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Research Article

Evaluation of a Charcoal-Sorbitol Mixture as an Antidote for Oral Aspirin Overdose

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Pages 561-567 | Published online: 25 Sep 2008

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Lotte C. G. Hoegberg, Greene Shepherd, David M. Wood, Jami Johnson, Robert S. Hoffman, E. Martin Caravati, Wui Ling Chan, Silas W. Smith, Kent R. Olson & Sophie Gosselin. (2021) Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clinical Toxicology 59:12, pages 1196-1227.
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Helen Senderovich & Megan J. Vierhout. (2018) Is there a role for charcoal in palliative diarrhea management?. Current Medical Research and Opinion 34:7, pages 1253-1259.
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Peter A. Chyka, Andrew R. Erdman, Gwenn Christianson, Paul M. Wax, Lisa L. Booze, Anthony S. Manoguerra, E. Martin Caravati, Lewis S. Nelson, Kent R. Olson, Daniel J. Cobaugh, Elizabeth J. Scharman, Alan D. Woolf & William G. Troutman. (2007) Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 45:2, pages 95-131.
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American Academy of Clinical Toxicology & European Association of Poisons Centres and Clinical Toxicologists. (2005) Position Paper: Single-Dose Activated Charcoal. Clinical Toxicology 43:2, pages 61-87.
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. (2004) Position Paper: Cathartics . Journal of Toxicology: Clinical Toxicology 42:3, pages 243-253.
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M. P. Flament, R. M'bisi, P. Leterme & A. T. Gayot. (2000) Formulation of Activated Charcoal for Per Os Administration to Addicted Subjects. Drug Development and Industrial Pharmacy 26:7, pages 731-736.
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. (1997) Position Statement: Cathartics. Journal of Toxicology: Clinical Toxicology 35:7, pages 743-752.
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. (1997) Position Statement: Single-Dose Activated Charcoal. Journal of Toxicology: Clinical Toxicology 35:7, pages 721-741.
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Cheryl D. Curd-Sneed, John G. Bordelon, K. Scott Parks & John J. Stewart. (1987) Effects of Activated Charcoal and Sorbitol on Sodium Pentobarbital Absorption in the Rat. Journal of Toxicology: Clinical Toxicology 25:7, pages 555-566.
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Cheryl D. Curd-Sneed, K. Scott Parks, John G. Bordelon & John J. Stewart. (1987) In vitro Adsorption of Sodium Pentobarbital by Superchar, USP and Darco G-60 Activated Charcoals. Journal of Toxicology: Clinical Toxicology 25:1-2, pages 1-11.
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Jan A. Cordonnier, Marc A. van den Heede & Aubin M. Heyndrickx. (1986) In vitro adsorption of tilidine HCL by activated charcoal. Journal of Toxicology: Clinical Toxicology 24:6, pages 503-517.
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Albert L. Picchioni, Lincoln Chin & Terrance Gillespie. (1982) Evaluation of Activated Charcoal-Sorbitol Suspension as an Antidote. Journal of Toxicology: Clinical Toxicology 19:5, pages 433-444.
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Alister Vale & Sally Bradberry. 2009. General and Applied Toxicology. General and Applied Toxicology.
M.-L. Chen, A. B. Straughn, N. Sadrieh, M. Meyer, P. J. Faustino, A. B. Ciavarella, B. Meibohm, C. R. Yates & A. S. Hussain. (2006) A Modern View of Excipient Effects on Bioequivalence: Case Study of Sorbitol. Pharmaceutical Research 24:1, pages 73-80.
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Lotte Christine Groth Hoegberg, Helle Riis Angelo, Anne Bolette Christophersen & Hanne Rolighed Christensen. (2003) The Effect of Food and Ice Cream on the Adsorption Capacity of Paracetamol to High Surface Activated Charcoal: In vitro Studies. Pharmacology and Toxicology 93:5, pages 233-237.
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Robert J. Hoffman & Kevin C. Osterhoudt. (2002) Evaluation and Management of Pediatric Poisonings. Pediatric Case Reviews 2:1, pages 51-63.
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Cyrus Rangan, Sean P. Nordt, Robert Hamilton, Marianne Ingels & Richard F. Clark. (2001) Treatment of acetaminophen ingestion with a superactivated charcoal–cola mixture. Annals of Emergency Medicine 37:1, pages 55-58.
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Edward P. Krenzelok & J. Allister Vale. (1998) Summary of American academy of clinical toxicology and european association of poison centres and clinical toxicologists position: Statements on gut decontamination. Medical Update for Psychiatrists 3:6, pages 187-195.
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Luke Yip, Michael S. Jastremski & Richard C. Dart. (1997) Salicylate Intoxication. Journal of Intensive Care Medicine 12:2, pages 66-78.
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Neil A Minton & John A Henry. (1996) Treatment of theophylline overdose. The American Journal of Emergency Medicine 14:6, pages 606-612.
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David Cooney. 1995. Activated Charcoal in Medical Applications, Second Edition. Activated Charcoal in Medical Applications, Second Edition 110 156 .
