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Acta Orthopaedica Scandinavica Volume 49, 1978 - Issue 6
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Original Article

The Penetration of Cefazolin, Erythromycin and Methicillin into Human Bone Tissue

T. Sandberg Sørensen Department of Orthopaedic Surgery, Rigshospitalet; Institute of Medical Microbiology, Department of Clinical Microbiology, University of Copenhagen, Denmark
,
H. Colding Department of Orthopaedic Surgery, Rigshospitalet; Institute of Medical Microbiology, Department of Clinical Microbiology, University of Copenhagen, Denmark
,
E. Schroeder Department of Orthopaedic Surgery, Rigshospitalet; Institute of Medical Microbiology, Department of Clinical Microbiology, University of Copenhagen, Denmark
&
V. Thamdrup Rosdahl Department of Orthopaedic Surgery, Rigshospitalet; Institute of Medical Microbiology, Department of Clinical Microbiology, University of Copenhagen, Denmark
Pages 549-553 | Accepted 21 May 1978, Published online: 08 Jul 2009

Citations (16)

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Fay R K Sanders, J Carel Goslings, Ron A A Mathôt & Tim Schepers. (2019) Target site antibiotic concentrations in orthopedic/trauma extremity surgery: is prophylactic cefazolin adequately dosed? A systematic review and meta-analysis. Acta Orthopaedica 90:2, pages 97-104.
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Articles from other publishers (15)

Abhijit M Bal. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 170 184 .
Martin Andreas, Markus Zeitlinger, Wilfried Wisser, Walter Jaeger, Alexandra Maier-Salamon, Florian Thalhammer, Alfred Kocher, Joerg-Michael Hiesmayr, Guenther Laufer & Doris Hutschala. (2015) Cefazolin and linezolid penetration into sternal cancellous bone during coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery 48:5, pages 758-764.
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Koji Yamada, Kunihiro Matsumoto, Fumiaki Tokimura, Hiroshi Okazaki & Sakae Tanaka. (2011) Are Bone and Serum Cefazolin Concentrations Adequate for Antimicrobial Prophylaxis?. Clinical Orthopaedics and Related Research® 469:12, pages 3486-3494.
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Baek-Nam Kim. (2011) Oral Agents for the Treatment of Orthopedic Infections Caused by Methicillin-resistant Staphylococci. Infection & Chemotherapy 43:4, pages 322.
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Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe & Fritz Sörgel. (2009) Penetration of Antibacterials into Bone. Clinical Pharmacokinetics 48:2, pages 89-124.
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Michael R. Baumgaertner & Matthew E. Oetgen. 2009. Skeletal Trauma. Skeletal Trauma 1913 1956 .
Bilal Al-Nawas, Marion Kinzig-Schippers, Fritz Soergel & Pramod M. Shah. (2008) Concentrations of piperacillin–tazobactam in human jaw and hip bone. Journal of Cranio-Maxillofacial Surgery 36:8, pages 468-472.
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Larry J. Peterson. (1994) Discussion. Journal of Oral and Maxillofacial Surgery 52:4, pages 400-401.
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G BenoniL CuzzolinR LeoneU ConsoloG FerronatoC BertrandV PuchettiM E Fracasso. (1988) Pharmacokinetics and human tissue penetration of flurithromycin. Antimicrobial Agents and Chemotherapy 32:12, pages 1875-1878.
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A L GrazianiL A LawsonG A GibsonM A SteinbergR R MacGregor. (1988) Vancomycin concentrations in infected and noninfected human bone. Antimicrobial Agents and Chemotherapy 32:9, pages 1320-1322.
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R.H. FitzgeraldJr.Jr.. (1984) Antibiotic Distribution in Normal and Osteomyelitic Bone. Orthopedic Clinics of North America 15:3, pages 537-546.
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Robert H. FitzgeraldJr.Jr.. (1983) Moxalactam penetration of normal and osteomyelitic bon. Archives of orthopaedic and traumatic surgery 101:4, pages 273-281.
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Bruce R Smith, Kenneth V Rolston, Jack L LeFrock & Charles Bayliff. (1983) Bone Penetration of Antibiotics. Orthopedics 6:2, pages 187-193.
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R C Daly, R H FitzgeraldJrJr & J A Washington2nd2nd. (1982) Penetration of cefazolin into normal and osteomyelitic canine cortical bone. Antimicrobial Agents and Chemotherapy 22:3, pages 461-469.
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Richard Quintiliani, Margaret French & Charles H. Nightingale. (1982) First and Second Generation Cephalosporins. Medical Clinics of North America 66:1, pages 183-197.
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