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Editorial and case reports

Atypical fracture of the femur in a patient using denosumab – a case report

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Maria V. Deligiorgi & Dimitrios T. Trafalis. (2021) The safety profile of denosumab in oncology beyond the safety of denosumab as an anti-osteoporotic agent: still more to learn. Expert Opinion on Drug Safety 20:2, pages 191-213.
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Emanuela Dell’Aquila, Grazia Armento, Michele Iuliani, Sonia Simonetti, Loretta D’Onofrio, Tea Zeppola, Cristina Madaudo, Marco Russano, Fabrizio Citarella, Giulia Ribelli, Francesco Pantano, Bruno Vincenzi, Giuseppe Tonini & Daniele Santini. (2020) Denosumab for cancer-related bone loss. Expert Opinion on Biological Therapy 20:11, pages 1261-1274.
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Maria V. Deligiorgi & Dimitrios T. Trafalis. (2020) Repurposing denosumab in lung cancer beyond counteracting the skeletal related events: an intriguing perspective. Expert Opinion on Biological Therapy 20:11, pages 1331-1346.
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A. Ludwig Meiss, Florian Barvencik, Kornelia Babin & Gerald Eggers-Stroeder. (2017) Denosumab and surgery for the treatment of Perthes’ disease in a 9-year-old boy: favorable course documented by comprehensive imaging— a case report. Acta Orthopaedica 88:3, pages 354-357.
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Daniel C Austin, Michael T Torchia, Christian M Klare & Robert V Cantu. (2017) Atypical femoral fractures mimicking metastatic lesions in 2 patients taking denosumab. Acta Orthopaedica 88:3, pages 351-353.
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Laura López-Delgado, Leyre Riancho-Zarrabeitia & José A. Riancho. (2016) Genetic and acquired factors influencing the effectiveness and toxicity of drug therapy in osteoporosis. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 389-398.
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. (2014) Addendum in print. Acta Orthopaedica 85:1, pages 2-2.
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Articles from other publishers (47)

Yao Xiao, Yiqian Chen, Yan Huang & Yuan Xiao. (2023) Atypical femur fracture associated with common anti-osteoporosis drugs in FDA adverse event reporting system. Scientific Reports 13:1.
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Takumi Kaku, Yoto Oh, Shingo Sato, Hirotaka Koyanagi, Yuki Funauchi, Takashi Hirai, Masato Yuasa, Yu Matsukura, Toshitaka Yoshii, Tsuyoshi Nakagawa, Satoshi Miyake & Atsushi Okawa. (2023) Prevalence of Precursory Signs of Atypical Femoral Fractures in Patients Receiving Bone‐Modifying Agents for Bone Metastases: A Cross‐Sectional Study. JBMR Plus 7:7.
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Willem H. Schreuder, Astrid Lipplaa, Arjen H.G. Cleven, Henk van den Berg, Peter H. Bisschop, Renate T. de Jongh, Max J.H. Witjes, Peter A.W.H. Kessler, Matthias A.W. Merkx, Esther Edelenbos, Cornelis Klop, Ruud Schreurs, Anneke M. Westermann, Jacqueline M. Tromp, Henriette Levenga, Hans Gelderblom & Jan de Lange. (2022) RANKL inhibition for giant cell lesions of the jaw: A retrospective cohort analysis. European Journal of Cancer 175, pages 263-273.
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Judith Everts‐Graber, Harald Bonel, Daniel Lehmann, Brigitta Gahl, HansJörg Häuselmann, Ueli Studer, Hans‐Rudolf Ziswiler, Stephan Reichenbach & Thomas Lehmann. (2022) Incidence of Atypical Femoral Fractures in Patients on Osteoporosis Therapy—A Registry‐Based Cohort Study. JBMR Plus 6:10.
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Yuta Tsukagoshi & Yuki Matsushita. (2022) Bone regeneration: A message from clinical medicine and basic science. Clinical Anatomy 35:6, pages 808-819.
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A. Strobbe, D. Slock & B. Maeyaert. (2022) Atypische femurfracturen: overzicht van de epidemiologie en de behandeling aan de hand van een casus. Tijdschrift voor Geneeskunde.
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A. Strobbe, D. Slock & B. Maeyaert. (2022) Atypische femurfracturen: overzicht van de epidemiologie en de behandeling aan de hand van een casus. Tijdschrift voor Geneeskunde.
