Advanced search
Publication Cover
Clinical Toxicology Volume 48, 2010 - Issue 5
Submit an article Journal homepage
601
Views
38
CrossRef citations to date
0
Altmetric
ArticlesResearch

A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose

The Toxicology Investigator Network
Pages 424-430 | Received 21 Aug 2009, Accepted 12 Apr 2010, Published online: 04 Jun 2010

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Jonathan G. Stine & James H. Lewis. (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Review of Gastroenterology & Hepatology 10:4, pages 517-536.
Read now
Wendy Klein-Schwartz & Suzanne Doyon. (2011) Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert Opinion on Pharmacotherapy 12:1, pages 119-130.
Read now
Mohan Punja, David H. Jang & Robert S. Hoffman. (2010) Response to “A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose”. Clinical Toxicology 48:7, pages 768-769.
Read now

Articles from other publishers (35)

Sophie Tieu, Armen Charchoglyan, Lauryn Paulsen, Lauri C. Wagter-Lesperance, Umesh K. Shandilya, Byram W. Bridle, Bonnie A. Mallard & Niel A. Karrow. (2023) N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals. Antioxidants 12:10, pages 1867.
Crossref
Matthew T. Stanton. (2022) Part II : Interactive case: Toxicology and poison control . JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 5:12, pages 1332-1337.
Crossref
Kyung-A Hwang, YuJin Hwang, Hye-Jeong Hwang & NaYeong Park. (2022) Hepatoprotective Effects of Radish (Raphanus sativus L.) on Acetaminophen-Induced Liver Damage via Inhibiting Oxidative Stress and Apoptosis. Nutrients 14:23, pages 5082.
Crossref
Jerly Maybelline Díaz Herrera, Lady Paola Castellanos Avendaño & Javier Roberto Rodríguez Buitrago. (2022) Intoxicación aguda por acetaminofén en atención primaria. Revista Med 29:2, pages 79-92.
Crossref
John Rague. 2022. History of Modern Clinical Toxicology. History of Modern Clinical Toxicology 201 212 .
Chantal Elise Mulkens, Marieke Staatsen, Lucie van Genugten, Barbara A M Snoeker, Kris C P Vissers, Jörgen Bruhn & Martin J L Bucx. (2021) Postoperative pain reduction by pre-emptive N-acetylcysteine: an exploratory randomized controlled clinical trial. Regional Anesthesia & Pain Medicine 46:11, pages 960-964.
Crossref
Micaely Cristina dos Santos Tenório, Nayara Gomes Graciliano, Fabiana Andréa Moura, Alane Cabral Menezes de Oliveira & Marília Oliveira Fonseca Goulart. (2021) N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants 10:6, pages 967.
Crossref
Ryan Serdenes & James GrahamIIIIII. (2020) Evaluating the Psychiatric Benefits of Formulating Acetaminophen With N-Acetylcysteine. Frontiers in Psychiatry 11.
Crossref
Ken M Stern & Bryan S Benn. (2019) A case of metastatic pancreatic adenocarcinoma confounded by complementary and alternative medicine therapies. BMJ Case Reports 12:10, pages e231356.
Crossref
Erik S. Fisher & Steven C. Curry. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury 263 272 .
Liang Shi, Zhanxia Hao, Shaobo Zhang, Mengjuan Wei, Bin Lu, Zhengtao Wang & Lili Ji. (2018) Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC. Biochemical Pharmacology 150, pages 9-23.
Crossref
Farrokhlaga Ahmadi, Mahsa Abbaszadeh, Effat Razeghi, Sima Maziar, Simin Dashti Khoidaki, Mohammad Taghi Najafi & Mahboob Lessan-Pezeshki. (2016) Effectiveness of N-acetylcysteine for preserving residual renal function in patients undergoing maintenance hemodialysis: multicenter randomized clinical trial. Clinical and Experimental Nephrology 21:2, pages 342-349.
Crossref
Benjamin L. Woolbright & Hartmut Jaeschke. 2017. Cellular Injury in Liver Diseases. Cellular Injury in Liver Diseases 55 76 .
Philip Moore & Keith Burkhart. 2017. Critical Care Toxicology. Critical Care Toxicology 693 739 .
David R. Skvarc, Olivia M. Dean, Linda K. Byrne, Laura J. Gray, Kathryn Ives, Stephen E. Lane, Matthew Lewis, Cameron Osborne, Richard Page, Douglas Stupart, Alyna Turner, Michael Berk & Andrew J. Marriott. (2016) The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial. Trials 17:1.
Crossref
