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Research Article

Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice

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Pages 165-172 | Received 20 Jan 2015, Accepted 10 Mar 2015, Published online: 27 Mar 2015

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Read on this site (6)

Rachel Baur, Michael Kashon, Ewa Lukomska, Lisa M. Weatherly, Hillary L. Shane & Stacey E. Anderson. (2023) Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis. Journal of Immunotoxicology 20:1.
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Samuel Buxton, Michael D. Taylor, Jeffrey T. Weinberg, James M. Randazzo, Vanessa L. Peachee & Adriana Oller. (2021) A T-dependent antibody response evaluation in CD-1 mice after an acute whole-body inhalation exposure to nickel (II) chloride hexahydrate. Journal of Immunotoxicology 18:1, pages 144-153.
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Stacey E. Anderson, Rachel Baur, Michael Kashon, Ewa Lukomska, Lisa Weatherly & Hillary L. Shane. (2020) Potential classification of chemical immunologic response based on gene expression profiles. Journal of Immunotoxicology 17:1, pages 122-134.
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Lisa M. Weatherly & Julie A. Gosse. (2017) Triclosan exposure, transformation, and human health effects. Journal of Toxicology and Environmental Health, Part B 20:8, pages 447-469.
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Joanna A Ruszkiewicz, Shaojun Li, Maliya B Rodriguez & Michael Aschner. (2017) Is Triclosan a neurotoxic agent?. Journal of Toxicology and Environmental Health, Part B 20:2, pages 104-117.
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Nikki B. Marshall, Ewa Lukomska, Ajay P. Nayak, Carrie M. Long, Justin M. Hettick & Stacey E. Anderson. (2017) Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway. Journal of Immunotoxicology 14:1, pages 50-59.
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Articles from other publishers (25)

