Advanced search
Publication Cover
Clinical Toxicology Volume 49, 2011 - Issue 3
Submit an article Journal homepage
921
Views
70
CrossRef citations to date
0
Altmetric
Review

The clinical toxicology of the designer “party pills” benzylpiperazine and trifluoromethylphenylpiperazine

Leo J. SchepDepartment of Preventive and Social Medicine, National Poisons Centre, University of Otago, Dunedin, New ZealandCorrespondence[email protected]
,
Robin J. SlaughterDepartment of Preventive and Social Medicine, National Poisons Centre, University of Otago, Dunedin, New Zealand
,
J. Allister ValeNational Poisons Information Service (Birmingham Unit) and West Midlands Poisons Unit, City Hospital, Birmingham, UK
,
D. Michael G. BeasleyDepartment of Preventive and Social Medicine, National Poisons Centre, University of Otago, Dunedin, New Zealand
&
Paul GeeEmergency Department, Christchurch Hospital, Christchurch, New Zealand
Pages 131-141 | Received 10 Mar 2011, Accepted 10 Mar 2011, Published online: 16 Apr 2011

Citations (70)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

David M. Wood & Paul I. Dargan. (2012) Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP). Clinical Toxicology 50:8, pages 727-732.
Read now
Craig N. Chatterton, Graham R. Jones & Peter P. Singer. (2012) A Case of Fatal Benzylpiperazine (BZP) and Trifluoromethylphenylpiperazine (TFMPP) Toxicity. Canadian Society of Forensic Science Journal 45:3, pages 150-154.
Read now
Simon L. Hill & Simon H. L. Thomas. (2011) Clinical toxicology of newer recreational drugs. Clinical Toxicology 49:8, pages 705-719.
Read now

Articles from other publishers (67)

Haley N. Phillips & Laura Tormoehlen. (2022) Toxin-Induced Seizures ∗Adapted from “Toxin-Induced Seizures” in Neurologic Clinics, November 2020. Emergency Medicine Clinics of North America 40:2, pages 417-430.
Crossref
Anna Welz, Marcin Koba, Piotr Kośliński & Joanna Siódmiak. (2022) Comparison of LC-MS and LC-DAD Methods of Detecting Abused Piperazine Designer Drugs. Journal of Clinical Medicine 11:7, pages 1758.
Crossref
Paul Gee & Leo J. Schep. 2022. Novel Psychoactive Substances. Novel Psychoactive Substances 301 332 .
Arie P. Francis & Silas W. Smith. 2022. Novel Psychoactive Substances. Novel Psychoactive Substances 57 84 .
Sarah Eller & Marcelo Dutra Arbo. 2022. Handbook of Substance Misuse and Addictions. Handbook of Substance Misuse and Addictions 3031 3040 .
Sarah Eller & Marcelo Dutra Arbo. 2021. Handbook of Substance Misuse and Addictions. Handbook of Substance Misuse and Addictions 1 11 .
Anna Welz, Marcin Koba, Piotr Kośliński & Joanna Siódmiak. (2021) Rapid Targeted Method of Detecting Abused Piperazine Designer Drugs. Journal of Clinical Medicine 10:24, pages 5813.
Crossref
Weberson P. Silva, Raquel G. Rocha, Luciano C. Arantes, Camila D. Lima, Larissa M.A. Melo, Rodrigo A.A. Munoz, Wallans T.P. dos Santos & Eduardo M. Richter. (2021) Development of a simple and rapid screening method for the detection of 1-(3-chlorophenyl)piperazine in forensic samples. Talanta 233, pages 122597.
Crossref
Raquel G. Rocha, Isabella C.O.F. Silva, Luciano C. Arantes, Jéssica S. Stefano, Camila D. Lima, Larissa M.A. Melo, Rodrigo A.A. Munoz, Wallans T.P. dos Santos & Eduardo M. Richter. (2021) Simple and rapid electrochemical detection of 1-benzylpiperazine on carbon screen-printed electrode. Microchemical Journal 167, pages 106282.
Crossref
Vera Lukić, Ružica Micić, Biljana Arsić, Bojan Nedović & Živana Radosavljević. (2021) Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs. Open Chemistry 19:1, pages 60-106.
Crossref
Laura M. Tormoehlen. 2021. Emergency Neurology. Emergency Neurology 373 401 .