Mateusz Ciejka, Khoa Nguyen, Martin H. Bluth & Elizabeth Dubey. (2016) Drug Toxicities of Common Analgesic Medications in the Emergency Department. Clinics in Laboratory Medicine 36:4, pages 761-776.
Crossref
Jacqueline R. Dunning, Jeanette D. Trella & Kevin C. Osterhoudt. (2016) A Novel Oral Formulation of N-Acetylcysteine. Pediatric Emergency Care 32:9, pages 652-652.
Crossref
Bahman Khameneh, Bibi Sedigheh Fazly Bazzaz, Alireza Amani, Javad Rostami & Nasser Vahdati-Mashhadian. (2016) Combination of anti-tuberculosis drugs with vitamin C or NAC against different Staphylococcus aureus and Mycobacterium tuberculosis strains. Microbial Pathogenesis 93, pages 83-87.
Crossref
Angela L. Chiew, Geoffrey K. Isbister, Stephen B. Duffull & Nicholas A. Buckley. (2016) Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology 81:3, pages 471-481.
Crossref
Spencer C. Greene, Patrick K. Noonan, Carlos Sanabria & W. Frank Peacock. (2016) Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study. Current Therapeutic Research 83, pages 1-7.
Crossref
Philip Moore & Keith Burkhart. 2016. Critical Care Toxicology. Critical Care Toxicology 1 47 .
SH Zyoud, SW Al-Jabi, WM Sweileh, R Awang & WS Waring. (2015) Global research productivity of N -acetylcysteine use in paracetamol overdose . Human & Experimental Toxicology 34:10, pages 1006-1016.
Crossref
Chun Pang, Yu-chen Sheng, Ping Jiang, Hai Wei & Li-li Ji. (2015) Chlorogenic acid prevents acetaminophen-induced liver injury: The involvement of CYP450 metabolic enzymes and some antioxidant signalsCYP450 代谢酶和一些抗氧化信号参与调控了绿原酸抑制对乙酰氨基酚的肝毒性. Journal of Zhejiang University-SCIENCE B 16:7, pages 602-610.
Crossref
Kathryn A. Pauley, Tracy L. Sandritter, Jennifer A. Lowry & D. Adam Algren. (2015) Evaluation of an Alternative Intravenous N-Acetylcysteine Regimen in Pediatric Patients. The Journal of Pediatric Pharmacology and Therapeutics 20:3, pages 178-185.
Crossref
Natasha Palipane, Estabrak Jiad & Jacob F de Wolff. (2015) Paracetamol overdose. British Journal of Hospital Medicine 76:2, pages C18-C22.
Crossref
Aaron J. Bobb & Kevin P. Hill. (2014) Behavioral Interventions and Pharmacotherapies for Cannabis Use Disorder. Current Treatment Options in Psychiatry 1:2, pages 163-174.
Crossref
Shawn M. Varney, Jennie A. Buchanan, Jamie Kokko & Kennon Heard. (2014) Acetylcysteine for Acetaminophen Overdose in Patients Who Weigh >100 Kg. American Journal of Therapeutics 21:3, pages 159-163.
Crossref
Lili Ji, Ping Jiang, Bin Lu, Yuchen Sheng, Xin Wang & Zhengtao Wang. (2013) Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. The Journal of Nutritional Biochemistry 24:11, pages 1911-1919.
Crossref
Jung-Ran Noh, Yong-Hoon Kim, Jung Hwan Hwang, Gil-Tae Gang, Kyoung-Shim Kim, In-Kyoung Lee, Bong-Sik Yun & Chul-Ho Lee. (2013) Davallialactone protects against acetaminophen overdose-induced liver injuries in mice. Food and Chemical Toxicology 58, pages 14-21.
Crossref
Cathrine Lund, Per Drottning, Birgitte Stiksrud, Javad Vahabi, Marianne Lyngra, Ivind Ekeberg, Dag Jacobsen & Knut Erik Hovda. (2012) A one-year observational study of all hospitalized acute poisonings in Oslo: complications, treatment and sequelae. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 20:1.
Crossref
W. Stephen Waring. (2012) Novel acetylcysteine regimens for treatment of paracetamol overdose. Therapeutic Advances in Drug Safety 3:6, pages 305-315.
Crossref
Jacqueline A. Hawkins-Salsbury, Elizabeth Y. Qin, Adarsh S. Reddy, Carole A. Vogler & Mark S. Sands. (2012) Oxidative stress as a therapeutic target in globoid cell leukodystrophy. Experimental Neurology 237:2, pages 444-452.
Crossref
Robert A. McPherson & Gil Hardy. (2012) Cysteine: The Fun-Ke Nutraceutical. Nutrition 28:3, pages 336-337.
Crossref
Sarah Bajorek, Roel Basaldua, Katherine McGoogan, Charla Miller & Craig B. Sussman. (2012) Neonatal Gastric Lactobezoar: Management with N-Acetylcysteine. Case Reports in Pediatrics 2012, pages 1-3.
Crossref
Colleen G. Le Prell & Jianxin Bao. 2012. Noise-Induced Hearing Loss. Noise-Induced Hearing Loss 285 338 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.