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Commentary

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(Director Emeritus, Professor) &
Pages 91-98 | Received 26 Nov 2011, Accepted 17 Jan 2012, Published online: 10 Feb 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Angela L. Chiew & Geoffrey K. Isbister. (2023) Advances in the understanding of acetaminophen toxicity mechanisms: a clinical toxicology perspective. Expert Opinion on Drug Metabolism & Toxicology 0:0, pages 1-16.
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J. C. Lewis, M. Lim, L. Lai, E. Mendoza, T. E. Albertson & J. A. Chenoweth. (2022) Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion. Clinical Toxicology 60:4, pages 507-513.
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Angela L. Chiew, Genaro Domingo, Nicholas A. Buckley, Paul Stathakis, Kirsty Ress & Darren M. Roberts. (2020) Hepatotoxicity in a child following an accidental overdose of liquid paracetamol. Clinical Toxicology 58:11, pages 1063-1066.
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Robert G. Hendrickson. (2019) What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clinical Toxicology 57:8, pages 686-691.
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Adam Mutsaers, Jason P. Green, Marco L. A. Sivilotti, Mark C. Yarema, Dylan Tucker, David W. Johnson, Daniel A. Spyker & Barry H. Rumack. (2019) Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clinical Toxicology 57:6, pages 380-386.
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Angela L. Chiew, Geoffrey K. Isbister, Katharine A. Kirby, Colin B. Page, Betty S. H. Chan & Nicholas A. Buckley. (2017) Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clinical Toxicology 55:10, pages 1055-1065.
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Geoffrey K. Isbister, Michael A. Downes, Kylie Mcnamara, Ingrid Berling, Ian M. Whyte & Colin B. Page. (2016) A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. Clinical Toxicology 54:2, pages 120-126.
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R. Mason Curtis & Marco L. A. Sivilotti. (2015) A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose. Clinical Toxicology 53:9, pages 849-855.
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D. Nicholas Bateman. (2014) Pack size and paracetamol overdose: 16 years later. Clinical Toxicology 52:8, pages 821-823.
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K. Heard, B. H. Rumack, J. L. Green, B. Bucher-Bartelson, S. Heard, A. C. Bronstein & R. C. Dart. (2014) A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clinical Toxicology 52:5, pages 512-518.
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M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
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Maiyen Tran Hawkins & James H Lewis. (2012) Latest advances in predicting DILI in human subjects: focus on biomarkers. Expert Opinion on Drug Metabolism & Toxicology 8:12, pages 1521-1530.
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