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Research Article

4-Methylpyrazole and Hemodialysis in Ethylene Glycol Poisoning

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Pages 373-377 | Published online: 25 Sep 2008

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Jessie Beaulieu, Darren M. Roberts, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Knut Erik Hovda, Bruno Megarbane, Derrick Lung, Ruben Thanacoody & Marc Ghannoum. (2022) Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. Clinical Toxicology 60:7, pages 784-797.
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Yvonne E. Lao, Trond Vartdal, Sten Froeyshov, Brian Latimer, Christiane Kvaerner, Marija Mataric, Peter Holm, Siri Foreid, Dag Jacobsen, Kenneth McMartin & Knut Erik Hovda. (2022) Fomepizole dosing during continuous renal replacement therapy – an observational study. Clinical Toxicology 60:4, pages 451-457.
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Kenneth E. McMartin, C. Simon Sebastian, David Dies & Dag Jacobsen. (2012) Kinetics and metabolism of fomepizole in healthy humans. Clinical Toxicology 50:5, pages 375-383.
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A. W. Jones & L. Hård. (2004) How good are clinical chemistry laboratories at analysing ethylene glycol?. Scandinavian Journal of Clinical and Laboratory Investigation 64:7, pages 629-634.
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The American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning:Donald G. Barceloux, G. Randall Bond, Edward P. Krenzelok, Hannah Cooper & J. Allister Vale. (2002) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. Journal of Toxicology: Clinical Toxicology 40:4, pages 415-446.
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Ives de Chazal, Bruce Houghton & James Frock. (1999) The ‘sweet killer’. Postgraduate Medicine 106:4, pages 221-230.
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Christophe Girault, Fabienne Tamion, Fabienne Moritz, Françoise Callonnec, Jean-Michel Droy, Guy Bonmarchand & Jacques Leroy. (1999) Fomepizole (4-Methylpyrazole) in Fatal Methanol Poisoning with Early CT Scan Cerebral Lesions. Journal of Toxicology: Clinical Toxicology 37:6, pages 777-780.
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Heather Miller, Donald G. Barceloux, Edward P. Krenzelok, Kent Olson & William Watson. (1999) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 37:5, pages 537-560.
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Dag Jacobsen & Kenneth McMartin. (1996) 4-Methylpyrazole–Present Status. Journal of Toxicology: Clinical Toxicology 34:4, pages 379-381.
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Articles from other publishers (37)

