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The World Journal of Biological Psychiatry Volume 16, 2015 - Issue 1
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ORIGINAL INVESTIGATION

The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain

Trehani M. FonsekaPharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, Canada;Department of Psychiatry, University Health Network, University of Toronto, Toronto, ON, Canada
,
Arun K. TiwariPharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, Canada
,
Vanessa F. GonçalvesPharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, Canada
,
Jeffrey A. LiebermanDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University and the New York State Psychiatric Institute, New York, NY, USA
,
Herbert Y. MeltzerNorthwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Benjamin I. GoldsteinDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
,
James L. KennedyPharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, Canada
,
Sidney H. KennedyDepartment of Psychiatry, University Health Network, University of Toronto, Toronto, ON, Canada
&
Daniel J. MüllerPharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]
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Pages 45-56 | Received 19 Aug 2014, Accepted 03 Nov 2014, Published online: 06 Jan 2015

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Yanmei Li, Ruibing Su, Shuqin Xu, Qingjun Huang & Haiyun Xu. (2017) Artesunate prevents rats from the clozapine-induced hepatic steatosis and elevation in plasma triglycerides. Neuropsychiatric Disease and Treatment 13, pages 2477-2487.
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Mark R. Libowitz & Erika L. Nurmi. (2021) The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome in Children. Frontiers in Psychiatry 12.
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Nana Li, Ting Cao, Xiangxin Wu, Mimi Tang, Daxiong Xiang & Hualin Cai. (2020) Progress in Genetic Polymorphisms Related to Lipid Disturbances Induced by Atypical Antipsychotic Drugs. Frontiers in Pharmacology 10.
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Xiufang Kong & Amr H Sawalha. (2019) Takayasu arteritis risk locus in IL6 represses the anti-inflammatory gene GPNMB through chromatin looping and recruiting MEF2–HDAC complex . Annals of the Rheumatic Diseases 78:10, pages 1388-1397.
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Chao Luo, Junyan Liu, Xu Wang, Xiaoyuan Mao, Honghao Zhou & Zhaoqian Liu. (2019) Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population. Neuroscience Bulletin 35:3, pages 561-580.
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Junhong Cai, Kaiying Cui, Fanglin Niu, Tianbo Jin, Sizhe Huang, Ying Zhang & Shan Bao. (2019) Genetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer. Molecular Genetics & Genomic Medicine 7:4, pages e00600.
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Raghunath Singh, Yashika Bansal, Bikash Medhi & Anurag Kuhad. (2019) Antipsychotics-induced metabolic alterations: Recounting the mechanistic insights, therapeutic targets and pharmacological alternatives. European Journal of Pharmacology 844, pages 231-240.
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A. E. Gareeva. (2018) Peculiarities of the Effect of Antipsychotics: Pharmacogenetic Studies. Human Physiology 44:6, pages 706-719.
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Jeizziani Aparecida Ferreira Pinto, Pedro Henrique Batista de Freitas, Fernanda Daniela Dorneles Nunes, Paulo Afonso Granjeiro, Luciana Lara dos Santos & Richardson Miranda Machado. (2018) Prevalence of polymorphisms in the ANKK1, DRD2, DRD3 genes and metabolic syndrome in refractory schizophrenia. Revista Latino-Americana de Enfermagem 26:0.
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Clement C. Zai, Arun K. Tiwari, Gwyneth C. Zai, Miriam S. Maes & James L. Kennedy. (2018) New findings in pharmacogenetics of schizophrenia. Current Opinion in Psychiatry 31:3, pages 200-212.
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Shih-Jen Tsai. (2017) Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions. Cytokine & Growth Factor Reviews 37, pages 89-97.
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Shen Li, Chengai Xu, Yuan Tian, Xueshi Wang, Rui Jiang, Miaomiao Zhang, Lili Wang, Guifu Yang, Ying Gao, Chenyu Song, Yukun He, Ying Zhang, Jie Li & Wei-Dong Li. (2017) TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese. Scientific Reports 7:1.
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Madison L. Gates, Thad Wilkins, Elizabeth Ferguson, Veronica Walker, Robert K. Bradford & Wonsuk Yoo. (2016) Gender and race disparities in weight gain among offenders prescribed antidepressant and antipsychotic medications. Health & Justice 4:1.
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Rif S. El-Mallakh, R. Jeannie Roberts, Peggy L. El-Mallakh, Lillian Jan Findlay & Kristen K. Reynolds. (2016) Pharmacogenomics in Psychiatric Practice. Clinics in Laboratory Medicine 36:3, pages 507-523.
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Trehani M. Fonseka, Daniel J. Müller & Sidney H. Kennedy. (2016) Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications. Complex Psychiatry 2:1, pages 1-14.
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J.C. Han. 2016. Genetics of Monogenic and Syndromic Obesity. Genetics of Monogenic and Syndromic Obesity 75 95 .
Malgorzata Maciukiewicz, Victoria S Marshe, Arun K Tiwari, Trehani M Fonseka, Natalie Freeman, Susan Rotzinger, Jane A Foster, James L Kennedy, Sidney H Kennedy & Daniel J Müller. (2015) Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder . Pharmacogenomics 16:17, pages 1919-1929.
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