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Amyotrophic Lateral Sclerosis Volume 10, 2009 - Issue 5-6
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Original Article

Erythropoietin in amyotrophic lateral sclerosis: A pilot, randomized, double-blind, placebo-controlled study of safety and tolerability

Giuseppe Lauria Neuromuscular Diseases UnitCorrespondence[email protected]
,
Angela Campanella Neuromuscular Diseases Unit
,
Graziella Filippini Epidemiology Unit
,
Alfredo Martini Research and Development Unit
,
Paola Penza Neuromuscular Diseases Unit
,
Lorenzo Maggi Neuromuscular Diseases Unit
,
Carlo Antozzi Neuromuscular Diseases Unit
,
Claudia Ciano Neurophysiology Unit
,
Pinuccia Beretta Anaesthesiology and Intensive Care Unit, IRCCS Foundation, National Neurological Institute ‘Carlo Besta’, Milan
,
Dario Caldiroli Anaesthesiology and Intensive Care Unit, IRCCS Foundation, National Neurological Institute ‘Carlo Besta’, Milan
,
Filippo Ghelma General Surgery Unit, S. Paolo Hospital, Milan
,
Giovanni Ferrara Department of Biochemistry and Molecular Pharmacology ‘Mario Negri’ Institute for Pharmacological Research, Milan, Italy
,
Pietro Ghezzi Department of Biochemistry and Molecular Pharmacology ‘Mario Negri’ Institute for Pharmacological Research, Milan, Italy
&
Renato Mantegazza Neuromuscular Diseases Unit
 show all
Pages 410-415 | Received 02 Jan 2009, Published online: 18 Nov 2009

