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Clinical Toxicology Volume 49, 2011 - Issue 9
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Brief Communications

Severe sodium channel blockade and cardiovascular collapse due to a massive Lamotrigine overdose

Joshua N. NogarUniversity of California San Diego, Division of Medical Toxicology, 200 West Arbor Drive, MC 8925, San Diego, United States;Veteran’s Affairs Medical Center - San Diego, Medical Toxicology, VA Medical Center, San Diego, United States;University of California - San Diego, Department of Emergency Medicine, 200 West Arbor Drive, MC8925, San Diego, United StatesCorrespondence[email protected]
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Alicia B. MinnsUniversity of California San Diego, Division of Medical Toxicology, 200 West Arbor Drive, MC 8925, San Diego, United States;University of California - San Diego, Department of Emergency Medicine, 200 West Arbor Drive, MC8925, San Diego, United States
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Davut J. SavaserUniversity of California - San Diego, Department of Emergency Medicine, 200 West Arbor Drive, MC8925, San Diego, United States
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Bihn T. LyUniversity of California San Diego, Division of Medical Toxicology, 200 West Arbor Drive, MC 8925, San Diego, United States;University of California - San Diego, Department of Emergency Medicine, 200 West Arbor Drive, MC8925, San Diego, United States
Pages 854-857 | Received 01 May 2011, Accepted 21 Aug 2011, Published online: 05 Oct 2011

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Maria Paneta & William Stephen Waring. (2019) Literature review of the evidence regarding intravenous lipid administration in drug-induced cardiotoxicity. Expert Review of Clinical Pharmacology 12:7, pages 591-602.
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Bader Alyahya, Marjorie Friesen, Bénédicte Nauche & Martin Laliberté. (2018) Acute lamotrigine overdose: a systematic review of published adult and pediatric cases. Clinical Toxicology 56:2, pages 81-89.
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Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt & Sophie Gosselin. (2016) Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clinical Toxicology 54:3, pages 194-221.
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P. W. Moore, J. W. Donovan, K. K. Burkhart & D. Haggerty. (2013) A case series of patients with lamotrigine toxicity at one center from 2003 to 2012. Clinical Toxicology 51:7, pages 545-549.
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W Stephen Waring. (2012) Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data. Expert Review of Clinical Pharmacology 5:4, pages 437-444.
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Articles from other publishers (18)

Wenyi Wang, Vera Battini, Carla Carnovale, Raymond Noordam, Ko Willems van Dijk, Kristian Hay Kragholm, Diana van Heemst, Hiie Soeorg & Maurizio Sessa. (2023) A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases: A case study using Danish registries for an FDA warning on lamotrigine. Pharmacological Research 193, pages 106811.
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Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin & Robert Dumaine. (2022) Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INa by Lamotrigine; A Potential for Acquired Arrythmias. Pharmaceuticals 15:10, pages 1208.
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Judith A. Restrepo, Rachel L. MacLean, Christopher M. Celano, Jeffery C. Huffman, James L. Januzzi & Scott R. Beach. (2022) The assessment of cardiac risk in patients taking lamotrigine; a systematic review. General Hospital Psychiatry 78, pages 14-27.
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N. A. Shnayder, M. M. Petrova, K. V. Petrov & R. F. Nasyrova. (2021) Pharmacological predictors of heart rate and conductivity disorders in juvenile myoclonic epilepsy. Epilepsy and paroxysmal conditions 13:2, pages 168-179.
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Alicia MastroccoAlex L. BlutingerSamantha A. BaineJennifer E. Prittie. (2021) Use of injectable lipid emulsion and sodium bicarbonate to treat severe cardiovascular collapse secondary to lamotrigine toxicosis in a dog. Journal of the American Veterinary Medical Association 258:5, pages 510-514.
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Abhinav Agrawal, Joshua N. Nogar & Seth Koenig. (2019) Management of lamotrigine overdose using hemodialysis. The American Journal of Emergency Medicine 37:8, pages 1603.e1-1603.e2.
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Tara J. Bellis & Laura Gibeon. (2018) The use of intralipid emulsion therapy to treat severe cardiotoxicity secondary to lamotrigine ingestion in a dog. Clinical Case Reports 6:10, pages 1982-1988.
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Kevin M.W. Leong, Henry Seligman & Amanda M. Varnava. (2017) Proarrhythmogenic effects of lamotrigine during ajmaline testing for Brugada syndrome. HeartRhythm Case Reports 3:3, pages 167-171.
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M. P. Emswiler & K. L. Cumpston. 2017. Critical Care Toxicology. Critical Care Toxicology 1 18 .
M. P. Emswiler & Kirk L. Cumpston. 2017. Critical Care Toxicology. Critical Care Toxicology 1065 1081 .
Sokratis E. Karaoulanis, Markos Syngelakis & Konstantinos Fokas. (2016) Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature. Annals of General Psychiatry 15:1.
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Akintunde Alabi, Adam Todd, Andrew Husband & Joe Reilly. (2016) Safety profile of lamotrigine in overdose. Therapeutic Advances in Psychopharmacology 6:6, pages 369-381.
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M. P. Emswiler & K. L. Cumpston. 2016. Critical Care Toxicology. Critical Care Toxicology 1 18 .
Patricia Chavez, Abel Casso Dominguez & Eyal Herzog. (2014) Evolving Electrocardiographic Changes in Lamotrigine Overdose: A Case Report and Literature Review. Cardiovascular Toxicology 15:4, pages 394-398.
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Dazhe Cao, Kennon Heard, Mark Foran & Alex Koyfman. (2015) Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. The Journal of Emergency Medicine 48:3, pages 387-397.
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Steve S. Chung & Courtney Schusse. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 133 169 .
Joseph K. Maddry, Klementyna Breyer, Kelly M. Cook & Kennon Heard. (2013) Monomorphic ventricular tachycardia after intentional citalopram overdose. The American Journal of Emergency Medicine 31:2, pages 447.e5-447.e8.
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. (2013) Lamotrigine overdose. Reactions Weekly 1387:1, pages 23-23.
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