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Nanotoxicology Volume 9, 2015 - Issue 2
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Original Article

The buccal mucosa as a route for TiO2 nanoparticle uptake

Birgit Johanna TeublDepartment of Pharmaceutical Technology, Institute of Pharmaceutical Sciences, Karl-Franzens University, Graz, Austria,
,
Gerd LeitingerCenter for Medical Research and ;Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria,
,
Marc SchneiderDepartment of Biopharmaceutics & Pharmaceutical Technology, Saarland University, Saarbrücken, Germany,
,
Claus-Michael LehrDepartment of Biopharmaceutics & Pharmaceutical Technology, Saarland University, Saarbrücken, Germany, ;Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany, and
,
Eleonore FröhlichCenter for Medical Research and
,
Andreas ZimmerDepartment of Pharmaceutical Technology, Institute of Pharmaceutical Sciences, Karl-Franzens University, Graz, Austria,
&
Eva RobleggDepartment of Pharmaceutical Technology, Institute of Pharmaceutical Sciences, Karl-Franzens University, Graz, Austria, ;Research Center Pharmaceutical Engineering, Graz, AustriaCorrespondence[email protected]
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Pages 253-261 | Received 12 Jun 2013, Accepted 25 Apr 2014, Published online: 29 May 2014

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Julien Vignard, Aurelie Pettes-Duler, Eric Gaultier, Christel Cartier, Laurent Weingarten, Antje Biesemeier, Tatjana Taubitz, Philippe Pinton, Cecilia Bebeacua, Laurent Devoille, Jacques Dupuy, Elisa Boutet-Robinet, Nicolas Feltin, Isabelle P. Oswald, Fabrice H. Pierre, Bruno Lamas, Gladys Mirey & Eric Houdeau. (2023) Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium. Nanotoxicology 17:4, pages 289-309.
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Muriel Mercier-Bonin, Bernard Despax, Patrice Raynaud, Eric Houdeau & Muriel Thomas. (2018) Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Critical Reviews in Food Science and Nutrition 58:6, pages 1023-1032.
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Articles from other publishers (38)

Ying Ma, Nairui Yu, Huaye Lu, Jiaqi Shi, Yi Zhang, Zhangjian Chen & Guang Jia. (2023) Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota. Archives of Toxicology 97:8, pages 2051-2067.
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Varsha V. Nair, Pablo Cabrera, Constanza Ramírez-Lecaros, Miguel O. Jara, David J. Brayden & Javier O. Morales. (2023) Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update. International Journal of Pharmaceutics 636, pages 122789.
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Mariela Gisele Domingo, Gabriela Alejandra Nalli, Deborah Ruth Tasat & Daniel Gustavo Olmedo. (2023) Exfoliated oral mucosa cells as bioindicators of short- and long-term systemic titanium contamination. Journal of Trace Elements in Medicine and Biology 76, pages 127114.
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Nimisha Srivastava & Sahifa Aslam. (2022) Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review. Recent Patents on Nanotechnology 16:4, pages 308-325.
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Raphaël Cornu, Arnaud Béduneau & Hélène Martin. (2022) Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny. Archives of Toxicology 96:10, pages 2655-2686.
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Dora Rolo, Ricardo Assunção, Célia Ventura, Paula Alvito, Lídia Gonçalves, Carla Martins, Ana Bettencourt, Peter Jordan, Nádia Vital, Joana Pereira, Fátima Pinto, Paulo Matos, Maria João Silva & Henriqueta Louro. (2022) Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials 12:19, pages 3275.
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Khaled Y. Abdel-Halim, Safaa R. Osman, Mohamed A.F. Abuzeid, Heba T.M. El-Danasoury & Alaa M. Khozimy. (2022) Apoptotic and histopathological defects enhanced by titanium dioxide nanoparticles in male mice after short-term exposure. Toxicology Reports 9, pages 1331-1346.