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Abigail DeLoach, Michael Cozart, Arianna Kiaei & Mahmoud Kiaei. (2015) A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies. Expert Opinion on Drug Discovery 10:10, pages 1099-1118.
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Kazumoto Shibuya, Sonoko Misawa, Hideki Kimura, Yu-Ichi Noto, Yasunori Sato, Yukari Sekiguchi, Yuta Iwai, Satsuki Mitsuma, Minako Beppu, Keisuke Watanabe, Yumi Fujimaki, Yukiko Tsuji, Toshio Shimizu, Toshiki Mizuno, Masanori Nakagawa, Kyoko Sawaguchi, Hideki Hanaoka & Satoshi Kuwabara. (2015) A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16:5-6, pages 353-358.
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Rita Carilho, Mamede de Carvalho, Ute Kuehl, Susana Pinto, Anabela Pinto, Arno Kromminga & Júlia Costa. (2011) Erythropoietin and amyotrophic lateral sclerosis: Plasma level determination. Amyotrophic Lateral Sclerosis 12:6, pages 439-443.
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Zeynep YILDIRIM, Dicle Naz TOKTAŞ, Öznur DEMİR, Zülfiye GÜL & Burcu ŞEN UTSUKARÇİ. (2023) Amyotrofik Lateral Skleroz Patofizyolojisi ve Tedavi YaklaşımlarıAn Evaluation of Amyotrophic Lateral Sclerosis and Current Situation in Its Treatment. Hacettepe University Journal of the Faculty of Pharmacy.
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Salman Hemani, Olabisi Lane, Sunil Agarwal, Shan Ping Yu & Anna Woodbury. (2021) Systematic Review of Erythropoietin (EPO) for Neuroprotection in Human Studies. Neurochemical Research 46:4, pages 732-739.
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Tereza Filipi, Zuzana Hermanova, Jana Tureckova, Ondrej Vanatko & Miroslava Anderova. (2020) Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment. Journal of Clinical Medicine 9:1, pages 261.
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Sylvia Boesch & Elisabetta Indelicato. (2019) Erythropoietin and Friedreich Ataxia: Time for a Reappraisal?. Frontiers in Neuroscience 13.
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Federica Rey, Alice Balsari, Toniella Giallongo, Sara Ottolenghi, Anna M. Di Giulio, Michele Samaja & Stephana Carelli. (2019) Erythropoietin as a Neuroprotective Molecule: An Overview of Its Therapeutic Potential in Neurodegenerative Diseases. ASN Neuro 11, pages 175909141987142.
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Kewal K. JainKewal K. Jain. 2019. The Handbook of Neuroprotection. The Handbook of Neuroprotection 609 641 .
Samuel Suarez-Mendez, Carlos Alfonso Tovilla-Zárate, Isela E. Juárez-Rojop & Deysi Y. Bermúdez-Ocaña. (2018) Erythropoietin: A potential drug in the management of diabetic neuropathy. Biomedicine & Pharmacotherapy 105, pages 956-961.
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Nakul Katyal & Raghav Govindarajan. (2017) Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement. Frontiers in Neurology 8.
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Dmitry Petrov, Colin Mansfield, Alain Moussy & Olivier Hermine. (2017) ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?. Frontiers in Aging Neuroscience 9.
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N. W. Galwey. (2017) Supplementation of a clinical trial by historical control data: is the prospect of dynamic borrowing an illusion?. Statistics in Medicine 36:6, pages 899-916.
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Alireza Nekoui & Gilbert Blaise. (2017) Erythropoietin and Nonhematopoietic Effects. The American Journal of the Medical Sciences 353:1, pages 76-81.
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Giuseppe Lauria, Eleonora Dalla Bella, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Raffaella Fazio, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Giancarlo Logroscino, Jessica Mandrioli, Letizia Mazzini, Maria Rosaria Monsurrò, Gabriele Mora, Vladimiro Pietrini, Rocco Quatrale, Romana Rizzi, Fabrizio Salvi, Gabriele Siciliano, Gianni Sorarù, Paolo Volanti, Irene Tramacere & Graziella Filippini. (2015) Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study. Journal of Neurology, Neurosurgery & Psychiatry 86:8, pages 879-886.
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Michael Jablonski, David S. Miller, Piera Pasinelli & Davide Trotti. (2015) ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research 1607, pages 1-14.
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Hiroshi Mitsumoto, Benjamin R Brooks & Vincenzo Silani. (2014) Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?. The Lancet Neurology 13:11, pages 1127-1138.
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Sabrina Paganoni, Merit Cudkowicz & James D Berry. (2014) Outcome measures in amyotrophic lateral sclerosis clinical trials. Clinical Investigation 4:7, pages 605-618.
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Wooyoung Jang, Jinse Park, Kyung Jin Shin, Joong-Seok Kim, Ji Sun Kim, Jinyoung Youn, Jin Whan Cho, Eungseok Oh, Jin Young Ahn, Ki-Wook Oh & Hee-Tae Kim. (2014) Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson's disease. Journal of the Neurological Sciences 337:1-2, pages 47-54.
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Hyun Young KimChanil MoonKyung Suk KimKi Wook OhSeong-il OhJuhan KimSeung Hyun Kim. (2014) Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis: A Pilot Study of Safety and Feasibility. Journal of Clinical Neurology 10:4, pages 342.
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Thomas BucherMarie-Anne ColleErin WakelingLaurence DubreilJohn FyfeDelphine Briot-NivardMaud MaquigneauSylvie RaoulYan CherelStéphanie AstordSandra DuqueThibaut MaraisThomas VoitPhilippe MoullierMartine BarkatsBéatrice Joussemet. (2013) scAAV9 Intracisternal Delivery Results in Efficient Gene Transfer to the Central Nervous System of a Feline Model of Motor Neuron Disease. Human Gene Therapy 24:7, pages 670-682.
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Pietro Ghezzi & Darrell Conklin. 2013. Tissue-Protective Cytokines. Tissue-Protective Cytokines 43 58 .
Matthew Gladman, Merit Cudkowicz & Lorne Zinman. (2012) Enhancing clinical trials in neurodegenerative disorders. Current Opinion in Neurology 25:6, pages 735-742.
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Erica A. Dale, Irawan Satriotomo & Gordon S. Mitchell. (2012) Cervical Spinal Erythropoietin Induces Phrenic Motor Facilitation via Extracellular Signal-Regulated Protein Kinase and Akt Signaling. The Journal of Neuroscience 32:17, pages 5973-5983.
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Reto Baldinger, Hans Dieter Katzberg & Markus Weber. (2012) Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews.
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Caterina Mariotti, Roberto Fancellu, Serena Caldarazzo, Lorenzo Nanetti, Daniela Di Bella, Massimo Plumari, Giuseppe Lauria, Maria D. Cappellini, Lorena Duca, Alessandra Solari & Franco Taroni. (2012) Erythropoietin in Friedreich ataxia: No effect on frataxin in a randomized controlled trial. Movement Disorders 27:3, pages 446-449.
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Bogusław Machaliñski, Piotr Łażewski-Banaszak, Elżbieta Dąbkowska, Edyta Paczkowska, Monika Gołąb-Janowska & Przemysław Nowacki. (2012) Rola czynników neurotroficznych w procesach regeneracji układu nerwowego. Neurologia i Neurochirurgia Polska 46:6, pages 579-590.
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Soon‐Tae Lee, Kon Chu, Jung‐Eun Park, Keun‐Hwa Jung, Daejong Jeon, Ji‐Youn Lim, Sang Kun Lee, Manho Kim & Jae‐Kyu Roh. (2011) Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid‐beta burden in Alzheimer’s disease models. Journal of Neurochemistry 120:1, pages 115-124.
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Carla Cerami Hand & Michael Brines. (2023) Promises and Pitfalls in Erythopoietin-Mediated Tissue Protection: Are Nonerythropoietic Derivatives a Way Forward?. Journal of Investigative Medicine 59:7, pages 1073-1082.
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Kewal K. JainKewal K. Jain. 2011. The Handbook of Neuroprotection. The Handbook of Neuroprotection 385 408 .
. (2010) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 19:6, pages i-xiii.
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Michael Benatar, Jerome Kurent & Dan H Moore. (2009) Treatment for familial amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database of Systematic Reviews.
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