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Editorial and case reports

Denosumab and atypical femoral fractures

Page 1 | Received 03 May 2013, Accepted 02 Sep 2013, Published online: 31 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Emanuela Dell’Aquila, Grazia Armento, Michele Iuliani, Sonia Simonetti, Loretta D’Onofrio, Tea Zeppola, Cristina Madaudo, Marco Russano, Fabrizio Citarella, Giulia Ribelli, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini & Daniele Santini. (2020) Denosumab for cancer-related bone loss. Expert Opinion on Biological Therapy 20:11, pages 1261-1274.
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A. Ludwig Meiss, Florian Barvencik, Kornelia Babin & Gerald Eggers-Stroeder. (2017) Denosumab and surgery for the treatment of Perthes’ disease in a 9-year-old boy: favorable course documented by comprehensive imaging— a case report. Acta Orthopaedica 88:3, pages 354-357.
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Zeina A. Habib. (2017) Bisphosphonates in the treatment of osteoporosis: a review of skeletal safety concerns. Expert Review of Endocrinology & Metabolism 12:1, pages 59-71.
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Sunil J. Wimalawansa. (2016) Optimum duration and safety of long-term use of potent anti-resorptive medications in osteoporosis. Expert Review of Endocrinology & Metabolism 11:4, pages 329-348.
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Maurizio Rossini, Giovanni Adami, Silvano Adami, Ombretta Viapiana & Davide Gatti. (2016) Safety issues and adverse reactions with osteoporosis management. Expert Opinion on Drug Safety 15:3, pages 321-332.
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David A. Hart. (2023) Are secondary effects of bisphosphonates on the vascular system of bone contributing to increased risk for atypical femoral fractures in osteoporosis?. BioEssays 45:4.
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Yuhan Xia, Kazuki Inoue, Yong Du, Stacey J. Baker, E. Premkumar Reddy, Matthew B. Greenblatt & Baohong Zhao. (2022) TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis. Nature Communications 13:1.
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Lanny V. Griffin, Elizabeth Warner, Saroj Palnitkar, Shijing Qiu, Mahalakshmi Honasoge, Shawna G. Griffin, George Divine & Sudhaker D. Rao. (2021) Bone Nanomechanical Properties and Relationship to Bone Turnover and Architecture in Patients With Atypical Femur Fractures: A Prospective Nested Case‐Control Study. JBMR Plus 5:9.
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Sayed Hashim AlQarooniUgo RuggieroSri Priya Suresh. (2021) Atypical fractures secondary to bisphosphonate therapy: A case series and pictorial review. Indian Journal of Musculoskeletal Radiology 3, pages 45-53.
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Javier Martínez-Reina, José L. Calvo-Gallego & Peter Pivonka. (2021) Combined Effects of Exercise and Denosumab Treatment on Local Failure in Post-menopausal Osteoporosis–Insights from Bone Remodelling Simulations Accounting for Mineralisation and Damage. Frontiers in Bioengineering and Biotechnology 9.
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N.H. Rasmussen, J. Dal, F. de Vries, J.P. van den Bergh, M.H. Jensen & P. Vestergaard. (2019) Diabetes and fractures: new evidence of atypical femoral fractures?. Osteoporosis International 31:3, pages 447-455.
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J. Brett Goodloe, Sarah Toner, Alyssa Althoff, Leah Herzog, Stacey Rothwell & Kristoff Reid. (2020) Bilateral Atypical Femur Fractures Complicated by Carbon Fiber Cephalomedullary Nail Fracture. JBJS Case Connector 10:3, pages e20.00182-e20.00182.
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E. Michael Lewiecki. 2020. Osteoporosis. Osteoporosis 309 322 .
E. Michael Lewiecki. (2018) New and emerging concepts in the use of denosumab for the treatment of osteoporosis. Therapeutic Advances in Musculoskeletal Disease 10:11, pages 209-223.
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Tsutomu SugiharaMitsuru KoizumiKeiko HayakawaYoshinori ItoNaohiro Sata. (2018) Impending Atypical Femoral Fracture in a Patient of Breast Cancer With Bone Metastases Receiving Long-term Denosumab. Clinical Nuclear Medicine 43:5, pages 365-366.
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Joseph L. Shaker. (2017) Stress and Insufficiency Fractures. Clinical Reviews in Bone and Mineral Metabolism 16:1, pages 3-15.
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Kenneth Pittman, Yoland C Antill, Amanda Goldrick, Jeffrey Goh & Richard H de Boer. (2017) Denosumab: Prevention and management of hypocalcemia, osteonecrosis of the jaw and atypical fractures. Asia-Pacific Journal of Clinical Oncology 13:4, pages 266-276.
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F. Vescini, R. Attanasio, A. Balestrieri, F. Bandeira, S. Bonadonna, V. Camozzi, S. Cassibba, R. Cesareo, I. Chiodini, C. Maria Francucci, L. Gianotti, F. Grimaldi, R. Guglielmi, B. Madeo, C. Marcocci, A. Palermo, A. Scillitani, E. Vignali, V. Rochira & M. Zini. (2016) Italian association of clinical endocrinologists (AME) position statement: drug therapy of osteoporosis. Journal of Endocrinological Investigation 39:7, pages 807-834.
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J. Selga, J. H. Nuñez, J. Minguell, M. Lalanza & M. Garrido. (2015) Simultaneous bilateral atypical femoral fracture in a patient receiving denosumab: case report and literature review. Osteoporosis International 27:2, pages 827-832.
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Muneaki Ishijima, Yoshitomo Saita, Haruka Kaneko, Mayuko Kinoshita & Kazuo Kaneko. 2016. Osteoporosis in Orthopedics. Osteoporosis in Orthopedics 103 134 .
D. T. Cawley, H. L. Barrett & P. Harrington. (2015) Obliteration of the medullary canal in an atypical bisphosphonate-related femoral fracture. Case Reports 2015:jan07 1, pages bcr2014205439-bcr2014205439.
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Per Aspenberg & Jörg Schilcher. (2014) Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress. Current Osteoporosis Reports 12:2, pages 189-193.
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