7,365
Views
72
CrossRef citations to date
0
Altmetric
Critical Care

Extracorporeal treatment for valproic acid poisoning: Systematic review and recommendations from the EXTRIP workgroup

, , , , , , & show all
Pages 454-465 | Received 30 Jan 2015, Accepted 23 Mar 2015, Published online: 07 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Anselm Wong, Robert S. Hoffman, Steven J. Walsh, Darren M. Roberts, Sophie Gosselin, Timothy E. Bunchman, Sofia Kebede, Valery Lavergne & Marc Ghannoum. (2021) Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup. Clinical Toxicology 59:5, pages 361-375.
Read now
Shaikha Al Jawder, Eiman AlJishi, Shaikhah Al-Otaibi & Mohammed S Al-Shahrani. (2018) All guns blazing: management and survival of massive valproic acid overdose - case report and literature review. Open Access Emergency Medicine 10, pages 31-36.
Read now
Eike Blohm, Jeffrey Lai & Mark Neavyn. (2017) Drug-induced hyperlactatemia. Clinical Toxicology 55:8, pages 869-878.
Read now
James B. Mowry, Emmanuel A. Burdmann, Kurt Anseeuw, Paul Ayoub, Marc Ghannoum, Robert S. Hoffman, Valery Lavergne, Thomas D. Nolin & Sophie Gosselin. (2016) Extracorporeal treatment for digoxin poisoning: systematic review and recommendations from the EXTRIP Workgroup. Clinical Toxicology 54:2, pages 103-114.
Read now

Articles from other publishers (68)

Nyier W Doar, Samaj Adhikari, Binit Aryal, Sushma Edara & Marie Schmidt. (2023) A Rare Case of Valproic Acid Toxicity Requiring Hemodialysis. Cureus.
Crossref
Ugur Orhan, Muge Gulen, Salim Satar, Selen Acehan, Hakan Nazik, Nurdan Unlu, Mustafa Gediklioglu, Cem Isikber, Ahmet Sonmez & Gökben Oral Sonmez. (2022) Hemodialysis treatment for poisoning patients in the emergency department. Therapeutic Apheresis and Dialysis 27:3, pages 580-586.
Crossref
Jan T. Kielstein. (2023) Hämoperfusion und Plasmapherese auf der IntensivstationHemoperfusion and plasmapheresis in the intensive care unit. Wiener klinisches Magazin.
Crossref
Marc Ghannoum & Darren M. Roberts. (2023) Management of Poisonings and Intoxications. Clinical Journal of the American Society of Nephrology.
Crossref
Randah Dahlan & Ali Alkatheeri. 2023. Updates on Renal Replacement Therapy [Working Title]. Updates on Renal Replacement Therapy [Working Title].
Marc Ghannoum & Darren M. Roberts. 2023. Handbook of Dialysis Therapy. Handbook of Dialysis Therapy 659 667 .
Jan T. Kielstein. (2022) Hämoperfusion und Plasmapherese auf der IntensivstationHemoperfusion and plasmapheresis in the intensive care unit. Die Nephrologie 18:1, pages 25-31.
Crossref
Philippe Nguyen, Lucie Chevillard, Ahmed S. Gouda, Hervé Gourlain, Laurence Labat, Isabelle Malissin, Nicolas Deye, Sebastian Voicu & Bruno Mégarbane. (2022) L-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships. Annals of Intensive Care 12:1.
Crossref
Matthew T. Stanton. (2022) Part II : Interactive case: Toxicology and poison control . JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY 5:12, pages 1332-1337.
Crossref
Shaista Chaudhary, Pinky & Suhel Parvez. (2022) Neuroprotective Effects of Natural Antioxidants Against Branched-Chain Fatty Acid-Induced Oxidative Stress in Cerebral Cortex and Cerebellum Regions of the Rat Brain. ACS Omega 7:43, pages 38269-38276.
