Citations (43)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (25)
Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
Read now
Read now
Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
Read now
Read now
Chun En Yau, Haoyang Chen, Bryant Po-Yuen Lim, Mingwei Ng, R. Ponampalam, Daniel Yan Zheng Lim, Yip Han Chin & Andrew Fu Wah Ho. (2023) Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis. Clinical Toxicology 61:1, pages 1-11.
Read now
Read now
Ari B. Filip, Sarah E. Berg, Michael E. Mullins & Evan S. Schwarz. (2022) Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015–2020. Clinical Toxicology 60:9, pages 1006-1011.
Read now
Read now
Stephanie L. Link, Garrett Rampon, Stephen Osmon, Anthony J. Scalzo & Barry H. Rumack. (2022) Reply to Comments on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:5, pages 668-669.
Read now
Read now
Sanjay Mohan, Sarah Mahonski & Robert S. Hoffman. (2022) Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:5, pages 666-666.
Read now
Read now
Jacob A. Lebin & Anita Mudan. (2022) Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:5, pages 665-665.
Read now
Read now
Stephanie L. Link, Garrett Rampon, Stephen Osmon, Anthony J. Scalzo & Barry H. Rumack. (2022) Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clinical Toxicology 60:4, pages 472-477.
Read now
Read now
Kartik R. Shah & Michael C. Beuhler. (2022) Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clinical Toxicology 60:4, pages 493-498.
Read now
Read now
Yvonne Gloor, Domitille Schvartz & Caroline F.Samer. (2019) Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity. Expert Opinion on Drug Metabolism & Toxicology 15:8, pages 659-669.
Read now
Read now
Harry Egan, Geoffrey K. Isbister, Jennifer Robinson, Michael Downes, Betty S. Chan, Elia Vecellio & Angela L. Chiew. (2019) Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol. Clinical Toxicology 57:8, pages 703-711.
Read now
Read now
Adam Mutsaers, Jason P. Green, Marco L. A. Sivilotti, Mark C. Yarema, Dylan Tucker, David W. Johnson, Daniel A. Spyker & Barry H. Rumack. (2019) Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clinical Toxicology 57:6, pages 380-386.
Read now
Read now
Anselm Wong, Marco L. A. Sivilotti, Naren Gunja, Richard McNulty & Andis Graudins. (2018) Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical Toxicology 56:3, pages 182-188.
Read now
Read now
Anselm Wong & Andis Graudins. (2017) Risk prediction of hepatotoxicity in paracetamol poisoning. Clinical Toxicology 55:8, pages 879-892.
Read now
Read now
Anselm Wong, Marco L. A. Sivilotti & Andis Graudins. (2017) Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clinical Toxicology 55:5, pages 346-351.
Read now
Read now
Mark C. Yarema, Jason P. Green, Marco L. A. Sivilotti, David W. Johnson, Alberto Nettel-Aguirre, Charlemaigne Victorino, Daniel A. Spyker & Barry H. Rumack. (2017) Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?. Clinical Toxicology 55:2, pages 102-108.
Read now
Read now
David G. Cairney, Hannah K. S. Beckwith, Khalid Al-Hourani, Michael Eddleston, D. Nicholas Bateman & James W. Dear. (2016) Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine. Clinical Toxicology 54:5, pages 405-410.
Read now
Read now
Morgan Riggan, Mireille Sayegh, Wayne Choi & Robert S. Hoffman. (2015) Letter in response to: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clinical Toxicology 53:10, pages 1155-1156.
Read now
Read now
Nicholas A. Buckley & Angela L. Chiew. (2015) Re: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clinical Toxicology 53:10, pages 1152-1153.
Read now
Read now
R. Mason Curtis & Marco L. A. Sivilotti. (2015) A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose. Clinical Toxicology 53:9, pages 849-855.
Read now
Read now
Anselm Wong, Marco L. A. Sivilotti, Paul I. Dargan, David M. Wood & Shaun L. Greene. (2015) External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose. Clinical Toxicology 53:8, pages 807-814.
Read now
Read now
M. J. Hodgman. (2014) Seeking a role, Psi and APAP×AT as acetaminophen risk assessment tools. Clinical Toxicology 52:5, pages 451-453.
Read now
Read now
S. Chomchai & C. Chomchai. (2014) Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter. Clinical Toxicology 52:5, pages 506-511.
Read now
Read now
M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
Read now
Read now
Jonathan G Stine & James H Lewis. (2011) Drug-induced liver injury: a summary of recent advances. Expert Opinion on Drug Metabolism & Toxicology 7:7, pages 875-890.
Read now
Read now
Articles from other publishers (18)
Mitchell R. McGill & Steven C. Curry. (2023) The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review. Livers 3:4, pages 569-596.
