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Clinical Toxicology Volume 50, 2012 - Issue 5
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Research Article

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: A retrospective cohort study

David N. JuurlinkInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;Department of Medicine, University of Toronto, Toronto, ON, Canada;Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;The Sunnybrook Research Institute, Toronto, ON, CanadaCorrespondence[email protected]
,
Tara GomesInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;The Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
,
Astrid GuttmannInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
,
Chelsea HellingsInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada
,
Marco L. A. SivilottiDepartments of Emergency Medicine, and Pharmacology & Toxicology, Queen's University, Kingston, ON, Canada
,
Marie-Andrée HarveyDepartments of Obstetrics & Gynaecology and of Urology, Queen's University, Kingston, ON, Canada
&
Muhammad M. MamdaniInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;The Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada;Department of Medicine, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada;Keenan Research Centre of the Li Ka-Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada;College of Medicine, King Saud University, Riyadh, Saudi Arabia
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Pages 390-395 | Received 12 Mar 2011, Accepted 26 Mar 2012, Published online: 27 Apr 2012

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Vincent Haufroid & Philippe Hantson. (2015) CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants. Clinical Toxicology 53:6, pages 501-510.
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Jonathan S Zipursky, Tara Gomes, Karl Everett, Andrew Calzavara, J Michael Paterson, Peter C Austin, Muhammad M Mamdani, Joel G Ray & David N Juurlink. (2023) Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study. BMJ, pages e074005.
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Jonathan S. Zipursky, Andrea Pang, J. Michael Paterson, Peter C. Austin, Muhammad Mamdani, Tara Gomes, Joel G. Ray & David N. Juurlink. (2021) Trends in Postpartum Opioid Prescribing: A Time Series Analysis. Clinical Pharmacology & Therapeutics 110:4, pages 1004-1010.
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Jonathan Zipursky & David N. Juurlink. (2020) The Implausibility of Neonatal Opioid Toxicity from Breastfeeding. Clinical Pharmacology & Therapeutics 108:5, pages 964-970.
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Sean AinsworthSean Ainsworth. 2020. Neonatal Formulary. Neonatal Formulary.
Shinya Ito. (2018) Opioids in Breast Milk: Pharmacokinetic Principles and Clinical Implications. The Journal of Clinical Pharmacology 58, pages S151-S163.
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Jamie Falk, Matthew Dahl, Colette B. Raymond, Dan Chateau, Alan Katz, Christine Leong & Shawn Bugden. (2017) Opioid use during pregnancy: a population-based cohort study. CMAJ Open 5:2, pages E517-E523.
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Kate S Wiles & Anita Banerjee. (2016) Acute kidney injury in pregnancy and the use of non-steroidal anti-inflammatory drugs. The Obstetrician & Gynaecologist 18:2, pages 127-135.
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Philip O. Anderson, Anthony S. Manoguerra & Verónica Valdés. (2015) A Review of Adverse Reactions in Infants From Medications in Breastmilk. Clinical Pediatrics 55:3, pages 236-244.
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Amuchou Singh Soraisham. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 392 398 .
S. D. Turner, T. Gomes, X. Camacho, Z. Yao, A. Guttmann, M. M. Mamdani, D. N. Juurlink & I. A. Dhalla. (2015) Neonatal opioid withdrawal and antenatal opioid prescribing. CMAJ Open 3:1, pages E55-E61.
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Suni Halder, Robin Russell & Jane Quinlan. (2015) Codeine and breast-feeding mothers. International Journal of Obstetric Anesthesia 24:1, pages 5-7.
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SG Nicholls, BJ Wilson, D Castle, H Etchegary & JC Carroll. (2014) Personalized medicine and genome-based treatments: Why personalized medicine ≠ individualized treatments. Clinical Ethics 9:4, pages 135-144.
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A. Palanisamy & C. R. Bailey. (2014) Codeine in mothers and children: where are we now?. Anaesthesia 69:7, pages 655-660.
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Marjorie Meyer. (2014) The Perils of Opioid Prescribing During Pregnancy. Obstetrics and Gynecology Clinics of North America 41:2, pages 297-306.
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Lauren E. Kelly, Shahnaz A. Chaudhry, Michael J. Rieder, Geert ?t Jong, Myla E. Moretti, Andrea Lausman, Colin Ross, Howard Berger, Bruce Carleton, Michael R. Hayden, Parvaz Madadi & Gideon Koren. (2013) A Clinical Tool for Reducing Central Nervous System Depression among Neonates Exposed to Codeine through Breast Milk. PLoS ONE 8:7, pages e70073.
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Susanne M. Matich. (2013) Just Pediatrics: Just Say ?No? to Codeine: The Story of Kids, Ultrarapid Metabolizers, and the CYP2D6 System. Journal of Radiology Nursing 32:2, pages 97-98.
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Chris R. Bain & Andrew D. Shaw. (2012) Genetics and epigenetics in perioperative medicine. Current Opinion in Critical Care 18:5, pages 548-554.
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Jessica Lam, Jeremy N. Matlow, Colin J.D. Ross, Michael R. Hayden, Bruce C. Carleton & Parvaz Madadi. (2012) Postpartum Maternal Codeine Therapy and the Risk of Adverse Neonatal Outcomes. Therapeutic Drug Monitoring 34:4, pages 378-380.
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