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Jeremy Keng Meng Goh, Joyce Suang Bee Koh, Alvin Choong Meng Ng, Meng Ai Png & Tet Sen Howe. (2022) Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report. Calcified Tissue International 111:1, pages 96-101.
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Dennis M. Black, Katherine Condra, Annette L. Adams & Richard Eastell. (2022) Bisphosphonates and the risk of atypical femur fractures. Bone 156, pages 116297.
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Shinya Toriumi, Akinobu Kobayashi, Hitoshi Sueki, Munehiro Yamamoto & Yoshihiro Uesawa. (2021) Exploring the Mechanisms Underlying Drug-Induced Fractures Using the Japanese Adverse Drug Event Reporting Database. Pharmaceuticals 14:12, pages 1299.
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H. E. Skibicki, D. Y. Ponzio, J. A. Brustein, Z. D. Post, A. C. Ong & F. R. Orozco. (2021) A cautionary case: osteoporotic femur fracture after robotic-assisted total knee arthroplasty. Osteoporosis International 32:10, pages 2125-2129.
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Lanny V. Griffin, Elizabeth Warner, Saroj Palnitkar, Shijing Qiu, Mahalakshmi Honasoge, Shawna G. Griffin, George Divine & Sudhaker D. Rao. (2021) Bone Nanomechanical Properties and Relationship to Bone Turnover and Architecture in Patients With Atypical Femur Fractures: A Prospective Nested Case‐Control Study. JBMR Plus 5:9.
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Yusuke Fuchioka, Kohji Suzuki, Hiroaki Kimura, Hideto Furuoka & Yuri Tamura. (2021) Two cases of atypical femoral fracture in cancer patients administered with bone-modifying agents. Journal of Rural Medicine 16:3, pages 170-173.
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Michael R. McClung. 2021. Marcus and Feldman's Osteoporosis. Marcus and Feldman's Osteoporosis 1737 1755 .
H. I. Piponov, J. M. Goldstein & G. M. Eisenberg. (2020) Multiple ipsilateral femoral stress fractures in a patient taking denosumab for osteoporosis—a case report. Osteoporosis International 31:11, pages 2263-2267.
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Merav Bar, Susan M. Ott, E. Michael Lewiecki, Kyriakie Sarafoglou, Joy Y. Wu, Matthew J. Thompson, Jonathan J. Vaux, David R. Dean, Kenneth G. Saag, Shahrukh K. Hashmi, Yoshihiro Inamoto, Bhagirathbhai R. Dholaria, Mohamed A. Kharfan-Dabaja, Arnon Nagler, Cesar Rodriguez, Betty K. Hamilton, Nina Shah, Mary E.D. Flowers, Bipin N. Savani & Paul A. Carpenter. (2020) Bone Health Management After Hematopoietic Cell Transplantation: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy. Biology of Blood and Marrow Transplantation 26:10, pages 1784-1802.
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Takumi Kaku, Yoto Oh, Shingo Sato, Hirotaka Koyanagi, Takashi Hirai, Masato Yuasa, Toshitaka Yoshii, Tsuyoshi Nakagawa, Satoshi Miyake & Atsushi Okawa. (2020) Incidence of atypical femoral fractures in the treatment of bone metastasis: An alert report. Journal of Bone Oncology 23, pages 100301.
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Denise M van de Laarschot, Malachi J McKenna, Bo Abrahamsen, Bente Langdahl, Martine Cohen-Solal, Núria Guañabens, Richard Eastell, Stuart H Ralston & M Carola Zillikens. (2020) Medical Management of Patients After Atypical Femur Fractures: a Systematic Review and Recommendations From the European Calcified Tissue Society. The Journal of Clinical Endocrinology & Metabolism 105:5, pages 1682-1699.
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J. Brett Goodloe, Sarah Toner, Alyssa Althoff, Leah Herzog, Stacey Rothwell & Kristoff Reid. (2020) Bilateral Atypical Femur Fractures Complicated by Carbon Fiber Cephalomedullary Nail Fracture. JBJS Case Connector 10:3, pages e20.00182-e20.00182.
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E. Michael Lewiecki. 2020. Osteoporosis. Osteoporosis 309 322 .
