798
Views
57
CrossRef citations to date
0
Altmetric
Original Article

Minimal oxidation and inflammogenicity of pristine graphene with residence in the lung

, , , , , & show all
Pages 824-832 | Received 04 Feb 2013, Accepted 30 Jul 2013, Published online: 05 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Young Hun Kim, Mi Seong Jo, Jin Kwon Kim, Jae Hoon Shin, Jin Ee Baek, Hye Seon Park, Hyo Jin An, Jong Seong Lee, Boo Wook Kim, Hoi Pin Kim, Kang Ho Ahn, KiSoo Jeon, Seung Min Oh, Ji Hyun Lee, Tomomi Workman, Elaine M. Faustman & Il Je Yu. (2018) Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 12:3, pages 224-238.
Read now
Jae Hoon Shin, Sung Gu Han, Jin Kwon Kim, Boo Wook Kim, Joo Hwan Hwang, Jong Seong Lee, Ji Hyun Lee, Jin Ee Baek, Tae Gyu Kim, Keun Soo Kim, Heon Sang Lee, Nam Woong Song, Kangho Ahn & Il Je Yu. (2015) 5-Day repeated inhalation and 28-day post-exposure study of graphene. Nanotoxicology 9:8, pages 1023-1031.
Read now

Articles from other publishers (55)

Luis Augusto Visani de LunaThomas LoretYilin He, Morgan Legnani, Hazel Lin, Anne Marie Galibert, Alexander FordhamSonja HolmeAntonio Esau Del Rio Castillo, Francesco Bonaccorso, Alberto Bianco, Emmanuel Flahaut, Kostas Kostarelos & Cyrill Bussy. (2023) Pulmonary Toxicity of Boron Nitride Nanomaterials Is Aspect Ratio Dependent. ACS Nano.
Crossref
Bahareh Vakili, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Farnaz Hosseini & Navid Nezafat. (2023) Graphene oxide as novel vaccine adjuvant. International Immunopharmacology 125, pages 111062.
Crossref
Sunggu Yang, Eunha Baeg, Kyungtae Kim, Donggue Kim, Duo Xu, Jong-Hyun Ahn & Sungchil Yang. (2023) Neurodiagnostic and neurotherapeutic potential of graphene nanomaterials. Biosensors and Bioelectronics, pages 115906.
Crossref
Premika Govindaraj, Azadeh Mirabedini, Xing Jin, Dennis Antiohos, Nisa Salim, Phil Aitchison, Jake Parker, Franz Konstantin Fuss & Nishar Hameed. (2023) Health and safety perspectives of graphene in wearables and hybrid materials. Journal of Materials Science & Technology 155, pages 10-32.
Crossref
Thomas Loret, Luis Augusto Visani de Luna, Matteo Andrea Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco, Kostas Kostarelos & Cyrill Bussy. (2023) Lung Persistence, Biodegradation, and Elimination of Graphene‐Based Materials are Predominantly Size‐Dependent and Mediated by Alveolar Phagocytes. Small.
Crossref
Elena V. Litasova, Victor V. Iljin, Maria A. Brusina & Levon B. Piotrovskiy. (2023) Toxicology of carbon nanostructures. Part 2. Nanoscale materials based on graphene sheets. Reviews on Clinical Pharmacology and Drug Therapy 21:1, pages 5-22.
Crossref
Elena V. Litasova, Victor V. Iljin, Maria A. Brusina & Levon B. Piotrovskiy. (2023) Toxicology of carbon nanostructures. Part 2. Nanoscale materials based on graphene sheets. Reviews on Clinical Pharmacology and Drug Therapy, pages 5-22.
Crossref
Daria Korejwo, Savvina Chortarea, Chrysovalanto Louka, Marija Buljan, Barbara Rothen-Rutishauser, Peter Wick & Tina Buerki-Thurnherr. (2023) Gene expression profiling of human macrophages after graphene oxide and graphene nanoplatelets treatment reveals particle-specific regulation of pathways. NanoImpact 29, pages 100452.