Ghadi I. Alqurashi, Fahad S. Alqurashi, Khalid M. Alhusayni, Alaa H. Falemban, Yosra Z. Alhindi, Safaa M. Alsanosi, Abdullah R. Alzahrani, Saeed S. Al-Ghamdi & Nahla Ayoub. (2023) Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia. Journal of Clinical Medicine 12:13, pages 4282.
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Marc Ghannoum, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Bruno Mégarbane, Hossein Hassanian-Moghaddam, Maria Rif, Siba Kallab, Steven Bird, David M. Wood, Darren M. Roberts, Badria Alhatali, Kurt Anseeuw, Ingrid Berling, Josée Bouchard, Timothy E. Bunchman, Diane P. Calello, Paul K. Chin, Kent Doi, Tais Galvao, David S. Goldfarb, Lotte C. G. Hoegberg, Sofia Kebede, Jan T. Kielstein, Andrew Lewington, Yi Li, Etienne M. Macedo, Rob MacLaren, James B. Mowry, Thomas D. Nolin, Marlies Ostermann, Ai Peng, Jean-Philippe Roy, Greene Shepherd, Anitha Vijayan, Steven J. Walsh, Anselm Wong & Christopher Yates. (2023) Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup. Critical Care 27:1.
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Rawan Eskandrani, Khalid Almulhim, Abdulla Altamimi, Abeer Alhaj, Shahd Alnasser, Laale Alawi, Eman Aldweikh, Khalid Alaufi & Bandr Mzahim. (2022) Methanol poisoning outbreak in Saudi Arabia: a case series. Journal of Medical Case Reports 16:1.
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Kenneth McMartin & Jeffrey Brent. (2021) Analysis of Fomepizole Elimination in Methanol- and Ethylene Glycol-Poisoned Patients. Journal of Medical Toxicology 18:1, pages 19-29.
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Michael H. Chiu, Natalia Jaworska, Nicholas L. Li & Mark Yarema. (2021) Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis. Case Reports in Critical Care 2021, pages 1-5.
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George Braitberg. 2019. Critical Care Nephrology. Critical Care Nephrology 574 588.e3 .
Kenneth McMartin, Knut Erik Hovda & Dag Jacobsen. 2017. Critical Care Toxicology. Critical Care Toxicology 1 14 .
Kenneth McMartin, Knut Erik Hovda & Dag Jacobsen. 2017. Critical Care Toxicology. Critical Care Toxicology 2829 2842 .
Allister Vale. (2016) Alcohols and glycols. Medicine 44:3, pages 128-132.
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Kenneth McMartin, Knut Erik Hovda & Dag Jacobsen. 2016. Critical Care Toxicology. Critical Care Toxicology 1 14 .
Lorri Beatty, Robert Green, Kirk Magee & Peter Zed. (2013) A Systematic Review of Ethanol and Fomepizole Use in Toxic Alcohol Ingestions. Emergency Medicine International 2013, pages 1-14.
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Mary Anna Thrall, Heather E. Connally, Gregory F. Grauer & Dwayne W. Hamar. 2013. Small Animal Toxicology. Small Animal Toxicology 551 567 .
James A. Kruse. (2012) Methanol and Ethylene Glycol Intoxication. Critical Care Clinics 28:4, pages 661-711.
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Allister Vale. (2012) Alcohols and glycols. Medicine 40:2, pages 89-93.
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James P. Smith & Ingrid J. Chang. 2012. Brenner and Rector's The Kidney. Brenner and Rector's The Kidney 2411 2431 .
George Braitberg. 2009. Critical Care Nephrology. Critical Care Nephrology 905 918 .
Larissa I. Velez, Rebeca Gracia & Michael F. Neerman. (2007) Ethylene Glycol Poisoning: Current Diagnostic and Management Issues. Journal of Emergency Nursing 33:4, pages 342-345.
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. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 605 633 .
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Nicole L. Ries & Richard C. Dart. (2005) New Developments in Antidotes. Medical Clinics of North America 89:6, pages 1379-1397.
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Bruno Mégarbane, Stephen W. Borron & Frédéric J. Baud. (2004) Current recommendations for treatment of severe toxic alcohol poisonings. Intensive Care Medicine 31:2, pages 189-195.
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A. Wayne Jones. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions 395 462 .
Mark B. Mycyk & Jerrold B. Leikin. (2003) Antidote Review: Fomepizole for Methanol Poisoning. American Journal of Therapeutics 10:1, pages 68-70.
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L.I.G. Worthley. (2002) Clinical Toxicology: Part I. Diagnosis and Management of Common Drug Overdosage. Critical Care and Resuscitation 4:3, pages 192-215.
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Marisa Battistella. (2016) Fomepizole as an Antidote for Ethylene Glycol Poisoning. Annals of Pharmacotherapy 36:6, pages 1085-1089.
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Deon P. Druteika, Peter J. Zed & Mary H. H. Ensom. (2012) Role of Fomepizole in the Management of Ethylene Glycol Toxicity. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 22:3, pages 365-372.
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. 2001. Dreisbach's Handbook of Poisoning. Dreisbach's Handbook of Poisoning 199 215 .
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Jeffrey Brent. (2001) Current Management of Ethylene Glycol Poisoning. Drugs 61:7, pages 979-988.
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Stuart Abramson & Ajay K. Singh. (2000) Treatment of the alcohol intoxications: ethylene glycol, methanol and isopropanol. Current Opinion in Nephrology and Hypertension 9:6, pages 695-701.
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Marco L.A. Sivilotti, Michael J. Burns, Kenneth E. McMartin & Jeffrey Brent. (2000) Toxicokinetics of ethylene glycol during fomepizole therapy: Implications for management. Annals of Emergency Medicine 36:2, pages 114-125.
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Patrick D. Brophy, Milton Tenenbein, John Gardner, Timothy E. Bunchman & William E. Smoyer. (2000) Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. American Journal of Kidney Diseases 35:5, pages 958-962.
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Milton Tenenbein. (1999) RECENT ADVANCEMENTS IN PEDIATRIC TOXICOLOGY. Pediatric Clinics of North America 46:6, pages 1179-1188.
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James R WileyIIII. (1999) Novel therapies for ethylene glycol intoxication. Current Opinion in Pediatrics 11:3, pages 269-274.
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Jeffrey Brent, Kenneth McMartin, Scott Phillips, Keith K. Burkhart, J. Ward Donovan, Melanie Wells & Ken Kulig. (1999) Fomepizole for the Treatment of Ethylene Glycol Poisoning. New England Journal of Medicine 340:11, pages 832-838.
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Brent Wisse, Smiley Thakur & Dana Baran. (1999) Recovery from prolonged metabolic acidosis due to accidental ethylene glycol poisoning. American Journal of Kidney Diseases 33:2, pages e4.1-e4.5.
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E Jobard, A Turcant, P Harry, A Le Bouil & P Allain. (1997) High-performance liquid chromatographic determination of 4-methylpyrazole in plasma and in dialysate. Journal of Chromatography B: Biomedical Sciences and Applications 695:2, pages 444-447.
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