Yu Han, Weixia Zhang, Yu Tang, Wei Shi, Zhiquan Liu, Imane Lamine, Hangjun Zhang, Jing Liu & Guangxu Liu. (2024) Triclosan exposure induces immunotoxic impacts by disrupting the immunometabolism, detoxification, and cellular homeostasis in blood clam (Tegillarca granosa). Aquatic Toxicology 266, pages 106778.
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Xiaolan Hu, Shilin Gong, Quan He, Jian-Lin Wu & Na Li. (2023) Less is more: A new perspective for toxicity of emerging contaminants by structures, protein adducts and proteomics. TrAC Trends in Analytical Chemistry 167, pages 117289.
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Sarikokba, Lalhmunsiama, Ricky Lalawmpuia, Diwakar Tiwari & Dong-Jin Kim. (2023) Thin Film Electrode for Trace and Efficient Detection of Triclosan: Stability of Electrode and Real Matrix Analyses. Water, Air, & Soil Pollution 234:7.
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Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen & Zongwei Cai. (2023) Adverse effects of triclosan on kidney in mice: Implication of lipid metabolism disorders. Journal of Environmental Sciences 124, pages 481-490.
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Charles Obinwanne Okoye, Raphael Nyaruaba, Richard Ekeng Ita, Samuel Ukpong Okon, Charles Izuma Addey, Chike C. Ebido, Adebayo Oluwole Opabunmi, Emmanuel Sunday Okeke & Kingsley Ikechukwu Chukwudozie. (2022) Antibiotic resistance in the aquatic environment: Analytical techniques and interactive impact of emerging contaminants. Environmental Toxicology and Pharmacology 96, pages 103995.
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Ravindra Semwal, Ruchi Badoni Semwal, Jörg Lehmann & Deepak Kumar Semwal. (2022) Recent advances in immunotoxicity and its impact on human health: causative agents, effects and existing treatments. International Immunopharmacology 108, pages 108859.
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Maria Stefania Sinicropi, Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Michele Pellegrino, Carmela Saturnino, Pasquale Longo & Stefano Aquaro. (2022) Triclosan: A Small Molecule with Controversial Roles. Antibiotics 11:6, pages 735.
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Chenxi Zhao, Ruihui Xie, Qiuhui Qian, Jin Yan, Huili Wang & Xuedong Wang. (2022) Triclosan induced zebrafish immunotoxicity by targeting miR-19a and its gene socs3b to activate IL-6/STAT3 signaling pathway. Science of The Total Environment 815, pages 152916.
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Ying Hao, Li Meng, Yan Zhang, Aixin Chen, Ye Zhao, Kaoqi Lian, Xiangfei Guo, Xinhao Wang, Yuru Du, Xi Wang, Xuzi Li, Li Song, Yun Shi, Xi Yin, Miao Gong & Haishui Shi. (2022) Effects of chronic triclosan exposure on social behaviors in adult mice. Journal of Hazardous Materials 424, pages 127562.
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Rachel Baur, Hillary L. Shane, Lisa M. Weatherly, Ewa Lukomska, Michael Kashon & Stacey E. Anderson. (2022) Exposure to the immunomodulatory chemical triclosan differentially impacts immune cell populations in the skin of haired (BALB/c) and hairless (SKH1) mice. Toxicology Reports 9, pages 1766-1776.
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Rachel Baur, Jasleen Gandhi, Nikki B Marshall, Ewa Lukomska, Lisa M Weatherly, Hillary L Shane, Gangqing Hu & Stacey E Anderson. (2021) Dermal Exposure to the Immunomodulatory Antimicrobial Chemical Triclosan Alters the Skin Barrier Integrity and Microbiome in Mice. Toxicological Sciences 184:2, pages 223-235.
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Sunil Sharma, Owias Iqbal Dar, Kirpal Singh, Arvinder Kaur & Caterina Faggio. (2021) Triclosan elicited biochemical and transcriptomic alterations in Labeo rohita larvae. Environmental Toxicology and Pharmacology 88, pages 103748.
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Wei Huang, Lin Zhu, Guodong Cao, Peisi Xie, Yuanyuan Song, Jialing Huang, Xiangfeng Chen & Zongwei Cai. (2021) Integrated Proteomics and Metabolomics Assessment Indicated Metabolic Alterations in Hypothalamus of Mice Exposed to Triclosan. Chemical Research in Toxicology 34:5, pages 1319-1328.
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Hillary L. Shane, Sreekumar Othumpangat, Nikki B. Marshall, Francoise Blachere, Ewa Lukomska, Lisa M. Weatherly, Rachel Baur, John D. Noti & Stacey E. Anderson. (2020) Topical exposure to triclosan inhibits Th1 immune responses and reduces T cells responding to influenza infection in mice. PLOS ONE 15:12, pages e0244436.
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Suraj Sangroula, Alan Y. Baez Vasquez, Prakash Raut, Bright Obeng, Juyoung K. Shim, Grace D. Bagley, Bailey E. West, John E. Burnell, Marissa S. Kinney, Christian M. Potts, Sasha R. Weller, Joshua B. Kelley, Samuel T. Hess & Julie A. Gosse. (2020) Triclosan disrupts immune cell function by depressing Ca2+ influx following acidification of the cytoplasm. Toxicology and Applied Pharmacology 405, pages 115205.
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Lisa M Weatherly, Hillary L Shane, Sherri A Friend, Ewa Lukomska, Rachel Baur & Stacey E Anderson. (2020) Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction. Toxicological Sciences 176:1, pages 147-161.
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Su-Jeong Joo, Ravi Gautam, JaeHee Lee, HyeonJi Kim, SuJeong Yang, JiHun Jo, Manju Acharya, Anju Maharjan, YeonGyeong Kim, Yeon-Mi Lim, ChangYul Kim, HyoungAh Kim & Yong Heo. (2019) Prediction of the skin sensitization potential of polyhexamethylene guanidine phosphate, oligo(2-(2-ethoxy)ethoxyethyl) guanidinium chloride, triclosan, and mixtures of these compounds with the excipient propylene glycol through the local lymph node assay: BrdU-FCM. Toxicology and Industrial Health 35:10, pages 638-646.
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Shaghayegh Alizadeh Tabari, Mahsa Loran Esfahani, Seyed Mohammad Hosseini & Atena Rahimi. (2019) Neurobehavioral toxicity of triclosan in mice. Food and Chemical Toxicology 130, pages 154-160.
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Soukaina Motia, Ioan Albert Tudor, Paulo Antonio Ribeiro, Maria Raposo, Benachir Bouchikhi & Nezha El Bari. (2019) Electrochemical sensor based on molecularly imprinted polymer for sensitive triclosan detection in wastewater and mineral water. Science of The Total Environment 664, pages 647-658.
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Max T. Aung, Kelly K. Ferguson, David E. Cantonwine, Kelly M. Bakulski, Bhramar Mukherjee, Rita Loch-Caruso, Thomas F. McElrath & John D. Meeker. (2019) Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study. Science of The Total Environment 650, pages 1131-1140.
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Kimberly P. Berger, Katherine R. Kogut, Asa Bradman, Jianwen She, Qi Gavin, Rana Zahedi, Kimberly L. Parra & Kim G. Harley. (2018) Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study. Journal of Exposure Science & Environmental Epidemiology 29:1, pages 21-32.
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Catherine Ley, Vandana Sundaram, Maria de la Luz Sanchez, Manisha Desai & Julie Parsonnet. (2018) Triclosan and triclocarban exposure, infectious disease symptoms and antibiotic prescription in infants—A community-based randomized intervention. PLOS ONE 13:6, pages e0199298.
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Zemin Wang, Xilin Li & James E. Klaunig. (2017) Investigation of the mechanism of triclosan induced mouse liver tumors. Regulatory Toxicology and Pharmacology 86, pages 137-147.
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Dirk W. Lachenmeier. 2017. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 209 215 .
Nikki B. Marshall, Ewa Lukomska, Carrie M. Long, Michael L. Kashon, Douglas D. Sharpnack, Ajay P. Nayak, Katie L. Anderson, B. Jean Meade & Stacey E. Anderson. (2015) Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. Toxicological Sciences 147:1, pages 127-139.
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