregulatory Potential of Particle Radiation in Cancer Therapy. Frontiers in Immunology 8.
Crossref
F. Eckert, U.S. Gaipl, G. Niedermann, M. Hettich, K. Schilbach, S.M. Huber & D. Zips. (2017) Beyond checkpoint inhibition – Immunotherapeutical strategies in combination with radiation. Clinical and Translational Radiation Oncology 2, pages 29-35.
Crossref
Jacques Bernier. (2016) Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing. Critical Reviews in Oncology/Hematology 108, pages 97-108.
Crossref
Anja Derer, Benjamin Frey, Rainer Fietkau & Udo S. Gaipl. (2015) Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors. Cancer Immunology, Immunotherapy 65:7, pages 779-786.
Crossref
Lisa Deloch, Anja Derer, Josefin Hartmann, Benjamin Frey, Rainer Fietkau & Udo S. Gaipl. (2016) Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation. Frontiers in Oncology 6.
Crossref
Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky & Alexandros G. Georgakilas. (2016) Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicology Research 5:1, pages 12-33.
Crossref
Benjamin Frey, Anja Derer, Heike Scheithauer, Roland Wunderlich, Rainer Fietkau & Udo S. Gaipl. 2016. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy 151 172 .
Bernhard Kötter, Benjamin Frey, Markus Winderl, Yvonne Rubner, Heike Scheithauer, Renate Sieber, Rainer Fietkau & Udo S. Gaipl. (2015) The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation. Radiation Oncology 10:1.
Crossref
Suresh J. Haikerwal, Jim Hagekyriakou, Michael MacManus, Olga A. Martin & Nicole M. Haynes. (2015) Building immunity to cancer with radiation therapy. Cancer Letters 368:2, pages 198-208.
Crossref
Anja Derer, Lisa Deloch, Yvonne Rubner, Rainer Fietkau, Benjamin Frey & Udo S. Gaipl. (2015) Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications. Frontiers in Immunology 6.
Crossref
M Weber, P Moebius, M Büttner-Herold, K Amann, R Preidl, F W Neukam & F Wehrhan. (2015) Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas—an immunohistochemical study. British Journal of Cancer 113:3, pages 510-519.
Crossref
Yingqi Zhang, Zhuixing Liu, Jun Lu & Yang Yang. (2022) Terelizumab Combined with Hypofractionated Radiation Therapy and GM-CSF as Dyspnea with Stage IV Lung Squamous Cell Carcinoma: A Case Report. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.