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Clinical Toxicology Volume 52, 2014 - Issue 8
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Research Article

Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: The recent United Kingdom experience

D. N. BatemanNational Poisons Information Service (Edinburgh) & Royal Infirmary of Edinburgh, Edinburgh, UK;Pharmacology, Toxicology and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UKCorrespondence[email protected]
,
J. W. DearNational Poisons Information Service (Edinburgh) & Royal Infirmary of Edinburgh, Edinburgh, UK;Pharmacology, Toxicology and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
,
R. CarrollSchool of Social and Community Medicine, University of Bristol, Bristol, UK
,
J. PettieNational Poisons Information Service (Edinburgh) & Royal Infirmary of Edinburgh, Edinburgh, UK
,
T. YamamotoGuy's and St Thomas’ NHS Foundation Trust and King's Health Partners, London, UK
,
M. E. M. O. ElaminNational Poisons Information Service (Newcastle) and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
,
L. PeartNational Poisons Information Service (Newcastle) and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
,
M. DowNational Poisons Information Service (Edinburgh) & Royal Infirmary of Edinburgh, Edinburgh, UK
,
J. CoyleDepartment of Emergency Medicine, Emergency Medicine Research Group, Royal Infirmary of Edinburgh, Edinburgh, UK
,
A. GrayDepartment of Emergency Medicine, Emergency Medicine Research Group, Royal Infirmary of Edinburgh, Edinburgh, UK
,
P. I. DarganGuy's and St Thomas’ NHS Foundation Trust and King's Health Partners, London, UK;King's College London, London, UK
,
D. M. WoodGuy's and St Thomas’ NHS Foundation Trust and King's Health Partners, London, UK;King's College London, London, UK
,
M. EddlestonNational Poisons Information Service (Edinburgh) & Royal Infirmary of Edinburgh, Edinburgh, UK;Pharmacology, Toxicology and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
&
S. H. L. ThomasNational Poisons Information Service (Newcastle) and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK;Institute of Cellular Medicine, Faculty of Medicine, Newcastle University, Newcastle, UK
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Pages 868-872 | Received 01 Jul 2014, Accepted 06 Aug 2014, Published online: 09 Sep 2014

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Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi & Rose Cairns. (2023) Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 297-317.
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Anselm Wong & Andis Graudins. (2017) Risk prediction of hepatotoxicity in paracetamol poisoning. Clinical Toxicology 55:8, pages 879-892.
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Michael Levine, Sam Stellpflug, Anthony F. Pizon, Stephen Traub, Rais Vohra, Timothy Wiegand, Nicole Traub, David Tashman, Shoma Desai, Jamie Chang, Dhruv Nathwani & Stephen Thomas. (2017) Estimating the impact of adopting the revised United Kingdom acetaminophen treatment nomogram in the U.S. population. Clinical Toxicology 55:6, pages 569-572.
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R. Mason Curtis & Marco L. A. Sivilotti. (2016) Reply to Cantrell and Nordt. Clinical Toxicology 54:6, pages 537-537.
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Jonathan G. Stine & James H. Lewis. (2016) Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Review of Gastroenterology & Hepatology 10:4, pages 517-536.
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Articles from other publishers (8)

A. Yu. Simonova, M. M. Potskhveriya, M. V. Belova, K. K. Ilyashenko, V. V. Kulabuhov, N. Y. Stolbova & A. E. Klyuev. (2022) On the Treatment of Acute Poisoning With Paracetamol. Russian Sklifosovsky Journal "Emergency Medical Care" 11:2, pages 249-257.
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Diego Castanares-Zapatero, Valérie Dinant, Ilaria Ruggiano, Harold Willem, Pierre-François Laterre & Philippe Hantson. (2018) Pattern of Paracetamol Poisoning: Influence on Outcome and Complications. Toxics 6:4, pages 58.
Crossref
D. Nicholas Bateman. 2017. Critical Care Toxicology. Critical Care Toxicology 1145 1169 .
Sa’ed H. Zyoud, W. Stephen Waring, Samah W. Al-Jabi, Waleed M. Sweileh & Rahmat Awang. (2016) The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. SpringerPlus 5:1.
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Girish L Gupte. (2016) Management of paracetamol overdose. Paediatrics and Child Health 26:10, pages 459-463.
Crossref
D. Nicholas Bateman. 2016. Critical Care Toxicology. Critical Care Toxicology 1 25 .
Elizabeth M. Lancaster, Jonathan R. Hiatt & Ali Zarrinpar. (2014) Acetaminophen hepatotoxicity: an updated review. Archives of Toxicology 89:2, pages 193-199.
Crossref
D. Nicholas Bateman. 2016. Critical Care Toxicology. Critical Care Toxicology 1 25 .

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