Momoko Takahashi, Yukinori Ozaki, Rika Kizawa, Jun Masuda, Kentaro Sakamaki, Keiichi Kinowaki, Taro Umezu, Chihiro Kondoh, Yuko Tanabe, Nobuko Tamura, Yuji Miura, Takashi Shigekawa, Hidetaka Kawabata, Noriyuki Baba, Haruo Iguchi & Toshimi Takano. (2019) Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review. BMC Cancer 19:1.
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Juan Tan, Hiroshige Sano & Kenneth Poole. (2019) Antiresorptive-associated spontaneous fractures of both tibiae, followed by an atypical femur fracture during the sequential treatment with alendronate, denosumab then teriparatide. BMJ Case Reports 12:7, pages e229366.
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E. Michael Lewiecki. (2018) New and emerging concepts in the use of denosumab for the treatment of osteoporosis. Therapeutic Advances in Musculoskeletal Disease 10:11, pages 209-223.
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Aline Granja Costa, E. Michael Lewiecki & John P. Bilezikian. 2018. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 553 558 .
Manish G. Agarwal, Manit K. Gundavda, Rajat Gupta & Rajeev Reddy. (2018) Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience. Clinical Orthopaedics & Related Research 476:9, pages 1773-1782.
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Yuval Zur, Lior Rosenfeld, Chen Anna Keshelman, Nofar Dalal, Gali Guterman-Ram, Ayelet Orenbuch, Yulia Einav, Noam Levaot & Niv Papo. (2018) A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy. PLOS Biology 16:8, pages e2002979.
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Tsutomu SugiharaMitsuru KoizumiKeiko HayakawaYoshinori ItoNaohiro Sata. (2018) Impending Atypical Femoral Fracture in a Patient of Breast Cancer With Bone Metastases Receiving Long-term Denosumab. Clinical Nuclear Medicine 43:5, pages 365-366.
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Mohammad Al-Ashqar, Michalis Panteli, Gautam Chakrabarty & Peter V. Giannoudis. (2018) Atypical fractures: An issue of concern or a myth?. Injury 49:3, pages 649-655.
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Kenneth Pittman, Yoland C Antill, Amanda Goldrick, Jeffrey Goh & Richard H de Boer. (2017) Denosumab: Prevention and management of hypocalcemia, osteonecrosis of the jaw and atypical fractures. Asia-Pacific Journal of Clinical Oncology 13:4, pages 266-276.
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David A. Hanley, Michael R. McClung, K. Shawn Davison, Larry Dian, Steve T. Harris, Paul D. Miller, E. Michael Lewiecki & David L. Kendler. (2017) Western Osteoporosis Alliance Clinical Practice Series: Evaluating the Balance of Benefits and Risks of Long-Term Osteoporosis Therapies. The American Journal of Medicine 130:7, pages 862.e1-862.e7.
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Samantha Peiling Yang, Tae Won B. Kim, Patrick J. Boland & Azeez Farooki. (2017) Retrospective Review of Atypical Femoral Fracture in Metastatic Bone Disease Patients Receiving Denosumab Therapy. The Oncologist 22:4, pages 438-444.
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Ammar Ismail, Amira Hassan Bekhet, Abdelrahman Ibrahim Abushouk, Sahar Mirbaha & Alireza Baratloo. (2017) Denosumab and Atypical Femoral Fractures: A Scoping Literature Review. Trauma Monthly 23:1.
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A.R.B. Silva & V.L. Szejnfeld. (2017) FRATURA DIAFISÁRIA DE FÊMUR APÓS TROCA DE RISEDRONATO PARA DENOSUMABE: FRATURA ATÍPICA POR DENOSUMABE OU EFEITO RESIDUAL DO BISFOSFONATO?. Revista Brasileira de Reumatologia 57, pages S74.
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Giuseppe Toro, Cristina Ojeda-Thies, Giampiero Calabrò, Gabriella Toro, Antimo Moretti, Guillermo Martínez-Díaz Guerra, Pedro Caba-Doussoux & Giovanni Iolascon. (2016) Management of atypical femoral fracture: a scoping review and comprehensive algorithm. BMC Musculoskeletal Disorders 17:1.
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J. Selga, J. H. Nuñez, J. Minguell, M. Lalanza & M. Garrido. (2015) Simultaneous bilateral atypical femoral fracture in a patient receiving denosumab: case report and literature review. Osteoporosis International 27:2, pages 827-832.
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