Crossref
Nikoo Saveh Shemshaki, Ho-Man Kan, Mohammed Barajaa, Takayoshi Otsuka, Amir Lebaschi, Neha Mishra, Lakshmi S. Nair & Cato T. Laurencin. (2022) Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix. Proceedings of the National Academy of Sciences 119:33.
Crossref
Shana J. Cameron, Jessica Sheng, Farah Hosseinian & William G. Willmore. (2022) Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions. International Journal of Molecular Sciences 23:14, pages 7962.
Crossref
Javier Frontiñan-Rubio, Viviana Jehová González, Ester Vázquez & Mario Durán-Prado. (2022) Rapid and efficient testing of the toxicity of graphene-related materials in primary human lung cells. Scientific Reports 12:1.
Crossref
Fatemehsadat Dehghani, Saied Shahmoradi, Matin Naghizadeh, Tahereh Firuzyar, Ahmad Vaez, Seyed Reza Kasaee, Ali Mohammad Amani & Sareh Mosleh-Shirazi. (2022) Magnetic graphite-ODA@CoFe2O4: attempting to produce and characterize the development of an innovative nanocomposite to investigate its antimicrobial properties. Applied Physics A 128:3.
Crossref
Shi-Xin Wang, Yu-Bao Lu, Xue-Xi Wang, Yan Wang, Yu-Jun Song, Xiao Wang & Munkhtuya Nyamgerelt. (2022) Graphene and graphene-based materials in axonal repair of spinal cord injury. Neural Regeneration Research 17:10, pages 2117.
Crossref
Somya Ranjan Dash & Chanakya Nath Kundu. (2022) Photothermal Therapy: A New Approach to Eradicate Cancer. Current Nanoscience 18:1, pages 31-47.
Crossref
Jie Li, Huamin Zeng, Zhaowu Zeng, Yiying Zeng & Tian Xie. (2021) Promising Graphene-Based Nanomaterials and Their Biomedical Applications and Potential Risks: A Comprehensive Review. ACS Biomaterials Science & Engineering 7:12, pages 5363-5396.
Crossref
Tereza Svadlakova, Martina Kolackova, Radka Vankova, Rumeysa Karakale, Andrea Malkova, Pavel Kulich, Frantisek Hubatka, Pavlina Turanek-Knotigova, Irena Kratochvilova, Milan Raska, Jan Krejsek & Jaroslav Turanek. (2021) Carbon-Based Nanomaterials Increase Reactivity of Primary Monocytes towards Various Bacteria and Modulate Their Differentiation into Macrophages. Nanomaterials 11:10, pages 2510.
Crossref
Andrea Malkova, Tereza Svadlakova, Avni Singh, Martina Kolackova, Radka Vankova, Pavel Borsky, Drahomira Holmannova, Adam Karas, Lenka Borska & Zdenek Fiala. (2021) In Vitro Assessment of the Genotoxic Potential of Pristine Graphene Platelets. Nanomaterials 11:9, pages 2210.
Crossref
Sarah S. Poulsen, Stefan Bengtson, Andrew Williams, Nicklas R. Jacobsen, Jesper T. Troelsen, Sabina Halappanavar & Ulla Vogel. (2021) A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide. Toxicology and Applied Pharmacology 410, pages 115343.
Crossref
Leila Daneshmandi, Mohammed Barajaa, Armin Tahmasbi Rad, Stefanie A. Sydlik & Cato T. Laurencin. (2020) Graphene‐Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation. Advanced Healthcare Materials 10:1, pages 2001414.
Crossref
Xiaying Han, Houshi Xu, Lingbin Che, Dongyong Sha, Chaojun Huang, Tong Meng & Dianwen Song. (2020) RETRACTED: Application of Inorganic Nanocomposite Hydrogels in Bone Tissue Engineering. iScience 23:12, pages 101845.
Crossref
Baojin Ma, Cristina Martín, Rajendra Kurapati & Alberto Bianco. (2020) Degradation-by-design: how chemical functionalization enhances the biodegradability and safety of 2D materials. Chemical Society Reviews 49:17, pages 6224-6247.
