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Nanotoxicology Volume 5, 2011 - Issue 2
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CONTENTS

Nano-TiO2 – feasibility and challenges for human health risk assessment based on open literature

Frans M. ChristensenNanobiosciences unit, European Commission – DG Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP), Ispra, ItalyCorrespondence[email protected]
,
Helinor J. JohnstonBiomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh
,
Vicki StoneBiomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh
,
Robert J. AitkenInstitute of Occupational Medicine (IOM) and SAFENANO, Riccarton, Edinburgh, UK
,
Steve HankinInstitute of Occupational Medicine (IOM) and SAFENANO, Riccarton, Edinburgh, UK
,
Sheona PetersInstitute of Occupational Medicine (IOM) and SAFENANO, Riccarton, Edinburgh, UK
&
Karin AschbergerNanobiosciences unit, European Commission – DG Joint Research Centre (JRC), Institute for Health and Consumer Protection (IHCP), Ispra, Italy
 show all
Pages 110-124 | Received 18 Dec 2009, Accepted 25 Jun 2010, Published online: 23 Aug 2010

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Wolfgang G. Kreyling, Uwe Holzwarth, Nadine Haberl, Ján Kozempel, Alexander Wenk, Stephanie Hirn, Carsten Schleh, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke & Neil Gibson. (2017) Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3. Nanotoxicology 11:4, pages 454-464.
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Wolfgang G. Kreyling, Uwe Holzwarth, Nadine Haberl, Ján Kozempel, Stephanie Hirn, Alexander Wenk, Carsten Schleh, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke & Neil Gibson. (2017) Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1. Nanotoxicology 11:4, pages 434-442.
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Pernille Høgh Danielsen, Yi Cao, Martin Roursgaard, Peter Møller & Steffen Loft. (2015) Endothelial cell activation, oxidative stress and inflammation induced by a panel of metal-based nanomaterials. Nanotoxicology 9:7, pages 813-824.
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Helinor Johnston, Giulio Pojana, Stefano Zuin, Nicklas Raun Jacobsen, Peter Møller, Steffen Loft, Manuela Semmler-Behnke, Catherine McGuiness, Dominique Balharry, Antonio Marcomini, Håkan Wallin, Wolfgang Kreyling, Ken Donaldson, Lang Tran & Vicki Stone. (2013) Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges. Critical Reviews in Toxicology 43:1, pages 1-20.
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Articles from other publishers (47)

K. Sowards & H. Medina. (2023) Hierarchical enhanced surface area structures and their associated applications with Titania. Applied Materials Today 35, pages 101962.
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Fatemeh Araste, Astrid Diana Bakker & Behrouz Zandieh-Doulabi. (2023) Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control. Journal of Nanoparticle Research 25:11.
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Jan Mast, Erik Van Miert, Lisa Siciliani, Karlien Cheyns, Marie-Noëlle Blaude, Charlotte Wouters, Nadia Waegeneers, Ruud Bernsen, Christiane Vleminckx, Joris Van Loco & Eveline Verleysen. (2023) Application of silver-based biocides in face masks intended for general use requires regulatory control. Science of The Total Environment 870, pages 161889.
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M. S. Ryabtseva, V. S. Krivobok, A. V. Kolobov, S. E. Dimitrieva, M. A. Shevchenko, S. I. Chentsov, I. Yu. Nikolaeva & M. E. Tarnopolskaya. (2023) Relationship between the Physical Properties and Mechanisms of Toxic Action for Nanopowders and Micropowders of Titanium Dioxide in the Form of Anatase. Nanobiotechnology Reports 17:6, pages 846-856.
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Filomena Mottola, Marianna Santonastaso, Concetta Iovine, Giada Frenzilli, Simona Picchietti, Viviana Genualdo & Lucia Rocco. (2021) TiO2-NPs and cadmium co-exposure: in vitro assessment of genetic and genomic DNA damage on Dicentrarchus labrax embryonic cells. Environmental Science and Pollution Research 29:41, pages 62208-62218.
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Yang Lei, Rong-Rong Cai, Rui-Qi Lin & Li-Zhi Zhang. (2022) Spectral selective composite mask media for personal cooling and efficient PM 2.5 removal . Journal of Industrial Textiles 52, pages 152808372211154.
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Mohammad Mamunur Rashid, Petra Forte Tavčer & Brigita Tomšič. (2021) Influence of Titanium Dioxide Nanoparticles on Human Health and the Environment. Nanomaterials 11:9, pages 2354.
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Mohammad N. Alomary & Mohammad Azam Ansari. (2021) Proanthocyanin‐Capped Biogenic TiO 2 Nanoparticles with Enhanced Penetration, Antibacterial and ROS Mediated Inhibition of Bacteria Proliferation and Biofilm Formation: A Comparative Approach . Chemistry – A European Journal 27:18, pages 5817-5829.
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Premlata K. Ambre, Chandan Rajendra Gupta, Elvis A.F. Martis & Evans C. Coutinho. 2021. Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications. Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications 151 189 .
Christie M. Sayes. 2020. Women in Nanotechnology. Women in Nanotechnology 43 55 .