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Javier O. Morales, Parameswara R. Vuddanda & Sitaram Velaga. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 433 448 .
Cristina Gomez-Casado, Javier Sanchez-Solares, Elena Izquierdo, Araceli Díaz-Perales, Domingo Barber & María M. Escribese. (2021) Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases. Foods 10:5, pages 970.
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Zehao Chen, Zhaodan Wang, Wei Qiu & Fuchun Fang. (2021) Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis. Bioconjugate Chemistry 32:4, pages 627-638.
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Valentina Andretto, Annalisa Rosso, Stéphanie Briançon & Giovanna Lollo. (2021) Nanocomposite systems for precise oral delivery of drugs and biologics. Drug Delivery and Translational Research 11:2, pages 445-470.
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Cinzia Lucia Ursini, Marco Di Basilio, Aureliano Ciervo, Anna Maria Fresegna, Raffaele Maiello, Giuliana Buresti, Antonella Campopiano, Federica Angelosanto, Maddalena Papacchini, Sergio Iavicoli & Delia Cavallo. (2021) Biomonitoring of workers employed in a titanium dioxide production plant: Use of buccal micronucleus cytome assay as noninvasive biomarker to evaluate genotoxic and cytotoxic effects. Environmental and Molecular Mutagenesis 62:4, pages 242-251.
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Rafał Pokrowiecki & Agnieszka Mielczarek. 2021. Nanotoxicology and Nanoecotoxicology Vol. 2. Nanotoxicology and Nanoecotoxicology Vol. 2 181 193 .
Nicolaj S. Bischoff, Theo M. de Kok, Dick T.H.M. Sijm, Simone G. van Breda, Jacco J. Briedé, Jacqueline J.M. Castenmiller, Antoon Opperhuizen, Yolanda I. Chirino, Hubert Dirven, David Gott, Eric Houdeau, Agnes G. Oomen, Morten Poulsen, Gerhard Rogler & Henk van Loveren. (2020) Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System. International Journal of Molecular Sciences 22:1, pages 207.
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Darsheen J. Kotak & Padma V. Devarajan. (2020) Bone targeted delivery of salmon calcitonin hydroxyapatite nanoparticles for sublingual osteoporosis therapy (SLOT). Nanomedicine: Nanotechnology, Biology and Medicine 24, pages 102153.
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Andrea C. Ortiz & Javier O. Morales. 2020. Mucosal Delivery of Drugs and Biologics in Nanoparticles. Mucosal Delivery of Drugs and Biologics in Nanoparticles 107 124 .
Susan Hua. (2019) Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration. Frontiers in Pharmacology 10.
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B. Dréno, A. Alexis, B. Chuberre & M. Marinovich. (2019) Safety of titanium dioxide nanoparticles in cosmetics. Journal of the European Academy of Dermatology and Venereology 33:S7, pages 34-46.
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Shogo Komiyama, Ryosuke Miyasaka, Keiichiro Kikukawa & Roslyn Hayman. (2019) Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models. PLOS ONE 14:4, pages e0215681.
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Ikjot Singh Sohal, Kevin S. O’Fallon, Peter Gaines, Philip Demokritou & Dhimiter Bello. (2018) Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs. Particle and Fibre Toxicology 15:1.
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Pauline Talbot, Joanna M. Radziwill-Bienkowska, Jasper B. J. Kamphuis, Karine Steenkeste, Sarah Bettini, Véronique Robert, Marie-Louise Noordine, Camille Mayeur, Eric Gaultier, Philippe Langella, Catherine Robbe-Masselot, Eric Houdeau, Muriel Thomas & Muriel Mercier-Bonin. (2018) Food-grade TiO2 is trapped by intestinal mucus in vitro but does not impair mucin O-glycosylation and short-chain fatty acid synthesis in vivo: implications for gut barrier protection. Journal of Nanobiotechnology 16:1.
