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Research Article

Hydroxocobalamin as a Cyanide Antidote: Safety, Efficacy and Pharmacokinetics in Heavily Smoking Normal Volunteers

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Pages 277-294 | Published online: 25 Sep 2008

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Emily Anne Kiernan, Joseph E. Carpenter, Camille A. Dunkley, Tim P. Moran, Lindsay Schaack Rothstein, Elizabeth Silver, Maryam Salehi, David D. Koch, Brent W. Morgan & Brian Patrick Murray. (2022) Elevated methemoglobin levels in patients treated with hydroxocobalamin: a case series and in-vitro analysis. Clinical Toxicology 60:9, pages 1012-1018.
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Adrian Thompson, Michael Dunn, Robert D Jefferson, Kosala Dissanayake, Frances Reed, Rachael Gregson, Stephen Greenhalgh, R Eddie Clutton, Peter G Blain, Simon HL Thomas & Michael Eddleston. (2020) Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning. Clinical Toxicology 58:3, pages 190-200.
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Philippe Haouzi, Bruno Chenuel & Takashi Sonobe. (2015) High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep. Clinical Toxicology 53:1, pages 28-36.
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R. Pace, M. Bon Homme, R. S. Hoffman & D. Lugassy. (2014) Effects of hydroxocobalamin on carboxyhemoglobin measured under physiologic and pathologic conditions. Clinical Toxicology 52:7, pages 647-650.
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John P. Thompson & Timothy C. Marrs. (2012) Hydroxocobalamin in cyanide poisoning. Clinical Toxicology 50:10, pages 875-885.
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Christian J. Carlsson, Heidi E. Hansen, Linda Hilsted, Johan Malm, Lars Ødum & Pal B. Szecsi. (2011) An evaluation of the interference of hydroxycobalamin with chemistry and co-oximetry tests on nine commonly used instruments. Scandinavian Journal of Clinical and Laboratory Investigation 71:5, pages 378-386.
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Alan H. Hall, Jane Saiers & Frédéric Baud. (2009) Which cyanide antidote?. Critical Reviews in Toxicology 39:7, pages 541-552.
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Wolfgang Uhl, Arno Nolting, Dieter Gallemann, Stefan Hecht & Andreas Kovar. (2008) Changes in blood pressure after administration of hydroxocobalamin: Relationship to changes in plasma cobalamins-(III) concentrations in healthy volunteers. Clinical Toxicology 46:6, pages 551-559.
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Jean-Luc Fortin, Jean-Pascal Giocanti, Michel Ruttimann & Jean-Jacques Kowalski. (2006) Prehospital Administration of Hydroxocobalamin for Smoke Inhalation-Associated Cyanide Poisoning: 8 Years of Experience in the Paris Fire Brigade. Clinical Toxicology 44:sup1, pages 37-44.
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Klaus Gerth, Thomas Ehring, Marian Braendle & Pierre Schelling. (2006) Nitric Oxide Scavenging by Hydroxocobalamin May Account for Its Hemodynamic Profile. Clinical Toxicology 44:sup1, pages 29-36.
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Wolfgang Uhl, Arno Nolting, Georg Golor, Karl Ludwig Rost & Andreas Kovar. (2006) Safety of Hydroxocobalamin in Healthy Volunteers in a Randomized, Placebo-Controlled Study. Clinical Toxicology 44:sup1, pages 17-28.
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Stephen W. Borron, Michael Stonerook & Frances Reid. (2006) Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs. Clinical Toxicology 44:sup1, pages 5-15.
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Michael J. Yeoh & George Braitberg. (2004) Carbon Monoxide and Cyanide Poisoning in Fire Related Deaths in Victoria, Australia. Journal of Toxicology: Clinical Toxicology 42:6, pages 855-863.
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. (1997) Editorial Comment-Hydroxocobalamin Analysis. Journal of Toxicology: Clinical Toxicology 35:4, pages 417-417.
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Paul Houeto, Stephen W. Borron, Frédéric J. Baud, Pierre Sandouk & Pierre Levillain. (1997) Hydroxocobalamin Analysis and Pharmacokinetics-Authors' Response. Journal of Toxicology: Clinical Toxicology 35:4, pages 413-415.
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John D. Osterloh & Alan H. Hall. (1997) Hydroxocobalamin Analysis and Pharmacokinetics. Journal of Toxicology: Clinical Toxicology 35:4, pages 409-411.
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Paul Houeto, Stephen W. Borron, Pierre Sandouk, Michel Imbert, Pierre Levillain & Frederic J. Baud. (1996) Pharmacokinetics of Hydroxocobalamin in Smoke Inhalation Victims. Journal of Toxicology: Clinical Toxicology 34:4, pages 397-404.
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Yu. V. Shatalin, V. S. Shubina, M. E. Solovieva & V. S. Akatov. (2023) The Redox-Catalytic Properties of Cobalamins. Molecular Biology 57:6, pages 1038-1051.
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Emmanuel Scalais, Christine Geron, Charlotte Pierron, Sandra Cardillo, Vincent Schlesser, Frédéric Mataigne, Patricia Borde & Luc Regal. (2023) Would, early, versus late hydroxocobalamin dose intensification treatment, prevent cognitive decline, macular degeneration and ocular disease, in 5 patients with early-onset cblC deficiency?. Molecular Genetics and Metabolism 140:3, pages 107681.
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Sai R. Velamuri, Yasmin Ali, Julio Lanfranco, Pooja Gupta & David M. Hill. (2023) Inhalation Injury, Respiratory Failure, and Ventilator Support in Acute Burn Care. Clinics in Plastic Surgery.
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Ilia A. Dereven’kov, Vladimir S. Osokin, Pavel A. Molodtsov, Anna S. Makarova & Sergei V. Makarov. (2022) Effect of complexation between cobinamides and bovine serum albumin on their reactivity toward cyanide. Reaction Kinetics, Mechanisms and Catalysis 135:3, pages 1469-1483.
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