Wolfgang G. Kreyling, Uwe Holzwarth, Carsten Schleh, Stephanie Hirn, Alexander Wenk, Martin Schäffler, Nadine Haberl, Manuela Semmler-Behnke & Neil Gibson. (2019) Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure. Particle and Fibre Toxicology 16:1.
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Laura M. Hernandez, Elvis Genbo Xu, Hans C. E. Larsson, Rui Tahara, Vimal B. Maisuria & Nathalie Tufenkji. (2019) Plastic Teabags Release Billions of Microparticles and Nanoparticles into Tea. Environmental Science & Technology 53:21, pages 12300-12310.
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Sreekanth Thota & Debbie C. CransIvan Pacheco & Cristina Buzea. 2018. Metal Nanoparticles. Metal Nanoparticles 203 259 .
Sreekanth Thota & Debbie C. CransIvan Pacheco & Cristina Buzea. 2018. Metal Nanoparticles. Metal Nanoparticles 237 293 .
Daniela Schwotzer, Heinrich Ernst, Dirk Schaudien, Heiko Kock, Gerhard Pohlmann, Clemens Dasenbrock & Otto Creutzenberg. (2017) Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats. Particle and Fibre Toxicology 14:1.
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Michelle Romero-Franco, Hilary A Godwin, Muhammad Bilal & Yoram Cohen. (2017) Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs). Beilstein Journal of Nanotechnology 8, pages 989-1014.
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Kim Ettrup, Anna Kounina, Steffen Foss Hansen, Johannes A. J. Meesters, Eldbjørg B. Vea & Alexis Laurent. (2017) Development of Comparative Toxicity Potentials of TiO 2 Nanoparticles for Use in Life Cycle Assessment . Environmental Science & Technology 51:7, pages 4027-4037.
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Alexis Laurent, Jack R. Harkema, Elisabeth W. Andersen, Mikołaj Owsianiak, Eldbjørg B. Vea & Olivier Jolliet. (2017) Human health no-effect levels of TiO2 nanoparticles as a function of their primary size. Journal of Nanoparticle Research 19:4.
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Laurent Gaté, Clémence Disdier, Frédéric Cosnier, François Gagnaire, Jérôme Devoy, Wadad Saba, Emilie Brun, Monique Chalansonnet & Aloise Mabondzo. (2017) Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats. Toxicology Letters 265, pages 61-69.
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Sheau-Fung Thai, Kathleen A. Wallace, Carlton P. Jones, Hongzu Ren, Eric Grulke, Benjamin T. Castellon, James Crooks & Kirk T. Kitchin. (2016) Differential Genomic Effects of Six Different TiO 2 Nanomaterials on Human Liver HepG2 Cells . Journal of Biochemical and Molecular Toxicology 30:7, pages 331-341.
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Brian D. Johnson, Samantha L. Gilbert, Bushra Khan, David L. Carroll & Amy H. Ringwood. (2015) Cellular responses of eastern oysters, Crassostrea virginica, to titanium dioxide nanoparticles. Marine Environmental Research 111, pages 135-143.
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Sylviane Pulvin. (2015) Toxicity Associated with the Photo Catalytic and Photo Stable Forms of Titanium Dioxide Nanoparticles Used in Sunscreen lotion. MOJ Toxicology 1:3.
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Rossella Alinovi, Matteo Goldoni, Silvana Pinelli, Marco Campanini, Irene Aliatis, Danilo Bersani, Pier Paolo Lottici, Sergio Iavicoli, Marta Petyx, Paola Mozzoni & Antonio Mutti. (2015) Oxidative and pro-inflammatory effects of cobalt and titanium oxide nanoparticles on aortic and venous endothelial cells. Toxicology in Vitro 29:3, pages 426-437.
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Ebany J. Martinez-Finley, Sam Caito, Stephanie Fretham, Pan Chen & Michael Aschner. 2015. Mammalian Toxicology. Mammalian Toxicology 171 185 .
O. L. Galkina, V. K. Ivanov, A. V. Agafonov, G. A. Seisenbaeva & V. G. Kessler. (2015) Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications. J. Mater. Chem. B 3:8, pages 1688-1698.
Crossref
Liesbeth Geraets, Agnes G Oomen, Petra Krystek, Nicklas R Jacobsen, Håkan Wallin, Michel Laurentie, Henny W Verharen, Esther FA Brandon & Wim H de Jong. (2014) Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Particle and Fibre Toxicology 11:1.
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Yu Yang, Kyle Doudrick, Xiangyu Bi, Kiril Hristovski, Pierre Herckes, Paul Westerhoff & Ralf Kaegi. (2014) Characterization of Food-Grade Titanium Dioxide: The Presence of Nanosized Particles. Environmental Science & Technology 48:11, pages 6391-6400.
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Baoyong Sha, Wei Gao, Shuqi Wang, Xingchun Gou, Wei Li, Xuan Liang, Zhiguo Qu, Feng Xu & Tian Jian Lu. (2014) Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats. Journal of Applied Toxicology 34:4, pages 345-356.