Crossref
Jigar Patel, Ivan Berezowski, Maryann Mazer-Amirshahi, Sarah E. Frasure, Quincy K. Tran & Ali Pourmand. (2022) Valproic Acid Overdose: Case Report and Literature Review. The Journal of Emergency Medicine 63:5, pages 651-655.
Crossref
Julian Yaxley & Tahira Scott. (2022) Dialysis and extracorporeal therapies for enhanced elimination of toxic ingestions and poisoning. Therapeutic Apheresis and Dialysis 26:5, pages 865-878.
Crossref
Zaccaria Ricci, Stefano Romagnoli, Thiago Reis, Rinaldo Bellomo & Claudio Ronco. (2022) Hemoperfusion in the intensive care unit. Intensive Care Medicine 48:10, pages 1397-1408.
Crossref
Elise J. Smolders, Rob Ter Heine, Stephanie Natsch & Kees Kramers. (2022) Meropenem to Treat Valproic Acid Intoxication. Therapeutic Drug Monitoring 44:3, pages 359-362.
Crossref
Grant Comstock, Kevin Kilgallon, George Sam Wang, David Bourne, Eliza Blanchette & Erin Stenson. (2022) Management and Associated Toxicokinetics of Massive Valproic Acid Ingestion with High Flow Continuous Venovenous Hemodiafiltration. Journal of Medical Toxicology.
Crossref
Junhong Wu, Jiyuan Li, Wei Jing, Xin Tian & Xuefeng Wang. (2021) Valproic acid-induced encephalopathy: A review of clinical features, risk factors, diagnosis, and treatment. Epilepsy & Behavior 120, pages 107967.
Crossref
Lara Prisco, Aarti Sarwal, Mario Ganau & Francesca Rubulotta. (2021) Toxicology of Psychoactive Substances. Critical Care Clinics 37:3, pages 517-541.
Crossref
Shyam Kiran Gandam Venkata, Kenneth Guillotte, BreeAnna Murphy, Sai Sruthi Bhuram & Sudeep Chakravarthy Bhuram. (2021) Rapid Rescue From Hyperammonemic Coma After Valproic Acid Poisoning: Dual Therapy With Continuous Renal Replacement Therapy and L-Carnitine Supplementation. Cureus.
Crossref
Daniel Kazmierski, Nishant Sharma, Kelly O'Leary & Pius Ochieng. (2021) Valproate-induced fatal acute hyperammonaemia-related encephalopathy in late-onset ornithine transcarbamylase deficiency. BMJ Case Reports 14:5, pages e241429.
Crossref
James B. Mowry, Greene Shepherd, Robert S. Hoffman, Valery Lavergne, Sophie Gosselin, Thomas D. Nolin, Anitha Vijayan, Jan T. Kielstein, Darren M. Roberts, Marc Ghannoum, Badria Alhatali, Kurt Anseeuw, Steven Bird, Ingrid Berling, Josée Bouchard, Timothy E. Bunchman, Diane P. Calello, Paul K. Chin, Kent Doi, Tais Galvao, David S. Goldfarb, Hossein Hassanian, Lotte C. Hoegberg, Siba Kallab, Sofia Kebede, Andrew Lewington, Yi Li, Etienne M. Macedo, Rob MacLaren, Bruno Megarbane, Marlies E. Ostermann, Ai Peng, Jean‐Philippe Roy, Steven J. Walsh, Anselm Wong, David M. Wood & Christopher Yates. (2021) Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41:5, pages 463-478.
Crossref
Sandeep Pagali, Christopher Edquist & Nicholas O'Rourke. (2021) Managing valproic acid toxicity-related hyperammonaemia: an unpredicted course. BMJ Case Reports 14:4, pages e241547.
