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Short report

Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose

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Pages 340-344 | Received 28 Jan 2011, Accepted 12 Mar 2011, Published online: 12 May 2011

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Joseph Clemons, Arvinder Jandu, Brandon Stein & Michael Chary. (2022) Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports. Clinical Toxicology 60:5, pages 550-558.
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Joseph Clemons, Arvinder Jandu, Brandon Stein & Michael A. Chary. (2021) Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report. Toxicology Communications 5:1, pages 15-18.
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Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt & Sophie Gosselin. (2016) Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clinical Toxicology 54:3, pages 194-221.
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Ami M. Grunbaum, Brian M. Gilfix, Sophie Gosselin & David W. Blank. (2012) Analytical interferences resulting from intravenous lipid emulsion. Clinical Toxicology 50:9, pages 812-817.
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W Stephen Waring. (2012) Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data. Expert Review of Clinical Pharmacology 5:4, pages 437-444.
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Deborah French, Craig Smollin, Weiming Ruan, Alicia Wong, Kenneth Drasner & Alan H. B. Wu. (2011) Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clinical Toxicology 49:9, pages 801-809.
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Karim Jaffal, Lucie Chevillard & Bruno Mégarbane. (2023) Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies. Pharmaceutics 15:5, pages 1396.
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Pınar Demir Gündoğmuş & Ersin Doğanözü. (2022) Successful Management of Extended- Release Verapamil Intoxication: A Case Report. e-Journal of Cardiovascular Medicine 10:1, pages 40-43.
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Sheila X. Soh, Tze Ping Loh, Sunil K. Sethi & Lizhen Ong. (2021) Methods to reduce lipemic interference in clinical chemistry tests: a systematic review and recommendations. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
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Merve Havan, Tanıl Kendirli, Serhan Özcan, MelihTimuçin Doğan, AhmetOnur Yiğit & Tayfun Uçar. (2021) A successful treatment with intravenous lipid emulsion therapy in a child with verapamil poisoning. Turkish Journal of Emergency Medicine 21:4, pages 217.
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Xusheng An, Yong Mei, Hao Sun & Jinsong Zhang. (2020) Detoxification effects of long-chain versus a mixture of medium- and long-chain triglyceride-based fat emulsion on propafenone poisoning. Brazilian Journal of Medical and Biological Research 53:7.
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Richard Koch, Christie Sun, Alicia Minns & Richard F. Clark. 2019. Cardiac Intensive Care. Cardiac Intensive Care 351 366.e6 .
S-H Ok, I-W Shin, SH Lee, J Park, MS Woo, J-M Hong, J Kim & J-T Sohn. (2017) Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model. Human & Experimental Toxicology 37:6, pages 636-646.
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K. Jaffal, L. Chevillard & B. Megarbane. (2017) Place des émulsions lipidiques intraveineuses en toxicologieLipid resuscitation in acute poisonning. Médecine Intensive Réanimation 26:5, pages 373-382.
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Seong-Ho Ok, Mun Hwan Choi, Il-Woo Shin, Soo Hee Lee, Sebin Kang, Jiah Oh, Jeong Yeol Han & Ju-Tae Sohn. (2016) Lipid Emulsion Inhibits Apoptosis Induced by a Toxic Dose of Verapamil via the Delta-Opioid Receptor in H9c2 Rat Cardiomyoblasts. Cardiovascular Toxicology 17:3, pages 344-354.
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Y. K. Günaydın, O. Özelbaykal, H. Ş. Akça, N. Muraçar, N. B. Akıllı, R. Köylü & B. Cander. (2016) Intravenous lipid emulsion therapy in calcium channel blocker and beta-blocker poisoningIntravenöse Lipidemulsionstherapie bei Kalziumkanalblocker- und Betablockerintoxikation. Notfall + Rettungsmedizin 20:1, pages 54-60.
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David M. Black & Robert W. Shaffer. 2017. Evidence-Based Critical Care. Evidence-Based Critical Care 65 71 .
Christine M. Murphy, Cliff Williams, Michael E. Quinn, Brian Nicholson, Thomas Shoe, Michael C. Beuhler & William P. KernsIIII. (2016) Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock. Journal of Medical Toxicology 12:4, pages 380-385.
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Jaclyn O’ConnorSuprat Saely Wilson. (2016) Intravenous Lipid Emulsion for Management of Systemic Toxic Effects of Drugs. AACN Advanced Critical Care 27:4, pages 394-404.
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Samuel H.F. Lam, Nima Majlesi & Gary M. Vilke. (2016) Use of Intravenous Fat Emulsion in the Emergency Department for the Critically Ill Poisoned Patient. The Journal of Emergency Medicine 51:2, pages 203-214.