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Shude Xiao, William Z. Xu & Paul A. Charpentier. (2014) Bifunctional 2-(alkoxycarbonothioylthio)acetic acids for the synthesis of TiO 2 -poly(vinyl acetate) nanocomposites via RAFT polymerization . Journal of Polymer Science Part A: Polymer Chemistry 52:5, pages 606-618.
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Nancy Monteiro-Riviere & C TranDanail Hristozov, Laura MacCalman, Keld Jensen, Vicki Stone, Janeck Scott-Fordsmand, Bernd Nowack, Teresa Fernandes & Antonio Marcomini. 2014. Nanotoxicology. Nanotoxicology 459 478 .
Arun Kumar, Prashant Kumar, Ananthitha Anandan, Teresa F. Fernandes, Godwin A. Ayoko & George Biskos. (2014) Engineered Nanomaterials: Knowledge Gaps in Fate, Exposure, Toxicity, and Future Directions. Journal of Nanomaterials 2014, pages 1-16.
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K Aschberger, Z Klöslova, G Falck & F M Christensen. (2013) Defining Occupational and Consumer Exposure Limits for Nanomaterials – First Experiences from REACH Registrations. Journal of Physics: Conference Series 429, pages 012069.
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Ivana Fenoglio, Jessica Ponti, Elisa Alloa, Mara Ghiazza, Ingrid Corazzari, Robin Capomaccio, Diana Rembges, Simonetta Oliaro-Bosso & François Rossi. (2013) Singlet oxygen plays a key role in the toxicity and DNA damage caused by nanometric TiO2 in human keratinocytes. Nanoscale 5:14, pages 6567.
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Sandra Gissela Márquez-Ramírez, Norma Laura Delgado-Buenrostro, Yolanda Irasema Chirino, Gisela Gutiérrez Iglesias & Rebeca López-Marure. (2012) Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells. Toxicology 302:2-3, pages 146-156.
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A. Noël, K. Maghni, Y. Cloutier, C. Dion, K.J. Wilkinson, S. Hallé, R. Tardif & G. Truchon. (2012) Effects of inhaled nano-TiO2 aerosols showing two distinct agglomeration states on rat lungs. Toxicology Letters 214:2, pages 109-119.
Crossref
Hongbo Ma, Amanda Brennan & Stephen A. Diamond. (2012) Photocatalytic reactive oxygen species production and phototoxicity of titanium dioxide nanoparticles are dependent on the solar ultraviolet radiation spectrum. Environmental Toxicology and Chemistry 31:9, pages 2099-2107.
Crossref
Khara D. Grieger, Alexis Laurent, Mirko Miseljic, Frans Christensen, Anders Baun & Stig I. Olsen. (2012) Analysis of current research addressing complementary use of life-cycle assessment and risk assessment for engineered nanomaterials: have lessons been learned from previous experience with chemicals?. Journal of Nanoparticle Research 14:7.
Crossref
Myung-Sil Hwang, Eun-Ji Lee, Se-Young Kweon, Mi-Sun Park, Ji-Yoon Jeong, Jun-Ho Um, Sun-Ah Kim, Bum-Suk Han, Kwang-Ho Lee & Hae-Jung Yoon. (2012) Risk Assessment Principle for Engineered Nanotechnology in Food and Drug. Toxicological Research 28:2, pages 73-79.
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Angélica Montiel-Dávalos, José Luis Ventura-Gallegos, Ernesto Alfaro-Moreno, Elizabeth Soria-Castro, Ethel García-Latorre, José Gerardo Cabañas-Moreno, María del Pilar Ramos-Godinez & Rebeca López-Marure. (2012) TiO 2 Nanoparticles Induce Dysfunction and Activation of Human Endothelial Cells . Chemical Research in Toxicology 25:4, pages 920-930.
Crossref
Kirsten Gerloff, Ivana Fenoglio, Emanuele Carella, Julia Kolling, Catrin Albrecht, Agnes W. Boots, Irmgard Förster & Roel P. F. Schins. (2012) Distinctive Toxicity of TiO 2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells . Chemical Research in Toxicology 25:3, pages 646-655.
Crossref
V. Bolis, C. Busco, M. Ciarletta, C. Distasi, J. Erriquez, I. Fenoglio, S. Livraghi & S. Morel. (2012) Hydrophilic/hydrophobic features of TiO2 nanoparticles as a function of crystal phase, surface area and coating, in relation to their potential toxicity in peripheral nervous system. Journal of Colloid and Interface Science 369:1, pages 28-39.
Crossref
Janez Valant, Damjana Drobne & Sara Novak. (2012) Effect of ingested titanium dioxide nanoparticles on the digestive gland cell membrane of terrestrial isopods. Chemosphere 87:1, pages 19-25.
Crossref
Ingrid Corazzari, Stefano Livraghi, Silvia Ferrero, Elio Giamello, Bice Fubini & Ivana Fenoglio. (2012) Inactivation of TiO2 nano-powders for the preparation of photo-stable sunscreens via carbon-based surface modification. Journal of Materials Chemistry 22:36, pages 19105.
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