Crossref
Crossref
Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
Crossref
Crossref
Kannan Sridharan, Muna Al Jufairi, Eman Al Ansari, Reem Al Marzooq, Zakariya Hubail, Sadeq Jaafar Radhi Hasan & Abdulraoof Al Madhoob. (2021) Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. Journal of Clinical Pharmacy and Therapeutics 46:4, pages 1010-1019.
Crossref
Crossref
Mark C. Yarema, David W. Johnson, Marco L.A. Sivilotti, Alberto Nettel‐Aguirre, Chris DeWitt, Sophie Gosselin, Nancy Murphy, Charlemagne Victorino, Benoit Bailey, Kathryn Dong, Elizabeth Haney, Roy Purssell, Margaret Thompson, Jason A. Lord, Daniel A. Spyker & Barry H. Rumack. (2021) Predicting mortality from acetaminophen poisoning shortly after hospital presentation. British Journal of Clinical Pharmacology 87:8, pages 3332-3343.
Crossref
Crossref
Iwona Popiolek, Piotr Hydzik, Pawel Jagielski, Monika Zrodlowska, Karol Mystek & Grzegorz Porebski. (2021) Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults. Medicina 57:8, pages 752.
Crossref
Crossref
Angela L. Chiew & Nicholas A. Buckley. (2021) Acetaminophen Poisoning. Critical Care Clinics 37:3, pages 543-561.
Crossref
Crossref
Richard L. Lambert. 2021. Pediatric Critical Care. Pediatric Critical Care
1289
1314
.
Angela L. Chiew, Laura P. James, Geoffrey K. Isbister, John W. Pickering, Kylie McArdle, Betty S.H. Chan & Nicholas A. Buckley. (2020) Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). Journal of Hepatology 72:3, pages 450-462.
Crossref
Crossref
D. Nicholas Bateman & James W. Dear. (2019) Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. Toxicology Research 8:4, pages 489-498.
Crossref
Crossref
Mark Real, Michele S. Barnhill, Cory Higley, Jessica Rosenberg & James H. Lewis. (2018) Drug-Induced Liver Injury: Highlights of the Recent Literature. Drug Safety 42:3, pages 365-387.
Crossref
Crossref
Anselm Wong, Richard McNulty, David Taylor, Marco Sivilotti, Shaun Greene, Naren Gunja, Zeff Koutsogiannis & Andis Graudins. (2019) The NACSTOP Trial: A Multicenter, Cluster‐Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose. Hepatology 69:2, pages 774-784.
Crossref
Crossref
Diego Castanares-Zapatero, Valérie Dinant, Ilaria Ruggiano, Harold Willem, Pierre-François Laterre & Philippe Hantson. (2018) Pattern of Paracetamol Poisoning: Influence on Outcome and Complications. Toxics 6:4, pages 58.
Crossref
Crossref
Anselm Wong, Cornelia Landersdorfer & Andis Graudins. (2017) Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. European Journal of Clinical Pharmacology 73:9, pages 1103-1110.
Crossref
Crossref
ADB Vliegenthart, RA Kimmitt, JH Seymour, NZ Homer, JI Clarke, M Eddleston, A Gray, DM Wood, PI Dargan, JG Cooper, DJ Antoine, DJ Webb, SC Lewis, DN Bateman & JW Dear. (2016) Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury. Clinical Pharmacology & Therapeutics 101:4, pages 531-540.
Crossref
Crossref
Scott N. Lucyk, Mark C. Yarema, Marco L.A. Sivilotti, David W. Johnson, Alberto Nettel-Aguirre, Charlemaigne Victorino, Benoit Bailey, Richard C. Dart, Kennon Heard, Daniel A. Spyker & Barry H. Rumack. (2016) Outcomes of Patients With Premature Discontinuation of the 21-h Intravenous N-Acetylcysteine Protocol After Acute Acetaminophen Overdose. The Journal of Emergency Medicine 50:4, pages 629-637.
Crossref
Crossref
D. Nicholas Bateman. (2015) Changing the Management of Paracetamol Poisoning. Clinical Therapeutics 37:9, pages 2135-2141.
Crossref
Crossref
Frédéric Baud, Philippe Hantson & Hafedh ThabetP. Wallemacq & P. Hantson. 2013. Intoxications aiguës. Intoxications aiguës
25
40
.
David Tonoli, Emmanuel Varesio & Gérard Hopfgartner. (2012) Quantification of acetaminophen and two of its metabolites in human plasma by ultra-high performance liquid chromatography–low and high resolution tandem mass spectrometry. Journal of Chromatography B 904, pages 42-50.
Crossref
Crossref