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Clinical Toxicology Volume 51, 2013 - Issue 10
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Critical Care

Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning

J. G. SchierDivision of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USACorrespondence[email protected]
,
D. R. HuntDivision of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
,
A. PeralaThe Dow Chemical Company, Atlanta, GA, USA
,
K. E. McMartinLSU Health Sciences Center – Shreveport, Shreveport, LA, USA
,
M. J. BartelsThe Dow Chemical Company, Atlanta, GA, USA
,
L. S. LewisDivision of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
,
M. A. McGeehinDivision of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
&
W. D. FlandersDivision of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
 show all
Pages 923-929 | Received 12 Jun 2013, Accepted 24 Sep 2013, Published online: 25 Nov 2013

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Julie D. Tobin, Courtney N. Jamison, Corie N. Robinson & Kenneth E. McMartin. (2023) Variable sensitivity to diethylene glycol poisoning is related to differences in the uptake transporter for the toxic metabolite diglycolic acid. Clinical Toxicology 61:4, pages 207-211.
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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2022) Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats. Clinical Toxicology 60:3, pages 324-331.
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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2021) Neurotoxic effects of nephrotoxic compound diethylene glycol. Clinical Toxicology 59:9, pages 810-821.
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Corie N. Robinson, Brian Latimer, Fleurette Abreo, Kiera Broussard & Kenneth E. McMartin. (2017) In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol. Clinical Toxicology 55:3, pages 196-205.
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Taylor Conrad, Greg M. Landry, Tak Yee Aw, Royce Nichols & Kenneth E. McMartin. (2016) Diglycolic acid, the toxic metabolite of diethylene glycol, chelates calcium and produces renal mitochondrial dysfunction in vitro. Clinical Toxicology 54:6, pages 501-511.
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Julie D. Tobin, Corie N. Robinson, Elliot S. Luttrell-Williams, Greg M. Landry & Kenneth E. McMartin. (2023) Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicology Letters 379, pages 48-55.
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Julie D Tobin, Corie N Robinson, Elliot S Luttrell-Williams, Greg M Landry, Donard Dwyer & Kenneth E McMartin. (2022) Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells. Toxicological Sciences 190:1, pages 1-12.
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Cristiano O L Goulart, Leonardo S Bordoni, Clésia C Nascentes & Letícia M Costa. (2022) Analysis of Diglycolic Acid after Mass Poisoning by Diethylene Glycol. Journal of Analytical Toxicology 46:1, pages 64-68.
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Kristi J. Reed, Dylan T. Freeman & Greg M. Landry. (2021) Diethylene glycol and its metabolites induce cell death in SH-SY5Y neuronal cells in vitro. Toxicology in Vitro 75, pages 105196.
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Celine Bolwerk, Larissa P. M. W. D. Govers, Hanna Knol, Thom F. Oostendorp & Roland Brock. (2018) Modeling the Accumulation of Degradable Polymer Drug Carriers in the Brain. ChemMedChem 13:13, pages 1308-1310.
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Kenneth E. McMartin. 2018. Mitochondrial Biology and Experimental Therapeutics. Mitochondrial Biology and Experimental Therapeutics 193 211 .
William M. Snellings, Kenneth E. McMartin, Marcy I. Banton, Fred Reitman & Joanna Klapacz. (2017) Human health assessment for long-term oral ingestion of diethylene glycol. Regulatory Toxicology and Pharmacology 87, pages S1-S20.
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Avneesh Gupta, Francisco J. Diaz, Anita Lal, Lokman Sung & Cynthia K. Aaron. (2017) Basal Ganglion Hemorrhage as Delayed Complication of Diethylene Glycol Ingestion. American Journal of Forensic Medicine & Pathology 38:1, pages 39-42.
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Knut Erik Hovda, Kenneth McMartin & Dag Jacobsen. 2017. Critical Care Toxicology. Critical Care Toxicology 1743 1760 .
Allister Vale. (2016) Alcohols and glycols. Medicine 44:3, pages 128-132.
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Knut Erik Hovda, Kenneth McMartin & Dag Jacobsen. 2016. Critical Care Toxicology. Critical Care Toxicology 1 18 .
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M. Famele, C. Ferranti, C. Abenavoli, L. Palleschi, R. Mancinelli & R. Draisci. (2014) The Chemical Components of Electronic Cigarette Cartridges and Refill Fluids: Review of Analytical Methods. Nicotine & Tobacco Research 17:3, pages 271-279.
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Greg M. Landry, Cody L. Dunning, Fleurette Abreo, Brian Latimer, Elysse Orchard & Kenneth E. McMartin. (2015) Diethylene glycol-induced toxicities show marked threshold dose response in rats. Toxicology and Applied Pharmacology 282:3, pages 244-251.
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Tomáš Hložek, Miroslava Bursová & Radomír Čabala. (2014) Fast determination of ethylene glycol, 1,2-propylene glycol and glycolic acid in blood serum and urine for emergency and clinical toxicology by GC-FID. Talanta 130, pages 470-474.
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Yahia Zakaria Bashier Imam, Saadat Kamran, Hanfa Karim, Osama Elalamy, Tageldin Sokrab, Yasir Osman & Dirk Deleu. (2014) Neurological Manifestation of Recreational Fatal and Near-Fatal Diethylene Glycol Poisonings. Medicine 93:10, pages e62.
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Nestor R. Sosa, Giselle M. Rodriguez, Joshua G. Schier & James J. Sejvar. (2014) Clinical, Laboratory, Diagnostic, and Histopathologic Features of Diethylene Glycol Poisoning—Panama, 2006. Annals of Emergency Medicine 64:1, pages 38-47.
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Adam W. Perala, Mark J. Filary, Michael J. Bartels & Kenneth E. McMartin. (2014) Quantitation of Diethylene Glycol and Its Metabolites by Gas Chromatography Mass Spectrometry or Ion Chromatography Mass Spectrometry in Rat and Human Biological Samples. Journal of Analytical Toxicology 38:4, pages 184-193.
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