Crossref
Moftah Alhagamhmad, Aisha Elarwah, Alia Alhassony, Shirin Alougly, Hamza Milad, Aziza Dehoam, Suliman Elbrgathy, Nuri Shembesh, Emhemed Mousa & Abdulhamid ElShiky. (2021) Valproate-Induced Hyperammonemic Encephalopathy Following Accidental Ingestion in a Toddler. The Journal of Pediatric Pharmacology and Therapeutics 26:2, pages 210-212.
Crossref
Anselm Wong & Andis Graudins. (2021) Efficacy of sustained low‐efficiency dialysis in the management of sodium valproate overdose. Internal Medicine Journal 51:2, pages 295-296.
Crossref
Alexander M. Sidlak, Samuel R. York, Adam J. Janicki & Anthony F. Pizon. (2021) Highest reported clearance of valproate by hemodialysis in massive overdose. The American Journal of Emergency Medicine 39, pages 255.e5-255.e6.
Crossref
Vimal Chadha. 2021. Pediatric Dialysis. Pediatric Dialysis 725 742 .
Bridget L. Blowey, J. Steven Leeder & Douglas L. Blowey. 2021. Pediatric Dialysis. Pediatric Dialysis 683 707 .
Bruno Mégarbane, Mathieu Oberlin, Jean-Claude Alvarez, Frederic Balen, Sébastien Beaune, Régis Bédry, Anthony Chauvin, Isabelle Claudet, Vincent Danel, Guillaume Debaty, Arnaud Delahaye, Nicolas Deye, Jean-Michel Gaulier, Francis Grossenbacher, Philippe Hantson, Frédéric Jacobs, Karim Jaffal, Magali Labadie, Laurence Labat, Jérôme Langrand, Frédéric Lapostolle, Philippe Le Conte, Maxime Maignan, Patrick Nisse, Philippe Sauder, Christine Tournoud, Dominique Vodovar, Sebastian Voicu, Pierre-Géraud Claret & Charles Cerf. (2020) Management of pharmaceutical and recreational drug poisoning. Annals of Intensive Care 10:1.
Crossref
G.M. Balan, A.G. Bogomol, O.P. Kravchuk, P.G. Zhminko & A.H. Kudriavtseva. (2020) Комплексна терапія гострих отруєнь сполуками талію (Огляд літератури та дані власних досліджень). Ukrainian Journal of Modern Toxicological Aspects 89:2, pages 40-47.
Crossref
G.M. Balan, A.G. Bogomol, O.P. Kravchuk, P.G. Zhminko & A.H. Kudriavtseva. (2020) Complex Therapy of Acute Poisoning by Thallium Compounds (Literature review and data from own research). Ukrainian Journal of Modern Toxicological Aspects 89:2, pages 32-39.
Crossref
Daniel Muñoz-Pichuante, Lorenzo Villa-Zapata & Russi Lolas. (2020) Meropenem for management of valproic acid overdose: a case report. Drug Metabolism and Drug Interactions 35:2.
Crossref
Masahiro Fukuda, Kunihiko Kooguchi, Yukinori Kato, Hiroya Chiba, Satoshi Nakajima, Ryutaro Oda, Sho Oka & Takayuki Kawai. (2020) Two cases of L-carnitine replacement therapy for valproic acid overdoseバルプロ酸多量服薬に対しL-カルニチン補充療法を行った2症例. Journal of the Japanese Society of Intensive Care Medicine 27:3, pages 227-228.
Crossref
Nikolas Harbord. (2020) Common Toxidromes and the Role of Extracorporeal Detoxification. Advances in Chronic Kidney Disease 27:1, pages 11-17.
Crossref
Shakuntala Murty. (2019) Antiepileptic Overdose. Indian Journal of Critical Care Medicine 23:S4, pages 0-0.
Crossref
Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M. Symons, Michael J. G. Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady & Maria Díaz-González de Ferris. (2019) Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup. Pediatric Nephrology 34:11, pages 2427-2448.
Crossref
Dong Fu, Panli Cardona, Henry Ho, Paul B Watkins & Kim L R Brouwer. (2019) Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization. Toxicological Sciences 171:2, pages 431-442.