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Nikola Geskovski, Simona Dimchevska Sazdovska, Silvana Gjosheva, Rumenka Petkovska, Mirjana Popovska, Liljana Anastasova, Kristina Mladenovska & Katerina Goracinova. (2018) Rational development of nanomedicines for molecular targeting in periodontal disease. Archives of Oral Biology 93, pages 31-46.
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Martin Reifarth, Ulrich S. Schubert & Stephanie Hoeppener. (2018) Considerations for the Uptake Characteristic of Inorganic Nanoparticles into Mammalian Cells-Insights Gained by TEM Investigations. Advanced Biosystems 2:8, pages 1700254.
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William Dudefoi, Ana Villares, Stéphane Peyron, Céline Moreau, Marie-Hélène Ropers, Nathalie Gontard & Bernard Cathala. (2018) Nanoscience and nanotechnologies for biobased materials, packaging and food applications: New opportunities and concerns. Innovative Food Science & Emerging Technologies 46, pages 107-121.
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Swapnil Talkar, Sagar Dhoble, Anuradha Majumdar & Vandana Patravale. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 37 57 .
Curt Hamann. 2018. Metal Allergy. Metal Allergy 443 466 .
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Javier O Morales & David J Brayden. (2017) Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles. Current Opinion in Pharmacology 36, pages 22-28.
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Marie-Hélène Ropers, Hélène Terrisse, Muriel Mercier-Bonin & Bernard Humbert. 2017. Application of Titanium Dioxide. Application of Titanium Dioxide.
Martina Lorenzetti, Anja Drame, Sašo Šturm & Saša Novak. (2017) TiO 2 (Nano)Particles Extracted from Sugar-Coated Confectionery . Journal of Nanomaterials 2017, pages 1-14.
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Luna Rahman, Dongmei Wu, Michael Johnston, Andrew Williams & Sabina Halappanavar. (2017) Toxicogenomics analysis of mouse lung responses following exposure to titanium dioxide nanomaterials reveal their disease potential at high doses. Mutagenesis 32:1, pages 59-76.
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Simone Schrank, Nicole Jedinger, Shengqian Wu, Michael Piller & Eva Roblegg. (2016) Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. International Journal of Pharmaceutics 509:1-2, pages 219-228.
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Simon W. Fage, Joris Muris, Stig S. Jakobsen & Jacob P. Thyssen. (2016) Titanium: a review on exposure, release, penetration, allergy, epidemiology, and clinical reactivity. Contact Dermatitis 74:6, pages 323-345.
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Steffen Dietzel, Stefanie Hermann, Yan Kugel, Sabine Sellner, Bernd Uhl, Stephanie Hirn, Fritz Krombach & Markus Rehberg. (2016) Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo. Small 12:24, pages 3245-3257.
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Saša Novak, Martina Lorenzetti, Anja Drame, Janja Vidmar, Janez Ščančar & Metka Filipič. (2016) Diversity of TiO2 nanopowders’ characteristics relevant to toxicity testing. Journal of Nanoparticle Research 18:5.
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L.L. Lin, M. Yamada & T.W. Prow. 2016. Nanoscience in Dermatology. Nanoscience in Dermatology 353 366 .
Alexandra K. Perras, Bertram Daum, Christine Ziegler, Lynelle K. Takahashi, Musahid Ahmed, Gerhard Wanner, Andreas Klingl, Gerd Leitinger, Dagmar Kolb-Lenz, Simonetta Gribaldo, Anna Auerbach, Maximilian Mora, Alexander J. Probst, Annett Bellack & Christine Moissl-Eichinger. (2015) S-layers at second glance? Altiarchaeal grappling hooks (hami) resemble archaeal S-layer proteins in structure and sequence. Frontiers in Microbiology 6.
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Sarah Bettini & Eric Houdeau. (2014) Exposition orale aux nanoparticules de dioxyde de titane (TiO 2 ) : du franchissement de l’épithélium buccal et intestinal au devenir et aux effets dans l’organisme . Biologie Aujourd'hui 208:2, pages 167-175.
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