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Original Article

Mechanical load and primary guinea pig osteoarthrosis

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Pages 351-357 | Received 15 Oct 1997, Accepted 11 Mar 1998, Published online: 08 Jul 2009

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JS Thomsen, TS Straarup, CC Danielsen, H Oxlund & A Brüel. (2011) Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis. Scandinavian Journal of Rheumatology 40:5, pages 391-399.
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Tamás Oláh, Jana Christin Michaelis, Xiaoyu Cai, Magali Cucchiarini & Henning Madry. (2021) Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals. Annals of Anatomy - Anatomischer Anzeiger 234, pages 151630.
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I.J. Wallace, A.M. Bendele, G. Riew, E.H. Frank, H.-H. Hung, N.B. Holowka, A.S. Bolze, E.M. Venable, A.K. Yegian, H.L. Dingwall, R.N. Carmody, A.J. Grodzinsky & D.E. Lieberman. (2019) Physical inactivity and knee osteoarthritis in guinea pigs. Osteoarthritis and Cartilage 27:11, pages 1721-1728.
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David Britzman, Ibidumo Igah, Theofano Eftaxiopoulou, Warren Macdonald & Anthony M. J. Bull. (2018) Tibial Osteotomy as a Mechanical Model of Primary Osteoarthritis in Rats. Scientific Reports 8:1.
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Naga Padmini Karamchedu, Josef N. Tofte, Kimberly A. Waller, Ling X. Zhang, Tarpit K. Patel & Gregory D. Jay. (2016) Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis. Arthritis Research & Therapy 18:1.
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Nathan P. Thomas, Pengcui Li, Braden C. Fleming, Qian Chen, Xiaochun Wei, Pan Xiao-Hua, Gang Li & Lei Wei. (2015) Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100. Journal of Orthopaedic Research 33:7, pages 1071-1078.
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Nirah H. Shomer, Hilda Holcombe & John E. Harkness. 2015. Laboratory Animal Medicine. Laboratory Animal Medicine 247 283 .
J.-y. Yan, F.-m. Tian, W.-Y. Wang, Y. Cheng, H.-P. Song, Y.-Z. Zhang & L. Zhang. (2014) Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis. Osteoarthritis and Cartilage 22:11, pages 1869-1877.
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Jin-Yin Yan, Fa-Ming Tian, Wen-Ya Wang, Ying Cheng, Hua-Fang Xu, Hui-Ping Song, Ying-Ze Zhang & Liu Zhang. (2014) Age Dependent Changes in Cartilage Matrix, Subchondral Bone Mass, and Estradiol Levels in Blood Serum, in Naturally Occurring Osteoarthritis in Guinea Pigs. International Journal of Molecular Sciences 15:8, pages 13578-13595.
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Jingming Zhou, Qian Chen, Beate Lanske, Braden C Fleming, Richard Terek, Xiaochun Wei, Ge Zhang, Shaowei Wang, Kai Li & Lei Wei. (2014) Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Research & Therapy 16:1, pages R11.
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F. Wei, J. Zhou, X. Wei, J. Zhang, B.C. Fleming, R. Terek, M. Pei, Q. Chen, T. Liu & L. Wei. (2012) Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage. Osteoarthritis and Cartilage 20:7, pages 755-763.
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Takaaki Shirai, Masahiko Kobayashi, Shinichiro Nakamura, Ryuzo Arai, Kohei Nishitani, Tsuyoshi Satake, Leif E. Dahlberg, Hiroshi Kuroki, Yasuaki Nakagawa, Tomohisa Okada, Kaori Togashi & Takashi Nakamura. (2012) Longitudinal evaluation of cartilage after osteochondral autogenous transfer with delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC). Journal of Orthopaedic Research 30:2, pages 221-225.
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Susanne X. Wang, Larry Arsenault & Ernst B. Hunziker. (2011) Stereologic Analysis of Tibial-Plateau Cartilage and Femoral Cancellous Bone in Guinea Pigs With Spontaneous Osteoarthritis. Clinical Orthopaedics and Related Research® 469:10, pages 2796-2805.
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V.B. Kraus, J.L. Huebner, J. DeGroot & A. Bendele. (2010) The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthritis and Cartilage 18, pages S35-S52.
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Lei Wei, Braden C. Fleming, Xiaojuan Sun, Erin Teeple, Wesley Wu, Gregory D. Jay, Khaled A. Elsaid, Junming Luo, Jason T. Machan & Qian Chen. (2010) Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model. Journal of Orthopaedic Research 28:7, pages 900-906.
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Jonathan Bowyer, Chris G. Heapy, Joanne K. Flannelly, John C. Waterton & Rose A. Maciewicz. (2009) Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig. International Journal of Experimental Pathology 90:2, pages 174-181.
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Helen L. Quasnichka, Janet M. Anderson-MacKenzie, John F. Tarlton, Trevor J. Sims, Michael E. J. Billingham & Allen J. Bailey. (2005) Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis. Arthritis & Rheumatism 52:10, pages 3100-3109.
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Janet M. Anderson-MacKenzie, Helen L. Quasnichka, Roger L. Starr, E. Jonathan Lewis, Michael E.J. Billingham & Allen J. Bailey. (2005) Fundamental subchondral bone changes in spontaneous knee osteoarthritis. The International Journal of Biochemistry & Cell Biology 37:1, pages 224-236.
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H. Anetzberger, E. Thein, G. Löffler & K. Messmer. (2004) Fluorescent microsphere method is suitable for chronic bone blood flow measurement: a long-term study after meniscectomy in rabbits. Journal of Applied Physiology 96:5, pages 1928-1936.
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J.J Tessier, J Bowyer, N.J Brownrigg, I.S Peers, F.R Westwood, J.C Waterton & R.A Maciewicz. (2003) Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging. Osteoarthritis and Cartilage 11:12, pages 845-853.
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U. HORAS, D. PELINKOVIC, G. HERR, T. AIGNER & R. SCHNETTLER. (2003) AUTOLOGOUS CHONDROCYTE IMPLANTATION AND OSTEOCHONDRAL CYLINDER TRANSPLANTATION IN CARTILAGE REPAIR OF THE KNEE JOINT. The Journal of Bone and Joint Surgery-American Volume 85:2, pages 185-192.
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L. Cai, F.W. Okumu, J.L. Cleland, M. Beresini, D. Hogue, Z. Lin & E.H. Filvaroff. (2002) A slow release formulation of insulin as a treatment for osteoarthritis. Osteoarthritis and Cartilage 10:9, pages 692-706.
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John E. Harkness, Kathleen A. Murray & Joseph E. Wagner. 2002. Laboratory Animal Medicine. Laboratory Animal Medicine 203 246 .
L. Wei, A. Hjerpe, B.H. Brismar & O. Svensson. (2001) Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis. Osteoarthritis and Cartilage 9:5, pages 447-453.
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R.D Kapadia, A.M Badger, J.M Levin, B Swift, A Bhattacharyya, R.A Dodds, R.W Coatney & M.W Lark. (2000) Meniscal ossification in spontaneous osteoarthritis in the guinea-pig. Osteoarthritis and Cartilage 8:5, pages 374-377.
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