Crossref
Tejs Jansen, Lotte C. G. Hoegberg, Thomas Eriksen, Kim P. Dalhoff, Bo Belhage & Sys S. Johansen. (2019) Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion—a randomized controlled animal poisoning model. Naunyn-Schmiedeberg's Archives of Pharmacology 392:10, pages 1285-1292.
Crossref
Joshua David King, Moritz H. Kern & Bernard G. Jaar. (2019) Extracorporeal Removal of Poisons and Toxins. Clinical Journal of the American Society of Nephrology 14:9, pages 1408-1415.
Crossref
Jaroslav Raděj, Jan Horák, Martin Harazim & Martin Matějovič. (2019) Extracorporeal removal techniques in toxicology: part 2. Vnitřní lékařství 65:6, pages 425-432.
Crossref
Victoria A. Jennings, Gina B. Scott, Ailsa M.S. Rose, Karen J. Scott, Gemma Migneco, Brian Keller, Katrina Reilly, Oliver Donnelly, Howard Peach, Donald Dewar, Kevin J. Harrington, Hardev Pandha, Adel Samson, Richard G. Vile, Alan A. Melcher & Fiona Errington-Mais. (2019) Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition. Molecular Therapy 27:6, pages 1139-1152.
Crossref
Gabriel H. Campion, Josh J. Wang, Robert S. Hoffman, Monique Cormier, Valéry Lavergne, James B. Mowry, Darren M. Roberts, Marc Ghannoum, Mark K. Su & Sophie Gosselin. (2018) Extracorporeal treatments in poisonings from four non‐traditionally dialysed toxins (acetaminophen, digoxin, opioids and tricyclic antidepressants): A combined single‐centre and national study. Basic & Clinical Pharmacology & Toxicology 124:3, pages 341-347.
Crossref
François Madore & Josée Bouchard. 2019. Critical Care Nephrology. Critical Care Nephrology 595 600.e3 .
Rupesh Raina, Stephanie Lam, Hershita Raheja, Michelle Bestic & Martha Blackford. 2019. Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook 251 283 .
Alessandra Morello Gearhart, John J. Guardiola & Karim El-Kersh. (2018) A 33-Year-Old Woman With Altered Mental Status and Elevated Ammonia Level. Chest 154:6, pages e169-e171.
Crossref
M. A. Khobrani, S. W. Dudley, Y. C. Huckleberry, B. J. Kopp, A. D. Biggs, R. N. E. French, F. M. Shirazi & B. L. Erstad. (2018) Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report. Journal of Clinical Pharmacy and Therapeutics 43:5, pages 723-725.
Crossref
Marc Ghannoum, Robert S. Hoffman, Sophie Gosselin, Thomas D. Nolin, Valery Lavergne & Darren M. Roberts. (2018) Use of extracorporeal treatments in the management of poisonings. Kidney International 94:4, pages 682-688.
Crossref
Tobias Tichelbäcker, Judith Herath, Björn Tampe & Peter Korsten. (2018) Hemodiafiltration Treatment for Severe Valproic Acid Intoxication: Case Report and Updated Systematic Literature Review. Frontiers in Medicine 5.
Crossref
Silvia Ferranti, Elisabetta Grande, Carla Gaggiano & Salvatore Grosso. (2018) Antiepileptic drugs: Role in paediatric poisoning. Journal of Paediatrics and Child Health 54:5, pages 475-479.
Crossref
Paul M. Palevsky. (2018) Acute renal replacement therapy during hospitalization: Is training adequate?. Seminars in Dialysis 31:2, pages 135-139.
Crossref
Krzysztof Pietruczuk, Katarzyna A. Lisowska, Karol Grabowski, Jerzy Landowski & Jacek M. Witkowski. (2018) Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder. Scientific Reports 8:1.
Crossref
Irfan Khan & Patrick D. Brophy. 2018. Critical Care Nephrology and Renal Replacement Therapy in Children. Critical Care Nephrology and Renal Replacement Therapy in Children 431 439 .