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O.E. Orisakwe & E. Ogbonna. (2016) Effect of Saline Cathartics on Gastrointestinal Transit Time of Activated Charcoal. Human & Experimental Toxicology 12:5, pages 403-405.
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Scott Phillips, Hernan Gomez & Jeffrey Brent. (2013) Pediatric Gastrointestinal Decontamination in Acute Toxin Ingestion. The Journal of Clinical Pharmacology 33:6, pages 497-507.
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Arthur Karl McFarlandIIIIII & Peter A. Chyka. (2016) Selection of Activated Charcoal Products for the Treatment of Poisonings. Annals of Pharmacotherapy 27:3, pages 358-361.
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Jeffrey P. Allerton & James A. Strom. (1991) Hypernatremia Due to Repeated Doses of Charcoal-Sorbitol. American Journal of Kidney Diseases 17:5, pages 581-584.
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Teddi F Eisen, Patricia A Grbcich, Peter G Lacouture, Michael W Shannon & Alan Woolf. (1991) The adsorption of salicylates by a milk chocolate-charcoal mixture. Annals of Emergency Medicine 20:2, pages 143-146.
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A. McLuckieA. M. ForbesK. F. Ilett. (2019) Role of Repeated Doses of Oral Activated Charcoal in the Treatment of Acute Intoxications. Anaesthesia and Intensive Care 18:3, pages 375-384.
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Ray E Keller, Robert A Schwab & Edward P Krenzelok. (1990) Contribution of sorbitol combined with activated charcoal in prevention of salicylate absorption. Annals of Emergency Medicine 19:6, pages 654-656.
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Paul J Rosenberg, Donald J Livingstone & Barry A McLellan. (1988) Effect of whole-bowel irrigation on the antidotal efficacy of oral activated charcoal. Annals of Emergency Medicine 17:7, pages 681-683.
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Robert M McNamara, Cynthia K Aaron, Mark Gemborys & Sharon Davidheiser. (1988) Sorbitol catharsis does not enhance efficacy of charcoal in a simulated acetaminophen overdose. Annals of Emergency Medicine 17:3, pages 243-246.
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Pertti J. Neuvonen & Klaus T. Olkkola. (2012) Oral Activated Charcoal in the Treatment of Intoxications. Medical Toxicology 3:1, pages 33-58.
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Edward P Krenzelok & Michael B Heller. (1987) Effectiveness of commercially available aqueous activated charcoal products. Annals of Emergency Medicine 16:12, pages 1340-1343.
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Andrew Heath & Kai Knudsen. (2012) Role of Extracorporeal Drug Removal in Acute Theophylline Poisoning. Medical Toxicology 2:4, pages 294-308.
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Milton Tenenbein. (1987) Cathartics for drug overdose. Annals of Emergency Medicine 16:7, pages 832-833.
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Michael Shannon, Susan S. Fish & Frederick H. Lovejoy. (2012) Cathartics and Laxatives. Medical Toxicology 1:4, pages 247-252.
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P.J. Neuvonen & K.T. Olkkola. (2016) Effect of Purgatives on Antidotal Efficacy of Oral Activated Charcoal. Human Toxicology 5:4, pages 255-263.
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George C. RodgersJr.Jr. & Nancy J. Matyunas. (1986) Gastrointestinal Decontamination for Acute Poisoning. Pediatric Clinics of North America 33:2, pages 261-285.
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Edward P Krenzelok, Ray Keller & Ronald D Stewart. (1985) Gastrointestinal transit times of cathartics combined with charcoal. Annals of Emergency Medicine 14:12, pages 1152-1155.
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Gillian M. Shenfield. (1985) Treatment of acute poisoning. Medical Journal of Australia 142:12, pages 632-635.
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Gary C. Cupit & Anthony R. Temple. (1984) Gastrointestinal Decontamination in the Management of the Poisoned Patient. Emergency Medicine Clinics of North America 2:1, pages 15-28.
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Brent T. Burton, Marc J. Bayer, Lauren Barron & John P. Aitchison. (1984) Comparison of activated charcoal and gastric lavage in the prevention of aspirin absorption. The Journal of Emergency Medicine 1:5, pages 411-416.
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INGRID S. SKETRIS, JAMES B. MOWRY, PETER A. CZAJKA, WILLIAM H. ANDERSON & DAVID T. STAFFORD. (2013) Saline Catharsis: Effect on Aspirin Bioavailability in Combination with Activated Charcoal. The Journal of Clinical Pharmacology 22:1, pages 59-64.
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Jill M. Riegel & Charles E. Becker. (1981) Use of cathartics in toxic ingestions. Annals of Emergency Medicine 10:5, pages 254-258.
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Joseph Greensher, Howard C. Mofenson & Albert L. Picchioni. (1980) Authors' Reply. Annals of Emergency Medicine 9:2, pages 111.
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Joseph Greensher, Howard C. Mofenson, Albert L. Picchioni & Peter Fallon. (1979) Activated charcoal updated. Journal of the American College of Emergency Physicians 8:7, pages 261-263.
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