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The World Journal of Biological Psychiatry Volume 13, 2012 - Issue 7
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REVIEW ARTICLE

Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood–brain barrier integrity

Johann SteinerDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany;Department of Pharmacology, University of Cambridge, Cambridge, UK;Pembroke College, University of Cambridge, Cambridge, UKCorrespondence[email protected]
,
Bernhard BogertsDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany
,
Zoltán SarnyaiDepartment of Pharmacology, University of Cambridge, Cambridge, UK;Pembroke College, University of Cambridge, Cambridge, UK
,
Martin WalterDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany
,
Tomasz GosDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany;Institute of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland
,
Hans-Gert BernsteinDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany
&
Aye-Mu MyintDepartment of Psychiatry, University of Magdeburg, Magdeburg, Germany;Department of Psychiatry, University of Munich, Munich, Germany
 show all
Pages 482-492 | Received 05 Oct 2010, Accepted 11 Apr 2011, Published online: 28 Jun 2011

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Haley A. Vecchiarelli, Chaitanya P. Gandhi & Matthew N. Hill. (2016) Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats. Neural Plasticity 2016, pages 1-12.
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Crossref
Jonathan Savitz. 2017. Inflammation-Associated Depression: Evidence, Mechanisms and Implications. Inflammation-Associated Depression: Evidence, Mechanisms and Implications 249 267 .
Dean Raffelock. 2015. Integrative Therapies for Depression. Integrative Therapies for Depression 61 72 .
U Lewitzka, E Severus, R Bauer, P Ritter, B Müller-Oerlinghausen & M Bauer. (2015) The suicide prevention effect of lithium: more than 20 years of evidence—a narrative review. International Journal of Bipolar Disorders 3:1.
Crossref
Andreas Baranyi, Andreas Meinitzer, Robert J. Breitenecker, Omid Amouzadeh-Ghadikolai, Rudolf Stauber & Hans-Bernd Rothenhäusler. (2015) Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. PLOS ONE 10:9, pages e0137022.
Crossref
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Crossref
Haiyun Xu. (2015) Neuroinflammation in Schizophrenia Focused on the Pharmacological and Therapeutic Evidence. Pharmacologia 6:8, pages 438-453.
Crossref
Mandy Busse, Stefan Busse, Aye Mu Myint, Tomasz Gos, Henrik Dobrowolny, Ulf J. Müller, Bernhard Bogerts, Hans-Gert Bernstein & Johann Steiner. (2014) Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?. European Archives of Psychiatry and Clinical Neuroscience 265:4, pages 321-329.
Crossref
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Crossref
Alexei Verkhratsky, Maiken Nedergaard & Leif Hertz. (2014) Why are Astrocytes Important?. Neurochemical Research 40:2, pages 389-401.
Crossref
Jonathan Savitz, Wayne C Drevets, Chelsey M Smith, Teresa A Victor, Brent E Wurfel, Patrick SF Bellgowan, Jerzy Bodurka, T Kent Teague & Robert Dantzer. (2014) Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder. Neuropsychopharmacology 40:2, pages 463-471.
Crossref
Hans-Gert Bernstein, Johann Steiner, Paul C. Guest, Henrik Dobrowolny & Bernhard Bogerts. (2015) Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy. Schizophrenia Research 161:1, pages 4-18.
Crossref
Michael Eriksen Benrós & Preben B. Mortensen. 2015. Immunology and Psychiatry. Immunology and Psychiatry 107 135 .
Alexei Verkhratsky, José J. Rodríguez & Luca Steardo. (2013) Astrogliopathology. The Neuroscientist 20:6, pages 576-588.
Crossref