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Dmytro O. Kryshtal, Sheila Dawling, Donna Seger & Bjorn C. Knollmann. (2015) In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning. Journal of Medical Toxicology 12:2, pages 165-171.
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Loes Mandigers, Pauline D.J. Bollen, Peter J. Bijlstra & Els Brands. (2016) Severe verapamil intoxication despite correct use of low-dose verapamil. Drug Metabolism and Personalized Therapy 31:1, pages 55-58.
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Melvin A. Shiffman. 2016. Liposuction. Liposuction 789 800 .
Sam H. Muller, James H. Diaz & Alan David Kaye. (2015) Clinical applications of intravenous lipid emulsion therapy. Journal of Anesthesia 29:6, pages 920-926.
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Rachel E. Peacock, Giselle Hosgood, Katrin L. Swindells & Lisa Smart. (2015) A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats. Journal of Veterinary Emergency and Critical Care 25:5, pages 597-605.
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Michael R. Fettiplace & Guy Weinberg. (2015) Past, Present, and Future of Lipid Resuscitation Therapy. Journal of Parenteral and Enteral Nutrition 39:1_suppl, pages 72S-83S.
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Dazhe Cao, Kennon Heard, Mark Foran & Alex Koyfman. (2015) Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. The Journal of Emergency Medicine 48:3, pages 387-397.
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Zhousheng Jin, Yun Xia, Fangfang Xia, Cong Wu, Zhe Chen, Fubei Nan, Bingjing Wu, Li Wan, Xianqin Wang, Thomas J. Papadimos & Xuzhong Xu. (2015) Epinephrine Administration in Lipid-Based Resuscitation in a Rat Model of Bupivacaine-Induced Cardiac Arrest. Regional Anesthesia and Pain Medicine 40:3, pages 223-231.
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Ramachandran Meenakshisundaram, Douglas Ewan Cannie, P. Ravi Shankar, Heidar Z. Zadeh, Omi Bajracharya & Ponniah Thirumalaikolundusubramanian. 2015. Heart and Toxins. Heart and Toxins 225 274 .
Grant Cave & Martyn G Harvey. (2014) Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?. Critical Care 18:5.
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Shasine Veli, Vasil Atanasov, Jordan Angelov & Kamen Kanev. (2014) Simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in quetiapine overdose case. Open Medicine 9:3, pages 505-507.
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Mark A. Kostic & Marc Gorelick. (2014) Review of the Use of Lipid Emulsion in Nonlocal Anesthetic Poisoning. Pediatric Emergency Care 30:6, pages 427-433.
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Grant Cave, Martyn Harvey, Johann Willers, David Uncles, Tim Meek, John Picard & Guy Weinberg. (2014) LIPAEMIC Report: Results of Clinical Use of Intravenous Lipid Emulsion in Drug Toxicity Reported to an Online Lipid Registry. Journal of Medical Toxicology 10:2, pages 133-142.
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Michael R. Fettiplace, Belinda S. Akpa, Richard Ripper, Brian Zider, Jason Lang, Israel Rubinstein & Guy Weinberg. (2014) Resuscitation with Lipid Emulsion. Anesthesiology 120:4, pages 915-925.
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Bruce Doepker, William Healy, Eric Cortez & Eric J. Adkins. (2014) High-Dose Insulin and Intravenous Lipid Emulsion Therapy for Cardiogenic Shock Induced by Intentional Calcium-Channel Blocker and Beta-Blocker Overdose: A Case Series. The Journal of Emergency Medicine 46:4, pages 486-490.
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Mehmet S. Ozcan & Guy Weinberg. (2012) Intravenous Lipid Emulsion for the Treatment of Drug Toxicity. Journal of Intensive Care Medicine 29:2, pages 59-70.
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Michael Levine, Aaron B. Skolnik, Anne-Michelle Ruha, Adam Bosak, Nathan Menke & Anthony F. Pizon. (2013) Complications Following Antidotal Use of Intravenous Lipid Emulsion Therapy. Journal of Medical Toxicology 10:1, pages 10-14.
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Derrick D. Lung, Alan H.B. Wu & Roy R. Gerona. (2013) Cardiotoxicity in a Citalopram and Olanzapine Overdose. The Journal of Emergency Medicine 45:4, pages 554-558.
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Melissa L. Givens. (2012) Toxic Bradycardias in the Critically Ill Poisoned Patient. Emergency Medicine International 2012, pages 1-6.
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Aikaterini Papadopoulou, Johann W. Willers, Theophilus L. Samuels & David R. Uncles. (2012) The Use of Dye Surrogates to Illustrate Local Anesthetic Drug Sequestration by Lipid Emulsion. Regional Anesthesia and Pain Medicine 37:2, pages 183-187.
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Conrad W Liang, Sarah J Diamond & Daniel S Hagg. (2011) Lipid rescue of massive verapamil overdose: a case report. Journal of Medical Case Reports 5:1.
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