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Journal of Toxicology: Clinical Toxicology Volume 24, 1986 - Issue 6
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Research Article

4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man

Frederic J. Baud Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
,
Chantal Bismuth Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
,
Robert Garnier Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
,
Martine Galliot Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
,
Alain Astier Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
,
Genevieve Maistre Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
&
Michel Soffer Ranimation Toxicologique Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Fernand Widal, 75010, Paris; Laboratoire de Toxicologie Hopital Henri Mondor, 94010, CRETEIL; Laboratoire de Biochimie Medicale Faculte de Medecine Pitie-Salpetriere, 75013, Paris
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Pages 463-483 | Published online: 25 Sep 2008

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Jessie Beaulieu, Darren M. Roberts, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Knut Erik Hovda, Bruno Megarbane, Derrick Lung, Ruben Thanacoody & Marc Ghannoum. (2022) Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. Clinical Toxicology 60:7, pages 784-797.
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Jamie Prashek, Adham Mohamed, Tyler E. Barnes & Andrew B. Schlachter. (2021) Continuous renal replacement therapy combined with fomepizole is effective in the clearance of ethylene glycol: a case report. Toxicology Communications 5:1, pages 143-146.
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Kenneth E. McMartin, C. Simon Sebastian, David Dies & Dag Jacobsen. (2012) Kinetics and metabolism of fomepizole in healthy humans. Clinical Toxicology 50:5, pages 375-383.
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Katherine J. Lepik, Jeffrey R. Brubacher, Christopher R. DeWitt, George S. S. Lam, Edward J. Lawson, Gunnar D. Erhardt, Roy A. Purssell, James R. Kennedy & Jane L. Brignall. (2008) Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. Clinical Toxicology 46:6, pages 570-573.
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Jeanna Marraffa, Alan Forrest, William Grant, Christine Stork, Kenneth McMartin & Mary Ann Howland. (2008) Oral administration of fomepizole produces similar blood levels as identical intravenous dose. Clinical Toxicology 46:3, pages 181-186.
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E. Martin Caravati, Andrew R. Erdman, Gwenn Christianson, Anthony S. Manoguerra, Lisa L. Booze, Alan D. Woolf, Kent R. Olson, Peter A. Chyka, Elizabeth J. Scharman, Paul M. Wax, Daniel C. Keyes & William G. Troutman. (2005) Ethylene Glycol Exposure: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Clinical Toxicology 43:5, pages 327-345.
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The American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning:Donald G. Barceloux, G. Randall Bond, Edward P. Krenzelok, Hannah Cooper & J. Allister Vale. (2002) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. Journal of Toxicology: Clinical Toxicology 40:4, pages 415-446.
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William H. Porter, Philip W. Rutter, Barbara A. Bush, Alex A. Pappas & James E. Dunnington. (2001) Ethylene Glycol Toxicity: The Role of Serum Glycolic Acid In Hemodialysis. Journal of Toxicology: Clinical Toxicology 39:6, pages 607-615.
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Rafik Bekka, Stephen W. Borron, Alain Astier, Pierre Sandouk, Chantal Bismuth & Frédéric J. Baud. (2001) Treatment of Methanol and Isopropanol Poisoning with Intravenous Fomepizole. Journal of Toxicology: Clinical Toxicology 39:1, pages 59-67.
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John G. Benitez, Brenda Swanson-Biearman, Edward P. Krenzelok & Edward Krenzelok. (2000) Nystagmus Secondary to Fomepizole Administration in a Pediatric Patient. Journal of Toxicology: Clinical Toxicology 38:7, pages 795-798.
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Heather Miller, Donald G. Barceloux, Edward P. Krenzelok, Kent Olson & William Watson. (1999) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 37:5, pages 537-560.
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Dag Jacobsen & Kenneth E. McMartin. (1997) Antidotes for Methanol and Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 35:2, pages 127-143.
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Dag Jacobsen & Kenneth McMartin. (1996) 4-Methylpyrazole–Present Status. Journal of Toxicology: Clinical Toxicology 34:4, pages 379-381.
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Eric Jobard, Patrick Harry, Alain Turcant, Pierre Marie Roy & Pierre Allain. (1996) 4-Methylpyrazole and Hemodialysis in Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 34:4, pages 373-377.
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Kenneth E. McMartin. (1988) Distribution of oral 4-methylpyrazole in the rat: Inhibition of elimination by ethanol. Journal of Toxicology: Clinical Toxicology 26:7, pages 451-466.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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Kenneth McMartin & Jeffrey Brent. (2021) Analysis of Fomepizole Elimination in Methanol- and Ethylene Glycol-Poisoned Patients. Journal of Medical Toxicology 18:1, pages 19-29.
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