Haley N. Phillips & Laura Tormoehlen. (2020) Toxin-Induced Seizures. Neurologic Clinics 38:4, pages 867-879.
Crossref
Máté Kapitány-Fövény, Ornella Corazza, Shanna Marrinan & Zsolt Demetrovics. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions 307 325 .
. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions 295 425 .
. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions.
Dino Luethi & Matthias E. Liechti. (2020) Designer drugs: mechanism of action and adverse effects. Archives of Toxicology 94:4, pages 1085-1133.
Crossref
Caroline Souto, Gabriela Göethel, Caroline Portela Peruzzi, Larissa Vivan Cestonaro, Ingrid Garcia, Daiana Silva Ávila, Vera Eifler‐Lima, Helena Carmo, Maria de Lurdes Bastos, Solange C. Garcia & Marcelo Dutra Arbo. (2019) Piperazine designer drugs elicit toxicity in the alternative in vivo model Caenorhabditis elegans . Journal of Applied Toxicology 40:3, pages 363-372.
Crossref
Ji Hyun Lee, Han Na Park, Nam Sook Kim, Seongsoo Park, Yong-Moon Lee & Hoil Kang. (2020) Development of a specific fragmentation pattern-based quadrupole-Orbitrap™ mass spectrometry method to screen drugs in illicit products. Science & Justice 60:1, pages 86-94.
Crossref
Carlo Alessandro Locatelli, Davide Lonati & Valeria Margherita Petrolini. 2020. Brain and Heart Dynamics. Brain and Heart Dynamics 1 27 .
Carlo Alessandro Locatelli, Davide Lonati & Valeria Margherita Petrolini. 2020. Brain and Heart Dynamics. Brain and Heart Dynamics 843 868 .
M. Rosaria Varì, Simona Pichini, Raffaele Giorgetti & Francesco P. Busardò. (2018) New psychoactive substances—Synthetic stimulants. WIREs Forensic Science 1:2.
Crossref
Mohammed Majrashi, Mohammed Almaghrabi, Maali Fadan, Ayaka Fujihashi, Wooseok Lee, Jack Deruiter, C. Randall Clark & Muralikrishnan Dhanasekaran. (2018) Dopaminergic neurotoxic effects of 3-TFMPP derivatives. Life Sciences 209, pages 357-369.
Crossref
Sean B Dolan, Ritu A Shetty, Michael J Forster & Michael B Gatch. (2018) Impure but not inactive: Behavioral pharmacology of dibenzylpiperazine, a common by-product of benzylpiperazine synthesis. Journal of Psychopharmacology 32:7, pages 802-810.
Crossref
Ryan Graddy, Megan E. Buresh & Darius A. Rastegar. (2018) New and Emerging Illicit Psychoactive Substances. Medical Clinics of North America 102:4, pages 697-714.
Crossref
Laura Hondebrink, Anne Zwartsen & Remco H.S. Westerink. (2018) Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?. Pharmacology & Therapeutics 182, pages 193-224.
Crossref
Andrew King, Mirjana Dimovska & Luke Bisoski. (2018) Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension. Current Hypertension Reports 20:1.
Crossref
Nicholas J. TaylorEnrico EmerSean PreshlockMichael SchedlerMatthew TredwellStefan VerhoogJoel Mercier, Christophe Genicot & Véronique Gouverneur. (2017) Derisking the Cu-Mediated 18 F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands . Journal of the American Chemical Society 139:24, pages 8267-8276.
Crossref
L. J. Schep, H. A. Poulsen & P. Gee. 2017. Detection of Drug Misuse: Biomarkers, Analytical Advances and Interpretation. Detection of Drug Misuse: Biomarkers, Analytical Advances and Interpretation 100 124 .
Diego Hernando Ângulo Florez, Ana Maria dos Santos Moreira, Pedro Rafael da Silva, Ricardo Brandão, Marcella Matos Cordeiro Borges, Fernando José Malagueño de Santana & Keyller Bastos Borges. (2017) Desomorphine (Krokodil): An overview of its chemistry, pharmacology, metabolism, toxicology and analysis. Drug and Alcohol Dependence 173, pages 59-68.
Crossref
Paul R. Smith & Stephen R. Morley. 2017. Essentials of Autopsy Practice. Essentials of Autopsy Practice 59 85 .
