517
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Inhibition of autophagy protects against PAMAM dendrimers-induced hepatotoxicity

, , , , , , & show all
Pages 344-355 | Received 10 Dec 2013, Accepted 18 May 2014, Published online: 01 Jul 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Barbara Ziemba, Maciej Borowiec & Ida Franiak-Pietryga. (2022) There and back again: a dendrimer’s tale. Drug and Chemical Toxicology 45:5, pages 2169-2184.
Read now
Agnieszka Maria Kołodziejczyk, Magdalena Maria Grala, Aleksandra Zimon, Kamila Białkowska, Bogdan Walkowiak & Piotr Komorowski. (2022) Investigation of HUVEC response to exposure to PAMAM dendrimers – changes in cell elasticity and vesicles release. Nanotoxicology 16:3, pages 375-392.
Read now

Articles from other publishers (41)

Dong Qiao, Ting Zhang & Meng Tang. (2023) Autophagy regulation by inorganic, organic, and organic/inorganic hybrid nanoparticles: Organelle damage, regulation factors, and potential pathways. Journal of Biochemical and Molecular Toxicology.
Crossref
Mariia Uzhytchak, Barbora Smolková, Mariia Lunova, Adam Frtús, Milan Jirsa, Alexandr Dejneka & Oleg Lunov. (2023) Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function. Advanced Drug Delivery Reviews 197, pages 114828.
Crossref
Débora A. Moreira, Sofia D. Santos, Victoria Leiro & Ana P. Pêgo. (2023) Dendrimers and Derivatives as Multifunctional Nanotherapeutics for Alzheimer’s Disease. Pharmaceutics 15:4, pages 1054.
Crossref
Kabi Raj Chaudhary, Sima Kujur & Karanvir Singh. (2023) Recent advances of nanotechnology in COVID 19: A critical review and future perspective. OpenNano 9, pages 100118.
Crossref
Jie-Feng Zhao, Fei-Long Zou, Jin-Feng Zhu, Chao Huang, Fan-Qin Bu, Zheng-Ming Zhu & Rong-Fa Yuan. (2022) Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis. Frontiers in Pharmacology 13.
Crossref
André Miguel Martinez Junior, Aline Margarete Furuyama Lima, Grazieli Olinda Martins, Vera Aparecida de Oliveira Tiera, Mohamed Benderdour, Julio Cesar Fernandes & Marcio José Tiera. (2022) Impact of Degree of Ionization and PEGylation on the Stability of Nanoparticles of Chitosan Derivatives at Physiological Conditions. Marine Drugs 20:8, pages 476.
Crossref
Xiang Li, Abid Naeem, Shanghua Xiao, Lei Hu, Jing Zhang & Qin Zheng. (2022) Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine. Pharmaceutics 14:6, pages 1292.
Crossref
Archna Panghal & Swaran Jeet Singh Flora. 2022. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology 323 345 .
Marziyeh Ajdary, Fariborz Keyhanfar, Mohammad Amin Moosavi, Ronak Shabani, Mehdi Mehdizadeh & Rajender S. Varma. (2021) Potential toxicity of nanoparticles on the reproductive system animal models: A review. Journal of Reproductive Immunology 148, pages 103384.
Crossref
Hadeel Kheraldine, Ousama Rachid, Abdella M Habib, Ala-Eddin Al Moustafa, Ibrahim F. Benter & Saghir Akhtar. (2021) Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential. Advanced Drug Delivery Reviews 178, pages 113908.
Crossref
Justyna Swieton, Joanna Miklosz, Shin-Ichi Yusa, Krzysztof Szczubialka, Dariusz Pawlak, Andrzej Mogielnicki & Bartlomiej Kalaska. (2021) Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice. International Journal of Molecular Sciences 22:20, pages 11149.
Crossref
Manman Jing, Yafei Li, Meimei Wang, Hao Zhang, Pengfei Wei, Yang Zhou, Nestor Ishimwe, Xiaowan Huang, Liansheng Wang, Longping Wen, Weiping Wang & Yunjiao Zhang. (2021) Photoresponsive PAMAM‐Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy. Small 17:38, pages 2102295.
