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Clinical Toxicology Volume 49, 2011 - Issue 9
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Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms

Marco VinettiCliniques St-Luc, Université catholique de Louvain, Intensive Care, Avenue Hippocrate 10, Brussels, 1200 BelgiumCorrespondence[email protected]
,
Vincent HaufroidUniversité catholique de Louvain, Louvain Centre for Toxicology and Applied Pharmacology, Avenue Hippocrate 10, Brussels, 1200 Belgium
,
Arnaud CapronUniversité catholique de Louvain, Louvain Centre for Toxicology and Applied Pharmacology, Avenue Hippocrate 10, Brussels, 1200 Belgium
,
Jean-François ClassenUniversité catholique de Louvain, Louvain Centre for Toxicology and Applied Pharmacology, Avenue Hippocrate 10, Brussels, 1200 Belgium
,
Sebastien MarchandiseCliniques St-Luc, Cardiology, Avenue Hippocrate 10, Brussels, 1200 Belgium
&
Philippe HantsonCliniques St-Luc, Université catholique de Louvain, Intensive Care, Avenue Hippocrate 10, Brussels, 1200 Belgium
Pages 865-869 | Received 27 Apr 2011, Accepted 16 Sep 2011, Published online: 14 Nov 2011

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Philippe Hantson. (2019) Mechanisms of toxic cardiomyopathy. Clinical Toxicology 57:1, pages 1-9.
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Vincent Haufroid & Philippe Hantson. (2015) CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants. Clinical Toxicology 53:6, pages 501-510.
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M. Batista, T. Dugernier, M. Simon, V. Haufroid, A. Capron, S. Fonseca, F. Bonbled & P. Hantson. (2013) The spectrum of acute heart failure after venlafaxine overdose. Clinical Toxicology 51:2, pages 92-95.
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Marianne K. Kringen, Line S. Bråten, Tore Haslemo & Espen Molden. (2020) The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O-Desmethylvenlafaxine Concentrations in a Large Patient Cohort. Journal of Clinical Psychopharmacology 40:2, pages 137-144.
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Harleen Singh, Barent DuBois, Zain Al-Jammali & Thomas Barrett. (2019) Pharmacogenomics in the clinic: genetic polymorphism contributing to venlafaxine-associated heart failure. Pharmacogenomics 20:17, pages 1175-1178.
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Melad G. Paulis, Essam M. Hafez, Nashwa F. El-Tahawy & Mohmed K. M. Aly. (2018) Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats. International Journal of Toxicology 37:4, pages 327-334.
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Adela Taranu, Romain Colle, Florence Gressier, Khalil El Asmar, Laurent Becquemont, Emmanuelle Corruble & Céline Verstuyft. (2017) Should a routine genotyping of CYP2D6 and CYP2C19 genetic polymorphisms be recommended to predict venlafaxine efficacy in depressed patients treated in psychiatric settings? . Pharmacogenomics 18:7, pages 639-650.
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Sofia Garcia, Michael Schuh, Anvir Cheema, Herjot Atwal & Paldeep S. Atwal. (2017) Palpitations and Asthenia Associated with Venlafaxine in a CYP2D6 Poor Metabolizer and CYP2C19 Intermediate Metabolizer. Case Reports in Genetics 2017, pages 1-4.
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Diego Castanares-Zapatero, Nathalie Gillard, Arnaud Capron, Vincent Haufroid & Philippe Hantson. (2016) Reversible cardiac dysfunction after venlafaxine overdose and possible influence of genotype and metabolism. Forensic Science International 266, pages e48-e51.
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Malik Nassan, Wayne T. Nicholson, Michelle A. Elliott, Carolyn R. Rohrer Vitek, John L. Black & Mark A. Frye. (2016) Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine. Mayo Clinic Proceedings 91:7, pages 897-907.
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Natalia M. Jasiak & Jolene R. Bostwick. (2014) Risk of QT/QTc Prolongation Among Newer Non-SSRI Antidepressants. Annals of Pharmacotherapy 48:12, pages 1620-1628.
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Philippe Hantson, Mélissa Batista, Sandhya Fonseca, Ingrid Ferreira, Vincent Haufroid, Arnaud Capron, Frédéric Bonbled & Jean-Pierre Cosyns. (2014) Acute heart failure after venlafaxine overdose: Post-mortem myocardial examination in two cases. Toxicologie Analytique et Clinique 26:4, pages 193-196.
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Katrin Sangkuhl, Julia C. Stingl, Miia Turpeinen, Russ B. Altman & Teri E. Klein. (2014) PharmGKB summary. Pharmacogenetics and Genomics 24:1, pages 62-72.
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C. Schroeder & J. Jordan. (2012) Norepinephrine transporter function and human cardiovascular disease. American Journal of Physiology-Heart and Circulatory Physiology 303:11, pages H1273-H1282.
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. (2013) Paracetamol/venlafaxine overdose. Reactions Weekly 1387:1, pages 33-33.
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