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Original Article

Surface functionalisation regulates polyamidoamine dendrimer toxicity on blood–brain barrier cells and the modulation of key inflammatory receptors on microglia

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Pages 158-168 | Received 12 Oct 2012, Accepted 20 Dec 2012, Published online: 30 Jan 2013

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Mehulkumar Patel, Silvia H. De Paoli, Oumsalama K. Elhelu, Sehrish Farooq & Jan Simak. (2019) Cell membrane disintegration and extracellular vesicle release in a model of different size and charge PAMAM dendrimers effects on cultured endothelial cells. Nanotoxicology 13:5, pages 664-681.
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Ghasem Ghalamfarsa, Mohammad Hojjat-Farsangi, Mousa Mohammadnia-Afrouzi, Enayat Anvari, Shohreh Farhadi, Mehdi Yousefi & Farhad Jadidi-Niaragh. (2016) Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis. Journal of Immunotoxicology 13:5, pages 603-619.
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Juan Encalada‐Alayola, Jorge A. Uribe‐Calderón, Wilberth A. Herrera‐Kao, Santiago Duarte‐Aranda, Gerardo M. Alonzo‐Medina, Rubén Domínguez‐Maldonado & José Manuel Cervantes‐Uc. (2023) Synthesis and characterization of low generation polyamidoamine dendrimers and release of 5‐fluorouracil from their complexes. Journal of Applied Polymer Science 140:25.
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Xiang Li, Abid Naeem, Shanghua Xiao, Lei Hu, Jing Zhang & Qin Zheng. (2022) Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine. Pharmaceutics 14:6, pages 1292.
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Shuting S. Cai, Tianyu Li, Tolulope Akinade, Yuefei Zhu & Kam W. Leong. (2021) Drug delivery carriers with therapeutic functions. Advanced Drug Delivery Reviews 176, pages 113884.
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Rohini Kharwade, Sachin More, Amol Warokar, Pratibha Agrawal & Nilesh Mahajan. (2020) Starburst pamam dendrimers: Synthetic approaches, surface modifications, and biomedical applications. Arabian Journal of Chemistry 13:7, pages 6009-6039.
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Renan Araújo, Soraya Santos, Elizabeth Igne Ferreira & Jeanine Giarolla. (2018) New Advances in General Biomedical Applications of PAMAM Dendrimers. Molecules 23:11, pages 2849.
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Manisha Singh, Himansu Sekhar Nanda, Richard D. O'Rorke, Adam E. Jakus, Ankur Harish Shah, Ramille N. Shah, Richard D. Webster & Terry W. J. Steele. (2018) Voltaglue Bioadhesives Energized with Interdigitated 3D‐Graphene Electrodes. Advanced Healthcare Materials 7:21, pages 1800538.
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Gururaj M. Neelgund & Aderemi Oki. (2018) Advancement in Photothermal Effect of Carbon Nanotubes by Grafting of Poly(amidoamine) and Deposition of CdS Nanocrystallites. Industrial & Engineering Chemistry Research 57:23, pages 7826-7833.
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Victoria Leiro, Sofia Duque Santos, Cátia D. F. Lopes & Ana Paula Pêgo. (2017) Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine. Advanced Functional Materials 28:12, pages 1700313.
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Pratap Naha, Sourav Mukherjee & Hugh Byrne. (2018) Toxicology of Engineered Nanoparticles: Focus on Poly(amidoamine) Dendrimers. International Journal of Environmental Research and Public Health 15:2, pages 338.
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Pierre P.D. Kondiah, Yahya E. Choonara, Pariksha J. Kondiah, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit, Girish Modi & Viness Pillay. 2018. Applications of Nanocomposite Materials in Drug Delivery. Applications of Nanocomposite Materials in Drug Delivery 391 408 .
Maria Natalia Calienni, Daniela Agustina Feas, Daniela Edith Igartúa, Nadia Silvia Chiaramoni, Silvia del Valle Alonso & Maria Jimena Prieto. (2017) Nanotoxicological and teratogenic effects: A linkage between dendrimer surface charge and zebrafish developmental stages. Toxicology and Applied Pharmacology 337, pages 1-11.
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Bhairavi Srinageshwar, Sarah Peruzzaro, Melissa Andrews, Kayla Johnson, Allison Hietpas, Brittany Clark, Crystal McGuire, Eric Petersen, Jordyn Kippe, Andrew Stewart, Olivia Lossia, Abeer Al-Gharaibeh, Aaron Antcliff, Rebecca Culver, Douglas Swanson, Gary Dunbar, Ajit Sharma & Julien Rossignol. (2017) PAMAM Dendrimers Cross the Blood–Brain Barrier When Administered through the Carotid Artery in C57BL/6J Mice. International Journal of Molecular Sciences 18:3, pages 628.
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X. Gao, X. Gu & H. Chen. 2017. Neurotoxicity of Nanomaterials and Nanomedicine. Neurotoxicity of Nanomaterials and Nanomedicine 59 74 .
Mariacristina Gagliardi. (2016) Novel biodegradable nanocarriers for enhanced drug delivery. Therapeutic Delivery 7:12, pages 809-826.
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Robert A. Yokel. (2016) Physicochemical properties of engineered nanomaterials that influence their nervous system distribution and effects. Nanomedicine: Nanotechnology, Biology and Medicine 12:7, pages 2081-2093.
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M. Rai, A.P. Ingle, S. Gaikwad, I. Gupta, A. Gade & S. Silvério da Silva. (2016) Nanotechnology based anti-infectives to fight microbial intrusions. Journal of Applied Microbiology 120:3, pages 527-542.
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Olimpia Gamucci & Giuseppe Bardi. (2014) Cerium dioxide nanoparticles selectively up-regulate C-C chemokine receptor 2 and CD16 expression on human monocytes. EURO-NanoTox-Letters 5:1, pages 1-16.
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Tin-Tin Win-Shwe, Hideko Sone, Yoshika Kurokawa, Yang Zeng, Qin Zeng, Hiroshi Nitta & Seishiro Hirano. (2014) Effects of PAMAM dendrimers in the mouse brain after a single intranasal instillation. Toxicology Letters 228:3, pages 207-215.
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Olimpia Gamucci, Alice Bertero, Mariacristina Gagliardi & Giuseppe Bardi. (2014) Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility. Coatings 4:1, pages 139-159.
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Adriano Boni, Lorenzo Albertazzi, Claudia Innocenti, Mauro Gemmi & Angelo Bifone. (2013) Water Dispersal and Functionalization of Hydrophobic Iron Oxide Nanoparticles with Lipid-Modified Poly(amidoamine) Dendrimers. Langmuir 29:35, pages 10973-10979.
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Seyed Mohammad Hosseini, Javad Mohammadnejad, Behrouz Alirezapour, Ali Hossein Rezayan & hasan Yousefnia. (2022) Preparation, Quality Control and Biological Evaluation of <sup>177</sup>Lu-Cetuximab-PAMAM Dendrimeric Nanosystem as a Novel Theranostic Radioimmunoconjugate. SSRN Electronic Journal.
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