Crossref
Feng Xiaoli, Chen Qiyue, Guo Weihong, Zhang Yaqing, Hu Chen, Wu Junrong & Shao Longquan. (2020) Toxicology data of graphene-family nanomaterials: an update. Archives of Toxicology 94:6, pages 1915-1939.
Crossref
Artur Filipe Rodrigues, Leon Newman, Dhifaf Jasim, Sourav P. Mukherjee, Jun Wang, Isabella A. Vacchi, Cécilia Ménard‐Moyon, Alberto Bianco, Bengt Fadeel, Kostas Kostarelos & Cyrill Bussy. (2020) Size‐Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe‐by‐Design. Advanced Science 7:12, pages 1903200.
Crossref
Evan P. Gray, Cynthia L. Browning, Charles A. Vaslet, Kyle D. Gion, Allen Green, Muchun Liu, Agnes B. Kane & Robert H. Hurt. (2020) Chemical and Colloidal Dynamics of MnO 2 Nanosheets in Biological Media Relevant for Nanosafety Assessment . Small 16:21, pages 2000303.
Crossref
Tereza Svadlakova, Frantisek Hubatka, Pavlina Turanek Knotigova, Pavel Kulich, Josef Masek, Jan Kotoucek, Jan Macak, Martin Motola, Martin Kalbac, Martina Kolackova, Radka Vankova, Petra Vicherkova, Andrea Malkova, Pavlina Simeckova, Yuri Volkov, Adriele Prina-Mello, Irena Kratochvilova, Zdenek Fiala, Milan Raska, Jan Krejsek & Jaroslav Turanek. (2020) Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes. Nanomaterials 10:3, pages 418.
Crossref
Nafiseh Nasirzadeh, Mansur Rezazadeh Azari, Yahya Rasoulzadeh & Yousef Mohammadian. (2019) An assessment of the cytotoxic effects of graphene nanoparticles on the epithelial cells of the human lung. Toxicology and Industrial Health 35:1, pages 79-87.
Crossref
Agnes B. Kane, Robert H. Hurt & Huajian Gao. (2018) The asbestos-carbon nanotube analogy: An update. Toxicology and Applied Pharmacology 361, pages 68-80.
Crossref
Bengt Fadeel, Cyrill Bussy, Sonia Merino, Ester Vázquez, Emmanuel Flahaut, Florence Mouchet, Lauris Evariste, Laury Gauthier, Antti J. Koivisto, Ulla Vogel, Cristina Martín, Lucia G. Delogu, Tina Buerki-Thurnherr, Peter Wick, Didier Beloin-Saint-Pierre, Roland Hischier, Marco Pelin, Fabio Candotto Carniel, Mauro Tretiach, Fabrizia Cesca, Fabio Benfenati, Denis Scaini, Laura Ballerini, Kostas Kostarelos, Maurizio Prato & Alberto Bianco. (2018) Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment. ACS Nano 12:11, pages 10582-10620.
Crossref
Artur Filipe Rodrigues, Leon Newman, Dhifaf A. Jasim, Isabella A. Vacchi, Cécilia Ménard-Moyon, Livia E. Crica, Alberto Bianco, Kostas Kostarelos & Cyrill Bussy. (2018) Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity. Archives of Toxicology 92:11, pages 3359-3379.
Crossref
Barbara Drasler, Melanie Kucki, Flavien Delhaes, Tina Buerki-Thurnherr, Dimitri Vanhecke, Daria Korejwo, Savvina Chortarea, Hana Barosova, Cordula Hirsch, Alke Petri-Fink, Barbara Rothen-Rutishauser & Peter Wick. (2018) Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model. Carbon 137, pages 125-135.
Crossref
Thabitha P. Dasari Shareena, Danielle McShan, Asok K. Dasmahapatra & Paul B. Tchounwou. (2018) A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health. Nano-Micro Letters 10:3.