Crossref
Imran Tariq, Muhammad Yasir Ali, Muhammad Farhan Sohail, Muhammad Umair Amin, Sajid Ali, Nadeem Irfan Bukhari, Abida Raza, Shashank Reddy Pinnapireddy, Jens Schäfer & Udo Bakowsky. (2020) Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation. Scientific Reports 10:1.
Crossref
Xiaoli Feng, Yaqing Zhang, Chao Zhang, Xuan Lai, Yanli Zhang, Junrong Wu, Chen Hu & Longquan Shao. (2020) Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine. Particle and Fibre Toxicology 17:1.
Crossref
Chen QinShimin WenSiqing ZhuDong LiuSiqi ChenJiqiao QieHao ChenQuankui Lin. (2020) Are Poly(amidoamine) Dendrimers Safe for Ocular Applications? Toxicological Evaluation in Ocular Cells and Tissues. Journal of Ocular Pharmacology and Therapeutics 36:10, pages 715-724.
Crossref
Emmanuel Naveen Raj, Yu‐Wei Lin, Chien‐Hung Chen, Kuang‐Kai Liu & Jui‐I Chao. (2020) Selective Autophagy Pathway of Nanoparticles and Nanodrugs: Drug Delivery and Pathophysiological Effects. Advanced Therapeutics 3:9, pages 2000085.
Crossref
Jun Yao, Huiping Long, Jianping Zhao, Gang Zhong & Jia Li. (2020) Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. Life Sciences 253, pages 117292.
Crossref
Lu Jia, Shuang-Li Hao & Wan-Xi Yang. (2020) Nanoparticles induce autophagy via mTOR pathway inhibition and reactive oxygen species generation. Nanomedicine 15:14, pages 1419-1435.
Crossref
Srinivasa Reddy Bonam, Aparna Areti, Prashanth Komirishetty & Sylviane Muller. 2020. Pharmaceutical Applications of Dendrimers. Pharmaceutical Applications of Dendrimers 233 249 .
Farooq Ahmad, Xiaoyan Wang & Wanwan Li. (2019) Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges. Advanced Functional Materials 29:51.
Crossref
Saghir Akhtar, Bindu Chandrasekhar, Mariam HM Yousif, Waleed Renno, Ibrahim F. Benter & Ahmed Z El-Hashim. (2019) Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction. Nanomedicine: Nanotechnology, Biology and Medicine 18, pages 78-89.
Crossref
Maija Pesonen & Kirsi Vähäkangas. (2019) Autophagy in exposure to environmental chemicals. Toxicology Letters 305, pages 1-9.
Crossref
Yubin Li, Jiajun Fan & Dianwen Ju. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 377 408 .
Fujing Wei & Yixiang Duan. (2018) Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination. Advanced Biosystems 3:1, pages 1800259.
Crossref
Gregory E Holt & Pirouz Daftarian. (2018) Non-small-cell lung cancer homing peptide-labeled dendrimers selectively transfect lung cancer cells. Immunotherapy 10:16, pages 1349-1360.
Crossref
Li LiuJingyun YangKe MenZhiyao HeMin LuoZhiyong QianXiawei WeiYuquan Wei. (2018) Current Status of Nonviral Vectors for Gene Therapy in China. Human Gene Therapy 29:2, pages 110-120.
Crossref
Wenjing Zai, Wei Chen, Jingyun Luan, Jiajun Fan, Xuyao Zhang, Zimei Wu, Tao Ding, Dianwen Ju & Hongrui Liu. (2017) Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy. Applied Microbiology and Biotechnology 102:3, pages 1443-1453.
Crossref
Subrata Ghosh, Anirban Roy, Anup Singhania, Somnath Chatterjee, Snehasikta Swarnakar, Daisuke Fujita & Anirban Bandyopadhyay. (2018) In-vivo & in-vitro toxicity test of molecularly engineered PCMS: A potential drug for wireless remote controlled treatment. Toxicology Reports 5, pages 1044-1052.
Crossref
Yubin Li & Dianwen Ju. 2018. Cellular and Molecular Toxicology of Nanoparticles. Cellular and Molecular Toxicology of Nanoparticles 71 84 .