Bryan Corbett. 2018. Quick Guide to Psychiatric Emergencies. Quick Guide to Psychiatric Emergencies 281 285 .
Yongchun Ge, Bin Xu, Shuhua Zhu, Chuan Li, Qunpeng He, Tingting Zhu, Rong Fan & Dehua Gong. (2017) Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy. Basic & Clinical Pharmacology & Toxicology 121:4, pages 368-370.
Crossref
Spencer Greene, Erin AufderHeide & Lindsay French-Rosas. (2017) Toxicologic Emergencies in Patients with Mental Illness. Psychiatric Clinics of North America 40:3, pages 519-532.
Crossref
T. Toimela, O. Huttala, E. Sabell, M. Mannerström, J.R. Sarkanen, T. Ylikomi & T. Heinonen. (2017) Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium. Reproductive Toxicology 70, pages 116-125.
Crossref
B. Tate Cutshall, Samarth P. Shah, Megan A. Van Berkel, Shanise Patterson, L. Jeff Harris & Jessica V. Rivera. (2017) Should Pharmacies Be Included in Medication Reconciliation? A Report of Recurrent Valproic Acid Toxicity. Clinical Practice and Cases in Emergency Medicine 1:2, pages 122-125.
Crossref
Josée Bouchard, Valery Lavergne, Darren M. Roberts, Monique Cormier, Genevieve Morissette & Marc Ghannoum. (2017) Availability and cost of extracorporeal treatments for poisonings and other emergency indications: a worldwide survey. Nephrology Dialysis Transplantation 32:4, pages 699-706.
Crossref
Marc Ghannoum & Darren M. Roberts. 2017. Handbook of Dialysis Therapy. Handbook of Dialysis Therapy 1095 1106.e3 .
Sherif Hanafy Mahmoud. (2016) Antiepileptic Drug Removal by Continuous Renal Replacement Therapy: A Review of the Literature. Clinical Drug Investigation 37:1, pages 7-23.
Crossref
Monique J. Cormier & Marc Ghannoum. 2017. Critical Care Toxicology. Critical Care Toxicology 267 278 .
Stephen W. Borron. 2017. Critical Care Toxicology. Critical Care Toxicology 325 358 .
Shruti Gupta, Andrew Z. Fenves & Robert Hootkins. (2016) The Role of RRT in Hyperammonemic Patients. Clinical Journal of the American Society of Nephrology 11:10, pages 1872-1878.
Crossref
Allister Vale. (2016) Anticonvulsants. Medicine 44:3, pages 133-134.
Crossref
Kurt Anseeuw, James B. Mowry, Emmanuel A. Burdmann, Marc Ghannoum, Robert S. Hoffman, Sophie Gosselin, Valery Lavergne & Thomas D. Nolin. (2016) Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup. American Journal of Kidney Diseases 67:2, pages 187-197.
Crossref
Aibek E. Mirrakhimov, Aram Barbaryan, Adam Gray & Taha Ayach. (2016) The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings. International Journal of Nephrology 2016, pages 1-12.
Crossref
Marc Ghannoum, Valery Lavergne, Sophie Gosselin, James B. Mowry, Lotte C. G. Hoegberg, Mark Yarema, Margaret Thompson, Nancy Murphy, John Thompson, Roy Purssell & Robert S. Hoffman. (2016) Practice Trends in the Use of Extracorporeal Treatments for Poisoning in Four Countries. Seminars in Dialysis 29:1, pages 71-80.
Crossref
Monique J. Cormier & Marc Ghannoum. 2016. Critical Care Toxicology. Critical Care Toxicology 1 12 .
Stephen W. Borron. 2016. Critical Care Toxicology. Critical Care Toxicology 1 34 .
Stephen W. Borron. 2016. Critical Care Toxicology. Critical Care Toxicology 1 34 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.