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Research Article

Phase II study of magnesium sulfate in acute organophosphate pesticide poisoning

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Pages 35-40 | Received 08 Aug 2012, Accepted 03 Dec 2012, Published online: 11 Jan 2013

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Ashok Kumar Pannu, Sahil Garg, Ashish Bhalla, Deba Prasad Dhibar & Navneet Sharma. (2022) Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial. Clinical Toxicology 60:5, pages 602-608.
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Kosala N. Dissanayake, Robert Chang-Chih Chou, Adrian Thompson, Filip Margetiny, Charlotte Davie, Scott McKinnon, Vishwendra Patel, Lester Sultatos, Joseph J. McArdle, Richard E. Clutton, Michael Eddleston & Richard R. Ribchester. (2021) Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure. Clinical Toxicology 59:12, pages 1239-1258.
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Maria Alozi & Mutasem Rawas-Qalaji. (2020) Treating organophosphates poisoning: management challenges and potential solutions. Critical Reviews in Toxicology 50:9, pages 764-779.
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Miran Brvar, Ming Yin Chan, Andrew H. Dawson, Richard R. Ribchester & Michael Eddleston. (2018) Magnesium sulfate and calcium channel blocking drugs as antidotes for acute organophosphorus insecticide poisoning – a systematic review and meta-analysis. Clinical Toxicology 56:8, pages 725-736.
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Articles from other publishers (21)

M.L. Zinovieva, N.V. Kurdil, P.G. Zhminko, M.G. Prodanchuk, O.P. Kravchuk & M.V. Velychko. (2023) Pharmacological therapeutic appliance for acute poisoning by organophosphorous compounds of anticholinesterase action (review of literature). Ukrainian Journal of Modern Toxicological Aspects 94:1, pages 42-54.
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Jayanta Kumar Mitra, Upendra Hansda, Debapriya Bandyopadhyay, Satyaki Sarkar & Joshna Sahoo. (2023) The role of a combination of N-acetylcysteine and magnesium sulfate as adjuvants to standard therapy in acute organophosphate poisoning: A randomized controlled trial. Heliyon 9:4, pages e15376.
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Mutasem Rawas-Qalaji, Hnin Ei Thu & Zahid Hussain. 2023. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects 539 568 .
Elisabeth Wigenstam, Elisabet Artursson, Anders Bucht & Lina Thors. (2022) Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction. Chemico-Biological Interactions 364, pages 110061.
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Kosala N. Dissanayake, Robert R. Redman, Harry Mackenzie, Michael Eddleston & Richard R. Ribchester. (2022) “Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions. Frontiers in Molecular Neuroscience 15.
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HMohan Kumar, AshokKumar Pannu, Susheel Kumar, Navneet Sharma & Ashish Bhalla. (2022) Magnesium sulfate in organophosphorus compound poisoning: A prospective open-label clinician-initiated intervention trial with historical controls. International Journal of Critical Illness and Injury Science 12:1, pages 33.
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Sakib Aman, Shrebash Paul & Fazle Rabbi Chowdhury. (2021) Management of Organophosphorus Poisoning. Critical Care Clinics 37:3, pages 673-686.
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Monika Jain, Priyanka Yadav, Bhavana Joshi, Abhijeet Joshi & Prashant Kodgire. (2020) A novel biosensor for the detection of organophosphorus (OP)-based pesticides using organophosphorus acid anhydrolase (OPAA)-FL variant. Applied Microbiology and Biotechnology 105:1, pages 389-400.
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Hammad Ahmed, Ali Sharif, Sahar Bakht, Faraza Javed & Waseem Hassan. 2021. Environmental Contaminants and Neurological Disorders. Environmental Contaminants and Neurological Disorders 231 247 .
S Shafeeq & T Mahboob. (2019) Magnesium supplementation ameliorates toxic effects of 2,4-dichlorophenoxyacetic acid in rat model. Human & Experimental Toxicology 39:1, pages 47-58.
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Christopher M. Timperley, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig, Djafer Benachour, Veronica Borrett, Flerida A. Cariño, Michael Geist, David Gonzalez, William Kane, Zrinka Kovarik, Roberto Martínez-Álvarez, Nicia Maria Fusaro Mourão, Slawomir Neffe, Syed K. Raza, Valentin Rubaylo, Alejandra Graciela Suárez, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Paula S. Vanninen, Slavica Vučinić, Volodymyr Zaitsev, Muhammad Zafar-Uz-Zaman, Mongia Saïd Zina, Stian Holen, Jonathan E. Forman, Wesam S. Alwan & Vivek Suri. (2019) Advice on assistance and protection by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents. Toxicology 413, pages 13-23.
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Alfredo F. Gei, Victor R. Suarez & James W. Van Hook. 2018. Critical Care Obstetrics. Critical Care Obstetrics 927 983 .
Fazle Rabbi Chowdhury, Gourab Dewan, Vasundhara R Verma, Duleeka W Knipe, Ishrat Tahsin Isha, M Abul Faiz, David J Gunnell & Michael Eddleston. (2018) Bans of WHO Class I Pesticides in Bangladesh—suicide prevention without hampering agricultural output. International Journal of Epidemiology 47:1, pages 175-184.
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Karla Alejo-González, Erik Hanson-Viana & Rafael Vazquez-Duhalt. (2018) Enzymatic detoxification of organophosphorus pesticides and related toxicants有機リン系殺虫剤よび関連毒物の酵素的無毒化. Journal of Pesticide Science 43:1, pages 1-9.
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James Philomena, Vajaravelu Sathi & Parthasarathy Prathiba. (2016) A CASE CONTROL STUDY OF INTRAVENOUS MAGNESIUM SULPHATE IN TREATMENT OF ACUTE ORGANOPHOSPHATE POISONING. Journal of Evolution of Medical and Dental Sciences 5:38, pages 2290-2294.
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Michael Eddleston & Fazle Rabbi Chowdhury. (2015) Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new. British Journal of Clinical Pharmacology 81:3, pages 462-470.
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Liang Sun, Guo-qiang Li, Peng-bo Yan, Yang Liu, Guo-feng Li & Lu-Qing Wei. (2015) Clinical management of organophosphate poisoning in pregnancy. The American Journal of Emergency Medicine 33:2, pages 305.e1-305.e3.
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Elspeth J. Hulse, James O. J. Davies, A. John Simpson, Alfred M. Sciuto & Michael Eddleston. (2014) Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning. Implications for Respiratory and Critical Care. American Journal of Respiratory and Critical Care Medicine 190:12, pages 1342-1354.
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Fang Zhang, Haoyang Wang, Li Zhang, Jing Zhang, Ruojing Fan, Chongtian Yu, Wenwen Wang & Yinlong Guo. (2014) Suspected-target pesticide screening using gas chromatography–quadrupole time-of-flight mass spectrometry with high resolution deconvolution and retention index/mass spectrum library. Talanta 128, pages 156-163.
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Darren M. Roberts & Jonathan Brett. 2014. Basic and Clinical Toxicology of Organophosphorus Compounds. Basic and Clinical Toxicology of Organophosphorus Compounds 141 175 .
Jayanta Kumar Mitra, Upendra Hansda, Debapriya Bandyopadhyay, Satyaki Sarkar & Joshna Sahoo. (2022) The Role of a Combination of N-Acetylcysteine and Magnesium Sulfate as Adjuvants to Standard Therapy in Acute Organophosphate Poisoning: A Randomized Controlled Trial. SSRN Electronic Journal.
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