Crossref
Daniela Guarnieri, Paola Sánchez‐Moreno, Antonio Esaú Del Rio Castillo, Francesco Bonaccorso, Francesca Gatto, Giuseppe Bardi, Cristina Martín, Ester Vázquez, Tiziano Catelani, Stefania Sabella & Pier Paolo Pompa. (2018) Biotransformation and Biological Interaction of Graphene and Graphene Oxide during Simulated Oral Ingestion. Small 14:24.
Crossref
Frank S. Bierkandt, Lars Leibrock, Sandra Wagener, Peter Laux & Andreas Luch. (2018) The impact of nanomaterial characteristics on inhalation toxicity. Toxicology Research 7:3, pages 321-346.
Crossref
Marco Pelin, Silvio Sosa, Maurizio Prato & Aurelia Tubaro. (2018) Occupational exposure to graphene based nanomaterials: risk assessment. Nanoscale 10:34, pages 15894-15903.
Crossref
Xiang Ji, Yahui Song, Jing Han, Lin Ge, Xiaoxiang Zhao, Chen Xu, Yongqiang Wang, Di Wu & Haixia Qiu. (2017) Preparation of a stable aqueous suspension of reduced graphene oxide by a green method for applications in biomaterials. Journal of Colloid and Interface Science 497, pages 317-324.
Crossref
Shih-Ming Tsai, Preeti Bangalore, Eric Y Chen, David Lu, Meng-Hsuen Chiu, Andrew Suh, Matthew Gehring, John P. Cangco, Santiago G. Garcia & Wei-Chun Chin. (2017) Graphene-induced apoptosis in lung epithelial cells through EGFR. Journal of Nanoparticle Research 19:7.
Crossref
Stefan Bengtson, Kristina B. Knudsen, Zdenka O. Kyjovska, Trine Berthing, Vidar Skaug, Marcus Levin, Ismo K. Koponen, Abhay Shivayogimath, Timothy J. Booth, Beatriz Alonso, Amaia Pesquera, Amaia Zurutuza, Birthe L. Thomsen, Jesper T. Troelsen, Nicklas R. Jacobsen & Ulla Vogel. (2017) Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide. PLOS ONE 12:6, pages e0178355.
Crossref
Makoto Ema, Masashi Gamo & Kazumasa Honda. (2017) A review of toxicity studies on graphene-based nanomaterials in laboratory animals. Regulatory Toxicology and Pharmacology 85, pages 7-24.
Crossref
Eun-Jung Park, Sang Jin Lee, Kyuhong Lee, Young Chul Choi, Byoung-Seok Lee, Gwang-Hee Lee & Dong-Wan Kim. (2017) Pulmonary persistence of graphene nanoplatelets may disturb physiological and immunological homeostasis. Journal of Applied Toxicology 37:3, pages 296-309.
Crossref
Jong Kwon Lee, A Young Jeong, Jiyeong Bae, Ji Hyun Seok, Jun-Young Yang, Hang Sik Roh, Jiyoung Jeong, Youngju Han, Jayoung Jeong & Wan-Seob Cho. (2016) The role of surface functionalization on the pulmonary inflammogenicity and translocation into mediastinal lymph nodes of graphene nanoplatelets in rats. Archives of Toxicology 91:2, pages 667-676.
Crossref
Dapeng Li, Tianjiao Liu, Xiaoqing Yu, Di Wu & Zhiqiang Su. (2017) Fabrication of graphene–biomacromolecule hybrid materials for tissue engineering application. Polymer Chemistry 8:30, pages 4309-4321.
Crossref
Xiaowei Wu, Shinn-Jyh Ding, Kaili Lin & Jiansheng Su. (2017) A review on the biocompatibility and potential applications of graphene in inducing cell differentiation and tissue regeneration. Journal of Materials Chemistry B 5:17, pages 3084-3102.
Crossref
Craig A. Poland & Ken Donaldson. 2017. Adverse Effects of Engineered Nanomaterials. Adverse Effects of Engineered Nanomaterials 225 242 .
Lingling Ou, Bin Song, Huimin Liang, Jia Liu, Xiaoli Feng, Bin Deng, Ting Sun & Longquan Shao. (2016) Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms. Particle and Fibre Toxicology 13:1.