Moataz Dowaidar, Maxime Gestin, Carmine Pasquale Cerrato, Mohammed Hakim Jafferali, Helerin Margus, Paula Ann Kivistik, Kariem Ezzat, Einar Hallberg, Margus Pooga, Mattias Hällbrink & Ülo Langel. (2017) Role of autophagy in cell-penetrating peptide transfection model. Scientific Reports 7:1.
Crossref
Yao-Xin Lin, Yi Wang & Hao Wang. (2017) Recent Advances in Nanotechnology for Autophagy Detection. Small 13:33, pages 1700996.
Crossref
Shaofei Wang, Yubin Li, Jiajun Fan, Xuyao Zhang, Jingyun Luan, Qi Bian, Tao Ding, Yichen Wang, Ziyu Wang, Ping Song, Daxiang Cui, Xiaobin Mei & Dianwen Ju. (2017) Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation. Cell Death & Disease 8:7, pages e2937-e2937.
Crossref
Yubin Li, Shaofei Wang, Jiajun Fan, Xuesai Zhang, Xiaolu Qian, Xuyao Zhang, Jingyun Luan, Ping Song, Ziyu Wang, Qicheng Chen & Dianwen Ju. (2017) Targeting TNFα Ameliorated Cationic PAMAM Dendrimer-Induced Hepatotoxicity via Regulating NLRP3 Inflammasomes Pathway. ACS Biomaterials Science & Engineering 3:5, pages 843-853.
Crossref
Shasha Zhu, Jiqian Zhang, Li Zhang, Wentao Ma, Na Man, Yiming Liu, Wei Zhou, Jun Lin, Pengfei Wei, Peipei Jin, Yunjiao Zhang, Yi Hu, Erwei Gu, Xianfu Lu, Zhilai Yang, Xuesheng Liu, Li Bai & Longping Wen. (2017) Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle-Induced Liver Injury. Advanced Healthcare Materials 6:9, pages 1601252.
Crossref
Ji-Qian Zhang, Wei Zhou, Sha-Sha Zhu, Jun Lin, Peng-Fei Wei, Fen-Fen Li, Pei-Pei Jin, Han Yao, Yun-Jiao Zhang, Yi Hu, Yi-Ming Liu, Ming Chen, Zheng-Quan Li, Xue-sheng Liu, Li Bai & Long-ping Wen. (2017) Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes. Small 13:7, pages 1602876.
Crossref
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z. El-Hashim, Bindu Chandrasekhar, Sreeja Attur & Ibrahim F. Benter. (2016) Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney. International Journal of Pharmaceutics 514:2, pages 353-363.
Crossref
Saghir Akhtar, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur & Ibrahim F. Benter. (2016) Naked Polyamidoamine Polymers Intrinsically Inhibit Angiotensin II-Mediated EGFR and ErbB2 Transactivation in a Dendrimer Generation- and Surface Chemistry-Dependent Manner. Molecular Pharmaceutics 13:5, pages 1575-1586.
Crossref
Laura Hulea, Zoran Markovic, Ivan Topisirovic, Thomas Simmet & Vladimir Trajkovic. (2016) Biomedical Potential of mTOR Modulation by Nanoparticles. Trends in Biotechnology 34:5, pages 349-353.
Crossref
Yubin Li, Xian Zeng, Shaofei Wang, Jiajun Fan, Ziyu Wang, Ping Song, Xiaobin Mei & Dianwen Ju. (2015) Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase. Tumor Biology 37:5, pages 6627-6635.
Crossref
Z-H Liu, J-L Hu, J-Z Liang, A-J Zhou, M-Z Li, S-M Yan, X Zhang, S Gao, L Chen, Q Zhong & M-S Zeng. (2015) Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression. Cell Death & Disease 6:10, pages e1920-e1920.
Crossref
Maomao Yu, Xu Jie, Lu Xu, Cong Chen, Wanli Shen, Yini Cao, Guan Lian & Rong Qi. (2015) Recent Advances in Dendrimer Research for Cardiovascular Diseases. Biomacromolecules 16:9, pages 2588-2598.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.