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Souhel Najjar, Daniel M. Pearlman, Scott Hirsch, Kent Friedman, John Strange, Jason Reidy, Maya Khoukaz, Richard B. Ferrell, Orrin Devinsky, Amanda Najjar & David Zagzag. (2014) Brain Biopsy Findings Link Major Depressive Disorder to Neuroinflammation, Oxidative Stress, and Neurovascular Dysfunction: A Case Report. Biological Psychiatry 75:12, pages e23-e26.
Crossref
Fang Liu, Xiaofeng Guo, Rengrong Wu, Jianjun Ou, Yingjun Zheng, Bingkui Zhang, Liqin Xie, Limei Zhang, Li Yang, Shuyun Yang, Junwei Yang, Ye Ruan, Yong Zeng, Xiufeng Xu & Jingping Zhao. (2014) Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: A double blind, randomized, controlled trial. Schizophrenia Research 153:1-3, pages 169-176.
Crossref
P. De Maricourt, T. Jay, P. Goncalvès, H. Lôo & R. Gaillard. (2014) Effet antidépresseur de la kétamine : revue de la littérature sur les mécanismes d’action de la kétamine. L'Encéphale 40:1, pages 48-55.
Crossref
Michael E. Benros, William W. Eaton & Preben B. Mortensen. (2014) The Epidemiologic Evidence Linking Autoimmune Diseases and Psychosis. Biological Psychiatry 75:4, pages 300-306.
Crossref
Szatmár Horváth & Károly Mirnics. (2014) Immune System Disturbances in Schizophrenia. Biological Psychiatry 75:4, pages 316-323.
Crossref
Johann Steiner, Hans-Gert Bernstein, Kolja Schiltz, Ulf J. Müller, Sabine Westphal, Hemmo A. Drexhage & Bernhard Bogerts. (2014) Immune system and glucose metabolism interaction in schizophrenia: A chicken–egg dilemma. Progress in Neuro-Psychopharmacology and Biological Psychiatry 48, pages 287-294.
Crossref
J.C. Hammond, D. Shan, J.H. Meador-Woodruff & R.E. McCullumsmith. 2014. Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders. Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders 265 294 .
Irena Smaga, Weronika Krzyżanowska, Bartosz Pomierny, Bogusława Budziszewska, Andrzej Pilc & Gabriel Nowak. 2014. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1567 1593 .
Souhel Najjar, Daniel M Pearlman, Kenneth Alper, Amanda Najjar & Orrin Devinsky. (2013) Neuroinflammation and psychiatric illness. Journal of Neuroinflammation 10:1.
Crossref
Souhel Najjar, Daniel M Pearlman, Orrin Devinsky, Amanda Najjar & David Zagzag. (2013) Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence. Journal of Neuroinflammation 10:1.
Crossref
Anne-Sofie Johansson, Björn Owe-Larsson, Linnéa Asp, Tomasz Kocki, Mats Adler, Jerker Hetta, Renee Gardner, Gabriella B.S. Lundkvist, Ewa M. Urbanska & Håkan Karlsson. (2013) Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine. Journal of Psychiatric Research 47:11, pages 1815-1823.
Crossref
Souhel Najjar, Daniel Pearlman, Orrin Devinsky, Amanda Najjar, Siddhartha Nadkarni, Tracy Butler & David Zagzag. (2013) Neuropsychiatric Autoimmune Encephalitis without VGKC-Complex, NMDAR, and GAD Autoantibodies. Cognitive and Behavioral Neurology 26:1, pages 36-49.
Crossref
Johann Steiner, Hans-Gert Bernstein, Bernhard Bogerts & Carlos-Alberto Gonçalves. (2012) Os possíveis papéis da S100B na esquizofrenia. Archives of Clinical Psychiatry (São Paulo) 40:1, pages 35-40.
Crossref
Jeannine S. Strobl, David G. Goodwin, Beverly A. Rzigalinski & David S. Lindsay. (2012) Dopamine Stimulates Propagation of Toxoplasma gondii Tachyzoites in Human Fibroblast and Primary Neonatal Rat Astrocyte Cell Cultures . Journal of Parasitology 98:6, pages 1296-1299.
Crossref
Gilles J. Guillemin. (2012) Quinolinic acid, the inescapable neurotoxin. FEBS Journal 279:8, pages 1356-1365.
Crossref
Johann Steiner & Bernhard Bogerts. 2012. Handbuch der Psychopharmakotherapie. Handbuch der Psychopharmakotherapie 297 313 .

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