Crossref
Todd A. Stueckle, Linda Sargent, Yon Rojanasakul & Liying Wang. 2016. Biomedical Applications and Toxicology of Carbon Nanomaterials. Biomedical Applications and Toxicology of Carbon Nanomaterials 267 332 .
Yingying Zha, Renjie Chai, Qin Song, Lin Chen, Xinxing Wang, Guosheng Cheng, Mingliang Tang & Ming Wang. (2016) Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo. Journal of Nanoparticle Research 18:5.
Crossref
A. P. A. Raju, S. C. Offerman, P. Gorgojo, C. Vallés, E. V. Bichenkova, H. S. Aojula, A. Vijayraghavan, R. J. Young, K. S. Novoselov, I. A. Kinloch & D. J. Clarke. (2016) Dispersal of pristine graphene for biological studies. RSC Advances 6:73, pages 69551-69559.
Crossref
M. Kucki, P. Rupper, C. Sarrieu, M. Melucci, E. Treossi, A. Schwarz, V. Le?n, A. Kraegeloh, E. Flahaut, E. V?zquez, V. Palermo & P. Wick. (2016) Interaction of graphene-related materials with human intestinal cells: an in vitro approach. Nanoscale 8:16, pages 8749-8760.
Crossref
Jenny R. Roberts, Robert R. Mercer, Aleksandr B. Stefaniak, Mohindar S. Seehra, Usha K. Geddam, Ishrat S. Chaudhuri, Angelos Kyrlidis, Vamsi K. Kodali, Tina Sager, Allison Kenyon, Suzan A. Bilgesu, Tracy Eye, James F. Scabilloni, Stephen S. Leonard, Natalie R. Fix, Diane Schwegler-Berry, Breanne Y. Farris, Michael G. Wolfarth, Dale W. Porter, Vincent Castranova & Aaron Erdely. (2016) Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family. Particle and Fibre Toxicology 13:1.
Crossref
Liang Mao, Maojie Hu, Bingcai Pan, Yongchao Xie & Elijah J. Petersen. (2016) Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation. Particle and Fibre Toxicology 13:1.
Crossref
Abhilash Sasidharan, Siddharth Swaroop, Chaitanya K. Koduri, Chundayil Madathil Girish, Parwathy Chandran, L.S. Panchakarla, Vijay H. Somasundaram, Genekehal S. Gowd, Shantikumar Nair & Manzoor Koyakutty. (2015) Comparative in vivo toxicity, organ biodistribution and immune response of pristine, carboxylated and PEGylated few-layer graphene sheets in Swiss albino mice: A three month study. Carbon 95, pages 511-524.
Crossref
Alexandros Askounis, Khellil Sefiane, Vasileios Koutsos & Martin E.R. Shanahan. (2015) Effect of particle geometry on triple line motion of nano-fluid drops and deposit nano-structuring. Advances in Colloid and Interface Science 222, pages 44-57.
Crossref
Michael R. Shurin, Naveena Yanamala, Elena R. Kisin, Alexey V. Tkach, Galina V. Shurin, Ashley R. Murray, Howard D. Leonard, Jeffrey S. Reynolds, Dmirtiy W. Gutkin, Alexander Star, Bengt Fadeel, Kai Savolainen, Valerian E. Kagan & Anna A. Shvedova. (2014) Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma. ACS Nano 8:6, pages 5585-5599.
Crossref
Kostas KostarelosKostya S. Novoselov. (2014) Exploring the Interface of Graphene and Biology. Science 344:6181, pages 261-263.
Crossref
Gui-Fang Shi, Jun-Tao Cao, Jing-Jing Zhang, Ke-Jing Huang, Yan-Ming Liu, Yong-Hong Chen & Shu-Wei Ren. (2014) Aptasensor based on tripetalous cadmium sulfide-graphene electrochemiluminescence for the detection of carcinoembryonic antigen. The Analyst 139:22, pages 5827-5834.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.