Marcelo Dutra Arbo, Simone Melega, Regina Stöber, Markus Schug, Eugen Rempel, Jörg Rahnenführer, Patricio Godoy, Raymond Reif, Cristina Cadenas, Maria de Lourdes Bastos, Helena Carmo & Jan G. Hengstler. (2016) Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis. Archives of Toxicology 90:12, pages 3045-3060.
Crossref
Simon Elliott. 2016. Forensic Toxicology: Drug Use and Misuse. Forensic Toxicology: Drug Use and Misuse 94 126 .
D.P. Katz, J. Deruiter, D. Bhattacharya, M. Ahuja, S. Bhattacharya, C.R. Clark, V. Suppiramaniam & M. Dhanasekaran. (2016) Benzylpiperazine: “A messy drug”. Drug and Alcohol Dependence 164, pages 1-7.
Crossref
Karolina Persona, Anna Polus, Joanna Góralska, Anna Gruca, Aldona Dembińska-Kieć & Wojciech Piekoszewski. (2016) An In Vitro Study of the Neurotoxic Effects of N-Benzylpiperazine: A Designer Drug of Abuse. Neurotoxicity Research 29:4, pages 558-568.
Crossref
Evan S. Herrmann, Patrick S. Johnson, Matthew W. Johnson & Ryan Vandrey. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 893 902 .
Milena Majchrzak, Marcin Rojkiewicz, Rafa? Celi?ski, Piotr Ku?Mieczys?aw Sajewicz. (2015) Identification and characterization of new designer drug 4-fluoro-PV9 and ?-PHP in the seized materials. Forensic Toxicology 34:1, pages 115-124.
Crossref
Laura Hondebrink, Elise J.P. Hermans, Stijn Schmeink, Regina G.D.M. van Kleef, Jan Meulenbelt & Remco H.S. Westerink. (2015) Structure-dependent inhibition of the human ? 1 ? 2 ? 2 GABA A receptor by piperazine derivatives: A novel mode of action. NeuroToxicology 51, pages 1-9.
Crossref
Edward Walter & Mike Carraretto. (2015) Drug-induced hyperthermia in critical care. Journal of the Intensive Care Society 16:4, pages 306-311.
Crossref
Kathleen S Bonnici, Paul I Dargan & David M Wood. (2015) Novel psychoactive substances or ‘legal highs'. British Journal of Hospital Medicine 76:9, pages C130-C134.
Crossref
Brenda Wasunna, Emily Thomas & Sally Morgan. (2015) Development of legal highs. Journal of Psychiatric Intensive Care 11:02, pages 128-137.
Crossref
Brian P. Kersten & Megan E. McLaughlin. (2014) Toxicology and Management of Novel Psychoactive Drugs. Journal of Pharmacy Practice 28:1, pages 50-65.
Crossref
Magi Farré, Liliana Galindo & Marta Torrens. 2015. Textbook of Addiction Treatment: International Perspectives. Textbook of Addiction Treatment: International Perspectives 567 596 .
Chris Wilkins, Paul Sweetsur & Karl Parker. (2014) The impact of the prohibition of benzylpiperazine (BZP) “legal highs” on the availability, price and strength of BZP in New Zealand. Drug and Alcohol Dependence 144, pages 47-52.
Crossref
Frank T Peters. (2014) Recent developments in urinalysis of metabolites of new psychoactive substances using LC–MS. Bioanalysis 6:15, pages 2083-2107.
Crossref
Marcelo Dutra Arbo, Renata Silva, Daniel José Barbosa, Diana Dias da Silva, Luciana Grazziotin Rossato, Maria de Lourdes Bastos & Helena Carmo. (2014) Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment. Toxicology Letters 229:1, pages 178-189.
Crossref
Megan E. Musselman & Jeremy P. Hampton. (2014) “ Not for Human Consumption”: A Review of Emerging Designer Drugs . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 34:7, pages 745-757.
Crossref
Randy L. Luciano & Mark A. Perazella. (2014) Nephrotoxic effects of designer drugs: synthetic is not better!. Nature Reviews Nephrology 10:6, pages 314-324.
Crossref
Michael E. Nelson, Sean M. Bryant & Steven E. Aks. (2014) Emerging drugs of abuse. Disease-a-Month 60:3, pages 110-132.
