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Clinical Toxicology Volume 48, 2010 - Issue 8
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ArticlesResearch

Addition of phenylephrine to high-dose insulin in dihydropyridine overdose does not improve outcome

Kristin M. Engebretsen Emergency Medicine Department, Regions Hospital, St. Paul, MN, USACorrespondence[email protected]
,
Matthew W. Morgan Emergency Medicine Department, Regions Hospital, St. Paul, MN, USA
,
Samuel J. Stellpflug Emergency Medicine Department, Regions Hospital, St. Paul, MN, USA
,
Jon B. Cole Emergency Medicine Department, Regions Hospital, St. Paul, MN, USA
&
Christopher P. Anderson Statistics, HealthPartners Research Foundation, Bloomington, MN, USA
Pages 806-812 | Received 01 Jul 2010, Accepted 02 Sep 2010, Published online: 25 Oct 2010

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Omar A Alshaya, Arwa Alhamed, Sara Althewaibi, Lolwa Fetyani, Shaden Alshehri, Fai Alnashmi, Shmeylan Alharbi, Mohammed Alrashed, Saleh F Alqifari & Abdulrahman I Alshaya. (2022) Calcium Channel Blocker Toxicity: A Practical Approach. Journal of Multidisciplinary Healthcare 15, pages 1851-1862.
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Jon B. Cole, Samantha C. Lee, Matthew E. Prekker, Nathan M. Kunzler, Kelly A. Considine, Brian E. Driver, Michael A. Puskarich & Travis D. Olives. (2022) Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines. Clinical Toxicology 60:11, pages 1205-1213.
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Katherine G. Katzung, Jenna M. Leroy, Sean P. Boley, Samuel J. Stellpflug, Joel S. Holger & Kristin M. Engebretsen. (2019) A randomized controlled study comparing high-dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock. Clinical Toxicology 57:11, pages 1073-1079.
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JoAn R. Laes, Chad Olinger & Jon B. Cole. (2017) Use of percutaneous left ventricular assist device (Impella) in vasodilatory poison-induced shock. Clinical Toxicology 55:9, pages 1014-1015.
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Cassandra A. Skoog & Kristin M. Engebretsen. (2017) Are vasopressors useful in toxin-induced cardiogenic shock?. Clinical Toxicology 55:4, pages 285-304.
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Ludovic Gérard, Anne-Cécile Galloy, Arnaud Capron & Philippe Hantson. (2015) Mixed amlodipine/valsartan overdose treated by the molecular adsorbent recirculating system (MARS™). Clinical Toxicology 53:6, pages 573-577.
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M. St-Onge, P.-A. Dubé, S. Gosselin, C. Guimont, J. Godwin, P. M. Archambault, J.-M. Chauny, A. J. Frenette, M. Darveau, N. Le sage, J. Poitras, J. Provencher, D. N. Juurlink & R. Blais. (2014) Treatment for calcium channel blocker poisoning: A systematic review. Clinical Toxicology 52:9, pages 926-944.
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J. B. Cole, S. J. Stellpflug, H. Ellsworth, C. P. Anderson, A. B. Adams, K. M. Engebretsen & J. S. Holger. (2013) A blinded, randomized, controlled trial of three doses of high-dose insulin in poison-induced cardiogenic shock. Clinical Toxicology 51:4, pages 201-207.
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Joel S. Holger, Samuel J. Stellpflug, Jon B. Cole, Carson R. Harris & Kristin M. Engebretsen. (2011) High-dose insulin: A consecutive case series in toxin-induced cardiogenic shock. Clinical Toxicology 49:7, pages 653-658.
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Kristin M. Engebretsen, Kathleen M. Kaczmarek, Jenifer Morgan & Joel S. Holger. (2011) High-dose insulin therapy in beta-blocker and calcium channel-blocker poisoning. Clinical Toxicology 49:4, pages 277-283.
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Articles from other publishers (15)

Jon B. Cole & Ann M. Arens. (2022) Cardiotoxic Medication Poisoning. Emergency Medicine Clinics of North America 40:2, pages 395-416.
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Justin N. Corcoran, Katherine J. Jacoby, Travis D. Olives, Stacey A. Bangh & Jon B. Cole. (2020) Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report. Journal of Medical Toxicology 16:4, pages 465-469.
Crossref
Jenna M. LeRoy, Sean P. Boley, Justin N. Corcoran, Kristin M. Engebretsen & Samuel J. Stellpflug. (2020) Effect of Methylene Blue on a Porcine Model of Amlodipine Toxicity. Journal of Medical Toxicology 16:4, pages 398-404.
Crossref
Jon B Cole, Justin N Corcoran, Kristin M Engebretsen & Samuel J Stellpflug. (2020) Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning. Journal of Medical Toxicology 16:2, pages 212-221.
Crossref
Thomas Chad, Marco Ulla, Vanesa Garnelo Rey & Carlos Gómez. (2020) High-Dose Insulin for Toxin Induced Cardiogenic Shock: Experience at a New High and Overview of the Evidence. The Journal of Emergency Medicine 58:2, pages 317-323.
Crossref
Sean P. Boley, Rebecca B. Mackenzie, Jenna M. LeRoy, Kristin M. Engebretsen & Samuel J. Stellpflug. (2019) Development and Feasibility of a Porcine Model of Amlodipine Toxicity. Journal of Medical Toxicology 16:1, pages 61-66.
Crossref
James R. Krenz & Yaman Kaakeh. (2018) An Overview of Hyperinsulinemic-Euglycemic Therapy in Calcium Channel Blocker and β-blocker Overdose. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:11, pages 1130-1142.
Crossref
Jon B. Cole, Ann M. Arens, JoAn R. Laes, Lauren R. Klein, Stacey A. Bangh & Travis D. Olives. (2018) High dose insulin for beta-blocker and calcium channel-blocker poisoning. The American Journal of Emergency Medicine 36:10, pages 1817-1824.
Crossref
Fiqry Fadhlillah & Shashank Patil. (2018) Pharmacological and mechanical management of calcium channel blocker toxicity. BMJ Case Reports, pages bcr-2018-225324.
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Raymond Kao, Yves Landry, Genevieve Chick & Andrew Leung. (2017) Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report. Journal of Medical Case Reports 11:1.
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Kelvin Tran. (2017) A Case of Amlodipine Overdose: Role of High Dose Insulin Therapy. Endocrinology&Metabolism International Journal 5:3.
Crossref
Christine M. Murphy, Cliff Williams, Michael E. Quinn, Brian Nicholson, Thomas Shoe, Michael C. Beuhler & William P. KernsIIII. (2016) Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock. Journal of Medical Toxicology 12:4, pages 380-385.
Crossref
Dmytro O. Kryshtal, Sheila Dawling, Donna Seger & Bjorn C. Knollmann. (2015) In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. Journal of Medical Toxicology 12:2, pages 165-171.
Crossref
Ramachandran Meenakshisundaram, Douglas Ewan Cannie, P. Ravi Shankar, Heidar Z. Zadeh, Omi Bajracharya & Ponniah Thirumalaikolundusubramanian. 2015. Heart and Toxins. Heart and Toxins 225 274 .
Simon W. Lam, Kristin M. Engebretsen & Seth R. Bauer. (2011) Toxicology Today. Journal of Pharmacy Practice 24:2, pages 174-188.
Crossref

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