Crossref
Linda D. Simmler, Anna Rickli, York Schramm, Marius C. Hoener & Matthias E. Liechti. (2014) Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives. Biochemical Pharmacology 88:2, pages 237-244.
Crossref
Michael E. Nelson, Sean M. Bryant & Steven E. Aks. (2014) Emerging Drugs of Abuse. Emergency Medicine Clinics of North America 32:1, pages 1-28.
Crossref
Bryan Wilson, Hamid Tavakoli, Daniel DeCecchis & Vimukta Mahadev. (2013) Synthetic Cannabinoids, Synthetic Cathinones, and Other Emerging Drugs of Abuse. Psychiatric Annals 43:12, pages 558-564.
Crossref
Andrew Herlich. (2013) Perioperative temperature elevation: not all hyperthermia is malignant hyperthermia. Pediatric Anesthesia 23:9, pages 842-850.
Crossref
Paul St John‐Smith, Daniel McQueen, Lindsey Edwards & Fabrizio Schifano. (2013) Classical and novel psychoactive substances: rethinking drug misuse from an evolutionary psychiatric perspective. Human Psychopharmacology: Clinical and Experimental 28:4, pages 394-401.
Crossref
Márcia Sá Monteiro, Maria de Lourdes Bastos, Paula Guedes de Pinho & Márcia Carvalho. (2013) Update on 1-benzylpiperazine (BZP) party pills. Archives of Toxicology 87:6, pages 929-947.
Crossref
Robert Dielenberg. (2013) The Speculative Neuroscience of the Future Human Brain. Humanities 2:2, pages 209-252.
Crossref
R. D. Johnson & S. R. Botch-Jones. (2013) The Stability of Four Designer Drugs: MDPV, Mephedrone, BZP and TFMPP in Three Biological Matrices under Various Storage Conditions. Journal of Analytical Toxicology 37:2, pages 51-55.
Crossref
P. M. O'Byrne, P. V. Kavanagh, S. M. McNamara & S. M. Stokes. (2013) Screening of Stimulants Including Designer Drugs in Urine Using a Liquid Chromatography Tandem Mass Spectrometry System. Journal of Analytical Toxicology 37:2, pages 64-73.
Crossref
G. T. C. Wong & M. G. Irwin. (2013) Poisoning with illicit substances: toxicology for the anaesthetist. Anaesthesia 68, pages 117-124.
Crossref
Paul Gee & Leo Schep. 2013. Novel Psychoactive Substances. Novel Psychoactive Substances 179 209 .
Silas W. Smith & Fiona M. Garlich. 2013. Novel Psychoactive Substances. Novel Psychoactive Substances 55 77 .
Kevin Woodward & Kevin WoodwardK. N. Woodward. 2012. Toxicological Effects of Veterinary Medicinal Products in Humans. Toxicological Effects of Veterinary Medicinal Products in Humans 95 154 .
Cho Rong Min, Mi Jie Kim, Yong Joo Park, Ha Ryong Kim, Soo Yeun Lee, Kyu Hyuck Chung & Seung Min Oh. (2012) Estrogenic effects and their action mechanism of the major active components of party pill drugs. Toxicology Letters 214:3, pages 339-347.
Crossref
F. Eyer & T. Zilker. (2012) DrogenintoxikationenDrug overdoses. Notfall + Rettungsmedizin 15:7, pages 569-576.
Crossref
M.D. Arbo, M.L. Bastos & H.F. Carmo. (2012) Piperazine compounds as drugs of abuse. Drug and Alcohol Dependence 122:3, pages 174-185.
Crossref
LINDA BERNEY-MEYER, TRACEY PUTT, JOHN SCHOLLUM & ROBERT WALKER. (2012) Nephrotoxicity of recreational party drugs. Nephrology 17:2, pages 99-103.
Crossref
Allister Vale. (2012) Drugs of abuse (amfetamines, BZP, cannabis, cocaine, GHB, LSD). Medicine 40:2, pages 84-87.
Crossref
Leo J. Schep, Robin J. Slaughter, Wayne A. Temple & Paul Gee. (2011) Comments on BZP and New Zealand's alternative approach to prohibition. Drug Testing and Analysis 4:1, pages 57-57.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.